{"id":"https://openalex.org/W7217020985","doi":null,"title":"The Impact of Calpain-10 Gene Polymorphisms on Therapeutic Response to Metformin at the crossroad Type Two Diabetes Mellitus Patients","display_name":"The Impact of Calpain-10 Gene Polymorphisms on Therapeutic Response to Metformin at the crossroad Type Two Diabetes Mellitus Patients","publication_year":2026,"publication_date":"2026-02-11","ids":{"openalex":"https://openalex.org/W7217020985"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.bcsdjournals.com:article/1030","doi":null,"is_oa":true,"landing_page_url":"https://bcsdjournals.com/index.php/jsrmbs/article/view/1030","pdf_url":"https://bcsdjournals.com/index.php/jsrmbs/article/download/1030/527","source":{"id":"https://openalex.org/S4210199278","display_name":"Journal of Scientific Research in Medical and Biological Sciences","issn_l":"2709-0159","issn":["2709-0159","2709-1511"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2709-0159","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bcsdjournals.com/index.php/jsrmbs/article/download/1030/527","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033915970","display_name":"Muntadher Noaman Jasim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jasim, Muntadher Noaman","raw_affiliation_strings":["a:1:{s:5:\"en_US\";s:114:\"B.Sc. pharmacy sciences, M.Sc. Pharmacology and Therapeutics, Ph.D. pharmacy sciences Diwaniyah Health Directorate\";}"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a:1:{s:5:\"en_US\";s:114:\"B.Sc. pharmacy sciences, M.Sc. Pharmacology and Therapeutics, Ph.D. pharmacy sciences Diwaniyah Health Directorate\";}","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085273996","display_name":"Ahmed Jalal Mohammed Albayati","orcid":"https://orcid.org/0000-0003-0440-4988","observed_orcids":["https://orcid.org/0000-0003-0440-4988"]},"institutions":[{"id":"https://openalex.org/I4405259362","display_name":"Islamic University of Najaf","ror":"https://ror.org/024dzaa63","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405259362"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mohammed, Ahmed J.","raw_affiliation_strings":["Department of Clinical laboratory sciences, College of Pharmacy, The Islamic University, Najaf 54001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical laboratory sciences, College of Pharmacy, The Islamic University, Najaf 54001","institution_ids":["https://openalex.org/I4405259362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5155609354","display_name":"Yahia Falih Mohammad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad, Yahia Falih","raw_affiliation_strings":["Consultant Orthopedic Surgeon, Diwaniyah Health Directorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Orthopedic Surgeon, Diwaniyah Health Directorate","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.18629999458789825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capn10","display_name":"CAPN10","score":0.8199999928474426},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6610000133514404},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5730000138282776},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9010000228881836},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6949999928474426},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7390000224113464},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.5860000252723694},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.6669999957084656},{"id":"https://openalex.org/keywords/quantitative-insulin-sensitivity-check-index","display_name":"QUICKI","score":0.996999979019165},{"id":"https://openalex.org/keywords/glut4-translocation","display_name":"GLUT4 translocation","score":0.734000027179718},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bmi-reduction","display_name":"BMI reduction","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8889999985694885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.84170001745224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.748199999332428},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7373999953269958},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7186999917030334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6676999926567078},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6201000213623047},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5479000210762024},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5128999948501587},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3889999985694885},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.3882000148296356},{"id":"https://openalex.org/C2777735490","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disorder","level":2,"score":0.29809999465942383},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2865999937057495}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ojs2.bcsdjournals.com:article/1030","doi":null,"is_oa":true,"landing_page_url":"https://bcsdjournals.com/index.php/jsrmbs/article/view/1030","pdf_url":"https://bcsdjournals.com/index.php/jsrmbs/article/download/1030/527","source":{"id":"https://openalex.org/S4210199278","display_name":"Journal of Scientific Research in Medical and Biological Sciences","issn_l":"2709-0159","issn":["2709-0159","2709-1511"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2709-0159","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ojs2.bcsdjournals.com:article/1030","doi":null,"is_oa":true,"landing_page_url":"https://bcsdjournals.com/index.php/jsrmbs/article/view/1030","pdf_url":"https://bcsdjournals.com/index.php/jsrmbs/article/download/1030/527","source":{"id":"https://openalex.org/S4210199278","display_name":"Journal of Scientific Research in Medical and Biological Sciences","issn_l":"2709-0159","issn":["2709-0159","2709-1511"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2709-0159","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7217020985.pdf","grobid_xml":"https://content.openalex.org/works/W7217020985.