{"id":"https://openalex.org/W7217486196","doi":null,"title":"The PAQR-2 and HIF-1 pathways are physiologically essential for unsaturated fatty acid homeostasis in C. elegans","display_name":"The PAQR-2 and HIF-1 pathways are physiologically essential for unsaturated fatty acid homeostasis in C. elegans","publication_year":2025,"publication_date":"2025-05-05","ids":{"openalex":"https://openalex.org/W7217486196"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/85850","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2077/85850","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050307835","display_name":"Delaney Kaper","orcid":"https://orcid.org/0000-0002-9929-8104","observed_orcids":["https://orcid.org/0000-0002-9929-8104"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kaper, Delaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050307835"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hif-1-signaling-pathway","display_name":"HIF-1 signaling","score":0.9580000042915344},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/membrane-rigidification","display_name":"membrane rigidification","score":0.8050000071525574},{"id":"https://openalex.org/keywords/fatty-acid-desaturation","display_name":"fatty acid desaturation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.7799999713897705},{"id":"https://openalex.org/keywords/omega-3-and-omega-6-fatty-acids","display_name":"omega-3 and omega-6 fatty acids","score":0.8209999799728394},{"id":"https://openalex.org/keywords/phospholipid-composition","display_name":"phospholipid composition","score":0.6809999942779541},{"id":"https://openalex.org/keywords/fatty-acid-elongation","display_name":"fatty acid elongation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.7501999735832214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7210999727249146},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.7132999897003174},{"id":"https://openalex.org/C3020713888","wikidata":"https://www.wikidata.org/wiki/Q127980","display_name":"Unsaturated fatty acid","level":3,"score":0.5956000089645386},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5266000032424927},{"id":"https://openalex.org/C2777129432","wikidata":"https://www.wikidata.org/wiki/Q83133906","display_name":"Fatty acid desaturase","level":4,"score":0.5220000147819519},{"id":"https://openalex.org/C122398194","wikidata":"https://www.wikidata.org/wiki/Q6815129","display_name":"Membrane fluidity","level":3,"score":0.4830000102519989},{"id":"https://openalex.org/C21387880","wikidata":"https://www.wikidata.org/wiki/Q24781050","display_name":"Free fatty acid receptor","level":4,"score":0.4796999990940094},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.4697999954223633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4666999876499176},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.42879998683929443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4140999913215637},{"id":"https://openalex.org/C2991897288","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fatty acid","level":3,"score":0.4059000015258789},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38760000467300415},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3668999969959259},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.3294999897480011},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.31769999861717224},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C48289651","wikidata":"https://www.wikidata.org/wiki/Q106916817","display_name":"Fatty acid synthase","level":3,"score":0.2890999913215637},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.2842999994754791},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C2776941171","wikidata":"https://www.wikidata.org/wiki/Q900209","display_name":"Fatty acid synthesis","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2599000036716461},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/85850","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2077/85850","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral thesis"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Since":[0],"the":[1,14,28,55,59,67,98,116,140,146,183,212,224,227,251,265],"1930s,":[2],"scientists":[3],"have":[4,83],"known":[5],"that":[6,121,168,190,226,239,250],"certain":[7],"unsaturated":[8,88,134,206,259],"fatty":[9,23,40,49,72,81,89,128,135,199,207,246,260],"acids":[10,53,73,82,90,136,208],"are":[11,256],"essential":[12,263],"in":[13,163,174,234],"human":[15],"diet":[16],"and":[17,37,65,131,151,158,166,202,253],"act":[18],"as":[19],"precursors":[20],"for":[21,47,77,102,198,203,264],"further":[22,181],"acid":[24,50,129,200,261],"synthesis.":[25],"Unlike":[26],"humans,":[27],"nematode":[29],"C.":[30,164,236,269],"elegans":[31,165,237],"can":[32,230],"de":[33],"novo":[34],"synthesize":[35],"omega-3":[36],"omega-6":[38],"polyunsaturated":[39,245],"acids,":[41],"making":[42],"it":[43],"a":[44,94,193,218,235],"useful":[45],"species":[46],"studying":[48],"function.":[51],"Fatty":[52],"form":[54],"tails":[56],"of":[57,62,69,133,143,148,186,205,215,244,258,268],"phospholipids,":[58],"main":[60],"component":[61],"cellular":[63,157],"membranes,":[64],"modulating":[66],"identity":[68],"these":[70],"tail":[71],"has":[74],"important":[75,197],"implications":[76],"membrane":[78,84,104,112,118,124,172],"homeostasis.":[79],"Saturated":[80],"rigidifying":[85],"effects,":[86],"while":[87],"fluidize":[91],"membranes;":[92],"thus,":[93],"proper":[95],"balance":[96],"between":[97],"two":[99],"is":[100,114,177,240],"crucial":[101],"several":[103,156],"properties.":[105],"One":[106],"way":[107],"by":[108,126],"which":[109],"cells":[110],"achieve":[111],"homeostasis":[113,262],"through":[115],"PAQR-2":[117,187,191,252],"fluidity":[119],"regulator":[120],"responds":[122],"to":[123,223],"rigidification":[125],"increasing":[127],"desaturation":[130],"incorporation":[132],"into":[137,209],"phospholipids.":[138,210],"In":[139,211],"first":[141],"part":[142,214],"this":[144,216],"thesis,":[145,217],"effect":[147],"excessively":[149,152],"rigid":[150],"fluid":[153],"membranes":[154],"on":[155],"physiological":[159,266],"traits":[160],"were":[161],"studied":[162],"revealed":[167],"deviation":[169],"from":[170],"optimal":[171],"composition":[173],"either":[175],"direction":[176],"deleterious.":[178],"Next,":[179],"we":[180],"characterized":[182],"molecular":[184],"basis":[185],"activity,":[188],"revealing":[189],"recruits":[192],"complex":[194],"containing":[195],"enzymes":[196],"elongation":[201],"channeling":[204],"final":[213],"forward":[219],"genetics":[220],"screen":[221],"led":[222],"discovery":[225],"HIF-1":[228,254],"pathway":[229],"potentiate":[231],"desaturase":[232],"activity":[233],"mutant":[238],"almost":[241],"wholly":[242],"devoid":[243],"acids.":[247],"We":[248],"conclude":[249],"pathways":[255],"regulators":[257],"health":[267],"elegans.":[270]},"counts_by_year":[],"updated_date":"2026-10-04T09:36:47.201465","created_date":"2026-10-03T00:00:00"}
