{"id":"https://openalex.org/W7219747155","doi":"https://doi.org/10.64898/2026.10.01.756094","title":"DNA polymerase kappa supports repair-associated DNA synthesis and genome maintenance in postmitotic neurons","display_name":"DNA polymerase kappa supports repair-associated DNA synthesis and genome maintenance in postmitotic neurons","publication_year":2026,"publication_date":"2026-10-04","ids":{"openalex":"https://openalex.org/W7219747155","doi":"https://doi.org/10.64898/2026.10.01.756094","pmid":"https://pubmed.ncbi.nlm.nih.gov/42990123","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13733698"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.01.756094","doi":"https://doi.org/10.64898/2026.10.01.756094","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756094","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.01.756094.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.01.756094.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054225075","display_name":"Gunjan Goyal","orcid":"https://orcid.org/0000-0002-1205-7077","observed_orcids":["https://orcid.org/0000-0002-1205-7077"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunjan Goyal","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104746260","display_name":"Premkumar Palanisamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Premkumar Palanisamy","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156999154","display_name":"Ainesh Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ainesh Paul","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075747621","display_name":"Vijay Laxmi Roy","orcid":"https://orcid.org/0000-0002-6879-8798","observed_orcids":["https://orcid.org/0000-0002-6879-8798"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay L. Roy","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0002-6879-8798","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065570052","display_name":"Paolo Cifani","orcid":"https://orcid.org/0000-0002-4403-1277","observed_orcids":["https://orcid.org/0000-0002-4403-1277"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Cifani","raw_affiliation_strings":["Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA"],"raw_orcid":"https://orcid.org/0000-0002-4403-1277","affiliations":[{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042421326","display_name":"Anirban Paul","orcid":"https://orcid.org/0000-0001-5347-9260","observed_orcids":["https://orcid.org/0000-0001-5347-9260"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirban Paul","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0001-5347-9260","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010779506","display_name":"Shilpi Paul","orcid":"https://orcid.org/0000-0001-5075-2081","observed_orcids":["https://orcid.org/0000-0001-5075-2081"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shilpi Paul","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0001-5075-2081","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010779506"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-polymerase-kappa","display_name":"DNA polymerase kappa","score":1.0},{"id":"https://openalex.org/keywords/postmitotic-neurons","display_name":"postmitotic neurons","score":0.8799999952316284},{"id":"https://openalex.org/keywords/genome-maintenance","display_name":"genome maintenance","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pcna-ubiquitination","display_name":"PCNA ubiquitination","score":0.7829999923706055},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cytoplasmic-dna","display_name":"cytoplasmic DNA","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8859999775886536},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.5249999761581421},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2778720973","wikidata":"https://www.wikidata.org/wiki/Q18040278","display_name":"POLK","level":2,"score":0.9476000070571899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.640999972820282},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5759999752044678},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.49900001287460327},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4230000078678131},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4099000096321106},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3813999891281128},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.3808000087738037},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.34790000319480896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34389999508857727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3287000060081482},{"id":"https://openalex.org/C115960442","wikidata":"https://www.wikidata.org/wiki/Q769863","display_name":"Nuclear DNA","level":4,"score":0.2935999929904938},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.29339998960494995},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.2660999894142151},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.2565000057220459}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.01.756094","doi":"https://doi.org/10.64898/2026.10.01.756094","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756094","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.01.756094.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42990123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42990123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13733698","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13733698/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.01.756094","doi":"https://doi.org/10.64898/2026.10.01.756094","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.756094","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.01.756094.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333195","display_name":"Penn State College of Medicine","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219747155.pdf","grobid_xml":"https://content.openalex.org/works/W7219747155.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2012711195","https://openalex.org/W2037936898","https://openalex.org/W2064361936","https://openalex.org/W2097049162","https://openalex.org/W2141023520","https://openalex.org/W2605080699","https://openalex.org/W2798230823","https://openalex.org/W2805798400","https://openalex.org/W3139535723","https://openalex.org/W3151212872","https://openalex.org/W4310496865","https://openalex.org/W4386185770","https://openalex.org/W4387136503","https://openalex.org/W4403249099","https://openalex.org/W7164126234"],"related_works":["https://openalex.org/W4404189980","https://openalex.org/W4387136503","https://openalex.org/W1978220414","https://openalex.org/W2605080699","https://openalex.org/W2166622785","https://openalex.org/W7161835956","https://openalex.org/W4283799404","https://openalex.org/W3093781296","https://openalex.org/W2118771226","https://openalex.org/W1535018042"],"abstract_inverted_index":{"Postmitotic":[0],"neurons":[1,54,88],"depend":[2],"on":[3],"continuous":[4],"DNA":[5,16,24,42,71,81,117,126,130,156],"repair":[6],"to":[7,159,165],"preserve":[8],"genome":[9,45,152],"integrity,":[10],"yet":[11],"the":[12],"polymerases":[13],"supporting":[14],"repair-associated":[15,73],"synthesis":[17,31,43,82,127],"remain":[18],"poorly":[19],"defined.":[20],"Here,":[21],"we":[22,63],"identify":[23],"polymerase":[25,32,157],"kappa":[26],"(POLK),":[27],"a":[28,39,145],"Y-family":[29],"translesion":[30],"studied":[33],"predominantly":[34],"in":[35,47,83,149],"proliferating":[36],"cells,":[37],"as":[38],"regulator":[40],"of":[41],"and":[44,55,72,86,89,92,100,118,138,162,167],"maintenance":[46],"postmitotic":[48,150],"neurons.":[49],"Using":[50],"primary":[51],"mouse":[52,85],"cortical":[53],"human":[56,87],"induced":[57],"pluripotent":[58],"stem":[59],"cell-derived":[60],"forebrain":[61],"neurons,":[62],"show":[64],"that":[65],"POLK":[66,78,111,122,148],"localizes":[67],"near":[68],"newly":[69],"synthesized":[70],"proteins,":[74],"including":[75],"ubiquitinated":[76],"PCNA.":[77],"depletion":[79,112],"reduces":[80],"both":[84],"promotes":[90],"nuclear":[91],"organelle":[93],"remodeling,":[94],"p21-associated":[95],"senescence-like":[96],"stress,":[97],"inflammatory":[98],"responses,":[99],"increased":[101],"p38":[102,133],"MAPK":[103,134],"immunoreactivity.":[104],"In":[105],"an":[106],"Alzheimer's":[107,139],"disease-risk":[108],"genetic":[109],"background,":[110],"also":[113],"increases":[114],"cytoplasmic":[115,136],"double-stranded":[116],"tau":[119],"phosphorylation.":[120],"Conversely,":[121],"overexpression":[123],"enhances":[124],"neuronal":[125,151,160],"while":[128],"reducing":[129],"damage-associated":[131],"signals,":[132],"immunoreactivity,":[135],"DNA,":[137],"disease-relevant":[140],"phenotypes.":[141],"These":[142],"findings":[143],"uncover":[144],"role":[146],"for":[147],"maintenance,":[153],"linking":[154],"specialized":[155],"function":[158],"stress":[161],"vulnerability":[163],"relevant":[164],"aging":[166],"neurodegeneration.":[168]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-05T00:00:00"}
