{"id":"https://openalex.org/W7219798050","doi":"https://doi.org/10.3389/fphar.2026.1840055","title":"Liver enzyme elevations during statin\u2013ezetimibe therapy in ABCG2 c.421C>A variant carriers: a case series and narrative review","display_name":"Liver enzyme elevations during statin\u2013ezetimibe therapy in ABCG2 c.421C>A variant carriers: a case series and narrative review","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7219798050","doi":"https://doi.org/10.3389/fphar.2026.1840055","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898243","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677550"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1840055","doi":"https://doi.org/10.3389/fphar.2026.1840055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1840055","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1840055/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1840055/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082098046","display_name":"Livija \u0160imi\u010devi\u0107","orcid":"https://orcid.org/0000-0002-2491-1920","observed_orcids":["https://orcid.org/0000-0002-2491-1920"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Livija \u0160imi\u010devi\u0107","raw_affiliation_strings":["Department for Chemistry and Biochemistry, University of Zagreb School of Medicine","Division for Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Chemistry and Biochemistry, University of Zagreb School of Medicine","institution_ids":["https://openalex.org/I181343428"]},{"raw_affiliation_string":"Division for Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071679774","display_name":"Lana Ganoci","orcid":"https://orcid.org/0000-0003-3898-4554","observed_orcids":["https://orcid.org/0000-0003-3898-4554"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Lana Ganoci","raw_affiliation_strings":["Department of Basic and Clinical Pharmacology, Zagreb University School of Medicine","Division for Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic and Clinical Pharmacology, Zagreb University School of Medicine","institution_ids":["https://openalex.org/I181343428"]},{"raw_affiliation_string":"Division for Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065920760","display_name":"Ena Kara\u010di\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ena Kara\u010di\u0107","raw_affiliation_strings":["University of Zagreb Faculty of Pharmacy and Biochemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zagreb Faculty of Pharmacy and Biochemistry","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025207109","display_name":"Tamara Bo\u017eina","orcid":"https://orcid.org/0000-0001-5883-7979","observed_orcids":["https://orcid.org/0000-0001-5883-7979"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Tamara Bo\u017eina","raw_affiliation_strings":["Department for Chemistry and Biochemistry, University of Zagreb School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Chemistry and Biochemistry, University of Zagreb School of Medicine","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009134046","display_name":"Ivan Pe\u0107in","orcid":"https://orcid.org/0000-0003-4425-6473","observed_orcids":["https://orcid.org/0000-0003-4425-6473"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ivan Pe\u0107in","raw_affiliation_strings":["Department of Internal Medicine, University of Zagreb School of Medicine","Division for Metabolic Diseases, Department of Internal Medicine, University Hospital Centre Zagreb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Zagreb School of Medicine","institution_ids":["https://openalex.org/I181343428"]},{"raw_affiliation_string":"Division for Metabolic Diseases, Department of Internal Medicine, University Hospital Centre Zagreb","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014187299","display_name":"Vladimir Trkulja","orcid":"https://orcid.org/0000-0002-0968-1194","observed_orcids":["https://orcid.org/0000-0002-0968-1194","https://orcid.org/0000-0001-8045-5846"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Vladimir Trkulja","raw_affiliation_strings":["Department of Basic and Clinical Pharmacology, Zagreb University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic and Clinical Pharmacology, Zagreb University School of Medicine","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037626813","display_name":"Nada Bo\u017eina","orcid":"https://orcid.org/0000-0001-6016-1699","observed_orcids":["https://orcid.org/0000-0001-6016-1699"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Nada Bo\u017eina","raw_affiliation_strings":["Department of Basic and Clinical Pharmacology, Zagreb University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic