{"id":"https://openalex.org/W7217822007","doi":null,"title":"CARDIOVASCULAR RISK IN TIRZEPATIDE MANAGEMENT FOR OBESITY IN TYPE 2 DIABETES PATIENTS: A SYSTEMATIC REVIEW","display_name":"CARDIOVASCULAR RISK IN TIRZEPATIDE MANAGEMENT FOR OBESITY IN TYPE 2 DIABETES PATIENTS: A SYSTEMATIC REVIEW","publication_year":2025,"publication_date":"2025-08-13","ids":{"openalex":"https://openalex.org/W7217822007"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.10n.324.mytemp.website:article/485","doi":null,"is_oa":true,"landing_page_url":"https://tpmap.org/submission/index.php/tpm/article/view/485","pdf_url":"https://tpmap.org/submission/index.php/tpm/article/download/485/360","source":{"id":"https://openalex.org/S4393917997","display_name":"TPM Testing, psychometrics, methodology in applied psychology","issn_l":"1972-6325","issn":["1972-6325"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-d","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6325","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://tpmap.org/submission/index.php/tpm/article/download/485/360","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5154897844","display_name":"MOHAMMED SAAD ALNAWMASI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALNAWMASI, MOHAMMED SAAD","raw_affiliation_strings":["SENIOR REGISTRAR FAMILY MEDICINE, PUBLIC HEALTH DEPARTMENT, TABUK HEALTH CLUSTER, SAUDI ARABIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SENIOR REGISTRAR FAMILY MEDICINE, PUBLIC HEALTH DEPARTMENT, TABUK HEALTH CLUSTER, SAUDI ARABIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117600284","display_name":"Wasan Suwailem Albalawi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALBALAWI, WASAN SUWAILEM","raw_affiliation_strings":["SENIOR REGISTRAR FAMILY MEDICINE, FAMILY MEDICINE DEPARTMENT, KING SALMAN ARMED FORCES HOSPITAL, TABUK, SAUDI ARABIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SENIOR REGISTRAR FAMILY MEDICINE, FAMILY MEDICINE DEPARTMENT, KING SALMAN ARMED FORCES HOSPITAL, TABUK, SAUDI ARABIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116102082","display_name":"Manar yahya Hayyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HAYYAN, MANAR YAHYA","raw_affiliation_strings":["SENIOR REGISTRAR FAMILY MEDICINE, FAMILY MEDICINE DEPARTMENT, KING SALMAN ARMED FORCES HOSPITAL, TABUK, SAUDI ARABIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SENIOR REGISTRAR FAMILY MEDICINE, FAMILY MEDICINE DEPARTMENT, KING SALMAN ARMED FORCES HOSPITAL, TABUK, SAUDI ARABIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155516585","display_name":"MAHA SALEEM SALEM ALHARBI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALHARBI, MAHA SALEEM SALEM","raw_affiliation_strings":["FAMILY MEDICINE RESIDENT, AL\u2011HAMRA PRIMARY HEALTHCARE CENTER, TABUK HEALTH CLUSTER, SAUDI ARABIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FAMILY MEDICINE RESIDENT, AL\u2011HAMRA PRIMARY HEALTHCARE CENTER, TABUK HEALTH CLUSTER, SAUDI ARABIA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5155631102","display_name":"MOHAMMED ABDULHAFITH RIBI ALOTAIBI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RIBI ALOTAIBI, MOHAMMED ABDULHAFITH","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirzepatide","display_name":"tirzepatide","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9430000185966492},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.9679999947547913},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.9950000047683716},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6899999976158142},{"id":"https://openalex.org/keywords/gip-glp-1-receptor-agonist","display_name":"GIP/GLP-1 receptor agonist","score":0.8040000200271606},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.871999979019165},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9075999855995178},{"id":"https://openalex.org/C2780739214","wikidata":"https://www.wikidata.org/wiki/Q6723023","display_name":"Mace","level":4,"score":0.7437000274658203},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7436000108718872},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6985999941825867},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6019999980926514},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5968999862670898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5577999949455261},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48500001430511475},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.41600000858306885},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.40380001068115234},{"id":"https://openalex.org/C2779952866","wikidata":"https://www.wikidata.org/wiki/Q6746705","display_name":"Management of obesity","level":4,"score":0.35089999437332153},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.3377000093460083},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C3017894415","wikidata":"https://www.wikidata.org/wiki/Q7979883","display_name":"Weight change","level":4,"score":0.3239000141620636},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.29440000653266907},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2896000146865845},{"id":"https://openalex.org/C3018127138","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Cardiovascular event","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C34320749","wikidata":"https://www.wikidata.org/wiki/Q17087302","display_name":"Weight management","level":4,"score":0.2825999855995178},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C2781223611","wikidata":"https://www.wikidata.org/wiki/Q357496","display_name":"Obesity