{"id":"https://openalex.org/W7217741014","doi":null,"title":"ANALISIS KADAR PROTEIN NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN-1 (NRAMP-1) BERDASARKAN TINGKAT KEPARAHAN, KOMORBID DAN KEMATIAN PADA PENDERITA COVID-19","display_name":"ANALISIS KADAR PROTEIN NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN-1 (NRAMP-1) BERDASARKAN TINGKAT KEPARAHAN, KOMORBID DAN KEMATIAN PADA PENDERITA COVID-19","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W7217741014"},"language":"id","primary_location":{"id":"pmh:oai:repository.unhas.ac.id:38541","doi":null,"is_oa":true,"landing_page_url":"http://repository.unhas.ac.id/id/eprint/38541/","pdf_url":"https://repository.unhas.ac.id/id/eprint/38541/2/C095191001_tesis_01-12-2023%201-2.pdf","source":{"id":"https://openalex.org/S4406922391","display_name":"Hasanuddin University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.unhas.ac.id/id/eprint/38541/2/C095191001_tesis_01-12-2023%201-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153600900","display_name":"Ressy Dwiyanti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dwiyanti, Ressy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5153600900"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8790000081062317},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7419999837875366},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9449999928474426},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.597000002861023},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.4659999907016754},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.7200000286102295},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.5789999961853027},{"id":"https://openalex.org/keywords/medico-legal-evidence","display_name":"medico-legal evidence","score":0.5690000057220459},{"id":"https://openalex.org/keywords/elisa-quantification","display_name":"ELISA quantification","score":0.5450000166893005},{"id":"https://openalex.org/keywords/sars-cov-2-rt-pcr","display_name":"SARS-CoV-2 RT-PCR","score":0.46700000762939453},{"id":"https://openalex.org/keywords/sars-cov-2-serology","display_name":"SARS-CoV-2 serology","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6568999886512756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4699999988079071},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3698999881744385},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33799999952316284},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25189998745918274},{"id":"https://openalex.org/C2776581183","wikidata":"https://www.wikidata.org/wiki/Q25104725","display_name":"Tissue remodeling","level":3,"score":0.23109999299049377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18799999356269836},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.15940000116825104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13830000162124634}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repository.unhas.ac.id:38541","doi":null,"is_oa":true,"landing_page_url":"http://repository.unhas.ac.id/id/eprint/38541/","pdf_url":"https://repository.unhas.ac.id/id/eprint/38541/2/C095191001_tesis_01-12-2023%201-2.pdf","source":{"id":"https://openalex.org/S4406922391","display_name":"Hasanuddin University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:repository.unhas.ac.id:38541","doi":null,"is_oa":true,"landing_page_url":"http://repository.unhas.ac.id/id/eprint/38541/","pdf_url":"https://repository.unhas.ac.id/id/eprint/38541/2/C095191001_tesis_01-12-2023%201-2.pdf","source":{"id":"https://openalex.org/S4406922391","display_name":"Hasanuddin University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7217741014.pdf","grobid_xml":"https://content.openalex.org/works/W7217741014.