{"id":"https://openalex.org/W7217449873","doi":null,"title":"Identificazione di nuove molecole coinvolte nell'omeostasi degli osteoblasti","display_name":"Identificazione di nuove molecole coinvolte nell'omeostasi degli osteoblasti","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7217449873"},"language":"en","primary_location":{"id":"pmh:oai:ricerca.univaq.it:11697/238839","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11697/238839","pdf_url":"https://ricerca.univaq.it/bitstream/11697/238839/2/Chiara%20Puri%20XXXVI%20ciclo.pdf","source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ricerca.univaq.it/bitstream/11697/238839/2/Chiara%20Puri%20XXXVI%20ciclo.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028313303","display_name":"Chiara Puri","orcid":"https://orcid.org/0009-0007-7564-335X","observed_orcids":["https://orcid.org/0009-0007-7564-335X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"PURI, CHIARA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028313303"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.777999997138977},{"id":"https://openalex.org/keywords/mechanical-unloading","display_name":"mechanical unloading","score":0.9440000057220459},{"id":"https://openalex.org/keywords/disuse-osteoporosis","display_name":"disuse osteoporosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.703000009059906},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/met-enkephalin","display_name":"met-enkephalin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.781000018119812},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.7620000243186951},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.7289999723434448},{"id":"https://openalex.org/keywords/rankl-opg-ratio","display_name":"RANKL/OPG ratio","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.3840000033378601},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7318000197410583},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6542999744415283},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6032999753952026},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5834000110626221},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5669000148773193},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.47859999537467957},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4729999899864197},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.47130000591278076},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.4693000018596649},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4251999855041504},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.3750999867916107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35690000653266907},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3467999994754791},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3456999957561493},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.3377000093460083},{"id":"https://openalex.org/C2779240191","wikidata":"https://www.wikidata.org/wiki/Q6822340","display_name":"Metabolic bone disease","level":3,"score":0.33340001106262207},{"id":"https://openalex.org/C2993373878","wikidata":"https://www.wikidata.org/wiki/Q9621","display_name":"Human bone","level":3,"score":0.3310999870300293},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3301999866962433},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2935999929904938},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2718999981880188},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C18969341","wikidata":"https://www.wikidata.org/wiki/Q1169129","display_name":"Skeleton (computer programming)","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ricerca.univaq.it:11697/238839","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11697/238839","pdf_url":"https://ricerca.univaq.it/bitstream/11697/238839/2/Chiara%20Puri%20XXXVI%20ciclo.pdf","source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:ricerca.univaq.it:11697/238839","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11697/238839","pdf_url":"https://ricerca.univaq.it/bitstream/11697/238839/2/Chiara%20Puri%20XXXVI%20ciclo.pdf","source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7217449873.pdf","grobid_xml":"https://content.openalex.org/works/W7217449873.