{"id":"https://openalex.org/W7218452202","doi":"https://doi.org/10.64898/2026.09.28.755031","title":"Cellular Density Homeostasis Is Governed by an Anisotropic Attractor and Predictive Feedback Control","display_name":"Cellular Density Homeostasis Is Governed by an Anisotropic Attractor and Predictive Feedback Control","publication_year":2026,"publication_date":"2026-10-03","ids":{"openalex":"https://openalex.org/W7218452202","doi":"https://doi.org/10.64898/2026.09.28.755031","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856431","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648594"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.755031","doi":"https://doi.org/10.64898/2026.09.28.755031","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755031","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/03/2026.09.28.755031.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/03/2026.09.28.755031.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010590929","display_name":"V\u00edctor Alcolea-Rodriguez","orcid":"https://orcid.org/0000-0002-2392-0817","observed_orcids":["https://orcid.org/0000-0002-2392-0817"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210134310","display_name":"Istituto di Fotonica e Nanotecnologie","ror":"https://ror.org/049ebw417","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210134310","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Victor Alcolea-Rodriguez","raw_affiliation_strings":["Johns Hopkins University; CNR-Institute for Photonics and Nanotechnologies (CNR-IFN); Physics Department, Politecnico di Milano;"],"raw_orcid":"https://orcid.org/0000-0002-2392-0817","affiliations":[{"raw_affiliation_string":"Johns Hopkins University; CNR-Institute for Photonics and Nanotechnologies (CNR-IFN); Physics Department, Politecnico di Milano;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210134310","https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091331095","display_name":"Abhya Gupta","orcid":"https://orcid.org/0009-0002-5409-1561","observed_orcids":["https://orcid.org/0009-0002-5409-1561"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anoushka Gupta","raw_affiliation_strings":["Johns Hopkins University;"],"raw_orcid":"https://orcid.org/0009-0002-5409-1561","affiliations":[{"raw_affiliation_string":"Johns Hopkins University;","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059992631","display_name":"Michael Ka Ho Lee","orcid":"https://orcid.org/0009-0005-3557-2062","observed_orcids":["https://orcid.org/0009-0005-3557-2062"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Ka Ho Lee","raw_affiliation_strings":["Johns Hopkins University;"],"raw_orcid":"https://orcid.org/0009-0005-3557-2062","affiliations":[{"raw_affiliation_string":"Johns Hopkins University;","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039440957","display_name":"Dario Polli","orcid":"https://orcid.org/0000-0002-6960-5708","observed_orcids":["https://orcid.org/0000-0002-6960-5708"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario Polli","raw_affiliation_strings":["CNR-Institute for Photonics and Nanotechnologies (CNR-IFN); Physics Department, Politecnico di Milano"],"raw_orcid":"https://orcid.org/0000-0002-6960-5708","affiliations":[{"raw_affiliation_string":"CNR-Institute for Photonics and Nanotechnologies (CNR-IFN); Physics Department, Politecnico di Milano","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075259650","display_name":"Renzo Vanna","orcid":"https://orcid.org/0000-0001-6218-8393","observed_orcids":["https://orcid.org/0000-0001-6218-8393"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renzo Vanna","raw_affiliation_strings":["CNR-Institute for Photonics and Nanotechnologies (CNR-IFN); Physics Department, Politecnico di Milano"],"raw_orcid":"https://orcid.org/0000-0001-6218-8393","affiliations":[{"raw_affiliation_string":"CNR-Institute for Photonics and Nanotechnologies (CNR-IFN); Physics Department, Politecnico di Milano","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085631728","display_name":"Ishan Barman","orcid":"https://orcid.org/0000-0003-0800-0825","observed_orcids":["https://orcid.org/0000-0003-0800-0825"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ishan Barman","raw_affiliation_strings":["Johns Hopkins University;"],"raw_orcid":"https://orcid.org/0000-0003-0800-0825","affiliations":[{"raw_affiliation_string":"Johns Hopkins University;","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085631728"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14299","display_name":"Complex Systems and Dynamics","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11520","display_name":"Advanced Thermodynamics and Statistical Mechanics","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optimal-transport","display_name":"optimal transport","score":0.699999988079071},{"id":"https://openalex.org/keywords/biomass-accumulation","display_name":"biomass accumulation","score":0.597000002861023},{"id":"https://openalex.org/keywords/cell-volume-expansion","display_name":"cell volume expansion","score":0.8040000200271606},{"id":"https://openalex.org/keywords/information-theory","display_name":"information theory","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cell-volume-regulation","display_name":"cell volume