{"id":"https://openalex.org/W7217678017","doi":null,"title":"The role of Cycline-dependent Kinase-Like 5 (CDKL5) in the organization of the excitatory post-synaptic compartment: indications of potential therapeutic targets for CDKL5 deficiency disorder","display_name":"The role of Cycline-dependent Kinase-Like 5 (CDKL5) in the organization of the excitatory post-synaptic compartment: indications of potential therapeutic targets for CDKL5 deficiency disorder","publication_year":2020,"publication_date":"2020-05-28","ids":{"openalex":"https://openalex.org/W7217678017"},"language":"en","primary_location":{"id":"pmh:oai:iris.unito.it:2318/2017308","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2318/2017308","pdf_url":"https://iris.unito.it/bitstream/2318/2017308/2/PhD%20Thesis%20Gurgone%20Antonia.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unito.it/bitstream/2318/2017308/2/PhD%20Thesis%20Gurgone%20Antonia.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008693949","display_name":"Antonia Gurgone","orcid":"https://orcid.org/0000-0002-6128-6466","observed_orcids":["https://orcid.org/0000-0002-6128-6466"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"GURGONE, ANTONIA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008693949"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdkl5","display_name":"CDKL5","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cdkl5-deficiency-disorder","display_name":"CDKL5 deficiency disorder","score":0.921999990940094},{"id":"https://openalex.org/keywords/synaptic-organization","display_name":"synaptic organization","score":0.7839999794960022},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6328999996185303},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.5866000056266785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4959999918937683},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2492000013589859},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.23759999871253967},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.2345000058412552}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:iris.unito.it:2318/2017308","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2318/2017308","pdf_url":"https://iris.unito.it/bitstream/2318/2017308/2/PhD%20Thesis%20Gurgone%20Antonia.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:iris.unito.it:2318/2017308","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2318/2017308","pdf_url":"https://iris.unito.it/bitstream/2318/2017308/2/PhD%20Thesis%20Gurgone%20Antonia.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7217678017.pdf","grobid_xml":"https://content.openalex.org/works/W7217678017.grobid-xml"},"referenced_works_count":204,"referenced_works":["https://openalex.org/W15376506","https://openalex.org/W851044123","https://openalex.org/W1073664769","https://openalex.org/W1254699444","https://openalex.org/W1508659364","https://openalex.org/W1586595784","https://openalex.org/W1591789812","https://openalex.org/W1624178692","https://openalex.org/W1878739498","https://openalex.org/W1945167963","https://openalex.org/W1967117930","https://openalex.org/W1967803220","https://openalex.org/W1968087072","https://openalex.org/W1969379644","https://openalex.org/W1970719523","https://openalex.org/W1975767206","https://openalex.org/W1976298967","https://openalex.org/W1976476169","https://openalex.org/W1980574091","https://openalex.org/W1982771749","https://openalex.org/W1982982007","https://openalex.org/W1983194657","https://openalex.org/W1983273836","https://openalex.org/W1984458059","https://openalex.org/W1987069566","https://openalex.org/W1988011192","https://openalex.org/W1992088096","https://openalex.org/W1994778254","https://openalex.org/W1994881764","https://openalex.org/W1995440079","https://openalex.org/W1995916662","https://openalex.org/W1996545009","https://openalex.org/W1999024554","https://openalex.org/W1999828796","https://openalex.org/W2002095654","https://openalex.org/W2003163064","https://openalex.org/W2005817756","https://openalex.org/W2007034511","https://openalex.org/W2007239691","https://openalex.org/W2011209444","https://openalex.org/W2011397887","https://openalex.org/W2012280281","https://openalex.org/W2015556634","https://openalex.org/W2016425872","https://openalex.org/W2017061363","https://openalex.org/W2018457010","https://openalex.org/W2018576843","https://openalex.org/W2019158962","https://openalex.org/W2022609707","https://openalex.org/W2023333383","https://openalex.org/W2024009242","https://openalex.org/W2024380057","https://openalex.org/W2024395506","https://openalex.org/W2027230597","https://openalex.org/W2031195859","https://openalex.org/W2031785254","https://openalex.org/W2032566875","https://openalex.org/W2033963984","https://openalex.org/W2035856577","https://openalex.org/W2036065817","https://openalex.org/W2037254491","https://openalex.org/W2037351588","https://openalex.org/W2042920344","https://openalex.org/W2043166209","https://openalex.org/W2045611288","https://openalex.org/W2046390430","https://openalex.org/W2048740604","https://openalex.org/W2049021349","https://openalex.org/W2049868560","https://openalex.org/W2053899262","https://openalex.org/W2056097987","https://openalex.org