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W151672201","https://openalex.org/W280215210","https://openalex.org/W606842358","https://openalex.org/W876816957","https://openalex.org/W1577617596","https://openalex.org/W1594526962","https://openalex.org/W1953570789","https://openalex.org/W1965666109","https://openalex.org/W1965860693","https://openalex.org/W1966550557","https://openalex.org/W1980292336","https://openalex.org/W1981147987","https://openalex.org/W1988170766","https://openalex.org/W1994596418","https://openalex.org/W1995229645","https://openalex.org/W1999322873","https://openalex.org/W2001294282","https://openalex.org/W2010618437","https://openalex.org/W2026191433","https://openalex.org/W2035356920","https://openalex.org/W2038948625","https://openalex.org/W2048299560","https://openalex.org/W2071801806","https://openalex.org/W2073426844","https://openalex.org/W2081263377","https://openalex.org/W2083960671","https://openalex.org/W2084774782","https://openalex.org/W2084979516","https://openalex.org/W2089133889","https://openalex.org/W2092186797","https://openalex.org/W2093395043","https://openalex.org/W2110802982","https://openalex.org/W2118807251","https://openalex.org/W2141954707","https://openalex.org/W2142491318","https://openalex.org/W2162830045","https://openalex.org/W2170507497","https://openalex.org/W2343972704","https://openalex.org/W2577584786","https://openalex.org/W2592143606","https://openalex.org/W2614903786","https://openalex.org/W2790161384","https://openalex.org/W2799946064","https://openalex.org/W2811337009","https://openalex.org/W2890611509","https://openalex.org/W2896747888","https://openalex.org/W2991610770","https://openalex.org/W3006279369","https://openalex.org/W3022649544","https://openalex.org/W3031580100","https://openalex.org/W3032045496","https://openalex.org/W3033561017","https://openalex.org/W3037456528","https://openalex.org/W3047951487","https://openalex.org/W3091420074","https://openalex.org/W3097593696","https://openalex.org/W3109057346","https://openalex.org/W3132892290","https://openalex.org/W3137955864","https://openalex.org/W3146292791","https://openalex.org/W3177819581","https://openalex.org/W3193767775","https://openalex.org/W3196742639","https://openalex.org/W4210657902","https://openalex.org/W4213390865","https://openalex.org/W4223893755","https://openalex.org/W4237593632","https://openalex.org/W4285729461","https://openalex.org/W4296099155","https://openalex.org/W4307201670","https://openalex.org/W4311303405","https://openalex.org/W4311869641","https://openalex.org/W4324009310","https://openalex.org/W4386054312","https://openalex.org/W4388380023"],"related_works":["https://openalex.org/W4393004994","https://openalex.org/W2111357695","https://openalex.org/W1577617596","https://openalex.org/W3037527028","https://openalex.org/W2008025728","https://openalex.org/W2774500889","https://openalex.org/W7202177168","https://openalex.org/W2144585497","https://openalex.org/W2074934538","https://openalex.org/W601907569"],"abstract_inverted_index":{"Osteoblasts":[0],"are":[1,452],"bone":[2,19,22,141,160,220,361,404],"forming":[3],"cells":[4,209,222],"that":[5,424,449],"work":[6,50,278,411],"in":[7,14,52,71,95,98,100,116,132,134,171,215,236,249,304,332,344,413,429,439,460,477],"cooperation":[8],"with":[9,201,253,258],"osteoclasts,":[10],"which":[11,461],"resorb":[12],"bone,":[13],"a":[15,48,202,216,228,242],"continuous":[16],"cycle":[17],"of":[18,92,122,130,178,194,230,247,256,276,285,293,312,328,336,353,381,403,419,437,469,479],"remodeling.":[20],"Since":[21],"remodeling":[23],"is":[24,355,371,443],"crucial":[25],"for":[26],"preserving":[27],"skeletal":[28],"integrity":[29],"and":[30,58,68,119,137,143,197,265,268,314,367,377,426,454],"functionality,":[31],"events,":[32],"such":[33],"as":[34,64,385,432,434,474,476],"mechanical":[35,75,103,114,123,349,365,408],"unloading,":[36,350,409],"perturb":[37],"this":[38,79,144,277,286,414,430],"equilibrium,":[39],"leading":[40],"to":[41,74,88,102,113,163,208,232,348