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382182186","https://openalex.org/W7220439529","https://openalex.org/W7218269076","https://openalex.org/W7217257415","https://openalex.org/W7217444291","https://openalex.org/W4389577667","https://openalex.org/W7113747497","https://openalex.org/W4389577655","https://openalex.org/W7162974430","https://openalex.org/W4321129076"],"abstract_inverted_index":{"Latar":[0],"Belakang:":[1],"Diagnosis":[2],"infeksi":[3,89],"Coronavirus":[4],"(COVID-19)":[5],"yang":[6,20,46,62,133,171,175,187,228,307],"cepat":[7],"dan":[8,25,33,50,80,82,91,116,137,164,186,213,256,281,309],"akurat":[9],"sangat":[10],"penting":[11,84],"untuk":[12,16,22,100,130],"pengendalian":[13],"pandemi":[14],"serta":[15],"menetapkan":[17],"strategi":[18],"terapeutik":[19],"memadai":[21],"mengurangi":[23],"morbiditas":[24],"mortalitas.":[26],"Infeksi":[27],"COVID-19":[28,119,132,306],"bereplikasi":[29],"pada":[30,48,59,64,155,304],"sel":[31],"makrofag":[32],"memperaruhi":[34],"sistim":[35,86],"pertahananan":[36],"tubuh.":[37,55],"Natural":[38],"Resistensi":[39],"Associated":[40],"Macrophage":[41],"Protein-1":[42],"(NRAMP-1)":[43],"adalah":[44],"gen":[45,58],"terdapat":[47,205],"mamalia":[49],"berpengaruh":[51],"dalam":[52,68,85],"sistem":[53],"kekebalan":[54],"NRAMP-1":[56,71,99,112,125,148,183,194,210,221,241,253,265,278,293,299],"merupakan":[57],"makrophage":[60],"intraseluler":[61],"berlokasi":[63],"membran":[65],"phagosomal":[66],"di":[67],"kromosom":[69],"2q35.":[70],"berfungsi":[72],"sebagai":[73,127],"pengangkut":[74],"ion":[75],"kation":[76],"yaitu":[77],"Fe2+,":[78],"Zn2+":[79],"Mn2+":[81],"berperan":[83],"imun":[87],"terhadap":[88],"mikroorganisme":[90],"eliminasi":[92],"bakteri":[93],"maupun":[94,141],"virus.":[95],"Disamping":[96],"itu":[97],"fungsi":[98],"membatasi":[101],"replikasi":[102],"patogen":[103],"dengan":[104,135,149,158,180,191,207,218,232,238,244,250,262,275,289],"mengubah":[105],"lingkungan":[106],"phagolisomal.":[107],"Dengan":[108],"diketahuinya":[109],"kadar":[110,122,146,182,193,209,220,240,252,264,277,292],"protein":[111,124,147,298],"berdasarkan":[113],"gejala":[114,159,233,245,257],"klinis":[115,160],"kematian":[117],"penderita":[118,156,305],"maka":[120,230],"memungkinkan":[121],"soluble":[123],"dipakai":[126],"biomarker":[128],"tambahan":[129],"kasus":[131],"berhubungan":[134],"medikolegal":[136],"penuntutan":[138],"dari":[139],"pasien":[140,170,179,190,204,215,237,249,261,274,288],"keluarga.":[142],"Metode":[143],"Penelitian:":[144,167],"Pemeriksaan":[145],"teknik":[150],"Enzyme":[151],"link-immunosorbent":[152],"Assay":[153],"(ELISA)":[154],"COVID":[157],"ringan,":[161],"sedang,":[162],"berat":[163,258],"mati.":[165],"Hasil":[166],"Dari":[168,197],"62":[169],"mendapat":[172],"perawatan":[173],"didapatkan":[174],"meninggal":[176,308],"sebanyak":[177,202,235,247,259,272,286],"10":[178,236],"rata-rata":[181,192,208,219,239,251,263,276,291],"650":[184],"ng/mL":[185,212,255,280],"hidup":[188],"52":[189],"1065,26":[195],"ng/mL.":[196,223,267,295],"hasil":[198],"penelitian":[199],"juga":[200],"ditemukan":[201,231],"34":[203,287],"komorbid":[206,217],"838,82":[211],"28":[214,273],"tanpa":[216],"1191,92":[222],"Berdasarkan":[224],"tingkat":[225],"keparahan":[226],"(pasien":[227],"hidup)":[229],"ringan":[234],"984,31":[242],"ng/mL,":[243],"sedang":[246],"31":[248],"1104,71":[254],"11":[260],"1027,71":[266],"Nilai":[268],"Ct":[269,283],"\u2264":[270],"24,48":[271,285],"1065,62":[279],"nilai":[282,290],">":[284],"994,31":[294],"Kesimpulan:":[296],"Kadar":[297],"lebih":[300],"rendah":[301],"secara":[302],"signifikan":[303],"mempunyai":[310],"komorbid.":[311]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-10-03T00:00:00"}