{"id":"https://openalex.org/W7219901113","doi":"https://doi.org/10.3389/fimmu.2026.1999950","title":"Editorial: Novel insights in insect immunity: regulators, signaling, and mechanisms","display_name":"Editorial: Novel insights in insect immunity: regulators, signaling, and mechanisms","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7219901113","doi":"https://doi.org/10.3389/fimmu.2026.1999950","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898151","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677342"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1999950","doi":"https://doi.org/10.3389/fimmu.2026.1999950","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1999950","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1999950/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1999950/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101646857","display_name":"Xin Hu","orcid":"https://orcid.org/0000-0002-0124-6032","observed_orcids":["https://orcid.org/0000-0002-0124-6032"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xin Hu","raw_affiliation_strings":["Department of Cancer Biology, The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043377881","display_name":"Aneta Strachecka","orcid":"https://orcid.org/0000-0003-1313-9880","observed_orcids":["https://orcid.org/0000-0003-1313-9880"]},"institutions":[{"id":"https://openalex.org/I158552681","display_name":"University of Life Sciences in Lublin","ror":"https://ror.org/03hq67y94","country_code":"PL","type":"education","lineage":["https://openalex.org/I158552681"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aneta Strachecka","raw_affiliation_strings":["Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin","institution_ids":["https://openalex.org/I158552681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157246549","display_name":"Fei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148006834","display_name":"Hong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Zhou","raw_affiliation_strings":["USDA/ARS Chlidren\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA/ARS Chlidren\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435154","display_name":"Kui Zhang","orcid":"https://orcid.org/0000-0001-9618-610X","observed_orcids":["https://orcid.org/0000-0001-9618-610X","https://orcid.org/0009-0006-0497-7961"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kui Zhang","raw_affiliation_strings":["The Pritzker School of Molecular Engineering, The University of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Pritzker School of Molecular Engineering, The University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071384282","display_name":"Ioannis Eleftherianos","orcid":"https://orcid.org/0000-0002-4822-3110","observed_orcids":["https://orcid.org/0000-0002-4822-3110"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ioannis Eleftherianos","raw_affiliation_strings":["School of Biological Sciences, Queen\u2019s University Belfast"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Queen\u2019s University Belfast","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5156852499","display_name":"Amr Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Amr Mohamed","raw_affiliation_strings":["Department of Entomology, Faculty of Science, Cairo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomology, Faculty of Science, Cairo University","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5071384282","https://openalex.org/A5101646857","https://openalex.org/A5156852499"],"corresponding_institution_ids":["https://openalex.org/I126231945","https://openalex.org/I1343551460","https://openalex.org/I145487455"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1999950","last_page":"1999950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insect-immunity","display_name":"insect immunity","score":0.996999979019165},{"id":"https://openalex.org/keywords/immune-signaling","display_name":"immune signaling","score":0.5889999866485596},{"id":"https://openalex.org/keywords/immune-regulators","display_name":"immune regulators","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C2777612826","wikidata":"https://www.wikidata.org/wiki/Q1390","display_name":"Insect","level":2,"score":0.5824999809265137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5090000033378601},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3621000051498413},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.34540000557899475},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2768000066280365},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23919999599456787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23119999468326569},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.219200000166893},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.219200000166893}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2026.1999950","doi":"https://doi.org/10.3389/fimmu.2026.1999950","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1999950","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1999950/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677342","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677342/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677342/pdf/fimmu-17-1999950.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42898151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Editorial"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/28991dca-aaa3-479e-a688-4b9c1a9abb87","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/28991dca-aaa3-479e-a688-4b9c1a9abb87","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hu, X, Strachecka, A, Wang, F, Zhou, H, Zhang, K, Eleftherianos, I & Mohamed, A 2026, 'Editorial: Novel insights in insect immunity: regulators, signaling, and mechanisms', Frontiers in Immunology, vol. 17, 1999950. https://doi.org/10.3389/fimmu.2026.1999950","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:d83490459cc045c78452de651dece2b1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d83490459cc045c78452de651dece2b1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1999950","doi":"https://doi.org/10.3389/fimmu.2026.1999950","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1999950","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1999950/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219901113.pdf","grobid_xml":"https://content.openalex.org/works/W7219901113.