{"id":"https://openalex.org/W7219618497","doi":"https://doi.org/10.64898/2026.10.02.756310","title":"A chemically modified promoter-targeted duplex RNA activates TCF4 expression","display_name":"A chemically modified promoter-targeted duplex RNA activates TCF4 expression","publication_year":2026,"publication_date":"2026-10-04","ids":{"openalex":"https://openalex.org/W7219618497","doi":"https://doi.org/10.64898/2026.10.02.756310","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648730"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.02.756310","doi":"https://doi.org/10.64898/2026.10.02.756310","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756310","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.02.756310.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.02.756310.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026186239","display_name":"Bethany A. Janowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethany A. Janowski","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116529269","display_name":"Tse Victor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Tse","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121015690","display_name":"Jiaxin Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaxin Hu","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044047506","display_name":"Sarah A. Cobb","orcid":"https://orcid.org/0000-0001-8725-4588","observed_orcids":["https://orcid.org/0000-0001-8725-4588"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A. Cobb","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157234774","display_name":"Khayden Dang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khayden Dong","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044865944","display_name":"David R. Corey","orcid":"https://orcid.org/0000-0001-8973-493X","observed_orcids":["https://orcid.org/0000-0001-8973-493X","https://orcid.org/0000-0002-7534-5834"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David R. Corey","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Lane, Dallas, TX 75390-9041","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044865944"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pitt-hopkins-syndrome","display_name":"Pitt-Hopkins syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tcf4","display_name":"TCF4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.8960000276565552},{"id":"https://openalex.org/keywords/rna-activation","display_name":"RNA activation","score":0.46399998664855957},{"id":"https://openalex.org/keywords/chemically-modified-oligonucleotides","display_name":"modified oligonucleotides","score":0.8880000114440918},{"id":"https://openalex.org/keywords/2-o-methyl-modification","display_name":"2'-O-methyl modification","score":0.9200000166893005},{"id":"https://openalex.org/keywords/phosphorothioate-modification","display_name":"phosphorothioate modification","score":0.9430000185966492},{"id":"https://openalex.org/keywords/argonaute-2","display_name":"Argonaute 2","score":0.7440000176429749},{"id":"https://openalex.org/keywords/rna-polymerase-ii-occupancy","display_name":"RNA polymerase II occupancy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C93501484","wikidata":"https://www.wikidata.org/wiki/Q14913982","display_name":"TCF4","level":5,"score":0.7350999712944031},{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.6486999988555908},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5821999907493591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5167999863624573},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.4855000078678131},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.45489999651908875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4526999890804291},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.43959999084472656},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43950000405311584},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4309000074863434},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4242999851703644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.398499995470047},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35679998993873596},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.33559998869895935},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32499998807907104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3181999921798706},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.2962000072002411},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.29600000381469727},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.2906000018119812},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.27140000462532043},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2651999890804291},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.25679999589920044}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.10.02.756310","doi":"https://doi.org/10.64898/2026.10.02.756310","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756310","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.02.756310.