{"id":"https://openalex.org/W7217440787","doi":null,"title":"MicroRNAs, cancer and cancer stem cells: From research to therapy","display_name":"MicroRNAs, cancer and cancer stem cells: From research to therapy","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W7217440787"},"language":"en","primary_location":{"id":"pmh:oai:https://helios.eie.gr:10442/17667","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10442/17667","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Hellenic Medicine, 30(4), 391-405, (2013)","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5155465697","display_name":"Skourti E.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Skourti E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154505247","display_name":"Christodoulou I.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christodoulou I.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014197611","display_name":"\u03a3\u03c4\u03ad\u03bb\u03bb\u03b1 \u039b\u03bf\u03b3\u03bf\u03b8\u03ad\u03c4\u03b7","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Logotheti S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084298569","display_name":"\u0392\u03b1\u03c3\u03af\u03bb\u03b7\u03c2 \u0396\u03bf\u03c5\u03bc\u03c0\u03bf\u03c5\u03c1\u03bb\u03ae\u03c2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0396\u03bf\u03c5\u03bc\u03c0\u03bf\u03c5\u03c1\u03bb\u03ae\u03c2, \u0392\u03b1\u03c3\u03af\u03bb\u03b7\u03c2","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019199803","display_name":"Zoumpourlis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoumpourlis, Vassilis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46957399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7699999809265137},{"id":"https://openalex.org/keywords/post-transcriptional-gene-silencing","display_name":"post-transcriptional gene silencing","score":0.9229999780654907},{"id":"https://openalex.org/keywords/oncosuppressor","display_name":"oncosuppressor","score":0.746999979019165},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mirna-therapeutic-targets","display_name":"miRNA therapeutic targets","score":0.5210000276565552},{"id":"https://openalex.org/keywords/stem-cell-proliferation","display_name":"stem cell proliferation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8414000272750854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6664000153541565},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6029999852180481},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5670999884605408},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5203999876976013},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5101000070571899},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.4611999988555908},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.44119998812675476},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4221000075340271},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4011000096797943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.392300009727478},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.37599998712539673},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.362199991941452},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3610000014305115},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35350000858306885},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.34610000252723694},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.31610000133514404},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28610000014305115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27649998664855957},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.257099986076355},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:https://helios.eie.gr:10442/17667","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10442/17667","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Hellenic Medicine, 30(4), 391-405, (2013)","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040489812","https://openalex.org/W2113112115","https://openalex.org/W1992424594","https://openalex.org/W7217461093","https://openalex.org/W1966461436","https://openalex.org/W2316112751","https://openalex.org/W1975483481","https://openalex.org/W2153131695","https://openalex.org/W2130376575","https://openalex.org/W20775107"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,93,191,206],"21-23":[3],"nucleotide":[4],"RNA":[5],"molecules":[6,141],"that":[7,190,205,219],"act":[8,137],"as":[9,138],"regulators":[10],"of":[11,23,43,84,88,98,105,124,130,155,163,177,183,188],"gene":[12,47,76],"expression":[13,77,186],"in":[14,19,54,65,114,160,166,193,196,200,222],"eukaryotic":[15],"cells":[16,204],"by":[17,95],"binding":[18],"a":[20,51],"non-coding":[21],"region":[22,31],"their":[24,112,120,230],"mRNA":[25,89],"targets,":[26],"specifically":[27],"the":[28,38,70,128,169,184,201,216],"3'":[29],"untranslated":[30],"(3'UTR).":[32],"Through":[33],"this":[34],"mechanism":[35],"miRNAs":[36,92,132,156,178,220],"regulate":[37,75,102],"self-renewal,":[39],"differentiation":[40,228],"and":[41,62,64,86,142,145,211,227,229],"division":[42],"cells,":[44,198],"via":[45,78],"post-translational":[46],"silencing.":[48],"They":[49],"have":[50,133],"significant":[52],"role":[53,218],"many":[55],"cellular":[56,125],"processes,":[57],"including":[58],"stem":[59,203,223],"cell":[60,224],"proliferation":[61],"apoptosis,":[63],"several":[66,161],"diseases,":[67],"cancer":[68,164,197,202,234],"being":[69],"most":[71],"prominent":[72],"example.":[73],"MiRNAs":[74],"two":[79],"separate":[80],"mechanisms,":[81],"namely":[82],"inhibition":[83],"translation":[85],"promotion":[87],"degradation.":[90],"Although":[91],"encoded":[94],"only":[96,111],"3%":[97],"human":[99],"genes,":[100,107],"they":[101],"approximately":[103],"30%":[104],"protein-coding":[106],"which":[108],"illustrates":[109],"not":[110],"significance":[113],"various":[115],"regulatory":[116],"pathways,":[117],"but":[118],"also":[119],"potential":[121,231],"for":[122,209],"manipulation":[123],"functions.":[126],"In":[127,150],"context":[129],"cancer,":[131],"been":[134,158],"shown":[135],"to":[136,233],"both":[139],"oncosuppressor":[140],"oncogenes,":[143],"inhibiting":[144],"inducing":[146],"tumor":[147],"development,":[148],"respectively.":[149],"addition,":[151],"an":[152],"overall":[153],"underexpression":[154],"has":[157],"observed":[159],"types":[162],"tissue":[165],"comparison":[167],"with":[168],"corresponding":[170],"normal":[171],"tissues.":[172],"A":[173],"possible":[174],"therapeutic":[175],"use":[176],"could":[179],"thus":[180],"involve":[181],"restoration":[182],"aberrant":[185],"levels":[187],"target-genes":[189],"implicated":[192],"signaling":[194],"pathways":[195],"particularly":[199],"primarily":[207],"responsible":[208],"carcinogen-esis":[210],"metastases.":[212],"This":[213],"article":[214],"highlights":[215],"crucial":[217],"play":[221],"proliferation,":[225],"apoptosis":[226],"contribution":[232],"therapeutics.":[235]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-03T00:00:00"}