{"id":"https://openalex.org/W7219648919","doi":"https://doi.org/10.64898/2026.09.28.754991","title":"A Novel NO Donor 3A72 Activates Mitochondrial-Associated Endoplasmic Reticulum Membrane Structures to Induce Ferroptosis in Triple-Negative Breast Cancer","display_name":"A Novel NO Donor 3A72 Activates Mitochondrial-Associated Endoplasmic Reticulum Membrane Structures to Induce Ferroptosis in Triple-Negative Breast Cancer","publication_year":2026,"publication_date":"2026-10-04","ids":{"openalex":"https://openalex.org/W7219648919","doi":"https://doi.org/10.64898/2026.09.28.754991","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856292","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648585"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.754991","doi":"https://doi.org/10.64898/2026.09.28.754991","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754991","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.754991.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.754991.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137751635","display_name":"Yunke Long","orcid":"https://orcid.org/0009-0002-1560-5064","observed_orcids":["https://orcid.org/0009-0002-1560-5064"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunke Long","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203"],"raw_orcid":"https://orcid.org/0009-0002-1560-5064","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157111389","display_name":"Yuxin Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Jiang","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157085111","display_name":"La Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"La Li","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156863299","display_name":"Xiufan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiufan Wu","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055037352","display_name":"Jiachen Weng","orcid":"https://orcid.org/0009-0007-1775-4238","observed_orcids":["https://orcid.org/0009-0007-1775-4238"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachen Weng","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101954485","display_name":"Ying Chen","orcid":"https://orcid.org/0000-0002-8197-3108","observed_orcids":["https://orcid.org/0000-0002-8197-3108"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Chen","raw_affiliation_strings":["Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China"],"raw_orcid":"https://orcid.org/0000-0002-8197-3108","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100657131","display_name":"Hongrui Liu","orcid":"https://orcid.org/0000-0003-3975-8196","observed_orcids":["https://orcid.org/0000-0003-3975-8196"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongrui Liu","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203"],"raw_orcid":"https://orcid.org/0000-0003-3975-8196","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100657131"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13833","display_name":"Ferrocene Chemistry and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mitochondrial-associated-endoplasmic-reticulum-membranes","display_name":"mitochondrial-associated endoplasmic reticulum membranes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/acsl4","display_name":"ACSL4","score":0.921999990940094},{"id":"https://openalex.org/keywords/mitochondrial-calcium-overload","display_name":"mitochondrial calcium overload","score":0.7440000176429749},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.652999997138977},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7817999720573425},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6013000011444092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5819000005722046},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5401999950408936},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5254999995231628},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46869999170303345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4526999890804291},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.424699991941452},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.3749000132083893},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.3671000003814697},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.3467999994754791},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3425999879837036},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.33489999175071716},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2702000141143799},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2687999904155731},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.26759999990463257},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.2623000144958496},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.2581999897956848},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2533000111579895}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.28.754991","doi":"https://doi.org/10.64898/2026.09.28.754991","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754991","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.754991.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648585","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648585/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648585/pdf/nihpp-2026.09.28.754991v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42856292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.754991","doi":"https://doi.org/10.64898/2026.09.28.754991","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.754991","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.754991.