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W110489919","https://openalex.org/W901067443","https://openalex.org/W1975588287","https://openalex.org/W2016449386","https://openalex.org/W2072660684","https://openalex.org/W2102574558","https://openalex.org/W2556453587","https://openalex.org/W2558443339","https://openalex.org/W2762120405","https://openalex.org/W2894993577","https://openalex.org/W2903916323","https://openalex.org/W2969791609","https://openalex.org/W3074135648","https://openalex.org/W3081655479","https://openalex.org/W3126341060","https://openalex.org/W3168234416"],"related_works":["https://openalex.org/W3168234416","https://openalex.org/W4415077444","https://openalex.org/W2016449386","https://openalex.org/W2041022408","https://openalex.org/W4399768319","https://openalex.org/W2182630736","https://openalex.org/W2362626287","https://openalex.org/W4410480456","https://openalex.org/W2334275904","https://openalex.org/W1965706951"],"abstract_inverted_index":{"Diabetes":[0],"is":[1,25,47,53,86,310],"a":[2,44,89,114,165,173,212,238,251,258,331],"complex":[3],"and":[4,63,71,91,101,164,193,229,348,373,400],"multifaceted":[5],"metabolic":[6],"disorder":[7],"characterized":[8],"by":[9,233,247,339],"elevated":[10],"blood":[11,179,196],"glucose":[12,69],"levels":[13,266],"resulting":[14],"from":[15],"either":[16],"insulin":[17,20,64,93,230,244,362,369,375],"resistance,":[18],"insufficient":[19],"synthesis,":[21],"or":[22],"both.":[23],"Metformin":[24,353],"often":[26],"administered":[27],"as":[28,66,68,337],"one":[29,128],"of":[30,58,79,118,162,168,187,207,272,301,326,334,342],"the":[31,48,56,77,83,98,102,108,177,185,194,205,216,234,248,262,270,276,368,374,394,401],"first":[32,37,178],"oral":[33],"hypoglycemic":[34],"medications.":[35],"The":[36,140,154,222],"diabetes":[38,61,121,138,386],"gene":[39,351,403],"to":[40,55,294,306,312,397],"be":[41],"discovered":[42,330],"via":[43],"genome":[45],"scan":[46],"Calpain-10":[49],"(CAPN10)":[50],"gene,":[51],"which":[52,181,198],"linked":[54],"onset":[57],"type":[59,119,136,384],"2":[60,120,137,385],"mellitus":[62],"resistance":[65,231],"well":[67],"metabolism":[70],"pancreatic":[72],"beta-cell":[73],"function.":[74],"It":[75],"makes":[76],"translocation":[78],"GLUT4":[80],"easier.":[81],"Within":[82],"beta-cell,":[84],"CAPN10":[85],"most":[87],"likely":[88],"sensor":[90],"an":[92,159,273],"exocytosis":[94],"that":[95,287,314],"acts":[96],"at":[97,184],"plasma":[99,224,226,365],"membrane":[100],"mitochondria,":[103],"respectively.":[104],"G":[105],"homozygous":[106],"for":[107],"recessive":[109],"model":[110],"SNP-43,":[111],"who":[112,131],"had":[113,172,191],"19%":[115],"increased":[116],"risk":[117],"mellitus.":[122,139,387],"This":[123],"prospective":[124],"cohort":[125],"study":[126],"included":[127],"hundred":[129],"patients":[130],"were":[132],"recently":[133,381],"diagnosed":[134,382],"with":[135,158,269,383],"research":[141],"was":[142,182,199,211,257,391],"conducted":[143],"in":[144,150,215,261,275,282,304,357,379],"Al":[145],"Diwaniyah":[146],"Teaching":[147],"Hospital,":[148],"located":[149],"Diwaniya":[151],"Governorate,":[152],"Iraq.":[153],"ages":[155],"exhibited":[156,250],"variation,":[157],"average":[160,217,263,277,291],"age":[161],"55.25":[163],"standard":[166],"deviation":[167],"9.88.":[169],"Each":[170],"patient":[171],"12-week":[174],"period":[175],"between":[176,393],"sample,":[180,197],"collected":[183],"time":[186],"diagnosis":[188],"before":[189],"treatment":[190,399],"started,":[192],"second":[195],"taken":[200],"12":[201],"weeks":[202],"later.":[203],"Following":[204],"administration":[206],"metformin":[208,398],"medicine,":[209],"there":[210],"significant":[213,252,259,332,389],"reduction":[214,260],"BMI":[218],"(p":[219,345],"<":[220,343],"0.01).":[221],"fasting":[223,364],"glucose,":[225,366],"insulin,":[227],"HbA1c,":[228,367],"(measured":[232,246],"HOMA-IR":[235],"index)":[236],"showed":[237],"substantial":[239],"drop":[240],"(p<":[241,254,267],"0.001),":[242,268],"whereas":[243],"sensitivity":[245,376],"QUICKI)":[249],"rise":[253],"0.001).":[255],"There":[256],"lipid":[264,302,360],"profile":[265],"exception":[271],"increase":[274],"HDL":[278],"level.":[279],"Gender":[280],"disparities":[281],"glycemic":[283,335],"control":[284,336],"measurements":[285],"suggest":[286],"males":[288],"exhibit":[289],"higher":[290],"values":[292],"compared":[293],"women,":[295],"while":[296],"women":[297],"demonstrate":[298],"superior":[299],"management":[300],"profiles":[303],"comparison":[305],"men.":[307],"However,":[308],"it":[309],"important":[311],"note":[313],"these":[315],"differences":[316],"do":[317],"not":[318],"reach":[319],"statistical":[320],"significance":[321],"(p<0.05).":[322],"After":[323],"three":[324],"months":[325],"using":[327],"metformin,":[328],"we":[329],"deterioration":[333],"measured":[338],"HbA1c":[340],"(threshold":[341],"7%)":[344],"=":[346],"0.01)":[347],"CAPN":[349],"10":[350],"SNP-43.":[352,404],"has":[354],"demonstrated":[355],"efficacy":[356],"enhancing":[358],"serum":[359],"profiles,":[361],"levels,":[363],"resistant":[370],"index":[371,377],"(HOMA-IR),":[372],"(QUICKI)":[378],"individuals":[380],"A":[388],"correlation":[390],"found":[392],"lower":[395],"response":[396],"CAPN-10":[402]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}