{"id":"https://openalex.org/W7219659525","doi":"https://doi.org/10.3389/fimmu.2026.1928875","title":"Supernatants from stored platelet concentrates modulate the inflammatory response in platelet-depleted blood ex vivo","display_name":"Supernatants from stored platelet concentrates modulate the inflammatory response in platelet-depleted blood ex vivo","publication_year":2026,"publication_date":"2026-10-05","ids":{"openalex":"https://openalex.org/W7219659525","doi":"https://doi.org/10.3389/fimmu.2026.1928875","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898267","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677499"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1928875","doi":"https://doi.org/10.3389/fimmu.2026.1928875","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1928875","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1928875/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1928875/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067086314","display_name":"Linnea I. Andersson","orcid":"https://orcid.org/0009-0002-0295-2120","observed_orcids":["https://orcid.org/0009-0002-0295-2120"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Linnea I. Andersson","raw_affiliation_strings":["Department of Chemistry and Biomedicine, Linnaeus University","Linnaeus Centre for Biomaterials Chemistry, Linnaeus University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomedicine, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]},{"raw_affiliation_string":"Linnaeus Centre for Biomaterials Chemistry, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043117515","display_name":"Dick J. Sj\u00f6str\u00f6m","orcid":"https://orcid.org/0000-0001-7050-3445","observed_orcids":["https://orcid.org/0000-0001-7050-3445"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dick J. Sj\u00f6str\u00f6m","raw_affiliation_strings":["Department of Chemistry and Biomedicine, Linnaeus University","Linnaeus Centre for Biomaterials Chemistry, Linnaeus University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomedicine, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]},{"raw_affiliation_string":"Linnaeus Centre for Biomaterials Chemistry, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084097154","display_name":"Nahreen Tynng\u00e5rd","orcid":"https://orcid.org/0000-0001-8591-6074","observed_orcids":["https://orcid.org/0000-0001-8591-6074"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I4391767699","display_name":"Region \u00d6sterg\u00f6tland","ror":"https://ror.org/024emf479","country_code":"SE","type":"government","lineage":["https://openalex.org/I4391767699"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Nahreen Tynng\u00e5rd","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences, Link\u00f6ping University","Healthcare Research Strategy Department, Region \u00d6sterg\u00f6tland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences, Link\u00f6ping University","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"Healthcare Research Strategy Department, Region \u00d6sterg\u00f6tland","institution_ids":["https://openalex.org/I4391767699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054434454","display_name":"Camilla Mohlin","orcid":"https://orcid.org/0000-0002-9301-1977","observed_orcids":["https://orcid.org/0000-0002-9301-1977"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Camilla Mohlin","raw_affiliation_strings":["Department of Chemistry and Biomedicine, Linnaeus University","Linnaeus Centre for Biomaterials Chemistry, Linnaeus University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomedicine, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]},{"raw_affiliation_string":"Linnaeus Centre for Biomaterials Chemistry, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013663619","display_name":"Huy Quang Quach","orcid":"https://orcid.org/0000-0003-2191-5771","observed_orcids":["https://orcid.org/0000-0003-2191-5771"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huy Quang Quach","raw_affiliation_strings":["Mayo Clinic Vaccine Research Group, Mayo Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Vaccine Research Group, Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035821482","display_name":"Ivar Tjernberg","orcid":"https://orcid.org/0000-0001-8657-2496","observed_orcids":["https://orcid.org/0000-0001-8657-2496"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I4210139554","display_name":"Landstinget i Kalmar l\u00e4n","ror":"https://ror.org/033bc9f34","country_code":"SE","type":"government","lineage":["https://openalex.org/I4210139554"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ivar Tjernberg","raw_affiliation_strings":["Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Link\u00f6ping University","Department of Clinical Chemistry and Transfusion Medicine, Region Kalmar County"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Link\u00f6ping University","institution_ids":["https://openalex.org/I102134673"]},{"raw_affiliation_string":"Department of Clinical Chemistry and Transfusion Medicine, Region Kalmar County","institution_ids":["https://openalex.org/I4210139554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090443577","display_name":"Sofia Ramstr\u00f6m","orcid":"https://orcid.org/0000-0002-1920-3962","observed_orcids":["https://orcid.org/0000-0002-1920-3962"]},"institutions":[{"id":"https://openalex.org/I26437253","display_name":"\u00d6rebro University","ror":"https://ror.org/05kytsw45","country_code":"SE","type":"education","lineage":["https://openalex.org/I26437253"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sofia