{"id":"https://openalex.org/W7218154497","doi":null,"title":"MODERN TRENDS IN PHARMACEUTICAL ANALYSIS: INTEGRATION OF HPLC, UPLC, UV, AND SEC-MALLS FOR DRUG PRODUCT EVALUATION","display_name":"MODERN TRENDS IN PHARMACEUTICAL ANALYSIS: INTEGRATION OF HPLC, UPLC, UV, AND SEC-MALLS FOR DRUG PRODUCT EVALUATION","publication_year":2026,"publication_date":"2026-05-31","ids":{"openalex":"https://openalex.org/W7218154497"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.uniquepubinternational.com:article/218","doi":null,"is_oa":true,"landing_page_url":"https://uniquepubinternational.com/journals/index.php/jcls/article/view/218","pdf_url":"https://uniquepubinternational.com/journals/index.php/jcls/article/download/218/203","source":{"id":"https://openalex.org/S7407059277","display_name":"UPI Journal of Chemical and Life Sciences","issn_l":"2581-4648","issn":["2581-4648"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2581-4648","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://uniquepubinternational.com/journals/index.php/jcls/article/download/218/203","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138246236","display_name":"Venkatanarayana Bypaneni","orcid":"https://orcid.org/0000-0002-8933-8117","observed_orcids":["https://orcid.org/0000-0002-8933-8117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bypaneni, Venkatanarayana","raw_affiliation_strings":["Senior Scientist, Department of Analytical Research and Development, Stira Pharmaceuticals, LLC, 161, Dwight Place, Fairfield, NJ 07004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Scientist, Department of Analytical Research and Development, Stira Pharmaceuticals, LLC, 161, Dwight Place, Fairfield, NJ 07004, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016684482","display_name":"Jayaram Kamma","orcid":"https://orcid.org/0009-0001-5266-6969","observed_orcids":["https://orcid.org/0009-0001-5266-6969"]},"institutions":[{"id":"https://openalex.org/I4210121222","display_name":"Lupin Pharmaceuticals (United States)","ror":"https://ror.org/01wxsyf11","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121222"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamma, Jayaram","raw_affiliation_strings":["Senior Manager,Analytical Research and Development,Lupin Pharmaceuticals, 400 Campus Dr., Somerset, NJ, 08873-1145, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Manager,Analytical Research and Development,Lupin Pharmaceuticals, 400 Campus Dr., Somerset, NJ, 08873-1145, USA","institution_ids":["https://openalex.org/I4210121222"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042746673","display_name":"Murugesan Palanivelu","orcid":"https://orcid.org/0009-0007-6661-993X","observed_orcids":["https://orcid.org/0009-0007-6661-993X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murugesan, Palanivelu","raw_affiliation_strings":["Associate Director, Analytical R&D, Carnegie Pharmaceuticals LLC, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Director, Analytical R&D, Carnegie Pharmaceuticals LLC, New Jersey, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-quantification","display_name":"pharmaceutical analysis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/high-performance-liquid-chromatography","display_name":"HPLC","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ultra-high-performance-liquid-chromatography","display_name":"UPLC","score":0.9950000047683716},{"id":"https://openalex.org/keywords/uv-vis-spectroscopy","display_name":"UV-Vis spectroscopy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/impurity-profiling","display_name":"impurity profiling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dissolution-testing","display_name":"dissolution testing","score":0.7139999866485596},{"id":"https://openalex.org/keywords/molecular-weight-determination","display_name":"molecular weight determination","score":0.7329999804496765},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8429999947547913},{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.7839999794960022},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.7900000214576721},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/online-process-monitoring","display_name":"real-time process monitoring","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C2779652045","wikidata":"https://www.wikidata.org/wiki/Q507443","display_name":"Pharmaceutical industry","level":2,"score":0.6100000143051147},{"id":"https://openalex.org/C178144697","wikidata":"https://www.wikidata.org/wiki/Q2111609","display_name":"Process analytical technology","level":3,"score":0.5907999873161316},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.5501999855041504},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5339999794960022},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.5320000052452087},{"id":"https://openalex.org/C2779535233","wikidata":"https://www.wikidata.org/wiki/Q12140","display_name":"Pharmaceutical drug","level":3,"score":0.5311999917030334},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.49300000071525574},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4810999929904938},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.4309999942779541},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4300999939441681},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.4253000020980835},{"id":"https://openalex.org/C2778938233","wikidata":"https://www.wikidata.org/wiki/Q7180757","display_name":"Pharmaceutical manufacturing","level":2,"score":0.41429999470710754},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.3959999978542328},{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.39579999446868896},{"id":"https://openalex.org/C2781047461","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutical","level":2,"score":0.3781000077724457},{"id":"https://openalex.org/C2780449318","wikidata":"https://www.wikidata.org/wiki/Q18344773","display_name":"Critical