{"id":"https://openalex.org/W7219984530","doi":null,"title":"Exploring the Role and Changes of a Disintegrin and Metalloproteinase with a Thrombospondin Type 1 Motif, Member 13 and Von Willebrand Factor Ag in Patients with Acute Myelogenous Leukemia: doi: 10.7417/CT.2026.2117","display_name":"Exploring the Role and Changes of a Disintegrin and Metalloproteinase with a Thrombospondin Type 1 Motif, Member 13 and Von Willebrand Factor Ag in Patients with Acute Myelogenous Leukemia: doi: 10.7417/CT.2026.2117","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7219984530"},"language":"en","primary_location":{"id":"pmh:oai::article/1749","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1749","pdf_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1749/1134","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1749/1134","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148617269","display_name":"Sajanlal Riyasat Ali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali, Sajanlal Riyasat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157186404","display_name":"Sabiqun Nahar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nahar, Sabiqun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134777781","display_name":"Loai Emam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emam, Loai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060997714","display_name":"Mohamed Hanafy Morsy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morsy, Mohamed Hanafy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061593940","display_name":"Saeed H. Halawani","orcid":"https://orcid.org/0000-0002-8842-1461","observed_orcids":["https://orcid.org/0000-0002-8842-1461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Halawani, Saeed H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005002443","display_name":"Asmaa A Basonbul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Basonbul, Asmaa A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017569488","display_name":"Yonis A. Allohibi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allohibi, Yonis Aqeel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001276015","display_name":"Mohamed Elwaseef","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elwaseef, Mohamed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009473024","display_name":"Doaa Aly Abd El-Fattah","orcid":"https://orcid.org/0000-0002-0683-1046","observed_orcids":["https://orcid.org/0000-0002-0683-1046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abd El-Fattah, Doaa Aly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091321326","display_name":"Nada Bajuaifer","orcid":"https://orcid.org/0009-0009-1136-5383","observed_orcids":["https://orcid.org/0009-0009-1136-5383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bajuaifer, Nada A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148597978","display_name":"Esraa Adel Ahmed Ayad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayad, Esraa Adel Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157232658","display_name":"Fatma M. Elsayed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Elsayed, Fatma M.","raw_affiliation_strings":["Department of Internal Medicine , Hematology Unit , Faculty of Medicine , Alexandria University , Alexandria , Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine , Hematology Unit , Faculty of Medicine , Alexandria University , Alexandria , Egypt;","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157242370","display_name":"Mona E. Hashem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hashem, Mona E.","raw_affiliation_strings":["Department of Clinical Pathology , Faculty of Medicine , Zagazig University , Zagazig , Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology , Faculty of Medicine , Zagazig University , Zagazig , Egypt;","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091355633","display_name":"Mohammed Ayad Alruqi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Alruqi, Mohammed Ayad","raw_affiliation_strings":["Department of Pharmacology and Toxicology , Faculty of Medicine , Umm Al-Qura University , Makkah , Saudi Arabia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology , Faculty of Medicine , Umm Al-Qura University , Makkah , Saudi Arabia;","institution_ids":["https://openalex.org/I199693650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086549718","display_name":"Ahmed Akef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Akef, Ahmed","raw_affiliation_strings":["Department of Clinical Pathology , Faculty of Medicine , Mansoura University , Mansoura , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology , Faculty of Medicine , Mansoura University , Mansoura , Egypt","institution_ids":["https://openalex.org/I159247623"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83464176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9670000076293945},{"id":"https://openalex.org/keywords/adamts13","display_name":"ADAMTS13","score":0.9459999799728394},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9660000205039978},{"id":"https://openalex.org/keywords/thrombotic-complications","display_name":"thrombotic complications","score":0.8289999961853027},{"id":"https://openalex.org/keywords/adamts13-activity","display_name":"ADAMTS13 