{"id":"https://openalex.org/W7219645897","doi":"https://doi.org/10.64898/2026.09.28.755097","title":"Median Preoptic Brs3 -Expressing Neurons Regulate Heat-Evoked Defensive Escalation","display_name":"Median Preoptic Brs3 -Expressing Neurons Regulate Heat-Evoked Defensive Escalation","publication_year":2026,"publication_date":"2026-10-04","ids":{"openalex":"https://openalex.org/W7219645897","doi":"https://doi.org/10.64898/2026.09.28.755097"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.755097","doi":"https://doi.org/10.64898/2026.09.28.755097","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755097","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.755097.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.755097.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5156987364","display_name":"Zixu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixu Zhang","raw_affiliation_strings":["School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]},{"raw_affiliation_string":"The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127471495","display_name":"Shengru Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengru Hu","raw_affiliation_strings":["School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]},{"raw_affiliation_string":"The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157171029","display_name":"Hongchao Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongchao Cao","raw_affiliation_strings":["Jiangsu Clinical Medicine Research Institute, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Clinical Medicine Research Institute, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062830747","display_name":"Wei Xie","orcid":"https://orcid.org/0000-0002-9179-4787","observed_orcids":["https://orcid.org/0000-0002-9179-4787","https://orcid.org/0000-0001-8941-2578"]},"institutions":[{"id":"https://openalex.org/I4405282086","display_name":"Fuyao University of Science and Technology","ror":"https://ror.org/05aak3d90","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405282086"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xie","raw_affiliation_strings":["School of Life and Health Sciences, Fuyao University of Science and Technology, Fuzhou 350109, China","The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China"],"raw_orcid":"https://orcid.org/0000-0002-9179-4787","affiliations":[{"raw_affiliation_string":"School of Life and Health Sciences, Fuyao University of Science and Technology, Fuzhou 350109, China","institution_ids":["https://openalex.org/I4405282086"]},{"raw_affiliation_string":"The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157060665","display_name":"Zhiping Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154481","display_name":"Eighth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/00xjwyj62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387154481"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiping Cao","raw_affiliation_strings":["Biological Laboratory of Hetao Cooperation Zone, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Laboratory of Hetao Cooperation Zone, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518031, China","institution_ids":["https://openalex.org/I4387154481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042058948","display_name":"Mingdao Mu","orcid":"https://orcid.org/0000-0003-0815-6555","observed_orcids":["https://orcid.org/0000-0003-0815-6555"]},"institutions":[{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingdao Mu","raw_affiliation_strings":["School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China"],"raw_orcid":"https://orcid.org/0000-0003-0815-6555","affiliations":[{"raw_affiliation_string":"School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","institution_ids":["https://openalex.org/I76569877"]},{"raw_affiliation_string":"The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, 2 Dongda Road, Nanjing 210088, China","institution_ids":["https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042058948"],"corresponding_institution_ids":["https://openalex.org/I76569877"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.3833000063896179,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.12759999930858612,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/median-preoptic-nucleus","display_name":"median preoptic nucleus","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bombesin-receptor-subtype-3","display_name":"bombesin receptor subtype 3","score":0.9570000171661377},{"id":"https://openalex.org/keywords/heat-avoidance","display_name":"heat avoidance","score":0.7450000047683716},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.5860000252723694},{"id":"https://openalex.org/keywords/optogenetic-stimulation","display_name":"optogenetic stimulation","score":0.5120000243186951},{"id":"https://openalex.org/keywords/place-avoidance","display_name":"place avoidance","score":0.593999981880188},{"id":"https://openalex.org/keywords/locomotion","display_name":"locomotion","score":0.8709999918937683},{"id":"https://openalex.org/keywords/climbing-behavior","display_name":"climbing behavior","score":0.5659999847412109},{"id":"https://openalex.org/keywords/jumping-behavior","display_name":"jumping