{"id":"https://openalex.org/W7217000504","doi":null,"title":"Farmacogen\u00f3mica de la Nitrofuranto\u00edna: Variantes gen\u00e9ticas implicadas en la respuesta y la toxicidad","display_name":"Farmacogen\u00f3mica de la Nitrofuranto\u00edna: Variantes gen\u00e9ticas implicadas en la respuesta y la toxicidad","publication_year":2026,"publication_date":"2026-05-27","ids":{"openalex":"https://openalex.org/W7217000504"},"language":"es","primary_location":{"id":"pmh:oai:ojs2.148.202.195.117:article/99","doi":null,"is_oa":true,"landing_page_url":"http://revistaosmosis.udg.mx/index.php/rc/article/view/99","pdf_url":"http://revistaosmosis.udg.mx/index.php/rc/article/download/99/86","source":{"id":"https://openalex.org/S5407052588","display_name":"\u00d3smosis Revista M\u00e9dica Estudiantil","issn_l":"2992-8486","issn":["2992-8486"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319650","host_organization_name":"University of Guadalajara","host_organization_lineage":["https://openalex.org/P4310319650"],"host_organization_lineage_names":["University of Guadalajara"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2992-8486","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://revistaosmosis.udg.mx/index.php/rc/article/download/99/86","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122278264","display_name":"Carlos Dom\u00ednguez-Vargas","orcid":"https://orcid.org/0009-0005-9873-1454","observed_orcids":["https://orcid.org/0009-0005-9873-1454"]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Dom\u00ednguez-Vargas, Carlos","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122117322","display_name":"Samantha Jonnue Ram\u00edrez-Flores","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ram\u00edrez-Flores, Samantha Jonnue","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156203235","display_name":"Salvador Emiliano Sustaita-Alcaraz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Sustaita-Alcaraz, Salvador Emiliano","raw_affiliation_strings":["Maestr\u00eda en Microbiolog\u00eda M\u00e9dica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maestr\u00eda en Microbiolog\u00eda M\u00e9dica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137345208","display_name":"Samuel Neri-Mendoza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173755004","display_name":"Universidad Michoacana de San Nicol\u00e1s de Hidalgo","ror":"https://ror.org/00z0kq074","country_code":"MX","type":"education","lineage":["https://openalex.org/I173755004"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Neri-Mendoza, Samuel","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Facultad de Ciencias M\u00e9dicas y Biol\u00f3gicas \"Dr. Ignacio Ch\u00e1vez\", Universidad Michoacana de San Nicol\u00e1s de Hidalgo, 58020, Morelia, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Facultad de Ciencias M\u00e9dicas y Biol\u00f3gicas \"Dr. Ignacio Ch\u00e1vez\", Universidad Michoacana de San Nicol\u00e1s de Hidalgo, 58020, Morelia, M\u00e9xico","institution_ids":["https://openalex.org/I173755004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154322755","display_name":"Carina Mariel \u00c1lvarez-D\u00e1valos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"\u00c1lvarez-D\u00e1valos, Carina Mariel","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137398110","display_name":"Diana Margarita Robles-Loera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Robles-Loera, Diana Margarita","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137326215","display_name":"Dante Joel M\u00e1rquez-Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M\u00e1rquez-Gonz\u00e1lez, Dante Joel","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147469428","display_name":"Diego Humberto Aceves-Castillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Aceves-Castillo, Diego Humberto","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122196817","display_name":"Jes\u00fas Eduardo Garc\u00eda-Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Garc\u00eda-Hern\u00e1ndez, Jes\u00fas Eduardo","raw_affiliation_strings":["Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Licenciatura en M\u00e9dico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340, Guadalajara, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005145062","display_name":"Ana M\u00edriam Salda\u00f1a-Cruz","orcid":"https://orcid.org/0000-0003-2272-9612","observed_orcids":["https://orcid.org/0000-0003-2272-9612"]},"institutions":[{"id":"https://openalex.org/I193181351","display_name":"Universidad de Guadalajara","ror":"https://ror.org/043xj7k26","country_code":"MX","type":"education","lineage":["https://openalex.org/I193181351"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Salda\u00f1a-Cruz, Ana Miriam","raw_affiliation_strings":["Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Calle Sierra Mojada 950, Independencia Oriente, Guadalajara 44340, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Calle Sierra Mojada 950, Independencia Oriente, Guadalajara 44340, M\u00e9xico","institution_ids":["https://openalex.org/I193181351"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrofurantoin","display_name":"nitrofurantoin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.5199999809265137},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gwas-catalog","display_name":"GWAS Catalog","score":0.7149999737739563},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.6119999885559082},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5690000057220459},{"id":"https://openalex.org/keywords/candidate-loci","display_name":"candidate