Ramstr\u00f6m","raw_affiliation_strings":["Cardiovascular Research Centre, School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Centre, School of Medical Sciences, Faculty of Medicine and Health, \u00d6rebro University","institution_ids":["https://openalex.org/I26437253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034439136","display_name":"Tom Eirik Mollnes","orcid":"https://orcid.org/0000-0002-5785-802X","observed_orcids":["https://orcid.org/0000-0002-5785-802X"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Tom Eirik Mollnes","raw_affiliation_strings":["Department of Immunology, Oslo University Hospital and University of Oslo","Research Laboratory, Nordland Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Oslo University Hospital and University of Oslo","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183"]},{"raw_affiliation_string":"Research Laboratory, Nordland Hospital","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047191679","display_name":"Per H. Nilsson","orcid":"https://orcid.org/0000-0002-7192-5794","observed_orcids":["https://orcid.org/0000-0002-7192-5794"]},"institutions":[{"id":"https://openalex.org/I223464139","display_name":"Linnaeus University","ror":"https://ror.org/00j9qag85","country_code":"SE","type":"education","lineage":["https://openalex.org/I223464139"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Per H. Nilsson","raw_affiliation_strings":["Department of Chemistry and Biomedicine, Linnaeus University","Linnaeus Centre for Biomaterials Chemistry, Linnaeus University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biomedicine, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]},{"raw_affiliation_string":"Linnaeus Centre for Biomaterials Chemistry, Linnaeus University","institution_ids":["https://openalex.org/I223464139"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5047191679"],"corresponding_institution_ids":["https://openalex.org/I223464139"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70526614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1928875","last_page":"1928875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.05990000069141388,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-concentrates","display_name":"platelet concentrates","score":0.8650000095367432},{"id":"https://openalex.org/keywords/platelet-storage","display_name":"platelet storage","score":0.7590000033378601},{"id":"https://openalex.org/keywords/platelet-derived-mediators","display_name":"platelet-derived mediators","score":0.7850000262260437},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/escherichia-coli-stimulation","display_name":"Escherichia coli stimulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8149999976158142},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8220000267028809},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/storage-time","display_name":"storage time","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.9088000059127808},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8546000123023987},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.6489999890327454},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6315000057220459},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.5990999937057495},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5149000287055969},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5127000212669373},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.48510000109672546},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4255000054836273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41929998993873596},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37860000133514404},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3686999976634979},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.34950000047683716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34700000286102295},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.3467999994754791},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3230000138282776},{"id":"https://openalex.org/C91219811","wikidata":"https://www.wikidata.org/wiki/Q14906031","display_name":"Interleukin 11","level":4,"score":0.30070000886917114},{"id":"https://openalex.org/C2908955001","wikidata":"https://www.wikidata.org/wiki/Q23925170","display_name":"Platelet concentrate","level":3,"score":0.29490000009536743},{"id":"https://openalex.org/C159973064","wikidata":"https://www.wikidata.org/wiki/Q3740205","display_name":"Platelet factor 4","level":3,"score":0.28119999170303345},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.26330000162124634}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001793","descriptor_name":"Blood Preservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2026.1928875","doi":"https://doi.org/10.3389/fimmu.2026.1928875","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1928875","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1928875/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:42898267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677499","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677499/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:lnu-150321","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-150321","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4ee49101d5e34342990c78dd1584e29f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4ee49101d5e34342990c78dd1584e29f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1928875","doi":"https://doi.org/10.3389/fimmu.2026.1928875","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1928875","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1928875/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8079030596","display_name":"Biomaterial-induced thromboinflammation - pathophysiological mechanisms in human whole blood upon contact with artificial materials","funder_award_id":"2018-04087","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320312350","display_name":"Forskningsr\u00e5det i Syd\u00f6stra Sverige","ror":"https://ror.org/00brmfv24"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219659525.pdf","grobid_xml":"https://content.openalex.org/works/W7219659525.