regulation","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C164380108","wikidata":"https://www.wikidata.org/wiki/Q507187","display_name":"Attractor","level":2,"score":0.8070999979972839},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5224999785423279},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4943000078201294},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4357999861240387},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41920000314712524},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3919000029563904},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3763999938964844},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.35249999165534973},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C2984801823","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Living cell","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C85725439","wikidata":"https://www.wikidata.org/wiki/Q466686","display_name":"Anisotropy","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.31790000200271606},{"id":"https://openalex.org/C2776184637","wikidata":"https://www.wikidata.org/wiki/Q6506039","display_name":"Living systems","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C189950617","wikidata":"https://www.wikidata.org/wiki/Q937228","display_name":"Property (philosophy)","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C33962884","wikidata":"https://www.wikidata.org/wiki/Q378637","display_name":"Dynamical system (definition)","level":3,"score":0.27219998836517334},{"id":"https://openalex.org/C198082294","wikidata":"https://www.wikidata.org/wiki/Q3399648","display_name":"Position (finance)","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2778179450","wikidata":"https://www.wikidata.org/wiki/Q17146472","display_name":"Intermittent control","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C72434380","wikidata":"https://www.wikidata.org/wiki/Q230930","display_name":"State space","level":2,"score":0.2540000081062317}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.28.755031","doi":"https://doi.org/10.64898/2026.09.28.755031","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755031","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/03/2026.09.28.755031.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648594","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648594/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.755031","doi":"https://doi.org/10.64898/2026.09.28.755031","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.755031","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/03/2026.09.28.755031.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7218452202.pdf","grobid_xml":"https://content.openalex.org/works/W7218452202.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2181523240","https://openalex.org/W3159456488"],"related_works":["https://openalex.org/W4409803038","https://openalex.org/W4413756059","https://openalex.org/W4304687606","https://openalex.org/W1979659894","https://openalex.org/W2081432751","https://openalex.org/W4393115697","https://openalex.org/W4224981598","https://openalex.org/W4316829820","https://openalex.org/W3163345704","https://openalex.org/W2419315653"],"abstract_inverted_index":{"Cell":[0],"density":[1,15,30,103,125],"is":[2],"a":[3,44],"fundamental":[4],"biophysical":[5],"property":[6],"of":[7,75,117,151],"living":[8],"cells,":[9],"yet":[10],"the":[11,22,148],"dynamical":[12,130],"architecture":[13],"underlying":[14],"homeostasis":[16,126],"remains":[17],"unknown.":[18],"Here,":[19],"we":[20],"reconstruct":[21],"geometry,":[23],"dynamics,":[24],"and":[25,91,133,140],"control":[26,79,100,131],"structure":[27],"governing":[28],"cellular":[29,118,124],"regulation":[31],"from":[32,39],"single-cell":[33],"mass-volume":[34,49],"measurements":[35],"acquired":[36],"during":[37],"recovery":[38,67],"osmotic":[40],"perturbation.":[41],"We":[42],"identify":[43],"persistent":[45],"anisotropic":[46],"attractor":[47,136],"in":[48,88],"state":[50],"space":[51],"that":[52,94],"permits":[53],"coordinated":[54,86],"density-preserving":[55],"fluctuations":[56],"while":[57],"strongly":[58],"suppressing":[59],"density-changing":[60],"deviations.":[61],"Optimal":[62],"transport":[63],"analysis":[64],"reveals":[65],"directed":[66],"trajectories":[68],"confined":[69],"to":[70,146],"this":[71],"attractor,":[72],"enabling":[73],"inference":[74],"an":[76,97,114,128],"effective":[77,98],"density-restoring":[78,99],"law.":[80,101],"Density":[81],"deviations":[82],"are":[83],"associated":[84],"with":[85],"changes":[87],"biomass":[89],"accumulation":[90],"volume":[92],"expansion":[93],"together":[95],"generate":[96],"Moreover,":[102],"error":[104],"contains":[105],"significant":[106],"predictive":[107],"information":[108,141],"regarding":[109],"future":[110],"corrective":[111],"behavior,":[112],"revealing":[113],"information-rich":[115],"component":[116],"regulation.":[119],"Together,":[120],"these":[121],"findings":[122],"establish":[123],"as":[127],"emergent":[129],"process":[132],"demonstrate":[134],"how":[135],"reconstruction,":[137],"optimal":[138],"transport,":[139],"theory":[142],"can":[143],"be":[144],"combined":[145],"uncover":[147],"organizing":[149],"principles":[150],"biological":[152],"homeostasis.":[153]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-04T00:00:00"}