{"id":"https://openalex.org/W7218914280","doi":"https://doi.org/10.64898/2026.09.30.755834","title":"Contact-dependent growth inhibition drives kin discrimination and shapes in vivo strain dominance in Pseudomonas aeruginosa infection","display_name":"Contact-dependent growth inhibition drives kin discrimination and shapes in vivo strain dominance in Pseudomonas aeruginosa infection","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7218914280","doi":"https://doi.org/10.64898/2026.09.30.755834"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.30.755834","doi":"https://doi.org/10.64898/2026.09.30.755834","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755834","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755834.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755834.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5156406158","display_name":"Natasha Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Peterson","raw_affiliation_strings":["Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156781430","display_name":"Brandi Cobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi L. Cobe","raw_affiliation_strings":["Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058278909","display_name":"Adam S. Bronson","orcid":"https://orcid.org/0000-0002-6459-4157","observed_orcids":["https://orcid.org/0000-0002-6459-4157"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam S. Bronson","raw_affiliation_strings":["Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001321051","display_name":"Jonathan P. Allen","orcid":"https://orcid.org/0000-0002-5930-1524","observed_orcids":["https://orcid.org/0000-0002-5930-1524"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan P. Allen","raw_affiliation_strings":["Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA"],"raw_orcid":"https://orcid.org/0000-0002-5930-1524","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA","institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001321051"],"corresponding_institution_ids":["https://openalex.org/I1925986","https://openalex.org/I4210159390"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/contact-dependent-growth-inhibition","display_name":"contact-dependent growth inhibition","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kin-discrimination","display_name":"kin discrimination","score":0.6890000104904175},{"id":"https://openalex.org/keywords/interference-competition","display_name":"interference competition","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mixed-strain-infection","display_name":"mixed-strain infection","score":0.7279999852180481},{"id":"https://openalex.org/keywords/acute-pneumonia","display_name":"acute pneumonia","score":0.7300000190734863},{"id":"https://openalex.org/keywords/bacterial-population-dynamics","display_name":"bacterial population dynamics","score":0.6959999799728394},{"id":"https://openalex.org/keywords/self-nonself-discrimination","display_name":"self/non-self discrimination","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7846999764442444},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7649000287055969},{"id":"https://openalex.org/C151913843","wikidata":"https://www.wikidata.org/wiki/Q3454555","display_name":"Dominance (genetics)","level":3,"score":0.5713000297546387},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.558899998664856},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5019999742507935},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47099998593330383},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.46070000529289246},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.43320000171661377},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3991999924182892},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3855000138282776},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.37599998712539673},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3589000105857849},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.3467999994754791},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2969000041484833},{"id":"https://openalex.org/C132533263","wikidata":"https://www.wikidata.org/wiki/Q2347362","display_name":"Mobile genetic elements","level":4,"score":0.2953999936580658},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28130000829696655}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.30.755834","doi":"https://doi.org/10.64898/2026.09.30.755834","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755834","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755834.