behavior","score":0.5680000185966492},{"id":"https://openalex.org/keywords/rearing-behavior","display_name":"rearing behavior","score":0.7310000061988831},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.6747000217437744},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.5439000129699707},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5249999761581421},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5217999815940857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5203999876976013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4481000006198883},{"id":"https://openalex.org/C95038775","wikidata":"https://www.wikidata.org/wiki/Q22857","display_name":"Climbing","level":2,"score":0.3971000015735626},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39340001344680786},{"id":"https://openalex.org/C100564792","wikidata":"https://www.wikidata.org/wiki/Q190259","display_name":"Thermoregulation","level":2,"score":0.37790000438690186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36010000109672546},{"id":"https://openalex.org/C2779897013","wikidata":"https://www.wikidata.org/wiki/Q1151752","display_name":"Jumping","level":2,"score":0.3492000102996826},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34119999408721924},{"id":"https://openalex.org/C81077568","wikidata":"https://www.wikidata.org/wiki/Q5397078","display_name":"Escape response","level":2,"score":0.3368000090122223},{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.321399986743927},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C2776451244","wikidata":"https://www.wikidata.org/wiki/Q7240592","display_name":"Preoptic area","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.2987000048160553},{"id":"https://openalex.org/C2779079380","wikidata":"https://www.wikidata.org/wiki/Q333495","display_name":"Falling (accident)","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.2939999997615814},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26010000705718994},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C2993566434","wikidata":"https://www.wikidata.org/wiki/Q509869","display_name":"Hot plate","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.28.755097","doi":"https://doi.org/10.64898/2026.09.28.755097","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755097","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.755097.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.755097","doi":"https://doi.org/10.64898/2026.09.28.755097","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755097","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.09.28.755097.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000856082","display_name":null,"funder_award_id":"2026A1515011895","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219645897.pdf","grobid_xml":"https://content.openalex.org/works/W7219645897.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220704945","https://openalex.org/W2144376940","https://openalex.org/W7098469788","https://openalex.org/W2030422991","https://openalex.org/W4381327980","https://openalex.org/W3205962002","https://openalex.org/W3134000664","https://openalex.org/W2318468297","https://openalex.org/W2912192285","https://openalex.org/W3176761050"],"abstract_inverted_index":{"Abstract":[0],"Animals":[1],"confronted":[2],"with":[3,62],"increasing":[4],"heat":[5,140,156],"must":[6],"switch":[7],"from":[8,46,55,128],"exploratory":[9],"behavior":[10,54,127],"to":[11,32,41],"vigorous":[12,114],"actions":[13],"that":[14],"limit":[15],"further":[16],"exposure,":[17],"but":[18],"the":[19,47,65,73,99],"forebrain":[20],"circuits":[21],"controlling":[22],"this":[23],"transition":[24],"are":[25],"poorly":[26],"understood.":[27],"We":[28],"exposed":[29],"male":[30],"mice":[31,97],"progressively":[33],"stronger":[34],"floor":[35],"heating":[36,48,110],"while":[37],"providing":[38],"continuous":[39],"access":[40],"a":[42,138],"climbing":[43,129],"mesh":[44],"separated":[45],"plate.":[49],"Higher":[50],"plate":[51],"settings":[52],"shifted":[53,126],"rearing":[56,133],"toward":[57,132],"wall-directed":[58],"digging":[59],"and":[60,68,90,102,116,130,134,155],"climbing,":[61],"jumping":[63,131],"at":[64],"highest":[66],"setting,":[67],"increased":[69,95,117],"c-Fos":[70,85],"labeling":[71],"in":[72],"median":[74,145],"preoptic":[75,146],"nucleus.":[76],"Neurons":[77],"expressing":[78],"bombesin":[79],"receptor":[80],"subtype":[81],"3":[82],"showed":[83],"greater":[84],"recruitment":[86],"under":[87],"strong":[88,124],"heating,":[89,125],"their":[91],"population":[92],"calcium":[93],"signals":[94],"when":[96,104],"entered":[98],"plate-controlled":[100],"zone":[101],"decreased":[103],"they":[105],"left.":[106],"Optogenetic":[107],"activation":[108],"without":[109],"produced":[111],"place":[112],"avoidance,":[113],"actions,":[115],"locomotion.":[118],"Inhibition":[119],"reduced":[120],"locomotion":[121],"and,":[122],"during":[123],"weakened":[135],"avoidance":[136],"of":[137,152],"localized":[139],"source.":[141],"These":[142],"findings":[143],"identify":[144],"Brs3":[147],"-expressing":[148],"neurons":[149],"as":[150],"regulators":[151],"behavioral":[153],"escalation":[154],"avoidance.":[157]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-05T00:00:00"}