activity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2780921031","wikidata":"https://www.wikidata.org/wiki/Q14873945","display_name":"ADAMTS13","level":4,"score":0.8360999822616577},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.8169999718666077},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.7099999785423279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6916000247001648},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.6739000082015991},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5690000057220459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4796000123023987},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4584999978542328},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44110000133514404},{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.4187000095844269},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.40400001406669617},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3714999854564667},{"id":"https://openalex.org/C2778585876","wikidata":"https://www.wikidata.org/wiki/Q1426491","display_name":"Thrombotic thrombocytopenic purpura","level":3,"score":0.34209999442100525},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3246999979019165},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.3111000061035156},{"id":"https://openalex.org/C21194631","wikidata":"https://www.wikidata.org/wiki/Q2113501","display_name":"Proteinase 3","level":4,"score":0.3059000074863434},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.28850001096725464},{"id":"https://openalex.org/C2911038020","wikidata":"https://www.wikidata.org/wiki/Q423712","display_name":"Factor XIIIa","level":3,"score":0.2824000120162964},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C2778780528","wikidata":"https://www.wikidata.org/wiki/Q709360","display_name":"Von Willebrand disease","level":4,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai::article/1749","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1749","pdf_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1749/1134","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai::article/1749","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1749","pdf_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1749/1134","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219984530.pdf","grobid_xml":"https://content.openalex.org/works/W7219984530.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Acute":[1],"myeloid":[2],"leukemia":[3],"(AML)":[4],"is":[5],"a":[6,25],"hematologic":[7],"malignancy":[8],"associated":[9],"with":[10,29,127],"significant":[11,192],"coagulation":[12],"abnormalities":[13],"and":[14,21,27,66,69,84,104,170,203,216,233],"endothelial":[15,214],"dysfunction.":[16],"Von":[17],"Willebrand":[18],"factor":[19],"(VWF)":[20],"its":[22],"regulatory":[23],"protease,":[24],"disintegrin":[26],"metalloproteinase":[28],"thrombospondin":[30],"type":[31],"1":[32],"motif":[33],"member":[34],"13":[35],"(ADAMTS13),":[36],"play":[37],"essential":[38],"roles":[39],"in":[40,53,146,150,194],"maintaining":[41],"vascular":[42],"homeostasis.":[43],"Disruption":[44],"of":[45,212,236],"this":[46,177],"balance":[47],"may":[48],"contribute":[49],"to":[50,109,220,229],"thrombotic":[51],"complications":[52],"AML.":[54],"Methods:":[55],"This":[56],"case-control":[57],"study":[58],"included":[59],"40":[60,67],"newly":[61],"diagnosed,":[62],"untreated":[63],"AML":[64,117,147,189],"patients":[65,118,148,190],"age-":[68],"sex-matched":[70],"healthy":[71],"controls":[72,128,151],"recruited":[73],"from":[74],"Al-Azhar":[75],"University":[76],"Hospitals,":[77],"Cairo,":[78],"Egypt.":[79],"Plasma":[80],"VWF":[81,123,168,201],"antigen":[82,124,169],"levels":[83,125,202],"ADAMTS13":[85,141,171,205],"activity":[86,142,172],"were":[87,98],"measured":[88],"using":[89,100],"enzyme-linked":[90],"immunosorbent":[91],"assay":[92],"(ELISA).":[93],"Statistical":[94],"comparisons":[95],"between":[96,113,167],"groups":[97],"performed":[99],"appropriate":[101],"parametric":[102],"tests,":[103],"correlation":[105,164],"analysis":[106],"was":[107,143,165],"conducted":[108],"assess":[110],"the":[111,195,210,231],"association":[112],"both":[114],"biomarkers.":[115,238],"Results:":[116],"showed":[119],"significantly":[120,144],"higher":[121],"plasma":[122],"compared":[126],"(274.44":[129],"\u00b1":[130,134,153,157],"139.72%":[131],"vs.":[132,155],"111.40":[133],"31.77%,":[135],"P":[136,159],"<":[137,160],"0.001).":[138,161],"In":[139],"contrast,":[140],"lower":[145],"than":[149],"(46.70":[152],"29.37%":[154],"99.01":[156],"27.09%,":[158],"An":[162],"inverse":[163],"observed":[166],"(r":[173],"=":[174,184],"\u22120.28),":[175],"although":[176],"did":[178],"not":[179],"reach":[180],"statistical":[181],"significance":[182,235],"(P":[183],"0.08).":[185],"Conclusions:":[186],"Newly":[187],"diagnosed":[188],"demonstrate":[191],"imbalance":[193],"VWF\u2013ADAMTS13":[196],"axis,":[197],"characterized":[198],"by":[199],"elevated":[200],"reduced":[204],"activity.":[206],"These":[207],"findings":[208],"support":[209],"presence":[211],"early":[213],"dysfunction":[215],"hemostatic":[217],"disturbance":[218],"prior":[219],"treatment":[221],"initiation.":[222],"Further":[223],"large-scale":[224],"prospective":[225],"studies":[226],"are":[227],"needed":[228],"determine":[230],"prognostic":[232],"clinical":[234],"these":[237]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2026-10-05T00:00:00"}