/W2061484882","https://openalex.org/W2064977733","https://openalex.org/W2065579814","https://openalex.org/W2069863147","https://openalex.org/W2071193814","https://openalex.org/W2071318481","https://openalex.org/W2072133859","https://openalex.org/W2073501423","https://openalex.org/W2074562018","https://openalex.org/W2074876991","https://openalex.org/W2075621633","https://openalex.org/W2075803148","https://openalex.org/W2076018693","https://openalex.org/W2076825430","https://openalex.org/W2077992380","https://openalex.org/W2078102739","https://openalex.org/W2080019131","https://openalex.org/W2081234982","https://openalex.org/W2084494997","https://openalex.org/W2084522972","https://openalex.org/W2084530920","https://openalex.org/W2087444241","https://openalex.org/W2087855393","https://openalex.org/W2088239473","https://openalex.org/W2088606582","https://openalex.org/W2090025294","https://openalex.org/W2091187766","https://openalex.org/W2093930782","https://openalex.org/W2094183469","https://openalex.org/W2094379124","https://openalex.org/W2098782685","https://openalex.org/W2099220311","https://openalex.org/W2100064902","https://openalex.org/W2100171700","https://openalex.org/W2101896923","https://openalex.org/W2103661790","https://openalex.org/W2106042714","https://openalex.org/W2106951973","https://openalex.org/W2110526976","https://openalex.org/W2113548375","https://openalex.org/W2115723482","https://openalex.org/W2117421244","https://openalex.org/W2119570806","https://openalex.org/W2120307371","https://openalex.org/W2124683806","https://openalex.org/W2125677514","https://openalex.org/W2129671042","https://openalex.org/W2130227962","https://openalex.org/W2134581110","https://openalex.org/W2134906491","https://openalex.org/W2135126450","https://openalex.org/W2139503851","https://openalex.org/W2139618161","https://openalex.org/W2141041915","https://openalex.org/W2141114982","https://openalex.org/W2143497500","https://openalex.org/W2146155881","https://openalex.org/W2146526204","https://openalex.org/W2147881724","https://openalex.org/W2149858533","https://openalex.org/W2150947848","https://openalex.org/W2151275022","https://openalex.org/W2153610480","https://openalex.org/W2157372215","https://openalex.org/W2157536563","https://openalex.org/W2157742595","https://openalex.org/W2165635063","https://openalex.org/W2168096237","https://openalex.org/W2168311770","https://openalex.org/W2169371082","https://openalex.org/W2169423035","https://openalex.org/W2170974481","https://openalex.org/W2172130553","https://openalex.org/W2184364263","https://openalex.org/W2224527671","https://openalex.org/W2237631658","https://openalex.org/W2260115926","https://openalex.org/W2292759204","https://openalex.org/W2293767109","https://openalex.org/W2303118532","https://openalex.org/W2326328531","https://openalex.org/W2328490594","https://openalex.org/W2337393647","https://openalex.org/W2338814967","https://openalex.org/W2344592563","https://openalex.org/W2412282165","https://openalex.org/W2423555771","https://openalex.org/W2460778061","https://openalex.org/W2505355368","https://openalex.org/W2508450936","https://openalex.org/W2528751872","https://openalex.org/W2550208751","https://openalex.org/W2555271159","https://openalex.org/W2556150593","https://openalex.org/W2582734929","https://openalex.org/W2586432482","https://openalex.org/W2595065707","https://openalex.org/W2598352451","https://openalex.org/W2605698725","https://openalex.org/W2609336947","https://openalex.org/W2625534955","https://openalex.org/W2733418771","https://openalex.org/W2734147076","https://openalex.org/W2734458034","https://openalex.org/W2739287754","https://openalex.org/W2760721217","https://openalex.org/W2761806141","https://openalex.org/W2765113723","https://openalex.org/W2770631390","https://openalex.org/W2775797405","https://openalex.org/W2793068278","https://openalex.org/W2795144929","https://openalex.org/W2797414570","https://openalex.org/W2799540341","https://openalex.org/W2799744427","https://openalex.org/W2800672823","https://openalex.org/W2803106339","https://openalex.org/W2803681583","https://openalex.org/W2809740256","https://openalex.org/W2810762414","https://openalex.org/W2892383969","https://openalex.org/W2892937632","https://openalex.org/W2894366250","https://openalex.org/W2898063395","https://openalex.org/W2905115911","https://openalex.org/W2915824690","https://openalex.org/W2923019381","https://openalex.org/W2924873081","https://openalex.org/W2944932135","https://openalex.org/W2948949781","https://openalex.org/W2949591853","https://openalex.org/W2955807832","https://openalex.org/W2971023713"],"related_works":["https://openalex.org/W2318539371","https://openalex.org/W2994776229","https://openalex.org/W2892852757","https://openalex.org/W4386555260","https://openalex.org/W4413772269","https://openalex.org/W6940488292","https://openalex.org/W6980442039","https://openalex.org/W7021176114","https://openalex.org/W4399679804","https://openalex.org/W3032951351"],"abstract_inverted_index":{"indications":[0],"of":[1],"potential":[2],"therapeutic":[3],"targets":[4],"for":[5],"CDKL5":[6],"deficiency":[7],"disorder.":[8]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-03T00:00:00"}