quality attributes","level":3,"score":0.37700000405311584},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3736000061035156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3700999915599823},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.357699990272522},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3481999933719635},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3422999978065491},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33309999108314514},{"id":"https://openalex.org/C170814935","wikidata":"https://www.wikidata.org/wiki/Q4751159","display_name":"Analytical technique","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.31630000472068787},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.31520000100135803},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.3027999997138977},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2824999988079071},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.259799987077713},{"id":"https://openalex.org/C2988729646","wikidata":"https://www.wikidata.org/wiki/Q838129","display_name":"Process development","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ojs2.uniquepubinternational.com:article/218","doi":null,"is_oa":true,"landing_page_url":"https://uniquepubinternational.com/journals/index.php/jcls/article/view/218","pdf_url":"https://uniquepubinternational.com/journals/index.php/jcls/article/download/218/203","source":{"id":"https://openalex.org/S7407059277","display_name":"UPI Journal of Chemical and Life Sciences","issn_l":"2581-4648","issn":["2581-4648"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2581-4648","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ojs2.uniquepubinternational.com:article/218","doi":null,"is_oa":true,"landing_page_url":"https://uniquepubinternational.com/journals/index.php/jcls/article/view/218","pdf_url":"https://uniquepubinternational.com/journals/index.php/jcls/article/download/218/203","source":{"id":"https://openalex.org/S7407059277","display_name":"UPI Journal of Chemical and Life Sciences","issn_l":"2581-4648","issn":["2581-4648"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2581-4648","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7218154497.pdf","grobid_xml":"https://content.openalex.org/works/W7218154497.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W7160529875","https://openalex.org/W7160612466"],"related_works":["https://openalex.org/W770321066","https://openalex.org/W7101440936","https://openalex.org/W7133868719","https://openalex.org/W4410457227","https://openalex.org/W7162770512","https://openalex.org/W4382561201","https://openalex.org/W2745180803","https://openalex.org/W2884546245","https://openalex.org/W7163359781","https://openalex.org/W7165146240"],"abstract_inverted_index":{"Modern":[0],"pharmaceutical":[1,58,78,91,147,157,180,193],"analysis":[2],"increasingly":[3],"relies":[4],"on":[5,125,186],"advanced":[6,119],"multidimensional":[7,137],"analytical":[8,48,131,135,159,188,191],"techniques":[9,132],"for":[10,66],"comprehensive":[11],"characterization":[12,110,138],"of":[13,51,90,111,129,171],"drug":[14,16,120],"substances,":[15],"products,":[17],"biopharmaceuticals,":[18],"and":[19,32,56,61,77,86,108,118,142,168,176,200,214],"nanomedicine":[20],"formulations.":[21,148],"High-Performance":[22],"Liquid":[23,27],"Chromatography":[24,28,35],"(HPLC),":[25],"Ultra-Performance":[26],"(UPLC),":[29],"UV-visible":[30,82,174],"spectroscopy,":[31,175],"Size":[33],"Exclusion":[34],"coupled":[36],"with":[37],"Multi-Angle":[38],"Laser":[39],"Light":[40],"Scattering":[41],"(SEC-MALLS)":[42],"have":[43],"emerged":[44],"as":[45],"highly":[46],"powerful":[47],"platforms":[49],"because":[50],"their":[52],"sensitivity,":[53],"selectivity,":[54],"reproducibility,":[55],"broad":[57],"applicability.":[59],"HPLC":[60],"UPLC":[62],"are":[63,218],"extensively":[64],"utilized":[65],"assay":[67],"determination,":[68,103],"impurity":[69,140],"profiling,":[70,105],"dissolution":[71],"testing,":[72],"degradation":[73],"studies,":[74],"stability-indicating":[75],"analysis,":[76,107],"quality":[79,194,202],"control,":[80],"while":[81],"spectroscopy":[83],"provides":[84],"rapid":[85],"economical":[87],"quantitative":[88],"estimation":[89],"compounds":[92],"containing":[93],"chromophoric":[94],"functional":[95],"groups.":[96],"SEC-MALLS":[97,177],"additionally":[98],"enables":[99],"absolute":[100],"molecular":[101],"weight":[102],"aggregation":[104],"conformational":[106],"structural":[109,143],"proteins,":[112],"monoclonal":[113],"antibodies,":[114],"biosimilars,":[115],"nanoparticles,":[116],"liposomes,":[117],"delivery":[121],"systems":[122],"without":[123],"dependence":[124],"calibration":[126],"standards.":[127],"Integration":[128],"orthogonal":[130],"significantly":[133],"improves":[134],"reliability,":[136],"capability,":[139],"identification,":[141],"elucidation":[144],"in":[145,178],"complex":[146],"The":[149],"present":[150],"review":[151],"comprehensively":[152],"discusses":[153],"the":[154],"principles,":[155],"instrumentation,":[156],"applications,":[158,199],"advantages,":[160],"method":[161],"development":[162],"strategies,":[163],"validation":[164],"requirements,":[165],"regulatory":[166,201],"significance,":[167],"future":[169],"perspectives":[170],"HPLC,":[172],"UPLC,":[173],"modern":[179],"analysis.":[181],"Particular":[182],"emphasis":[183],"is":[184],"placed":[185],"multidetector":[187,210],"systems,":[189],"integrated":[190],"workflows,":[192],"assessment,":[195],"biosimilar":[196],"evaluation,":[197],"nanotechnology":[198],"control.":[203],"Emerging":[204],"advancements":[205],"involving":[206],"AI-assisted":[207],"analytics,":[208],"automated":[209],"platforms,":[211],"high-resolution":[212],"chromatography,":[213],"real-time":[215],"process":[216],"monitoring":[217],"also":[219],"highlighted.":[220]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}