loci","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.30059999227523804},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.26829999685287476},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.24490000307559967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2353000044822693},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.23109999299049377},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.22990000247955322},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.22380000352859497},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.20679999887943268},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19210000336170197},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.16830000281333923}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ojs2.148.202.195.117:article/99","doi":null,"is_oa":true,"landing_page_url":"http://revistaosmosis.udg.mx/index.php/rc/article/view/99","pdf_url":"http://revistaosmosis.udg.mx/index.php/rc/article/download/99/86","source":{"id":"https://openalex.org/S5407052588","display_name":"\u00d3smosis Revista M\u00e9dica Estudiantil","issn_l":"2992-8486","issn":["2992-8486"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319650","host_organization_name":"University of Guadalajara","host_organization_lineage":["https://openalex.org/P4310319650"],"host_organization_lineage_names":["University of Guadalajara"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2992-8486","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ojs2.148.202.195.117:article/99","doi":null,"is_oa":true,"landing_page_url":"http://revistaosmosis.udg.mx/index.php/rc/article/view/99","pdf_url":"http://revistaosmosis.udg.mx/index.php/rc/article/download/99/86","source":{"id":"https://openalex.org/S5407052588","display_name":"\u00d3smosis Revista M\u00e9dica Estudiantil","issn_l":"2992-8486","issn":["2992-8486"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319650","host_organization_name":"University of Guadalajara","host_organization_lineage":["https://openalex.org/P4310319650"],"host_organization_lineage_names":["University of Guadalajara"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2992-8486","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7217000504.pdf","grobid_xml":"https://content.openalex.org/works/W7217000504.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2566636187","https://openalex.org/W2792978829","https://openalex.org/W2901303766","https://openalex.org/W4309712847","https://openalex.org/W4387296925"],"related_works":["https://openalex.org/W3007977848","https://openalex.org/W1978329490","https://openalex.org/W7056964829","https://openalex.org/W7135157131","https://openalex.org/W2781584050","https://openalex.org/W2414785401","https://openalex.org/W7001574618","https://openalex.org/W7206544321","https://openalex.org/W7163985796","https://openalex.org/W2756758085"],"abstract_inverted_index":{"Antecedentes.":[0],"La":[1,141],"nitrofuranto\u00edna":[2],"(NIT)":[3],"es":[4],"un":[5,24,92,101],"antimicrobiano":[6],"de":[7,46,71,100,145,153,170,174,187,196],"primera":[8],"l\u00ednea":[9],"para":[10,182],"infecciones":[11],"urinarias":[12],"no":[13,147],"complicada;":[14],"la":[15],"variabilidad":[16],"interindividual":[17],"en":[18,38],"eficacia":[19],"y":[20,28,76,89,112,135,158,192],"seguridad":[21],"podr\u00eda":[22],"tener":[23],"componente":[25],"gen\u00e9tico.Objetivo.":[26],"Describir":[27],"contextualizar":[29],"las":[30],"variantes":[31],"asociadas":[32],"a":[33,35,184],"\u201crespuesta":[34],"nitrofuranto\u00edna\u201d":[36],"registradas":[37],"el":[39,54,81,167],"GWAS":[40,49],"Catalog":[41,50],"(rasgo":[42],"OBA_2040118).M\u00e9todos.":[43],"Estudio":[44],"secundario":[45],"registros":[47],"del":[48,143],"(descarga:":[51],"24-oct-2025),":[52],"filtrando":[53],"rasgo":[55],"\u201ctrait":[56],"in":[57],"response":[58],"to":[59],"nitrofurantoin\u201d.":[60],"Se":[61,84,95],"extrajeron":[62],"rsID,":[63],"regi\u00f3n":[64],"g\u00e9nica":[65],"mapeada,":[66],"odds":[67],"ratio":[68],"(OR),":[69],"intervalo":[70],"confianza":[72],"(IC95%),":[73],"valor":[74],"p":[75,160],"tama\u00f1o":[77],"muestral":[78],"reportado":[79],"por":[80,86],"estudio":[82,103],"fuente.":[83],"ordenaron":[85],"evidencia":[87],"estad\u00edstica":[88],"se":[90,162],"gener\u00f3":[91],"resumen":[93],"descriptivo.Resultados.":[94],"identificaron":[96],"4":[97],"asociaciones":[98,177],"provenientes":[99],"solo":[102],"(PMID":[104],"28043905;":[105],"Gastroenterology,":[106],"2016)":[107],"con":[108,172],"64":[109],"casos":[110],"europeos":[111],"10,588":[113],"controles":[114],"europeos.":[115],"Las":[116,176],"se\u00f1ales":[117],"correspondieron":[118],"a:":[119],"rs72696020":[120],"(HISLA,":[121],"OR":[122,127,132,138],"7.8;":[123],"p=6\u00d710\u207b\u2078),":[124],"rs6694270":[125],"(PAX7\u2013TAS1R2,":[126],"2.59;":[128],"p=2\u00d710\u207b\u2077),":[129],"rs10404821":[130],"(C19orf81,":[131],"2.56;":[133],"p=2\u00d710\u207b\u2077)":[134],"rs61858823":[136],"(NEK4P3\u2013MYL6P3,":[137],"5.63;":[139],"p=5\u00d710\u207b\u2077).":[140],"frecuencia":[142],"alelo":[144],"riesgo":[146],"estuvo":[148],"disponible":[149],"(NR).Limitaciones.":[150],"\u00danica":[151],"cohorte":[152],"descubrimiento,":[154],"ascendencia":[155],"europea":[156],"exclusiva":[157],"valores":[159],"que":[161],"aproximan":[163],"o":[164,200],"superan":[165],"marginalmente":[166],"umbral":[168],"cl\u00e1sico":[169],"GWAS,":[171],"ausencia":[173],"replicaci\u00f3n.Conclusi\u00f3n.":[175],"actuales":[178],"sugieren":[179],"loci":[180],"candidatos":[181],"susceptibilidad":[183],"eventos":[185],"adversos/efecto":[186],"NIT,":[188],"pero":[189],"requieren":[190],"replicaci\u00f3n":[191],"caracterizaci\u00f3n":[193],"funcional":[194],"antes":[195],"cualquier":[197],"aplicaci\u00f3n":[198],"cl\u00ednica":[199],"farmacogen\u00f3mica.":[201]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}