{"id":"https://openalex.org/W7219733735","doi":"https://doi.org/10.3389/fmed.2026.1745748","title":"ADH7 and plasma proteins mediate smoking-related esophageal cancer: genetic causality and therapeutic insight","display_name":"ADH7 and plasma proteins mediate smoking-related esophageal cancer: genetic causality and therapeutic insight","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7219733735","doi":"https://doi.org/10.3389/fmed.2026.1745748","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898182","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677505"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.1745748","doi":"https://doi.org/10.3389/fmed.2026.1745748","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1745748","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1745748/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1745748/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109535080","display_name":"Liangbin Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]},{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangbin Pan","raw_affiliation_strings":["Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University","Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]},{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4392738115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049775159","display_name":"Xiangzhe Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangzhe Yang","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4392738115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138513704","display_name":"Qingxu Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingxu Hao","raw_affiliation_strings":["Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101650643","display_name":"Kai Xie","orcid":"https://orcid.org/0000-0003-4284-9646","observed_orcids":["https://orcid.org/0000-0003-4284-9646"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Xie","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4392738115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104336485","display_name":"Haitao Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]},{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haitao Ma","raw_affiliation_strings":["Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University","Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]},{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Suzhou Dushu Lake Hospital, Suzhou Key Laboratory of Chest Disease Diagnosis and Treatment, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4392738115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101650643","https://openalex.org/A5104336485"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519","https://openalex.org/I4392738115"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76745614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1745748","last_page":"1745748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.925000011920929},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9909999966621399},{"id":"https://openalex.org/keywords/adh7","display_name":"ADH7","score":0.9279999732971191},{"id":"https://openalex.org/keywords/plasma-proteins","display_name":"plasma proteins","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.921999990940094},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/stat-pathway","display_name":"STAT pathway","score":0.8349999785423279},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.6460000276565552},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6949999928474426},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.7246000170707703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6072999835014343},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5016999840736389},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43140000104904175},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.3926999866962433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3806000053882599},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.359499990940094},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3562999963760376},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3456999957561493},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.34299999475479126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3384000062942505},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.3352999985218048},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.32510000467300415},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.321399986743927},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32100000977516174},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.31189998984336853},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.298799991607666},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.29249998927116394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29179999232292175},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2858999967575073},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2773999869823456},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27230000495910645},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.2711000144481659},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C23085057","wikidata":"https://www.wikidata.org/wiki/Q5532877","display_name":"Genetic analysis","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmed.2026.1745748","doi":"https://doi.org/10.3389/fmed.2026.1745748","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1745748","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1745748/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmid:42898182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677505","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677505/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:684e4a57d0b940339eb935166806d036","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/684e4a57d0b940339eb935166806d036","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.1745748","doi":"https://doi.org/10.3389/fmed.2026.1745748","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1745748","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1745748/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219733735.pdf","grobid_xml":"https://content.openalex.org/works/W7219733735.