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1560136707","https://openalex.org/W1766382842","https://openalex.org/W1976954262","https://openalex.org/W2002767954","https://openalex.org/W2018031998","https://openalex.org/W2023602786","https://openalex.org/W2030148186","https://openalex.org/W2034551997","https://openalex.org/W2061141931","https://openalex.org/W2061729543","https://openalex.org/W2064653038","https://openalex.org/W2080149026","https://openalex.org/W2082308378","https://openalex.org/W2087542769","https://openalex.org/W2092415524","https://openalex.org/W2100109792","https://openalex.org/W2109982451","https://openalex.org/W2111403445","https://openalex.org/W2113542718","https://openalex.org/W2114381479","https://openalex.org/W2134094618","https://openalex.org/W2161100350","https://openalex.org/W2336085971","https://openalex.org/W2508051727","https://openalex.org/W2559292551","https://openalex.org/W2614206045","https://openalex.org/W2796405468","https://openalex.org/W2800047272","https://openalex.org/W2884705408","https://openalex.org/W2886289396","https://openalex.org/W2916526154","https://openalex.org/W2945112972","https://openalex.org/W2952050594","https://openalex.org/W2966769619","https://openalex.org/W3087052666","https://openalex.org/W3087279172","https://openalex.org/W3112902030","https://openalex.org/W3152345913","https://openalex.org/W4213293409","https://openalex.org/W4214925106","https://openalex.org/W4220696370","https://openalex.org/W4225566381","https://openalex.org/W4282912918","https://openalex.org/W4291021319","https://openalex.org/W4307428745","https://openalex.org/W4389450143","https://openalex.org/W4390918131","https://openalex.org/W4400470854","https://openalex.org/W4401443120","https://openalex.org/W4405903055","https://openalex.org/W4406281330","https://openalex.org/W4406663669","https://openalex.org/W4411665074","https://openalex.org/W7125191913","https://openalex.org/W7144053921"],"related_works":["https://openalex.org/W2007992504","https://openalex.org/W4386174937","https://openalex.org/W2793588367","https://openalex.org/W3117383955","https://openalex.org/W2058300564","https://openalex.org/W2897279400","https://openalex.org/W78931606","https://openalex.org/W4404176957","https://openalex.org/W2588803131","https://openalex.org/W4408777630"],"abstract_inverted_index":{"Introduction":[0],"Platelets":[1],"contain":[2],"a":[3],"wide":[4],"range":[5],"of":[6,10,15,103,108,115,117,149,165],"bioactive":[7],"mediators,":[8,96],"many":[9],"which":[11],"accumulate":[12],"during":[13],"storage":[14,66,173],"platelet":[16,32,56,62,109,185],"concentrates":[17,33,63,186],"and":[18,71,73,97,134,145,202],"have":[19],"immunomodulatory":[20,204],"properties.":[21],"Our":[22,177],"objective":[23],"was":[24,52],"to":[25],"investigate":[26],"how":[27],"mediators":[28,158],"derived":[29],"from":[30,48,60,153,184],"stored":[31],"modulate":[34,188],"the":[35,101,113,129,139,171],"acute":[36],"inflammatory":[37,120,189],"response":[38],"using":[39],"an":[40,195],"ex":[41,196],"vivo":[42,197],"model.":[43],"Methods":[44],"Platelet-depleted":[45],"whole":[46],"blood":[47,193],"healthy":[49],"donors":[50],"(n=8)":[51],"supplemented":[53],"with":[54,75,199],"pooled":[55],"concentrate":[57,110],"supernatants":[58,111,130],"generated":[59],"six":[61],"sampled":[64],"on":[65],"days":[67],"1,":[68],"3,":[69],"5,":[70],"7,":[72],"incubated":[74],"or":[76,161],"without":[77],"heat-inactivated":[78],"Escherichia":[79],"coli":[80,105,126],"for":[81],"four":[82],"hours":[83],"at":[84],"37":[85],"\u00b0C.":[86],"Inflammatory":[87],"responses":[88,190],"were":[89,159],"assessed":[90],"by":[91],"measuring":[92],"complement":[93],"activation,":[94],"platelet-derived":[95],"cytokines.":[98],"Results":[99],"In":[100,122],"absence":[102],"E.":[104,125],",":[106],"addition":[107],"increased":[112,131],"levels":[114],"24":[116],"32":[118],"measured":[119],"mediators.":[121],"contrast,":[123],"under":[124],"-stimulated":[127],"conditions,":[128],"10":[132],"markers":[133],"attenuated":[135],"14":[136],"markers,":[137],"including":[138],"key":[140],"pro-inflammatory":[141],"cytokines":[142,151],"IL-1\u03b2,":[143],"IL-6,":[144],"TNF.":[146],"The":[147,163],"attenuation":[148],"these":[150],"ranged":[152],"25-43%,":[154],"whereas":[155],"several":[156],"other":[157],"unchanged":[160],"increased.":[162],"majority":[164],"biomarkers":[166],"showed":[167],"limited":[168],"differences":[169],"across":[170],"investigated":[172],"time":[174],"points.":[175],"Conclusions":[176],"findings":[178],"demonstrate":[179],"that":[180],"soluble":[181],"factors":[182],"released":[183],"can":[187],"in":[191,194],"platelet-depleted":[192],"setting,":[198],"context-dependent,":[200],"bidirectional,":[201],"selective":[203],"effects.":[205]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-05T00:00:00"}