{"id":"https://openalex.org/W7218852333","doi":"https://doi.org/10.64898/2026.09.28.26364185","title":"Spectral Analysis of the T Cell Repertoire Recovery Following Allogeneic Stem Cell Transplantation","display_name":"Spectral Analysis of the T Cell Repertoire Recovery Following Allogeneic Stem Cell Transplantation","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7218852333","doi":"https://doi.org/10.64898/2026.09.28.26364185"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.26364185","doi":"https://doi.org/10.64898/2026.09.28.26364185","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.26364185","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.28.26364185.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.28.26364185.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085875329","display_name":"Amir Ahmed Toor","orcid":"https://orcid.org/0000-0001-5317-8433","observed_orcids":["https://orcid.org/0000-0001-5317-8433"]},"institutions":[{"id":"https://openalex.org/I4210098033","display_name":"Virginia Cancer Institute","ror":"https://ror.org/00st10j60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098033"]},{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amir A. Toor","raw_affiliation_strings":["Virginia Cancer Institute and Sarah Cannon Transplant and Cellular Therapy Network"],"raw_orcid":"https://orcid.org/0000-0001-5317-8433","affiliations":[{"raw_affiliation_string":"Virginia Cancer Institute and Sarah Cannon Transplant and Cellular Therapy Network","institution_ids":["https://openalex.org/I4210098033","https://openalex.org/I4210100810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006537103","display_name":"Alejandro Marinos Velarde","orcid":"https://orcid.org/0000-0001-8179-5789","observed_orcids":["https://orcid.org/0000-0001-8179-5789"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Marinos-Velarde","raw_affiliation_strings":["University of Texas Southwestern"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047124391","display_name":"Rehan Qayyum","orcid":"https://orcid.org/0000-0003-3086-8014","observed_orcids":["https://orcid.org/0000-0003-3086-8014"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rehan Qayyum","raw_affiliation_strings":["Eastern Virginia Medical School, Old Dominion University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Virginia Medical School, Old Dominion University","institution_ids":["https://openalex.org/I156802259","https://openalex.org/I81365321"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5085875329"],"corresponding_institution_ids":["https://openalex.org/I4210098033","https://openalex.org/I4210100810"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.45089998841285706,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.7020000219345093},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/spectral-analysis","display_name":"spectral analysis","score":0.5070000290870667},{"id":"https://openalex.org/keywords/lomb-scargle-periodogram","display_name":"Lomb-Scargle periodogram","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.6769999861717224},{"id":"https://openalex.org/keywords/busulfan-conditioning","display_name":"busulfan conditioning","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6148999929428101},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5368000268936157},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4544999897480011},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.44749999046325684},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4471000134944916},{"id":"https://openalex.org/C2983668108","wikidata":"https://www.wikidata.org/wiki/Q280453","display_name":"Spectral analysis","level":3,"score":0.41429999470710754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3970000147819519},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.3628999888896942},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.359499990940094},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30820000171661377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30730000138282776},{"id":"https://openalex.org/C168110828","wikidata":"https://www.wikidata.org/wiki/Q1331626","display_name":"Spectral density","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C6260449","wikidata":"https://www.wikidata.org/wiki/Q41364","display_name":"Wavelength","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.29170000553131104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2903999984264374},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C19118579","wikidata":"https://www.wikidata.org/wiki/Q786423","display_name":"Frequency domain","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C4839761","wikidata":"https://www.wikidata.org/wiki/Q212111","display_name":"Spectral line","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C1547928","wikidata":"https://www.wikidata.org/wiki/Q1660177","display_name":"Immunogenetics","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C146599234","wikidata":"https://www.wikidata.org/wiki/Q511093","display_name":"Centroid","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.28.26364185","doi":"https://doi.org/10.64898/2026.09.28.26364185","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.26364185","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.28.26364185.