and Clinical Pharmacology, Zagreb University School of Medicine","institution_ids":["https://openalex.org/I181343428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014187299"],"corresponding_institution_ids":["https://openalex.org/I181343428"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58774373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1840055","last_page":"1840055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elevated-liver-enzymes","display_name":"elevated liver enzymes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/rhabdomyolysis","display_name":"rhabdomyolysis","score":0.859000027179718},{"id":"https://openalex.org/keywords/creatine-kinase-elevation","display_name":"creatine kinase elevation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.5659999847412109},{"id":"https://openalex.org/keywords/slco1b1","display_name":"SLCO1B1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ugt1a1","display_name":"UGT1A1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.6290000081062317},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.786899983882904},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.646399974822998},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6047999858856201},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4790000021457672},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47099998593330383},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.4708000123500824},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.4675999879837036},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4383000135421753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4293999969959259},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.42309999465942383},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.36489999294281006},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2728999853134155},{"id":"https://openalex.org/C2776598434","wikidata":"https://www.wikidata.org/wiki/Q18035517","display_name":"SLCO1B1","level":5,"score":0.2696000039577484},{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.2685000002384186},{"id":"https://openalex.org/C2779379848","wikidata":"https://www.wikidata.org/wiki/Q917069","display_name":"Rhabdomyolysis","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1840055","doi":"https://doi.org/10.3389/fphar.2026.1840055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1840055","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1840055/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677550","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677550/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677550/pdf/fphar-17-1840055.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42898243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:13676921812441bdbfe5210ab0bead6b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/13676921812441bdbfe5210ab0bead6b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1840055","doi":"https://doi.org/10.3389/fphar.2026.1840055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1840055","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1840055/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2619971444","display_name":null,"funder_award_id":"HRZZ-UIP-2020-02-8189","funder_id":"https://openalex.org/F4320322674","funder_display_name":"Hrvatska Zaklada za Znanost"},{"id":"https://openalex.org/G6591691989","display_name":"Pharmacogenomics in prediction of cardiovascular drugs adverse reaction","funder_award_id":"UIP-2020-02-8189","funder_id":"https://openalex.org/F4320322674","funder_display_name":"Hrvatska Zaklada za Znanost"}],"funders":[{"id":"https://openalex.org/F4320322674","display_name":"Hrvatska Zaklada za Znanost","ror":"https://ror.org/03n51vw80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219798050.pdf","grobid_xml":"https://content.openalex.org/works/W7219798050.grobid-xml"},"referenced_works_count":169,"referenced_works":["https://openalex.org/W1604547439","https://openalex.org/W1646645101","https://openalex.org/W1783939843","https://openalex.org/W1923201889","https://openalex.org/W1964694228","https://openalex.org/W1967077419","https://openalex.org/W1968329055","https://openalex.org/W1969464487","https://openalex.org/W1976469346","https://openalex.org/W1982690466","https://openalex.org/W1990713353","https://openalex.org/W1992084132","https://openalex.org/W1992296963","https://openalex.org/W1993337516","https://openalex.org/W1993783526","https://openalex.org/W1997069890","https://openalex.org/W1999164183","https://openalex.org/W2001852299","https://openalex.org/W2027313575","https://openalex.org/W2028211844","https://openalex.org/W2030350400","https://