{"id":"https://openalex.org/W7218654764","doi":"https://doi.org/10.7759/cureus.117378","title":"Evaluating the Sealing Potential of Different Materials for Perforation Repair: An In Vitro Study","display_name":"Evaluating the Sealing Potential of Different Materials for Perforation Repair: An In Vitro Study","publication_year":2026,"publication_date":"2026-10-03","ids":{"openalex":"https://openalex.org/W7218654764","doi":"https://doi.org/10.7759/cureus.117378","pmid":"https://pubmed.ncbi.nlm.nih.gov/42974152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13725315"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.117378","doi":"https://doi.org/10.7759/cureus.117378","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117378","pdf_url":"https://www.cureus.com/articles/524160-evaluating-the-sealing-potential-of-different-materials-for-perforation-repair-an-in-vitro-study.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/524160-evaluating-the-sealing-potential-of-different-materials-for-perforation-repair-an-in-vitro-study.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5156488535","display_name":"Kanupriya Kanupriya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266329","display_name":"Sri Guru Ram Das University of Health Sciences Sri Amritsar","ror":"https://ror.org/025jjtj85","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4405266329"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kanupriya Kanupriya","raw_affiliation_strings":["Department of Conservative Dentistry and Endodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Conservative Dentistry and Endodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, IND","institution_ids":["https://openalex.org/I4405266329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156496324","display_name":"Amit Choudhary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Choudhary","raw_affiliation_strings":["Department of Orthodontics and Dentofacial Orthopaedics, Maharaja Ganga Singh Dental College and Research Centre, Sri Ganganagar, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics and Dentofacial Orthopaedics, Maharaja Ganga Singh Dental College and Research Centre, Sri Ganganagar, IND","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110975837","display_name":"Shantun Malhotra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405266329","display_name":"Sri Guru Ram Das University of Health Sciences Sri Amritsar","ror":"https://ror.org/025jjtj85","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4405266329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shantun Malhotra","raw_affiliation_strings":["Department of Conservative Dentistry and Endodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Conservative Dentistry and Endodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, IND","institution_ids":["https://openalex.org/I4405266329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062723558","display_name":"Kanwalpreet Kaur Bhullar","orcid":"https://orcid.org/0000-0001-9279-4271","observed_orcids":["https://orcid.org/0000-0001-9279-4271"]},"institutions":[{"id":"https://openalex.org/I4405266329","display_name":"Sri Guru Ram Das University of Health Sciences Sri Amritsar","ror":"https://ror.org/025jjtj85","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4405266329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kanwalpreet K Bhullar","raw_affiliation_strings":["Department of Conservative Dentistry and Endodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Conservative Dentistry and Endodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, IND","institution_ids":["https://openalex.org/I4405266329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156599207","display_name":"Navchandan Kaur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Navchandan Kaur","raw_affiliation_strings":["Department of Paediatric and Preventive Dentistry, Genesis Institute of Dental Sciences and Research, Firozpur, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric and Preventive Dentistry, Genesis Institute of Dental Sciences and Research, Firozpur, IND","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5156677773","display_name":"Monica Monica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Monica","raw_affiliation_strings":["Department of Paediatric and Preventive Dentistry, Private Practitioner, Delhi, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric and Preventive Dentistry, Private Practitioner, Delhi, IND","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5156488535"],"corresponding_institution_ids":["https://openalex.org/I4405266329"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74277635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"10","first_page":"e117378","last_page":"e117378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/root-perforation-repair","display_name":"root perforation repair","score":0.8930000066757202},{"id":"https://openalex.org/keywords/microleakage","display_name":"microleakage","score":0.871999979019165},{"id":"https://openalex.org/keywords/bio-c-repair","display_name":"Bio-C Repair","score":0.7630000114440918},{"id":"https://openalex.org/keywords/guttaflow-bioseal","display_name":"GuttaFlow Bioseal","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biodentine","display_name":"Biodentine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dye-extraction","display_name":"dye extraction","score":0.42899999022483826},{"id":"https://openalex.org/keywords/root-canal-sealers","display_name":"endodontic sealers","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9319999814033508},{"id":"https://openalex.org/C2778456384","wikidata":"https://www.wikidata.org/wiki/Q1508510","display_name":"Perforation","level":3,"score":0.6306999921798706},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4194999933242798},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40290001034736633},{"id":"https://openalex.org/C2988617437","wikidata":"https://www.wikidata.org/wiki/Q6627318","display_name":"Materials testing","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2980000078678131},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.20659999549388885},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.19920000433921814},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.1776999980211258}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.117378","doi":"https://doi.org/10.7759/cureus.117378","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117378","pdf_url":"https://www.cureus.com/articles/524160-evaluating-the-sealing-potential-of-different-materials-for-perforation-repair-an-in-vitro-study.