{"id":"https://openalex.org/W7219665902","doi":"https://doi.org/10.64898/2026.09.28.755003","title":"Tumor cell-intrinsic mtDNA instability drives cGAS-dependent temporal remodeling of the melanoma immune microenvironment","display_name":"Tumor cell-intrinsic mtDNA instability drives cGAS-dependent temporal remodeling of the melanoma immune microenvironment","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7219665902","doi":"https://doi.org/10.64898/2026.09.28.755003","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648598"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.755003","doi":"https://doi.org/10.64898/2026.09.28.755003","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755003","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.28.755003.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.28.755003.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013611529","display_name":"Abate Assefa Bashaw","orcid":"https://orcid.org/0000-0001-6575-5402","observed_orcids":["https://orcid.org/0000-0001-6575-5402"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abate Assefa Bashaw","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074704949","display_name":"Ashley D. Winters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley D. Winters","raw_affiliation_strings":["Texas A&M University College of Medicine, Bryan, TX, 77807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College of Medicine, Bryan, TX, 77807, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084687371","display_name":"Yuanjiu Lei","orcid":"https://orcid.org/0000-0002-7486-4261","observed_orcids":["https://orcid.org/0000-0002-7486-4261"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanjiu Lei","raw_affiliation_strings":["Texas A&M University College of Medicine, Bryan, TX, 77807, USA","Yale School of Medicine, New Haven, CT, 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College of Medicine, Bryan, TX, 77807, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT, 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157019599","display_name":"Luiza Ferreira Araujo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luiza Ferreira Araujo","raw_affiliation_strings":["Texas A&M University College of Medicine, Bryan, TX, 77807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College of Medicine, Bryan, TX, 77807, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157003247","display_name":"Do Gia Tam Vo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Do Gia Tam Vo","raw_affiliation_strings":["Genetics, Molecular and Cellular Biology Graduate Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA","The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics, Molecular and Cellular Biology Graduate Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064201892","display_name":"Arunachalam Sekar","orcid":"https://orcid.org/0000-0002-4659-5260","observed_orcids":["https://orcid.org/0000-0002-4659-5260"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arunachalam Sekar","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030811128","display_name":"John F. Bachman","orcid":"https://orcid.org/0000-0002-2912-9911","observed_orcids":["https://orcid.org/0000-0002-2912-9911"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Bachman","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156867383","display_name":"Paige S Graves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige S. Graves","raw_affiliation_strings":["Texas A&M University College of Medicine, Bryan, TX, 77807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College of Medicine, Bryan, TX, 77807, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157017191","display_name":"Melissa Pineda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Pineda","raw_affiliation_strings":["Texas A&M University College of Medicine, Bryan, TX, 77807, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College of Medicine, Bryan, TX, 77807, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049903801","display_name":"Jill Carol Rubinstein","orcid":"https://orcid.org/0000-0002-1222-8657","observed_orcids":["https://orcid.org/0000-0002-1222-8657"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill C. Rubinstein","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079476247","display_name":"Gerald S. Shadel","orcid":"https://orcid.org/0000-0003-2899-8717","observed_orcids":["https://orcid.org/0000-0003-2899-8717"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald S. Shadel","raw_affiliation_strings":["Salk Institute for Biological Studies, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076813249","display_name":"Marcus Bosenberg","orcid":"https://orcid.org/0000-0003-0166-1612","observed_orcids":["https://orcid.org/0000-0003-0166-1612"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Bosenberg","raw_affiliation_strings":["Yale School of Medicine, New Haven, CT, 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine, New Haven, CT, 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020025290","display_name":"Laura Ciaccia West","orcid":"https://orcid.org/0000-0002-8303-3582","observed_orcids":["https://orcid.org/0000-0002-8303-3582"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Ciaccia West","raw_affiliation_strings":["Texas A&M University College of Medicine, Bryan, TX, 77807, USA","The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M University College of Medicine, Bryan, TX, 77807, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079896062","display_name":"Andrew Phillip West","orcid":"https://orcid.org/0000-0003-2884-6895","observed_orcids":["https://orcid.org/0000-0003-2884-6895"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Phillip West","raw_affiliation_strings":["Department of Immunology, Tufts University School of Medicine, Boston, MA, 02111, USA","Genetics, Molecular and Cellular Biology Graduate Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA","Texas A&M University College of Medicine, Bryan, TX, 77807, USA","The Jackson Laboratory, Bar Harbor, ME 04609, USA"],"raw_orcid":"https://orcid.org/0000-0003-2884-6895","affiliations":[{"raw_affiliation_string":"Department of Immunology, Tufts University School of Medicine, Boston, MA, 02111, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Genetics, Molecular and Cellular Biology Graduate Program, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Texas A&M University College of Medicine, Bryan, TX, 77807, USA","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME 04609, USA","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna-instability","display_name":"mitochondrial DNA