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648730","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648730/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.10.02.756310","doi":"https://doi.org/10.64898/2026.10.02.756310","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.02.756310","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/04/2026.10.02.756310.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000872227","display_name":"Recognition of Cellular Targets by single and double-stranded nucleic acids","funder_award_id":"R35GM118103","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309495","display_name":"Pitt Hopkins Research Foundation","ror":"https://ror.org/0108ddn29"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7219618497.pdf","grobid_xml":"https://content.openalex.org/works/W7219618497.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1972401591","https://openalex.org/W1977623733","https://openalex.org/W1978026413","https://openalex.org/W1986223165","https://openalex.org/W1988261092","https://openalex.org/W2017695960","https://openalex.org/W2036802778","https://openalex.org/W2058711543","https://openalex.org/W2066449582","https://openalex.org/W2067742553","https://openalex.org/W2069009920","https://openalex.org/W2069697511","https://openalex.org/W2080381799","https://openalex.org/W2082213106","https://openalex.org/W2085516557","https://openalex.org/W2089107511","https://openalex.org/W2092261551","https://openalex.org/W2105444747","https://openalex.org/W2111831519","https://openalex.org/W2137505881","https://openalex.org/W2147380886","https://openalex.org/W2155167158","https://openalex.org/W2165033383","https://openalex.org/W2329281045","https://openalex.org/W2502698579","https://openalex.org/W2789114047","https://openalex.org/W2793761009","https://openalex.org/W2888674886","https://openalex.org/W2913776613","https://openalex.org/W2939848875","https://openalex.org/W2947548722","https://openalex.org/W2965851198","https://openalex.org/W3010225431","https://openalex.org/W3019082705","https://openalex.org/W3045910546","https://openalex.org/W3119364326","https://openalex.org/W3172242766","https://openalex.org/W3211772434","https://openalex.org/W4225278364","https://openalex.org/W4229453310","https://openalex.org/W4281688566","https://openalex.org/W4310184841","https://openalex.org/W4317497256","https://openalex.org/W4323352404","https://openalex.org/W4378070663","https://openalex.org/W4387408570","https://openalex.org/W4396574803","https://openalex.org/W4403243439","https://openalex.org/W4404535307","https://openalex.org/W4407819008","https://openalex.org/W4413345814","https://openalex.org/W4413768540","https://openalex.org/W4415461494","https://openalex.org/W7116967568","https://openalex.org/W7117124838","https://openalex.org/W7133495662","https://openalex.org/W7155210126","https://openalex.org/W7223469606"],"related_works":["https://openalex.org/W3032225395","https://openalex.org/W2105444747","https://openalex.org/W7217359366","https://openalex.org/W3011570262","https://openalex.org/W2518841168","https://openalex.org/W4205898092","https://openalex.org/W2058711543","https://openalex.org/W7129040807","https://openalex.org/W1533058439","https://openalex.org/W2071740662"],"abstract_inverted_index":{"ABSTRACT":[0],"Pitt-Hopkins":[1],"syndrome":[2],"(PTHS)":[3],"is":[4],"a":[5,30,69,79,134],"severe":[6],"neurodevelopmental":[7],"disorder":[8],"caused":[9],"by":[10,58,78],"haploinsufficient":[11,138],"expression":[12,21,128],"of":[13,51,64],"transcription":[14],"factor":[15],"4":[16],"(":[17],"TCF4":[18,26,53,73,127],").":[19],"Increasing":[20],"from":[22,100],"the":[23,52,101],"remaining":[24],"functional":[25],"allele":[27],"could":[28],"provide":[29],"mutation-independent":[31,135],"strategy":[32,136],"for":[33,56,71,125,137],"patients":[34],"with":[35,43,97,109],"diverse":[36],"pathogenic":[37],"variants.":[38],"We":[39],"integrated":[40],"genomic":[41],"datasets":[42],"strand-specific":[44],"RNA":[45,98,111],"analysis":[46],"to":[47],"identify":[48],"transcribed":[49,99],"regions":[50],"promoter":[54,103],"suitable":[55],"targeting":[57],"activating":[59],"double-stranded":[60],"RNAs":[61],"(dsRNAs).":[62],"Screening":[63],"overlapping":[65],"promoter-targeted":[66,118],"dsRNAs":[67,119],"identified":[68],"hotspot":[70],"increased":[72,110],"expression.":[74],"Activation":[75],"was":[76,107],"retained":[77],"lead":[80],"dsRNA":[81],"containing":[82],"extensive":[83],"2\u2032-fluoro,":[84],"2\u2032-O-methyl,":[85],"and":[86,129],"phosphorothioate":[87],"modifications":[88],"used":[89],"in":[90],"therapeutic":[91],"oligonucleotides.":[92],"Anti-AGO2":[93],"immunoprecipitation":[94],"showed":[95],"association":[96],"targeted":[102],"region.":[104],"dsRNA-mediated":[105],"activation":[106],"associated":[108],"polymerase":[112],"II":[113],"occupancy.":[114],"These":[115],"findings":[116],"establish":[117],"as":[120,133],"chemically":[121],"tractable":[122],"starting":[123],"points":[124],"increasing":[126],"support":[130],"their":[131],"investigation":[132],"disease.":[139]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-05T00:00:00"}