{"id":"https://openalex.org/W7217640552","doi":null,"title":"A mixture of Bisphenol-A analogues elicits neuro-hepatic dysfunction in female rat model","display_name":"A mixture of Bisphenol-A analogues elicits neuro-hepatic dysfunction in female rat model","publication_year":2026,"publication_date":"2026-02-24","ids":{"openalex":"https://openalex.org/W7217640552"},"language":"en","primary_location":{"id":"pmh:oai:ajol.info:article/318071","doi":null,"is_oa":true,"landing_page_url":"https://www.ajol.info/index.php/aujst/article/view/318071","pdf_url":null,"source":{"id":"https://openalex.org/S5407026214","display_name":"Anchor University Journal of Science and Technology","issn_l":"2736-0059","issn":["2736-0059","2736-0067"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2736-0059","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ajol.info/index.php/aujst/article/view/318071","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5156276704","display_name":"Okoh Olayinka Sunday","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunday, Okoh Olayinka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154711713","display_name":"Akinbode Otitololuwa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Otitololuwa, Akinbode","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092624098","display_name":"Eunice Toluwalope Adebamiji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eunice T, Adebamiji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106492502","display_name":"Abimbola Mary Oluwajembola","orcid":"https://orcid.org/0000-0002-8626-6015","observed_orcids":["https://orcid.org/0000-0002-8626-6015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary, Oluwajembola Abimbola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154765500","display_name":"Akamo Adio Jamiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamiu, Akamo Adio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027416336","display_name":"Akpan Ubong","orcid":"https://orcid.org/0000-0002-5294-4105","observed_orcids":["https://orcid.org/0000-0002-5294-4105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akpan, Ubong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045500151","display_name":"Jacob Kehinde Akintunde","orcid":"https://orcid.org/0000-0001-5228-9705","observed_orcids":["https://orcid.org/0000-0001-5228-9705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kehinde, Akintunde Jacob","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphenol-a-analogues","display_name":"bisphenol A analogues","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bisphenol-b","display_name":"bisphenol B","score":0.9129999876022339},{"id":"https://openalex.org/keywords/bisphenol-f","display_name":"bisphenol F","score":1.0},{"id":"https://openalex.org/keywords/bisphenol-s","display_name":"bisphenol S","score":1.0},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.699999988079071},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.921999990940094},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8479999899864197},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hippocampal-neurodegeneration","display_name":"hippocampal neurodegeneration","score":0.8140000104904175},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9210000038146973},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6924999952316284},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6758000254631042},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6049000024795532},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5942000150680542},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.5429999828338623},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.47450000047683716},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.42579999566078186},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4196000099182129},{"id":"https://openalex.org/C2908939727","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Hepatic dysfunction","level":2,"score":0.40959998965263367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3986999988555908},{"id":"https://openalex.org/C2994203108","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Hepatic function","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.39089998602867126},{"id":"https://openalex.org/C2988377048","wikidata":"https://www.wikidata.org/wiki/Q93165","display_name":"Olive oil","level":2,"score":0.38960000872612},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C2991928575","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver dysfunction","level":2,"score":0.36230000853538513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35120001435279846},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.34689998626708984},{"id":"https://openalex.org/C2992208609","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neuronal