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13725315","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725315/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725315/pdf/cureus-0018-00000117378.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:42974152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42974152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.117378","doi":"https://doi.org/10.7759/cureus.117378","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117378","pdf_url":"https://www.cureus.com/articles/524160-evaluating-the-sealing-potential-of-different-materials-for-perforation-repair-an-in-vitro-study.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7218654764.pdf","grobid_xml":"https://content.openalex.org/works/W7218654764.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1968292144","https://openalex.org/W1971376554","https://openalex.org/W1985873686","https://openalex.org/W2021336798","https://openalex.org/W2028942458","https://openalex.org/W2058794599","https://openalex.org/W2076996921","https://openalex.org/W2101680227","https://openalex.org/W2129738559","https://openalex.org/W2131889267","https://openalex.org/W2325078025","https://openalex.org/W2597792379","https://openalex.org/W2745422335","https://openalex.org/W2756241051","https://openalex.org/W2761366612","https://openalex.org/W2954042082","https://openalex.org/W2969226372","https://openalex.org/W2981954593","https://openalex.org/W2993120621","https://openalex.org/W3043701485","https://openalex.org/W3109611508","https://openalex.org/W4377246903","https://openalex.org/W4387156906","https://openalex.org/W4388091446","https://openalex.org/W4409297850","https://openalex.org/W4410883566"],"related_works":["https://openalex.org/W7215121759","https://openalex.org/W7171779938","https://openalex.org/W4226343511","https://openalex.org/W3024845193","https://openalex.org/W4414554397","https://openalex.org/W2054693081","https://openalex.org/W4231291557","https://openalex.org/W7166774084","https://openalex.org/W3088870123","https://openalex.org/W2960390886"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Root":[1,107],"perforations":[2,116],"pose":[3],"a":[4],"significant":[5,87,187],"challenge":[6],"in":[7,22,71,74,89,97,119,189,235],"endodontic":[8],"treatment,":[9],"necessitating":[10],"effective":[11,247],"sealing":[12],"materials":[13,24,48,239],"to":[14,27],"prevent":[15],"microleakage":[16,73,90,153,190],"and":[17,37,55,114,144,147,159,173,210,225],"ensure":[18],"long-term":[19],"success.":[20],"Advances":[21],"biocompatible":[23],"have":[25],"led":[26],"the":[28,44,62,92,120,155,174,194,197,203,229],"introduction":[29],"of":[30,46,133,171,233],"various":[31],"repair":[32,219],"options,":[33],"including":[34,137],"injectable":[35,47,217],"bioceramics":[36],"conventional":[38,63,230],"powder-liquid":[39,64],"systems.":[40],"This":[41],"study":[42,99],"compared":[43],"performance":[45],"(Bio-C":[49],"Repair,":[50,143],"Angelus,":[51],"Londrina,":[52],"Paran\u00e1,":[53],"Brazil;":[54],"Guttaflow":[56,145,208,226],"Bioseal,":[57,227],"Colt\u00e8ne/Whaledent,":[58],"Langenau,":[59],"Germany)":[60],"with":[61,179],"system":[65,232],"(Biodentine,":[66,141],"Septodont":[67],"S.A.S.,":[68],"Saint-Maur-des-Foss\u00e9s,":[69],"France)":[70],"minimizing":[72,236],"strip":[75,115],"perforation":[76],"repairs.":[77],"The":[78,126,213],"null":[79],"hypothesis":[80],"stated":[81],"that":[82,216],"there":[83],"would":[84],"be":[85],"no":[86],"difference":[88],"among":[91,193],"tested":[93],"materials.":[94],"METHODS:":[95],"An":[96],"vitro":[98],"was":[100,167],"conducted":[101],"using":[102,111,123,154,169],"50":[103],"extracted":[104],"human":[105],"molars.":[106],"canals":[108],"were":[109,117,128,191],"prepared":[110],"rotary":[112],"files,":[113],"created":[118],"mesiobuccal":[121],"canal":[122],"Gates-Glidden":[124],"drills.":[125],"teeth":[127],"divided":[129],"into":[130],"five":[131],"groups":[132,140],"10":[134],"samples":[135],"each,":[136],"three":[138],"experimental":[139,198],"Bio-C":[142,200,223],"Bioseal)":[146],"two":[148],"control":[149],"groups.":[150,195],"We":[151],"assessed":[152],"dye":[156],"extraction":[157],"method":[158],"Ultraviolet-Visible":[160],"spectrophotometry":[161],"at":[162],"550":[163],"nm.":[164],"Statistical":[165],"analysis":[166,170],"performed":[168],"variance":[172],"Tukey":[175],"post":[176],"hoc":[177],"test,":[178],"p":[180],"<":[181],"0.05":[182],"considered":[183],"significant.":[184],"RESULTS:":[185],"Statistically":[186],"differences":[188],"observed":[192],"Among":[196],"groups,":[199],"Repair":[201,224],"exhibited":[202],"least":[204],"microleakage,":[205],"followed":[206],"by":[207],"Bioseal":[209],"Biodentine.":[211],"CONCLUSION:":[212],"findings":[214],"indicate":[215],"root":[218,248],"materials,":[220],"such":[221],"as":[222],"outperform":[228],"powder-and-liquid":[231],"Biodentine":[234],"microleakage.":[237],"These":[238],"present":[240],"potential":[241],"advantages":[242],"for":[243],"clinical":[244],"applications":[245],"requiring":[246],"repair.":[249]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-04T00:00:00"}