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W4223956505","https://openalex.org/W4404059798","https://openalex.org/W4411872659"],"related_works":["https://openalex.org/W7222923820","https://openalex.org/W7131357330","https://openalex.org/W7222846416","https://openalex.org/W4387058824","https://openalex.org/W3142133590","https://openalex.org/W3089466563","https://openalex.org/W1545725892","https://openalex.org/W2044720008","https://openalex.org/W1682728450","https://openalex.org/W2491312792"],"abstract_inverted_index":{"this":[0,63],"regulatory":[1,308],"network,":[2],"with":[3,76,105,176,201,234],"their":[4],"respective":[5],"roles":[6],"varying":[7],"among":[8,360],"insect":[9,124,232,407],"species,":[10],"tissues":[11,265],"and":[12,24,35,51,57,89,92,133,146,180,187,190,239,258,266,281,291,297,319,329,334,358,373,396,412],"infection":[13,196,221,304],"contexts":[14],"(Figure":[15,376],"1).":[16,377],"Effective":[17],"immunity":[18],"requires":[19],"coordination":[20],"between":[21,101],"recognition,":[22],"signalling":[23],"effector":[25],"responses":[26,41,74,103],"to":[27,54,85,127,143,150,250,277,326,381],"achieve":[28],"pathogen":[29,292,382],"control":[30],"while":[31],"preserving":[32],"tissue":[33],"homeostasis":[34],"survival":[36,186],"(1).":[37],"Understanding":[38],"how":[39,73,79,90,322],"these":[40,67,208,247],"are":[42,403],"regulated":[43],"is":[44,269,274],"therefore":[45],"essential":[46,404],"for":[47,117,405],"explaining":[48],"host-pathogen":[49],"interactions":[50],"identifying":[52],"opportunities":[53],"manage":[55],"pests":[56],"disease":[58],"vectors.":[59],"The":[60,140],"articles":[61],"in":[62,82,220],"Research":[64],"Topic":[65],"approach":[66],"questions":[68,252,367],"from":[69,163,207,313],"complementary":[70,229],"perspectives.They":[71],"examine":[72],"vary":[75],"the":[77,106,114,151,165,240,275,282,301,337,346,350,353],"challenge,":[78],"molecules":[80],"involved":[81],"defence":[83,149,233,286,339],"contribute":[84],"other":[86],"host":[87,155,289,384],"functions,":[88],"communication":[91,359],"resource":[93,237],"allocation":[94,238],"across":[95,264,300],"physiological":[96,283,317,361,399],"systems":[97],"shape":[98,288],"immune":[99,102,128,131,138,262,279,323,356,371],"responses.Differences":[100],"begin":[104],"challenges":[107],"insects":[108],"encounter.":[109],"In":[110,194],"Coordination":[111],"also":[112,160,365],"involves":[113],"resources":[115,136],"available":[116],"defence.":[118],"Adamo":[119],"(2026)":[120],"synthesises":[121],"evidence":[122],"that":[123,172,253,310,315],"muscle":[125,144],"responds":[126],"signals,":[129],"produces":[130],"molecules,":[132],"redistributes":[134],"metabolic":[135],"during":[137],"activation.":[139],"resulting":[141],"costs":[142],"performance":[145],"behaviour":[147],"link":[148],"wider":[152],"demands":[153],"of":[154,285,303,345,355],"fitness.":[156],"Resource":[157],"availability":[158],"can":[159],"be":[161],"influenced":[162],"outside":[164],"insect.":[166],"Menezes":[167],"et":[168],"al.":[169],"(2025)":[170],"found":[171],"feeding":[173],"on":[174],"mice":[175,209],"a":[177,217,342],"diet-induced":[178],"obese":[179],"diabetic":[181],"phenotype":[182],"reduced":[183],"Aedes":[184],"aegypti":[185],"altered":[188],"lipid":[189],"gut":[191],"transcriptional":[192],"profiles.":[193],"separate":[195],"assays":[197],"using":[198],"blood":[199],"supplemented":[200],"equivalent":[202],"Zika":[203],"virus":[204],"titres,":[205],"samples":[206],"yielded":[210],"lower":[211],"midgut":[212],"viral":[213],"RNA":[214],"levels":[215],"without":[216],"significant":[218],"change":[219],"prevalence;":[222],"onward":[223],"transmission":[224,389],"was":[225],"not":[226,270],"measured.":[227],"These":[228,401],"perspectives":[230],"connect":[231],"both":[235],"internal":[236],"nutritional":[241,259],"inputs":[242],"supplied":[243],"by":[244,349],"another":[245],"host.Together,":[246],"studies":[248],"point":[249],"several":[251],"remain":[254],"open.":[255],"How":[256],"environmental":[257,369],"variation":[260],"reshapes":[261],"regulation":[263],"life":[267],"stages":[268],"yet":[271],"clear,":[272],"nor":[273],"extent":[276],"which":[278,392,397],"priming":[280,372],"trade-offs":[284],"jointly":[287],"fitness":[290,385],"transmission.":[293],"Tracking":[294],"molecular,":[295],"cellular":[296],"organismal":[298],"measures":[299],"course":[302],"may":[305],"help":[306],"distinguish":[307],"mechanisms":[309,393],"enhance":[311],"protection":[312,395],"those":[314],"impose":[316,398],"costs,":[318],"could":[320],"clarify":[321,391],"plasticity":[324],"contributes":[325],"insect-pathogen":[327,374],"co-evolution":[328,375],"informs":[330],"more":[331],"targeted":[332,410],"pest":[333,411],"vector":[335,413],"management.Across":[336],"collection,":[338],"emerges":[340],"as":[341],"context-dependent":[343],"property":[344],"host,":[347],"shaped":[348],"challenge":[351],"encountered,":[352],"functions":[354],"regulators":[357],"systems.":[362],"This":[363],"perspective":[364],"opens":[366],"about":[368],"modulation,":[370],"Linking":[378],"molecular":[379],"changes":[380],"burden,":[383],"and,":[386],"where":[387],"relevant,":[388],"will":[390],"support":[394],"costs.":[400],"distinctions":[402],"translating":[406],"immunology":[408],"into":[409],"management.":[414]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-05T00:00:00"}