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G570685692","display_name":null,"funder_award_id":"2023FGS2","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G8760597890","display_name":null,"funder_award_id":"R01-GM129325","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"},{"id":"https://openalex.org/G9000909391","display_name":"ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling","funder_award_id":"R01GM129325","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219648919.pdf","grobid_xml":"https://content.openalex.org/works/W7219648919.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1793434462","https://openalex.org/W2022972602","https://openalex.org/W2574836938","https://openalex.org/W2736730167","https://openalex.org/W2767377392","https://openalex.org/W3033869790","https://openalex.org/W3091877976","https://openalex.org/W3127173425","https://openalex.org/W3205635146","https://openalex.org/W4205456778","https://openalex.org/W4206965224","https://openalex.org/W4207033714","https://openalex.org/W4213370488","https://openalex.org/W4221014473","https://openalex.org/W4225383721","https://openalex.org/W4281485235","https://openalex.org/W4282913408","https://openalex.org/W4285105720","https://openalex.org/W4293435090","https://openalex.org/W4308834893","https://openalex.org/W4319310796","https://openalex.org/W4362524033","https://openalex.org/W4364378374","https://openalex.org/W4376275281","https://openalex.org/W4378980763","https://openalex.org/W4392683638","https://openalex.org/W4395027993","https://openalex.org/W4401422361","https://openalex.org/W4404312849","https://openalex.org/W4405982876","https://openalex.org/W4406230626","https://openalex.org/W4410216174","https://openalex.org/W4410918011","https://openalex.org/W4411830550","https://openalex.org/W4412493122","https://openalex.org/W4412868210","https://openalex.org/W4413858371","https://openalex.org/W4415196204","https://openalex.org/W4415249086","https://openalex.org/W4417100822","https://openalex.org/W7117298713","https://openalex.org/W7125514655","https://openalex.org/W7134058812","https://openalex.org/W7154486491"],"related_works":["https://openalex.org/W4388580508","https://openalex.org/W4400956945","https://openalex.org/W4413287970","https://openalex.org/W4387812789","https://openalex.org/W4394989905","https://openalex.org/W4393302204","https://openalex.org/W4394931326","https://openalex.org/W4390340116","https://openalex.org/W7211959658","https://openalex.org/W7148867584"],"abstract_inverted_index":{"Abstract":[0],"Triple-negative":[1],"breast":[2,92],"cancer":[3,93],"(TNBC)":[4,94],"remains":[5],"a":[6,12,33,41,97,140,168,224],"major":[7],"clinical":[8],"challenge":[9],"due":[10],"to":[11,29,106,115,131],"lack":[13],"of":[14,143],"effective":[15],"interventions":[16],"and":[17,52,64,81,122,139,160,210],"severe":[18],"drug":[19,75,230],"resistance.":[20],"Disrupting":[21],"tumor":[22,67],"metabolism":[23],"using":[24],"nitric":[25],"oxide":[26],"(NO)":[27],"donors":[28],"drive":[30],"ferroptosis":[31,88],"represents":[32],"promising":[34,225],"therapeutic":[35],"strategy.":[36],"Here,":[37],"we":[38],"developed":[39],"3A72,":[40],"novel":[42],"furan-coumarin-based":[43],"NO":[44,105],"donor":[45],"with":[46,78,177,189,201],"potent":[47],"anti-TNBC":[48],"efficacy.":[49],"In":[50],"vitro":[51],"in":[53,89],"vivo":[54],"studies":[55],"demonstrated":[56],"that":[57,164],"3A72":[58,86,102],"significantly":[59],"suppresses":[60],"TNBC":[61],"cell":[62],"proliferation":[63],"restricts":[65],"xenograft":[66],"growth.":[68],"Notably,":[69],"its":[70,174],"efficacy":[71],"matches":[72],"the":[73,184,218],"first-line":[74],"paclitaxel":[76],"but":[77],"enhanced":[79],"safety":[80],"reduced":[82],"systemic":[83],"toxicity.":[84],"Mechanistically,":[85],"induces":[87],"triple":[90],"negative":[91],"cells":[95],"via":[96],"synergistic":[98],"dual-pathway":[99],"mechanism.":[100],"Initially,":[101],"releases":[103],"intracellular":[104],"trigger":[107],"cytoplasmic":[108],"calcium":[109,137],"overload,":[110],"followed":[111],"by":[112],"high-affinity":[113],"binding":[114],"both":[116],"inositol":[117],"1,4,5-trisphosphate":[118],"receptor":[119],"(IP":[120],"R)":[121],"acyl-CoA":[123],"synthetase":[124],"long-chain":[125],"family":[126],"member":[127],"4":[128],"(ACSL4).":[129],"Binding":[130],"IP":[132,178,197],"3":[133,179],"R":[134,180],"provokes":[135],"mitochondrial":[136],"overload":[138],"massive":[141],"burst":[142],"reactive":[144],"oxygen":[145],"species":[146],"(ROS),":[147],"while":[148,165],"concurrent":[149],"ACSL4":[150,166],"activation":[151],"drives":[152],"essential":[153],"membrane":[154],"phospholipid":[155],"remodeling.":[156],"Crucially,":[157],"our":[158],"transcriptomic":[159],"structural":[161,226],"predictions":[162],"reveal":[163],"exhibits":[167],"broader":[169],"distribution":[170],"across":[171],"organelle":[172],"membranes,":[173],"functional":[175],"association":[176],"spatially":[181],"converges":[182],"at":[183],"endoplasmic":[185],"reticulum":[186],"membranes":[187],"associated":[188],"mitochondria":[190],"(MAMs).":[191],"This":[192],"subcellular":[193],"niche":[194],"closely":[195],"couples":[196],"R-mediated":[198],"ROS":[199],"generation":[200],"ACSL4-driven":[202],"lipid":[203],"remodeling,":[204],"accelerating":[205],"lethal":[206],"malondialdehyde":[207],"(MDA)":[208],"accumulation":[209],"triggering":[211],"irreversible":[212],"ferroptosis.":[213],"Overall,":[214],"these":[215],"findings":[216],"highlight":[217],"MAMs":[219],"calcium\u2013lipid":[220],"metabolic":[221],"hub":[222],"as":[223],"scaffold":[227],"for":[228],"antitumor":[229],"development.":[231]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-05T00:00:00"}
