{"id":"https://openalex.org/W7217646384","doi":"https://doi.org/10.1136/bmjopen-2026-117955","title":"Structured medication reviews for adults with multimorbidity and polypharmacy in primary care: a systematic review","display_name":"Structured medication reviews for adults with multimorbidity and polypharmacy in primary care: a systematic review","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7217646384","doi":"https://doi.org/10.1136/bmjopen-2026-117955","pmid":"https://pubmed.ncbi.nlm.nih.gov/42914541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13691817"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2026-117955","doi":"https://doi.org/10.1136/bmjopen-2026-117955","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-117955","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e117955.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e117955.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044604104","display_name":"Elena Lammila-Escalera","orcid":"https://orcid.org/0000-0001-6805-5241","observed_orcids":["https://orcid.org/0000-0001-6805-5241"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Elena Lammila-Escalera","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-6805-5241","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012946911","display_name":"Geva Greenfield","orcid":"https://orcid.org/0000-0001-9779-2486","observed_orcids":["https://orcid.org/0000-0001-9779-2486"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geva Greenfield","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-9779-2486","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102986767","display_name":"Reham Aldakhil","orcid":"https://orcid.org/0000-0002-6975-3858","observed_orcids":["https://orcid.org/0000-0002-6975-3858"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Reham Aldakhil","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-6975-3858","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078121378","display_name":"Hadar Zaman","orcid":"https://orcid.org/0000-0002-4252-2822","observed_orcids":["https://orcid.org/0000-0002-4252-2822"]},"institutions":[{"id":"https://openalex.org/I139894009","display_name":"University of Bradford","ror":"https://ror.org/00vs8d940","country_code":"GB","type":"education","lineage":["https://openalex.org/I139894009"]},{"id":"https://openalex.org/I4210086565","display_name":"North Cumbria Integrated Care NHS Foundation Trust","ror":"https://ror.org/003hq9m95","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210086565"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hadar Zaman","raw_affiliation_strings":["Department of Pharmacy, North Cumbria Integrated Care NHS Foundation Trust, Penrith, UK","School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, North Cumbria Integrated Care NHS Foundation Trust, Penrith, UK","institution_ids":["https://openalex.org/I4210086565"]},{"raw_affiliation_string":"School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK","institution_ids":["https://openalex.org/I139894009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107931351","display_name":"Linwei Li","orcid":"https://orcid.org/0000-0002-8331-1060","observed_orcids":["https://orcid.org/0000-0002-8331-1060"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Linwei Li","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102096117","display_name":"Thomas Woodcock","orcid":"https://orcid.org/0000-0002-4735-4856","observed_orcids":["https://orcid.org/0000-0002-4735-4856"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Woodcock","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-4735-4856","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154968397","display_name":"Ana Lu\u00edsa Neves","orcid":"https://orcid.org/0000-0002-7107-7211","observed_orcids":["https://orcid.org/0000-0002-7107-7211"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana Luisa Neves","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7107-7211","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155348897","display_name":"Azeem Majeed","orcid":"https://orcid.org/0000-0002-2357-9858","observed_orcids":["https://orcid.org/0000-0002-2357-9858"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Azeem Majeed","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-2357-9858","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051710954","display_name":"Benedict W. J. Hayhoe","orcid":"https://orcid.org/0000-0002-2645-6191","observed_orcids":["https://orcid.org/0000-0002-2645-6191"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benedict Hayhoe","raw_affiliation_strings":["Department of Primary Care and Public Health, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-2645-6191","affiliations":[{"raw_affiliation_string":"Department of Primary Care and Public Health, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044604104"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51841085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"e117955","last_page":"e117955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12246","display_name":"Chronic Disease Management Strategies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/structured-medication-review","display_name":"structured medication review","score":0.9629999995231628},{"id":"https://openalex.org/keywords/multimorbidity","display_name":"multimorbidity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":1.0},{"id":"https://openalex.org/keywords/medication-optimization","display_name":"medication optimization","score":0.8610000014305115},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.8539999723434448},{"id":"https://openalex.org/keywords/inappropriate-prescribing","display_name":"inappropriate