openalex.org/W2030663513","https://openalex.org/W2031083224","https://openalex.org/W2040440041","https://openalex.org/W2044444556","https://openalex.org/W2048047193","https://openalex.org/W2048729835","https://openalex.org/W2053657477","https://openalex.org/W2054377125","https://openalex.org/W2054458932","https://openalex.org/W2056150647","https://openalex.org/W2063566560","https://openalex.org/W2068203449","https://openalex.org/W2069315083","https://openalex.org/W2069999878","https://openalex.org/W2079785947","https://openalex.org/W2084969952","https://openalex.org/W2085411041","https://openalex.org/W2085448380","https://openalex.org/W2089303289","https://openalex.org/W2095115792","https://openalex.org/W2102196336","https://openalex.org/W2105311148","https://openalex.org/W2109107848","https://openalex.org/W2109229072","https://openalex.org/W2114139854","https://openalex.org/W2117592927","https://openalex.org/W2118654523","https://openalex.org/W2118667947","https://openalex.org/W2136466059","https://openalex.org/W2136487679","https://openalex.org/W2136930977","https://openalex.org/W2141941946","https://openalex.org/W2142507996","https://openalex.org/W2143587240","https://openalex.org/W2143855840","https://openalex.org/W2145159095","https://openalex.org/W2169441188","https://openalex.org/W2172043314","https://openalex.org/W2227220935","https://openalex.org/W2288239617","https://openalex.org/W2335196532","https://openalex.org/W2415731917","https://openalex.org/W2491257519","https://openalex.org/W2551755856","https://openalex.org/W2558677829","https://openalex.org/W2559896499","https://openalex.org/W2560785130","https://openalex.org/W2613826229","https://openalex.org/W2614817248","https://openalex.org/W2624724023","https://openalex.org/W2745511617","https://openalex.org/W2759415648","https://openalex.org/W2762670530","https://openalex.org/W2769906387","https://openalex.org/W2780320767","https://openalex.org/W2795248758","https://openalex.org/W2796552195","https://openalex.org/W2797734285","https://openalex.org/W2799514315","https://openalex.org/W2892878175","https://openalex.org/W2897727952","https://openalex.org/W2905331745","https://openalex.org/W2909765747","https://openalex.org/W2913325786","https://openalex.org/W2918409259","https://openalex.org/W2921868293","https://openalex.org/W2923928888","https://openalex.org/W2924328881","https://openalex.org/W2944502747","https://openalex.org/W2944963263","https://openalex.org/W2965220254","https://openalex.org/W2969439204","https://openalex.org/W2973595439","https://openalex.org/W2977338802","https://openalex.org/W2981364752","https://openalex.org/W2985294902","https://openalex.org/W2989624959","https://openalex.org/W2991386173","https://openalex.org/W2996315557","https://openalex.org/W2998426872","https://openalex.org/W3016672286","https://openalex.org/W3021390585","https://openalex.org/W3032314402","https://openalex.org/W3036936160","https://openalex.org/W3046108694","https://openalex.org/W3047501331","https://openalex.org/W3088068042","https://openalex.org/W3089092537","https://openalex.org/W3093447658","https://openalex.org/W3095267497","https://openalex.org/W3111301842","https://openalex.org/W3133174138","https://openalex.org/W3156882403","https://openalex.org/W3175402593","https://openalex.org/W3177861453","https://openalex.org/W3183219133","https://openalex.org/W3202567193","https://openalex.org/W3207461217","https://openalex.org/W3207565547","https://openalex.org/W4205108080","https://openalex.org/W4213127162","https://openalex.org/W4229042565","https://openalex.org/W4281658656","https://openalex.org/W4284711739","https://openalex.org/W4285801414","https://openalex.org/W4288077670","https://openalex.org/W4293253252","https://openalex.org/W4293451328","https://openalex.org/W4309167125","https://openalex.org/W4310275976","https://openalex.org/W4311135703","https://openalex.org/W4311774542","https://openalex.org/W4312186290","https://openalex.org/W4318250429","https://openalex.org/W4318948364","https://openalex.org/W4319019486","https://openalex.org/W4385235646","https://openalex.org/W4387297230","https://openalex.org/W4387769766","https://openalex.org/W4388526543","https://openalex.org/W4390562129","https://openalex.org/W4392893213","https://openalex.org/W4393983528","https://openalex.org/W4394570448","https://openalex.org/W4399130273","https://openalex.org/W4401449137","https://openalex.org/W4403502599","https://openalex.org/W4404548226","https://openalex.org/W4405185408","https://openalex.org/W4405402432","https://openalex.org/W4405662197","https://openalex.org/W4406080391","https://openalex.org/W4408017011","https://openalex.org/W4408515180","https://openalex.org/W4409804