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.26364185","doi":"https://doi.org/10.64898/2026.09.28.26364185","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.26364185","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/29/2026.09.28.26364185.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7218852333.pdf","grobid_xml":"https://content.openalex.org/works/W7218852333.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1974230429","https://openalex.org/W1981862374","https://openalex.org/W2004606785","https://openalex.org/W2137654247","https://openalex.org/W2295037013","https://openalex.org/W2336513938","https://openalex.org/W2949347086","https://openalex.org/W2949553672","https://openalex.org/W4384346123"],"related_works":["https://openalex.org/W7204265619","https://openalex.org/W2559182883","https://openalex.org/W1981862374","https://openalex.org/W2792803914","https://openalex.org/W2561209065","https://openalex.org/W2574086629","https://openalex.org/W2389902077","https://openalex.org/W2363314771","https://openalex.org/W2011640335","https://openalex.org/W2578222464"],"abstract_inverted_index":{"Abstract":[0],"The":[1,245],"human":[2],"T":[3,14,24,27,36,326],"cell":[4,15,25,28,37,102,133,327],"repertoire":[5,322],"is":[6],"generated":[7],"through":[8],"recombination":[9],"of":[10,13,23,116,171,296,316,325],"a":[11,20,57,114,207,256,292,321],"multitude":[12],"receptor":[16,29],"gene":[17,33,48,239],"segments,":[18,76],"yielding":[19],"complex":[21],"array":[22],"clones.":[26],"beta":[30],"(TRB)":[31],"V":[32,47,95,172,238,298],"segment":[34,49,72,240,299],"defined,":[35],"clonal":[38,96,328],"frequency":[39,164,213,266],"when":[40],"organized":[41,294],"in":[42,61,158,210,219,227,235,264,301],"correspondence":[43],"with":[44,162,196,231,272,291,304],"the":[45,52,62,66,70,74,93,138,143,159,185,189,211,220,232,236,243,251,265,276],"respective":[46,186],"positions":[50],"on":[51,275],"TRB":[53,94,297,317],"genomic":[54,67],"locus":[55],"yields":[56],"periodic,":[58],"undulating":[59],"curve":[60],"spatial":[63],"domain.":[64],"Using":[65],"distance":[68],"from":[69,98,155],"TRB-D1":[71],"to":[73,87,184,204,261,282],"TRB-V1-29":[75],"spectral":[77,89,150,166,197,257],"analysis":[78,315],"was":[79,217],"performed":[80],"utilizing":[81],"Lomb-Scargle":[82],"periodogram":[83],"(modified":[84],"Fourier":[85],"analysis)":[86],"obtain":[88],"power":[90,180,216],"curves":[91,147],"quantifying":[92],"frequencies":[97,202],"12":[99,160],"allogeneic":[100],"stem":[101,132],"transplant":[103],"donors":[104,205,254],"(baseline)":[105],"and":[106,140,206,223],"recipients":[107,178,191,270,280],"(<100":[108],"days":[109],"or":[110,127],"b/w":[111],"100-365)":[112],"using":[113,135],"variety":[115],"analytic":[117],"software.":[118],"Patients":[119],"either":[120],"underwent":[121],"HLA":[122,128],"matched":[123,129],"related":[124],"bone":[125],"marrow":[126],"unrelated":[130],"blood":[131],"transplantation,":[134],"PT-CY":[136,177,305],"for":[137,142],"former":[139],"ATG":[141,190,279],"latter.":[144],"Spectral":[145,215,313],"Power":[146],"revealed":[148],"dominant":[149],"peaks":[151],"at":[152],"wavelengths":[153,226],"ranging":[154],"113-335":[156],"millicycles/kb":[157],"donors,":[161,187],"consistent":[163,230,290],"domain":[165],"patterns,":[167],"supporting":[168],"similar":[169],"use":[170],"segments":[173],"across":[174,242],"healthy":[175,252,302],"individuals.":[176],"had":[179,192],"spectra":[181,274],"closely":[182],"corresponding":[183],"however":[188,278],"relatively":[193],"dispersed":[194],"spectra,":[195],"centroid":[198],"shifted":[199],"towards":[200,284],"higher":[201,285],"compared":[203],"reciprocal":[208],"decline":[209],"low":[212],"indices.":[214],"concentrated":[218],"<3":[221],"kb":[222,225],"3-12":[224],"both":[228],"groups,":[229],"periodicity":[233],"observed":[234],"relative":[237],"usage":[241,300],"repertoire.":[244],"analyses":[246],"reported":[247],"here":[248],"demonstrate":[249],"that":[250],"SCT":[253],"have":[255],"signature":[258],"occupying":[259],"short":[260],"intermediate":[262],"wavelegnths":[263],"domain,":[267],"PT":[268],"CY":[269],"recover":[271],"donor-like":[273],"average,":[277],"tend":[281],"shift":[283],"frequencies.":[286],"These":[287],"findings":[288],"are":[289],"normal":[293],"distribution":[295],"individuals,":[303],"preserving":[306],"this":[307],"organization":[308],"more":[309],"consistently":[310],"than":[311],"ATG.":[312],"(Fourier)":[314],"sequencing":[318],"data":[319],"provides":[320],"wide":[323],"summary":[324],"distribution.":[329]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-04T00:00:00"}