,358,364,373,387,398,446,456,468],"pathological":[42,458],"conditions,":[43],"like":[44],"disuse":[45,464],"osteoporosis.":[46],"In":[47,105,251,272,390],"previous":[49],"conducted":[51],"our":[53],"laboratory,":[54],"Lipocalin":[55],"2":[56,107],"(LCN2)":[57],"Pre-proenkephalin":[59],"1":[60,170],"(PENK1)":[61],"were":[62],"identified":[63],"the":[65,90,164,179,273,290,310,326,333,345,351,360,375,378,401,410,422,435],"most":[66],"up-":[67],"down-regulated":[69],"genes":[70],"osteoblasts":[72,96,173,184,257,338,382],"subjected":[73,347],"unloading.":[76,104,124],"Starting":[77],"from":[78,140,186,211,224,383],"data,":[80],"during":[81,148],"my":[82,86],"PhD":[83],"I":[84],"focused":[85],"research":[87],"evaluate":[89],"involvement":[91],"these":[93,450],"molecules":[94],"homeostasis,":[97],"particular":[99],"response":[101],"Chapter":[106],"we":[108,174,226,280],"confirmed":[109],"PENK1":[110],"downregulation":[111],"due":[112,363,467],"unloading":[115,341,366],"both":[117],"human":[118],"animal":[120],"models":[121],"We":[125],"also":[126,324,444],"observed":[127,175,227,331],"high":[128],"expression":[129,145,317],"Penk1":[131,152,187,248,260,425,438],"mouse":[133,135,189],"femurs":[136],"calvariae":[138,190],"cleaned":[139],"marrow,":[142],"progressively":[146],"increased":[147,263],"osteoblast":[149,296,440],"differentiation.":[150,297],"Surprisingly,":[151],"knock":[153],"out":[154,448],"(Penk1-/-)":[155],"mice":[156,346],"did":[157],"not":[158,356],"show":[159],"phenotype":[161],"compared":[162,207,386],"WT":[165,212,239,337,388],"littermates;":[166],"however":[167],"silenced":[168],"Penk":[169],"mature":[172],"an":[176,192],"impairment":[177,193],"Wnt":[180],"pathway,":[181],"while":[182],"primary":[183],"isolated":[185,210,223],"-/-":[188],"showed":[191],"their":[195],"metabolic":[196],"Alp":[198],"activities,":[199],"along":[200],"lower":[203],"nodule":[204,270],"mineralization":[205],"ability,":[206],"mice.":[213],"Moreover,":[214,321],"CFU-Fibroblastic":[217],"assay,":[218],"using":[219],"marrow":[221],"tibias,":[225],"decrease":[229],"ability":[231],"form":[233],"Alp-positive":[234],"colonies":[235],"Penk1-/-":[237],"versus":[238],"mice,":[240],"suggesting":[241],"cell":[243],"autonomous":[244],"positive":[245],"effect":[246,292],"osteoblasts.":[250],"line":[252],"this,":[254],"treatment":[255],"Met-enkephalin,":[259],"encoded":[261],"peptide,":[262],"Osx":[264,315],"Col1a1":[266],"mRNAs,":[267],"enhanced":[269],"mineralization.":[271],"second":[274],"part":[275],"(Chapter3)":[279],"investigated":[281],"whether":[282],"genetic":[283,307],"ablation":[284,308,323],"gene":[287],"can":[288],"counteract":[289,359],"inhibitory":[291],"microgravity":[294],"on":[295],"Our":[298],"results":[299],"demonstrated":[300],"that,":[301],"at":[302],"least":[303],"vitro,":[305],"Lcn2":[306,322,354,427],"counteracts":[309],"reduction":[311],"Runx2":[313],"transcriptional":[316],"induced":[318],"by":[319],"microgravity.":[320],"prevents":[325],"increase":[327],"RANKL/OPG":[329],"ratio":[330],"conditioned":[334],"media":[335],"cultured":[339],"under":[340],"conditions.":[342],"However,":[343],"lack":[352],"sufficient":[357],"loss":[362,466],"disuse,":[368],"although":[369,392],"it":[370],"enough":[372],"prevent":[374],"number":[376],"surface":[379],"area":[380],"decreasing,":[384],"littermates.":[389],"conclusion,":[391],"future":[393],"studies":[394,451],"will":[395],"be":[396],"required":[397],"fully":[399],"understand":[400],"mechanism":[402],"detrimental":[405],"adaptation":[406],"after":[407],"reported":[412],"dissertation":[415],"adds":[416],"another":[417],"piece":[418],"knowledge,":[420],"demonstrating":[421],"role":[423],"play":[428],"event,":[431],"well":[433,475],"contribution":[436],"homeostasis.":[441],"It":[442],"important":[445],"point":[447],"exploitable":[453],"applicable":[455],"those":[457],"circumstances":[459],"patients":[462],"experience":[463],"induced-bone":[465],"paralysis":[470],"or":[471],"neuromuscular":[472],"disorders,":[473],"case":[478],"long-duration":[480],"space":[481],"flights.":[482]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}