993","https://openalex.org/W4410990986","https://openalex.org/W4412124724","https://openalex.org/W4412882007","https://openalex.org/W4413308915","https://openalex.org/W4413472825","https://openalex.org/W4413612932","https://openalex.org/W4413803350","https://openalex.org/W4413804012","https://openalex.org/W4414445232","https://openalex.org/W7125909140","https://openalex.org/W7125975838","https://openalex.org/W7128013235","https://openalex.org/W7129342525"],"related_works":["https://openalex.org/W2981666865","https://openalex.org/W2998426872","https://openalex.org/W2048534498","https://openalex.org/W2084969952","https://openalex.org/W2016617467","https://openalex.org/W4409804993","https://openalex.org/W4415285391","https://openalex.org/W3091387850","https://openalex.org/W6920723246","https://openalex.org/W6939866293"],"abstract_inverted_index":{"Introduction":[0],"Statin\u2013ezetimibe":[1],"combination":[2,118,251],"therapy":[3,68,119,181,252,280],"is":[4],"widely":[5],"used":[6],"and":[7,19,29,47,74,87,101,148,218,238,262,286,318],"generally":[8],"well":[9],"tolerated;":[10],"however,":[11],"liver":[12,63,114,247,275],"enzyme":[13,64,115,248,276],"elevations":[14,65,160,277],"may":[15],"occur":[16],"during":[17,66,117,198,250,278],"treatment":[18,72,83],"can":[20],"be":[21],"difficult":[22],"to":[23,71,133,178,309],"interpret":[24],"in":[25,40,98,163,183,188,231,259,265,281],"patients":[26,55,212,261,282],"with":[27,111,168,223,283],"polypharmacy":[28],"other":[30,287],"contributing":[31,288],"factors.":[32,289],"The":[33,143,290],"potential":[34,244],"role":[35],"of":[36,53,76,105,128,185,273],"drug\u2013drug\u2013gene":[37],"interactions":[38],"(DDGIs)":[39],"this":[41],"context":[42],"remains":[43],"insufficiently":[44],"explored.":[45],"Materials":[46],"Methods":[48],"We":[49],"present":[50],"a":[51,135,294],"series":[52,144,303],"11":[54],"from":[56],"the":[57,77,129,139,214,224,242,271,301,310,319],"PGx-CardioDrug":[58],"study,":[59],"selected":[60],"for":[61,95,122,138,208,297],"documented":[62,112],"statin\u2013ezetimibe":[67,279],"that":[69],"led":[70],"modification":[73],"carriage":[75],"ABCG2":[78,108,215],"c.421A":[79],"allele.":[80],"Clinical":[81],"characteristics,":[82],"history,":[84],"laboratory":[85,186,203,257],"findings,":[86],"outcomes":[88],"were":[89,120,161,205,253],"reviewed":[90,121],"alongside":[91],"available":[92,207],"pharmacogenetic":[93],"results":[94,204],"genes":[96],"involved":[97],"drug":[99,174],"transport":[100],"metabolism.":[102],"Available":[103],"records":[104],"five":[106,149,243],"additional":[107],"c.421CA":[109,216],"carriers":[110],"normal":[113,246],"findings":[116,228,249],"descriptive":[123,321],"comparison.":[124],"A":[125],"narrative":[126,291],"review":[127,292],"literature":[130],"was":[131],"conducted":[132],"provide":[134],"mechanistic":[136],"interpretation":[137],"observed":[140,162,311],"findings.":[141],"Results":[142],"included":[145,229],"six":[146,164],"women":[147],"men,":[150],"aged":[151],"27\u201378":[152],"years.":[153],"Muscle":[154],"symptoms":[155],"and/or":[156],"creatine":[157],"kinase":[158],"(CK)":[159],"patients,":[165,193],"including":[166],"two":[167,192],"rhabdomyolysis":[169],"requiring":[170],"hospitalization.":[171],"Dose":[172],"reduction,":[173],"discontinuation,":[175],"or":[176,196],"switching":[177],"alternative":[179],"lipid-lowering":[180],"resulted":[182],"improvement":[184],"parameters":[187],"several":[189],"patients.":[190,210],"In":[191,241],"abnormalities":[194],"persisted":[195],"increased":[197],"subsequent":[199],"ezetimibe":[200],"monotherapy.":[201],"Follow-up":[202],"not":[206,305],"all":[209],"Eight":[211],"had":[213,220],"genotype":[217],"three":[219,260],"c.421AA,":[221],"consistent":[222],"selection":[225],"criterion.":[226],"Additional":[227],"variants":[230],"SLCO1B1":[232],",":[233,235,237],"ABCC2":[234],"ABCB1":[236],"UGT1A1":[239],".":[240],"comparators,":[245],"supported":[254],"by":[255],"numerical":[256],"values":[258],"clinical":[263,316],"documentation":[264],"two.":[266],"Discussion":[267],"These":[268,326],"cases":[269],"illustrate":[270],"difficulty":[272],"interpreting":[274],"concomitant":[284],"medications":[285],"provides":[293],"pharmacokinetic":[295],"rationale":[296],"considering":[298],"DDGIs,":[299],"but":[300],"case":[302],"does":[304],"establish":[306],"their":[307],"contribution":[308],"abnormalities.":[312],"Genotype-based":[313],"selection,":[314],"incomplete":[315],"data,":[317],"small":[320],"comparator":[322],"group":[323],"limit":[324],"interpretation.":[325],"observations":[327],"remain":[328],"hypothesis-generating.":[329]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-05T00:00:00"}