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.30.755834","doi":"https://doi.org/10.64898/2026.09.30.755834","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755834","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755834.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7218914280.pdf","grobid_xml":"https://content.openalex.org/works/W7218914280.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7048145171","https://openalex.org/W2941951765","https://openalex.org/W1966688540","https://openalex.org/W3011793369","https://openalex.org/W1975221762","https://openalex.org/W3003565807","https://openalex.org/W2265903773","https://openalex.org/W7116067791","https://openalex.org/W3095717246","https://openalex.org/W7154734375"],"abstract_inverted_index":{"Abstract":[0],"Pseudomonas":[1,261],"aeruginosa":[2,42,89,156,199,262],"is":[3,55,68],"a":[4,26,44,77,174,203,242,294,323],"ubiquitous":[5],"environmental":[6,19],"bacterium":[7],"and":[8,20,99,134,165,214,219,236,255,308,333],"an":[9],"opportunistic":[10],"pathogen.":[11],"Rather":[12],"than":[13],"existing":[14],"as":[15,202,322],"single":[16],"clonal":[17],"lineages,":[18],"clinical":[21],"populations":[22,225],"often":[23],"consist":[24,227],"of":[25,28,46,87,115,130,154,177,228,244,260,297],"mixture":[27],"distinct":[29],"strains":[30,86,110,153,230,259],"that":[31,182,197,209,267,282,302,319],"directly":[32,210,329],"compete":[33],"to":[34,70,82,111,253,273,288],"dominate":[35],"the":[36,63,113,127,167,233],"niche.":[37,238],"To":[38],"eliminate":[39],"rivals,":[40],"P.":[41,88,155,198],"deploys":[43],"form":[45,243],"interference":[47,184],"competition":[48,149,185,246],"termed":[49],"contact-dependent":[50,248,271],"growth":[51,249],"inhibition":[52,250],"(CDI).":[53],"CDI":[54,201,303,320],"mediated":[56],"by":[57],"CdiA,":[58],"where,":[59],"upon":[60],"cell":[61],"contact,":[62],"CdiA":[64,92,132,162],"C-terminal":[65,96],"toxin":[66,97,163],"domain":[67],"delivered":[69],"prey":[71],"cells.":[72],"Toxin-producing":[73],"cells":[74],"encode":[75,90],"for":[76,91,120,232,326],"cognate":[78,100],"CdiI":[79,101],"immunity":[80,102],"protein":[81],"prevent":[83],"self-intoxication.":[84],"Different":[85],"proteins":[93],"with":[94],"different":[95],"domains":[98,164],"proteins.":[103],"Most":[104],"studies":[105],"have":[106],"relied":[107],"on":[108,137],"engineered":[109],"investigate":[112],"mechanism":[114,208,325],"CDI.":[116],"While":[117],"extremely":[118],"useful":[119],"studying":[121],"CdiA-mediated":[122],"intoxication,":[123],"such":[124],"work":[125,317],"masks":[126],"true":[128],"diversity":[129],"wild-type":[131],"variants":[133],"their":[135],"impact":[136],"competitive":[138,168,280],"interactions":[139],"between":[140],"strains.":[141],"In":[142],"this":[143],"study,":[144],"we":[145,180,300],"systematically":[146],"investigated":[147,240],"CDI-mediated":[148,183],"using":[150,173,293],"unique":[151],"conspecific":[152],".":[157,263],"We":[158,239],"identified":[159],"several":[160],"novel":[161],"mapped":[166],"outcomes":[169],"they":[170],"govern.":[171],"Furthermore,":[172],"mouse":[175,295],"model":[176,296],"acute":[178,298],"pneumonia,":[179,299],"demonstrate":[181,266],"actively":[186,304],"occurs":[187],"during":[188,313],"mixed-strain":[189],"infections":[190],"in":[191,336],"vivo.":[192],"Together,":[193,315],"our":[194,316],"findings":[195,265],"reveal":[196],"leverages":[200],"potent,":[204],"strain-dependent":[205],"kin":[206],"discrimination":[207],"shapes":[211,309],"population":[212,331],"dynamics":[213],"strain":[215,306,327,334],"dominance":[216,307],"within":[217],"host":[218],"natural":[220],"environments.":[221,338],"Author":[222],"Summary":[223],"Bacterial":[224],"frequently":[226],"diverse":[229,258],"competing":[231],"same":[234],"resources":[235],"spatial":[237],"how":[241],"interbacterial":[245],"called":[247],"(CDI)":[251],"contributed":[252],"fitness":[254],"survival":[256],"among":[257],"Our":[264],"bacteria":[268],"deploy":[269],"these":[270],"weapons":[272],"distinguish":[274],"self":[275],"from":[276,284],"non-self,":[277],"governing":[278],"complex":[279,337],"relationships":[281],"range":[283],"aggressive":[285],"offensive":[286],"killing":[287],"specialized":[289],"defensive":[290],"protection.":[291],"Finally,":[292],"confirmed":[301],"dictates":[305],"overall":[310],"bacterial":[311],"burdens":[312],"infection.":[314],"shows":[318],"acts":[321],"vital":[324],"discrimination,":[328],"driving":[330],"structure":[332],"succession":[335]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-04T00:00:00"}