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1892744082","https://openalex.org/W1990848510","https://openalex.org/W1995275059","https://openalex.org/W2013997037","https://openalex.org/W2015452353","https://openalex.org/W2057366613","https://openalex.org/W2131602863","https://openalex.org/W2153860431","https://openalex.org/W2168407710","https://openalex.org/W2783660792","https://openalex.org/W2885364352","https://openalex.org/W2937611850","https://openalex.org/W2959067642","https://openalex.org/W2987555752","https://openalex.org/W3004290453","https://openalex.org/W3049506346","https://openalex.org/W3120309400","https://openalex.org/W3174084468","https://openalex.org/W3191451220","https://openalex.org/W4306932543","https://openalex.org/W4320494955","https://openalex.org/W4321370552","https://openalex.org/W4323035146","https://openalex.org/W4387697251","https://openalex.org/W4388294725","https://openalex.org/W4388522420","https://openalex.org/W4388599498","https://openalex.org/W4389220116","https://openalex.org/W4393935425"],"related_works":["https://openalex.org/W4393231191","https://openalex.org/W4411041255","https://openalex.org/W3085711216","https://openalex.org/W4412487881","https://openalex.org/W4408073347","https://openalex.org/W4408272066","https://openalex.org/W2966184233","https://openalex.org/W7213542624","https://openalex.org/W4393095643","https://openalex.org/W4393938910"],"abstract_inverted_index":{"Background":[0],"Smoking":[1,158],"has":[2],"been":[3],"linked":[4],"to":[5,46,64,161,165,251],"alterations":[6],"in":[7,26,40,80,92,135,186,209,247,282,285,293,306,319,326],"plasma":[8,24,38,89,175],"protein":[9,78,197,368],"profiles":[10],"and":[11,57,71,120,126,134,147,170,198,240,255,266,284,352,359],"increased":[12,333],"risk":[13],"of":[14,23,37,101,104,117,128,227,261,269,303,363],"esophageal":[15,344],"cancer":[16],"(EC).":[17],"However,":[18],"the":[19,34,66,99,115,171,264,289,361],"precise":[20],"mediating":[21],"roles":[22],"proteins":[25,39,90,176],"this":[27,52],"relationship":[28],"remain":[29],"unclear.":[30],"This":[31,310],"study":[32,311],"explores":[33],"mediation":[35,84],"effects":[36],"smoking-associated":[41],"EC,":[42,148],"utilizing":[43],"genetic":[44,351],"proxies":[45],"uncover":[47],"potential":[48,122],"biological":[49],"mechanisms":[50],"underpinning":[51],"association.":[53],"Methods":[54],"Genetic":[55,139],"correlation":[56,140],"Mendelian":[58],"randomization":[59],"(MR)":[60],"analyses":[61],"were":[62,130,182,235,280],"applied":[63],"examine":[65],"association":[67,111],"between":[68,145],"smoking":[69,146,203,294],"traits":[70],"EC.":[72],"Pathway":[73],"enrichment":[74],"analysis":[75,86,97,141],"explored":[76],"circulatory":[77],"changes":[79],"smokers.":[81],"A":[82],"two-step":[83],"MR":[85,151],"identified":[87,183],"key":[88,196],"involved":[91],"smoking-related":[93,320,356],"EC":[94,107,188,210,248,270,286,295,307,334,357],"pathogenesis.":[95],"Survival":[96],"assessed":[98],"impact":[100],"transcriptional":[102],"levels":[103,291],"mediators":[105,185],"on":[106],"prognosis,":[108],"while":[109],"phenome-wide":[110],"studies":[112],"(PheWAS)":[113],"evaluated":[114,131],"safety":[116],"targeted":[118],"molecules":[119],"investigated":[121],"pleiotropy.":[123],"The":[124],"expression":[125,208],"function":[127,369],"ADH7":[129,192,206,244,262,278,305,318,337],"by":[132,150,328],"qRT-PCR":[133,239],"vitro":[136],"experiments.":[137],"Results":[138],"showed":[142,242],"significant":[143],"links":[144],"supported":[149],"findings":[152,348],"that":[153,221,243,259,276],"confirmed":[154],"a":[155,195,298,313,340],"causal":[156],"relationship.":[157],"was":[159,199,213,245],"found":[160],"influence":[162],"pathways":[163],"related":[164],"cytokine":[166],"signaling,":[167],"immune":[168],"activation,":[169],"STAT":[172],"pathway.":[173],"Five":[174],"(ADH7,":[177],"CPXM1,":[178],"FUT3,":[179],"GZMM,":[180],"LYPD3)":[181],"as":[184,194,339],"smoking-driven":[187,301],"risk.":[189,308],"Among":[190],"these,":[191],"emerged":[193],"consistently":[200],"associated":[201,214,331],"with":[202,215,288,332],"traits;":[204],"high":[205],"mRNA":[207],"tumor":[211,341,345],"tissue":[212],"reduced":[216],"progression-free":[217],"survival.":[218],"PheWAS":[219],"inferred":[220],"ADH7-targeted":[222],"interventions":[223],"might":[224],"pose":[225],"risks":[226],"neurological":[228],"or":[229],"psychiatric":[230],"side":[231],"effects,":[232],"though":[233],"these":[234],"not":[236],"statistically":[237],"significant.":[238],"immunohistochemistry":[241],"downregulated":[246],"tissues":[249],"relative":[250],"adjacent":[252],"normal":[253],"mucosa,":[254],"functional":[256],"assays":[257],"demonstrated":[258],"overexpression":[260],"suppressed":[263],"proliferative":[265],"migratory":[267],"capacity":[268],"cells.":[271],"Serum":[272],"ELISA":[273],"further":[274],"revealed":[275],"circulating":[277,304,323,365],"concentrations":[279],"elevated":[281,322],"smokers":[283],"patients,":[287,296],"highest":[290],"observed":[292],"supporting":[297],"role":[299,316],"for":[300,317],"elevation":[302],"Conclusions":[309],"reveals":[312],"compartment-specific,":[314],"dual":[315],"EC:":[321],"ADH7,":[324],"driven":[325],"part":[327],"smoking,":[329],"is":[330],"risk,":[335],"whereas":[336],"acts":[338],"suppressor":[342],"within":[343],"tissue.":[346],"These":[347],"provide":[349],"novel":[350],"mechanistic":[353],"insights":[354],"into":[355],"pathogenesis":[358],"highlight":[360],"importance":[362],"distinguishing":[364],"from":[366],"tissue-level":[367],"when":[370],"interpreting":[371],"biomarker-disease":[372],"associations.":[373]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-05T00:00:00"}