instability","score":0.9179999828338623},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cgas","display_name":"cGAS","score":0.777999997138977},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.6959999799728394},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8809999823570251},{"id":"https://openalex.org/keywords/efferocytosis","display_name":"efferocytosis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.796999990940094},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.7770000100135803},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.701200008392334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7009000182151794},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6603999733924866},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6473000049591064},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6326000094413757},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6251999735832214},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5985999703407288},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5421000123023987},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5120000243186951},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.40400001406669617},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.39959999918937683},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.39089998602867126},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.38909998536109924},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31679999828338623},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.30410000681877136},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.30000001192092896},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2815999984741211},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25870001316070557}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.28.755003","doi":"https://doi.org/10.64898/2026.09.28.755003","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755003","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.28.755003.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648598","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648598/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.755003","doi":"https://doi.org/10.64898/2026.09.28.755003","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755003","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/30/2026.09.28.755003.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7159649488","display_name":"Mitochondrial DNA Instability Engages a Cancer-Related Interferon Program to Modify the Immune Microenvironment and NAD+ Metabolome and Enhance Melanoma Growth","funder_award_id":"RP170734","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G8469143654","display_name":"Type I Interferon Responses in the Pathobiology of Anthracycline-induced Cardiotoxicity","funder_award_id":"R01HL148153","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000917281","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219665902.pdf","grobid_xml":"https://content.openalex.org/works/W7219665902.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1970195561","https://openalex.org/W1983496282","https://openalex.org/W2027242478","https://openalex.org/W2035232303","https://openalex.org/W2072317074","https://openalex.org/W2280480282","https://openalex.org/W2762347490","https://openalex.org/W2886206256","https://openalex.org/W2890799860","https://openalex.org/W3004462687","https://openalex.org/W3007604420","https://openalex.org/W3090978739","https://openalex.org/W3140448916","https://openalex.org/W3152326806","https://openalex.org/W3163977271","https://openalex.org/W4282975734","https://openalex.org/W4283379897","https://openalex.org/W4293004941","https://openalex.org/W4316506885","https://openalex.org/W4376873003","https://openalex.org/W4381682244","https://openalex.org/W4384661701","https://openalex.org/W4386090060","https://openalex.org/W4386438541","https://openalex.org/W4391322681","https://openalex.org/W4398231688","https://openalex.org/W4400084645","https://openalex.org/W4403114813","https://openalex.org/W4403969360","https://openalex.org/W4404164420","https://openalex.org/W4406731670","https://openalex.org/W4409329566","https://openalex.org/W4410521507","https://openalex.org/W4411069151","https://openalex.org/W4413894643","https://openalex.org/W4414110337","https://openalex.org/W7163650974"],"related_works":["https://openalex.org/W7120688717","https://openalex.org/W7122471954","https://openalex.org/W4406731670","https://openalex.org/W4412978630","https://openalex.org/W4220656079","https://openalex.org/W3165330938","https://openalex.org/W3207209419","https://openalex.org/W7164863434","https://openalex.org/W4391322681","https://openalex.org/W7073604466"],"abstract_inverted_index":{"Abstract":[0],"Mitochondrial":[1],"DNA":[2],"(mtDNA)":[3],"instability":[4,52,74,190],"is":[5],"an":[6,37,85],"emerging":[7],"feature":[8],"of":[9,30,65,78,119,168,194],"cancer,":[10],"yet":[11],"its":[12],"biological":[13],"effects":[14],"on":[15],"the":[16,79,104,148,179],"tumor":[17,21,49,69,80,111,187],"microenvironment":[18,81],"(TME)":[19],"and":[20,56,67,122,144,158,202],"progression":[22,167,201],"remain":[23],"incompletely":[24],"defined.":[25],"Using":[26],"melanocyte-specific":[27],"conditional":[28],"silencing":[29],"mitochondrial":[31],"transcription":[32],"factor":[33],"A":[34],"(TFAM)":[35],"in":[36,59],"autochthonous":[38],"Braf":[39],"V600E":[40],"/":[41],"Pten":[42],"-/-":[43],"melanoma":[44,54,138,200],"model,":[45],"we":[46],"demonstrate":[47],"that":[48,72,93,198],"cell-intrinsic":[50,112,188],"mtDNA":[51,73,113,131,189],"accelerates":[53],"growth":[55],"metastatic":[57],"dissemination":[58],"a":[60,123,173,192],"cGAS-dependent":[61],"manner.":[62],"Transcriptomic":[63],"profiling":[64],"early":[66,86,117,130,180],"late":[68,149],"stages":[70],"revealed":[71],"drives":[75],"temporal":[76,195],"remodeling":[77,197],"(TME),":[82],"characterized":[83],"by":[84,110],"type":[87,108],"I":[88],"interferon":[89],"(IFN)-rich":[90],"inflammatory":[91,120],"state":[92],"licenses":[94],"immunoregulatory":[95],"programs":[96],"as":[97,103,191],"tumors":[98],"progress.":[99],"Tumor-associated":[100],"macrophages":[101],"emerged":[102],"principal":[105],"immune":[106,182],"cell":[107],"reshaped":[109],"stress":[114],"signaling,":[115],"with":[116,141,155,172,178],"enrichment":[118],"states":[121,139,153],"shift":[124],"toward":[125],"efferocytosis-associated,":[126],"tissue-adaptive":[127],"states.":[128],"The":[129],"instability-associated":[132],"macrophage":[133],"signatures":[134,150],"mapped":[135,151],"to":[136,152],"human":[137],"associated":[140,154,177],"favorable":[142],"survival":[143],"therapy":[145,159],"response,":[146],"whereas":[147],"poor":[156],"prognosis":[157],"resistance":[160],"across":[161],"independent":[162],"cohorts.":[163],"Anti-PD-1":[164],"treatment":[165],"delayed":[166],"mtDNA-instable":[169],"tumors,":[170],"consistent":[171],"therapeutic":[174,204],"sensitivity":[175],"window":[176],"IFN-rich":[181],"state.":[183],"These":[184],"findings":[185],"establish":[186],"driver":[193],"immune-stromal":[196],"promotes":[199],"shapes":[203],"response.":[205]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-05T00:00:00"}