prescribing","score":0.949999988079071},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.9089999794960022},{"id":"https://openalex.org/keywords/falls","display_name":"falls","score":0.6380000114440918},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pharmacist-led-care","display_name":"pharmacist-led care","score":0.41999998688697815},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.90829998254776},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.8593000173568726},{"id":"https://openalex.org/C2781145037","wikidata":"https://www.wikidata.org/wiki/Q5011772","display_name":"CINAHL","level":3,"score":0.6538000106811523},{"id":"https://openalex.org/C2776484012","wikidata":"https://www.wikidata.org/wiki/Q16251540","display_name":"Deprescribing","level":3,"score":0.6218000054359436},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5238000154495239},{"id":"https://openalex.org/C2777466982","wikidata":"https://www.wikidata.org/wiki/Q5227287","display_name":"Data extraction","level":3,"score":0.5195000171661377},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.44920000433921814},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.4361000061035156},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43299999833106995},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C2909273474","wikidata":"https://www.wikidata.org/wiki/Q1952420","display_name":"Multimorbidity","level":3,"score":0.4023999869823456},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3707999885082245},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3560999929904938},{"id":"https://openalex.org/C2780670349","wikidata":"https://www.wikidata.org/wiki/Q12061588","display_name":"Medication therapy management","level":4,"score":0.34880000352859497},{"id":"https://openalex.org/C53875530","wikidata":"https://www.wikidata.org/wiki/Q814106","display_name":"Beers Criteria","level":3,"score":0.34860000014305115},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.311599999666214},{"id":"https://openalex.org/C3018457447","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Healthcare delivery","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C3019006561","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Health related quality of life","level":3,"score":0.2777000069618225},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C2779328685","wikidata":"https://www.wikidata.org/wiki/Q1475557","display_name":"Patient safety","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2741999924182892},{"id":"https://openalex.org/C163432668","wikidata":"https://www.wikidata.org/wiki/Q623543","display_name":"Primary health care","level":3,"score":0.27219998836517334},{"id":"https://openalex.org/C2780454255","wikidata":"https://www.wikidata.org/wiki/Q7111916","display_name":"Outcomes research","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C2780877353","wikidata":"https://www.wikidata.org/wiki/Q2518253","display_name":"Health services research","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2549999952316284},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.25110000371932983},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1136/bmjopen-2026-117955","doi":"https://doi.org/10.1136/bmjopen-2026-117955","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-117955","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e117955.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13691817","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13691817/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13691817/pdf/bmjopen-16-10.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:42914541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42914541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5961512addd94c5e84a6ae6cd5466525","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5961512addd94c5e84a6ae6cd5466525","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, Vol 16, Iss 10 (2026)","raw_type":"article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/141429","doi":null,"is_oa":true,"landing_page_url":"https://spiral.imperial.ac.uk/handle/10044/1/141429","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2026-117955","doi":"https://doi.org/10.1136/bmjopen-2026-117955","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-117955","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/16/10/e117955.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319994","display_name":"Department of Health and Social Care","ror":"https://ror.org/03sbpja79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7217646384.pdf","grobid_xml":"https://content.openalex.org/works/W7217646384.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1966756094","https://openalex.org/W1995695723","https://openalex.org/W2031367983","https://openalex.org/W2033792377","https://openalex.org/W2044028841","https://openalex.org/W2076663604","https://openalex.org/W2084057982","https://openalex.org/W2097206036","https://openalex.org/W2117659595","https://openalex.org/W2131779687","https://openalex.org/W2161374186","https://openalex.org/W2164297140","https://openalex.org/W2274276369","https://openalex.org/W2295734069","https://openalex.org/W2573571364","https://openalex.org/W2622629370","https://openalex.org/W2763920048","https://openalex.org/W2765967463","https://openalex.org/W2799864530","https://openalex.org/W2810797036","https://openalex.org/W2887289383","https://openalex.org/W2912761177","https://openalex.org/W2994525509","https://openalex.org/W2996206452","https://openalex.org/W3003384780","https://openalex.org/W3003735