paradox","level":4,"score":0.26919999718666077},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.265500009059906},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2547000050544739}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ojs2.10n.324.mytemp.website:article/485","doi":null,"is_oa":true,"landing_page_url":"https://tpmap.org/submission/index.php/tpm/article/view/485","pdf_url":"https://tpmap.org/submission/index.php/tpm/article/download/485/360","source":{"id":"https://openalex.org/S4393917997","display_name":"TPM Testing, psychometrics, methodology in applied psychology","issn_l":"1972-6325","issn":["1972-6325"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-d","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6325","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ojs2.10n.324.mytemp.website:article/485","doi":null,"is_oa":true,"landing_page_url":"https://tpmap.org/submission/index.php/tpm/article/view/485","pdf_url":"https://tpmap.org/submission/index.php/tpm/article/download/485/360","source":{"id":"https://openalex.org/S4393917997","display_name":"TPM Testing, psychometrics, methodology in applied psychology","issn_l":"1972-6325","issn":["1972-6325"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-d","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6325","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7217822007.pdf","grobid_xml":"https://content.openalex.org/works/W7217822007.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2061044005","https://openalex.org/W2146264128","https://openalex.org/W2307508267","https://openalex.org/W2425644022","https://openalex.org/W2519510391","https://openalex.org/W2542456927","https://openalex.org/W2737611067","https://openalex.org/W2748400555","https://openalex.org/W2915948028","https://openalex.org/W3049003652","https://openalex.org/W3157780595","https://openalex.org/W3177122952","https://openalex.org/W3205201678","https://openalex.org/W4386154055","https://openalex.org/W4388592674","https://openalex.org/W4401836390","https://openalex.org/W4403213875","https://openalex.org/W4404437149","https://openalex.org/W4404448817","https://openalex.org/W4404479815"],"related_works":["https://openalex.org/W7171511742","https://openalex.org/W4392244988","https://openalex.org/W7164932658","https://openalex.org/W7168131347","https://openalex.org/W7220693644","https://openalex.org/W4411592344","https://openalex.org/W4415811023","https://openalex.org/W7161170026","https://openalex.org/W7167645336","https://openalex.org/W7213511092"],"abstract_inverted_index":{"Background:":[0],"Obesity":[1],"and":[2,14,23,36,55,74,91,99,116,126,137,159,181,195,209,220,228,237],"type":[3],"2":[4,136],"diabetes":[5],"(T2D)":[6],"are":[7],"major":[8,106],"contributors":[9],"to":[10,40,231],"cardiovascular":[11,66,108],"(CV)":[12],"morbidity":[13],"mortality.":[15],"Tirzepatide,":[16],"a":[17,82],"dual":[18],"glucose-dependent":[19],"insulinotropic":[20],"polypeptide":[21],"(GIP)":[22],"glucagon-like":[24],"peptide-1":[25],"(GLP-1)":[26],"receptor":[27,43],"agonist,":[28],"has":[29],"shown":[30],"superior":[31,196],"efficacy":[32,197],"in":[33,51,70,119,170,205,218,233,248],"glycemic":[34,226],"control":[35,227],"weight":[37,229],"loss":[38,166,230],"compared":[39],"selective":[41],"GLP-1":[42,199],"agonists.":[44],"However,":[45],"its":[46,246],"impact":[47],"on":[48],"CV":[49,103,148,160,216,249],"risk":[50,217,250],"patients":[52,71],"with":[53,72,121,222],"obesity":[54,73,122,219],"T2D":[56],"remains":[57],"incompletely":[58],"synthesized.":[59],"Objective:":[60],"This":[61],"systematic":[62],"review":[63],"evaluates":[64],"the":[65],"effects":[67],"of":[68,88,129],"tirzepatide":[69],"T2D.":[75,127],"Methods:":[76],"Following":[77],"PRISMA":[78],"guidelines,":[79],"we":[80],"conducted":[81],"comprehensive":[83],"search":[84],"across":[85],"PubMed,":[86],"Web":[87],"Science,":[89],"Scopus,":[90],"Embase.":[92],"Eligible":[93],"studies":[94,142,187,202],"included":[95],"RCTs,":[96],"cohort":[97],"studies,":[98],"post-hoc":[100],"analyses":[101],"assessing":[102],"outcomes":[104],"(e.g.,":[105,241],"adverse":[107],"events":[109],"[MACE],":[110],"heart":[111],"failure":[112],"[HF]":[113],"hospitalization,":[114],"mortality,":[115],"biomarker":[117],"changes)":[118],"adults":[120],"(BMI":[123],"\u226530":[124],"kg/m\u00b2)":[125],"Risk":[128],"bias":[130],"was":[131],"assessed":[132],"using":[133],"Cochrane":[134],"RoB":[135],"Newcastle-Ottawa":[138],"Scale.":[139],"Results:":[140],"Nineteen":[141],"were":[143],"included.":[144],"Tirzepatide":[145,213],"demonstrated":[146],"significant":[147],"benefits,":[149],"including":[150],"reduced":[151],"MACE":[152],"(HR":[153,157,163,193],"0.44\u20130.60),":[154],"HF":[155,162],"hospitalization":[156],"0.54),":[158],"death/worsening":[161],"0.62).":[164],"Weight":[165],"(12\u201323.4%)":[167],"mediated":[168],"improvements":[169,232],"left":[171],"ventricular":[172],"mass":[173],"(-11":[174],"g),":[175],"6-minute":[176],"walk":[177],"distance":[178],"(+18.3":[179],"m),":[180],"inflammatory":[182],"markers":[183],"(\u2193hsCRP,":[184],"\u2193NT-proBNP).":[185],"Real-world":[186],"reported":[188],"lower":[189],"limb":[190],"event":[191],"risks":[192],"0.44)":[194],"versus":[198],"RAs.":[200],"Mechanistic":[201],"highlighted":[203],"reductions":[204],"atherogenic":[206],"lipoproteins":[207],"(\u2193apoC-III)":[208],"cardiac":[210,234],"fibrosis.":[211],"Conclusion:":[212],"significantly":[214],"reduces":[215],"T2D,":[221],"benefits":[223],"extending":[224],"beyond":[225],"structure,":[235],"atherosclerosis,":[236],"inflammation.":[238],"Ongoing":[239],"trials":[240],"SURPASS-CVOT)":[242],"will":[243],"further":[244],"clarify":[245],"role":[247],"management.":[251]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}