degeneration","level":3,"score":0.3431999981403351},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3400000035762787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3228999972343445},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3197000026702881},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.31850001215934753},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C2993436365","wikidata":"https://www.wikidata.org/wiki/Q925958","display_name":"Locomotor activity","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C3020251336","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Cell bodies","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C2985495968","wikidata":"https://www.wikidata.org/wiki/Q422453","display_name":"Motor activity","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ajol.info:article/318071","doi":null,"is_oa":true,"landing_page_url":"https://www.ajol.info/index.php/aujst/article/view/318071","pdf_url":null,"source":{"id":"https://openalex.org/S5407026214","display_name":"Anchor University Journal of Science and Technology","issn_l":"2736-0059","issn":["2736-0059","2736-0067"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2736-0059","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ajol.info:article/318071","doi":null,"is_oa":true,"landing_page_url":"https://www.ajol.info/index.php/aujst/article/view/318071","pdf_url":null,"source":{"id":"https://openalex.org/S5407026214","display_name":"Anchor University Journal of Science and Technology","issn_l":"2736-0059","issn":["2736-0059","2736-0067"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310321518","host_organization_name":"African Journals OnLine","host_organization_lineage":["https://openalex.org/P4310321518"],"host_organization_lineage_names":["African Journals OnLine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2736-0059","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6941431411","https://openalex.org/W7165119620","https://openalex.org/W4410761322","https://openalex.org/W7155001642","https://openalex.org/W4414075716","https://openalex.org/W7203617102","https://openalex.org/W7221905075","https://openalex.org/W3091554002","https://openalex.org/W3047020515","https://openalex.org/W4413186414"],"abstract_inverted_index":{"Background:":[0],"Bisphenol-A":[1,107,236],"is":[2],"important":[3],"in":[4,117,153,159],"the":[5,106,137,188,207],"industry;":[6],"it":[7],"enhances":[8],"rigidity":[9],"of":[10,28,31,87,123,129,136,139,178,187,195,206,241],"products.":[11],"However,":[12],"its":[13,23],"numerous":[14],"toxicities":[15],"have":[16],"been":[17],"established,":[18],"hence":[19],"a":[20,176],"shift":[21],"to":[22,105,132,142,149,235],"analogues.":[24],"Objectives:":[25],"The":[26],"impact":[27],"varying":[29],"concentrations":[30],"Bisphenols-B,":[32],"F":[33],"and":[34,40,64,75,84,90,134,146,165,199,210,223,244],"S":[35],"mixture":[36,92,109,238],"on":[37],"hepatic":[38,114,172],"function":[39],"neuronal":[41,245],"cell":[42],"integrity":[43],"was":[44],"assessed.":[45],"Methods:":[46],"Forty-two":[47],"female":[48],"rats":[49],"were":[50,77],"randomly":[51],"divided":[52],"into":[53],"seven":[54],"groups":[55],"(n":[56],"=":[57],"6).":[58],"Group":[59],"1":[60],"served":[61],"as":[62,175],"control":[63],"received":[65],"olive":[66],"oil":[67],"only.":[68],"Groups":[69],"2,":[70],"3,":[71],"4,":[72],"5,":[73],"6,":[74],"7":[76],"administered":[78],"12,":[79],"24,":[80],"48,":[81],"96,":[82],"192":[83,198],"384":[85,200],"\u00b5g":[86,216,220,225],"Bisphenol-B,":[88],"Bisphenol-F":[89],"Bisphenol-S":[91],"per":[93],"kg":[94],"body":[95,202],"weight":[96],"respectively.":[97],"Exposure":[98,104],"lasted":[99],"for":[100,110,217,221,226],"forty-nine":[101,111],"days.":[102],"Results:":[103],"analogues":[108,237],"days":[112],"increased":[113],"oxidative":[115],"stress":[116],"dose-":[118],"dependent":[119],"manner":[120],"via":[121],"elevation":[122],"MDA":[124],"(53%":[125],"-":[126,163,168,183],"232%),":[127],"depletion":[128],"GSH":[130],"(27.3%":[131],"63.6%),":[133],"inhibition":[135],"activities":[138],"GST":[140],"(75%":[141],"87.5%),":[143],"SOD":[144],"(0.05%)":[145],"CAT":[147],"(up":[148],"90%).":[150],"These":[151],"culminated":[152],"liver":[154,189,242],"dysfunction":[155,243],"evident":[156],"by":[157],"increase":[158],"serum":[160],"ALT":[161],"(53.6%":[162],"783.5%)":[164],"AST":[166],"(241%":[167],"1,013%)":[169],"coupled":[170],"with":[171,193],"energy":[173],"deficiency":[174],"result":[177],"decreased":[179],"LDH":[180],"activity":[181],"(14.9%":[182],"58.2%).":[184],"Histological":[185],"examination":[186],"corroborates":[190],"our":[191],"findings":[192],"signs":[194],"degeneration":[196,213],"at":[197,214],"\u00b5g/kg":[201],"weight.":[203],"Histopathological":[204],"examinations":[205],"hippocampus,":[208],"cortex":[209,222],"striatum":[211],"reveal":[212],"24":[215],"striatum,":[218],"48":[219],"96":[224],"hippocampus.":[227],"Conclusion:":[228],"Our":[229],"results":[230],"suggest":[231],"that":[232],"increasing":[233],"exposure":[234],"increases":[239],"risks":[240],"impairment.":[246]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-10-03T00:00:00"}