349","https://openalex.org/W3014565015","https://openalex.org/W3016802478","https://openalex.org/W3035574358","https://openalex.org/W3036625496","https://openalex.org/W3095435689","https://openalex.org/W3111301888","https://openalex.org/W3118615836","https://openalex.org/W3157144001","https://openalex.org/W3158438084","https://openalex.org/W3159251374","https://openalex.org/W3186454670","https://openalex.org/W3214891986","https://openalex.org/W4206243259","https://openalex.org/W4214846329","https://openalex.org/W4281399888","https://openalex.org/W4281555223","https://openalex.org/W4283020482","https://openalex.org/W4286218443","https://openalex.org/W4301964686","https://openalex.org/W4308688705","https://openalex.org/W4377989624","https://openalex.org/W4383878636","https://openalex.org/W4391470213","https://openalex.org/W4399148898","https://openalex.org/W4399155648","https://openalex.org/W4401905535","https://openalex.org/W4404190655","https://openalex.org/W4405856986","https://openalex.org/W4406981008","https://openalex.org/W4407381363"],"related_works":["https://openalex.org/W4399148898","https://openalex.org/W4416057451","https://openalex.org/W7154589240","https://openalex.org/W4412649381","https://openalex.org/W7171862560","https://openalex.org/W7128055418","https://openalex.org/W4402036286","https://openalex.org/W4409080233","https://openalex.org/W4414708196","https://openalex.org/W4405856986"],"abstract_inverted_index":{"Objectives":[0],"Structured":[1],"medication":[2],"reviews":[3],"(SMRs)":[4],"in":[5,94,157,181,190,199],"primary":[6,95,321],"care":[7,322],"offer":[8],"a":[9,127],"patient-centred":[10],"approach":[11],"to":[12,159,270],"optimising":[13],"medicines":[14,41],"for":[15,73],"adults":[16,86],"with":[17,87,98,187,210,227,239],"multimorbidity":[18,88],"and":[19,39,67,79,89,108,115,126,140,173,184,230,247,311,319],"polypharmacy,":[20],"but":[21,292],"their":[22,34,306],"effect":[23,288],"on":[24,36,40,289,296,328],"endpoint":[25,290],"outcomes":[26,38,175,195,219,224],"is":[27,331],"not":[28],"yet":[29],"well-established.":[30],"This":[31],"review":[32,54],"summarises":[33],"impact":[35],"these":[37],"optimisation,":[42],"while":[43],"also":[44],"highlighting":[45],"common":[46],"delivery":[47,277,315],"methods":[48,316],"(in-person":[49,278],"or":[50,201,267,279],"remote).":[51],"Design":[52],"Systematic":[53],"using":[55,135],"narrative":[56],"synthesis.":[57],"Data":[58,113],"sources":[59],"Ovid":[60,62],"MEDLINE,":[61],"EMBASE,":[63],"Web":[64],"of":[65,85,276],"Science":[66],"CINAHL":[68],"via":[69],"OVID":[70],"were":[71,111,147,225,237,260],"searched":[72],"studies":[74,152,294],"published":[75],"between":[76],"January":[77],"1997":[78],"August":[80],"2025.":[81],"Eligibility":[82],"criteria":[83],"Studies":[84],"polypharmacy":[90],"receiving":[91],"an":[92],"SMR":[93],"care,":[96],"compared":[97],"usual":[99],"care.":[100],"Randomised":[101],"controlled":[102,105],"trials,":[103,106],"non-randomised":[104],"cohort":[107],"cross-sectional":[109],"designs":[110],"eligible.":[112],"extraction":[114],"synthesis":[116],"Two":[117],"reviewers":[118],"independently":[119],"screened":[120],"studies;":[121],"one":[122,212],"reviewer":[123],"extracted":[124],"data":[125],"second":[128],"verified":[129],"them.":[130],"Study":[131],"quality":[132,143],"was":[133,206,281],"assessed":[134,155],"the":[136,274],"National":[137],"Heart,":[138],"Lung,":[139],"Blood":[141],"Institute":[142],"assessment":[144],"tools.":[145],"Findings":[146],"synthesised":[148],"narratively.":[149],"Results":[150],"Nine":[151],"(8213":[153],"participants)":[154],"SMRs":[156,236,259,285,330],"relation":[158],"physical":[160,182],"health":[161,183],"(n=5),":[162,165,186],"functional":[163,191],"status":[164,192],"safety":[166],"(n=2),":[167,250],"healthcare":[168],"utilisation":[169],"(n=7),":[170,209],"cost-effectiveness":[171],"(n=3)":[172,229,246],"person-centred":[174],"(n=3).":[176],"Most":[177],"reported":[178],"no":[179,188,197,256],"changes":[180,241],"falls":[185],"improvement":[189],"(n=5).":[193],"Safety":[194],"showed":[196,255,286],"differences":[198],"survival":[200],"mortality":[202],"(n=2).":[203,222,235],"Healthcare":[204],"use":[205],"largely":[207],"unchanged":[208,221],"only":[211],"study":[213],"reporting":[214],"fewer":[215],"medication-related":[216],"admissions.":[217],"Person-centred":[218],"remained":[220],"Cost":[223],"favourable,":[226],"savings":[228],"quality-adjusted":[231],"life":[232],"year":[233],"gains":[234],"associated":[238],"prescription":[240],"(n=4),":[242],"reduced":[243],"inappropriate":[244],"prescribing":[245,297],"improved":[248],"adherence":[249],"although":[251,273],"several":[252],"between-group":[253],"comparisons":[254],"significant":[257],"differences.":[258],"usually":[261],"delivered":[262],"by":[263],"general":[264],"practitioners,":[265],"pharmacists":[266],"multidisciplinary":[268],"teams":[269],"older":[271],"adults,":[272],"mode":[275],"remote)":[280],"often":[282],"unclear.":[283],"Conclusions":[284],"little":[287],"outcomes,":[291],"most":[293],"focused":[295],"rather":[298],"than":[299],"clinical":[300],"effects,":[301],"limiting":[302],"this":[303],"conclusion.":[304],"Realising":[305],"potential":[307],"requires":[308],"supportive":[309],"policy":[310],"collaborative":[312],"practice.":[313],"Unclear":[314],"hinder":[317],"evaluation,":[318],"as":[320],"adopts":[323],"digital":[324],"solutions,":[325],"further":[326],"research":[327],"remote":[329],"needed.":[332],"Trial":[333],"registration":[334],"number":[335],"PROSPERO":[336],"CRD42023454965.":[337]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-03T00:00:00"}