{"id":"https://openalex.org/W7216851063","doi":null,"title":"Come diventare una cellula secretoria: lezioni dalla decidualizzazione delle cellule stromali endometriali","display_name":"Come diventare una cellula secretoria: lezioni dalla decidualizzazione delle cellule stromali endometriali","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7216851063"},"language":"en","primary_location":{"id":"pmh:oai:iris.unisr.it:20.500.11768/160180","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11768/160180","pdf_url":"https://iris.unisr.it/bitstream/20.500.11768/160180/2/Marco%20Dalla%20Torre%20-%20PhD%20thesis%20-definitive%20version.pdf","source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.unisr.it/bitstream/20.500.11768/160180/2/Marco%20Dalla%20Torre%20-%20PhD%20thesis%20-definitive%20version.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039648881","display_name":"Marco Dalla Torre","orcid":"https://orcid.org/0000-0001-6319-5106","observed_orcids":["https://orcid.org/0000-0001-6319-5106"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"DALLA TORRE, MARCO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039648881"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decidualization","display_name":"decidualization","score":0.8650000095367432},{"id":"https://openalex.org/keywords/endometrial-stromal-cells","display_name":"endometrial stromal cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/secretory-differentiation","display_name":"secretory differentiation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/secretory-cells","display_name":"secretory cells","score":0.5139999985694885},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.7789999842643738},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/er-to-golgi-transport","display_name":"ER-Golgi transport","score":0.515999972820282},{"id":"https://openalex.org/keywords/er-golgi-intermediate-compartment","display_name":"ER-Golgi intermediate compartment","score":0.4860000014305115},{"id":"https://openalex.org/keywords/creb3l1","display_name":"CREB3L1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/creb3l2","display_name":"CREB3L2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5683000087738037},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4449999928474426},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4169999957084656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29840001463890076},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.1362999975681305},{"id":"https://openalex.org/C3018587665","wikidata":"https://www.wikidata.org/wiki/Q7268696","display_name":"Qualitative analysis","level":3,"score":0.12129999697208405},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10869999974966049},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.10540000349283218},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.09700000286102295},{"id":"https://openalex.org/C3019258254","wikidata":"https://www.wikidata.org/wiki/Q1423317","display_name":"Second line","level":3,"score":0.08709999918937683}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:iris.unisr.it:20.500.11768/160180","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11768/160180","pdf_url":"https://iris.unisr.it/bitstream/20.500.11768/160180/2/Marco%20Dalla%20Torre%20-%20PhD%20thesis%20-definitive%20version.pdf","source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:iris.unisr.it:20.500.11768/160180","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11768/160180","pdf_url":"https://iris.unisr.it/bitstream/20.500.11768/160180/2/Marco%20Dalla%20Torre%20-%20PhD%20thesis%20-definitive%20version.pdf","source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216851063.pdf","grobid_xml":"https://content.openalex.org/works/W7216851063.grobid-xml"},"referenced_works_count":223,"referenced_works":["https://openalex.org/W121477089","https://openalex.org/W1586442162","https://openalex.org/W1965786906","https://openalex.org/W1967963412","https://openalex.org/W1968037462","https://openalex.org/W1968147666","https://openalex.org/W1968327914","https://openalex.org/W1972375269","https://openalex.org/W1972710810","https://openalex.org/W1973463353","https://openalex.org/W1975195151","https://openalex.org/W1975334062","https://openalex.org/W1976187110","https://openalex.org/W1977603207","https://openalex.org/W1978014671","https://openalex.org/W1978940943","https://openalex.org/W1979158821","https://openalex.org/W1981049765","https://openalex.org/W1983078722","https://openalex.org/W1984027634","https://openalex.org/W1985715079","https://openalex.org/W1986185155","https://openalex.org/W1987250056","https://openalex.org/W1989956075","https://openalex.org/W1991793418","https://openalex.org/W1992563874","https://openalex.org/W1993697882","https://openalex.org/W1993866784","https://openalex.org/W1994256819","https://openalex.org/W1996797799","https://openalex.org/W2004465970","https://openalex.org/W2006032860","https://openalex.org/W2006081040","https://openalex.org/W2008013667","https://openalex.org/W2010668098","https://openalex.org/W2011393200","https://openalex.org/W2011861484","https://openalex.org/W2012324563","https://openalex.org/W2013725492","https://openalex.org/W2013774412","https://openalex.org/W2017243396","https://openalex.org/W2017469965","https://openalex.org/W2019931546","https://openalex.org/W2020692108","https://openalex.org/W2020981013","https://openalex.org/W2021918003","https://openalex.org/W2024440558","https://openalex.org/W2025071348","https://openalex.org/W2025846979","https://openalex.org/W2028625301","https://openalex.org/W2028748494","https://openalex.org/W2030529885","https://openalex.org/W2031854250","https://openalex.org/W2031902273","https://openalex.org/W2032191750","https://openalex.org/W2032234589","https://openalex.org/W2033133173","https://openalex.org/W2034384974","https://openalex.org/W2034612866","https://openalex.org/W2034738471","https://openalex.org/W2034802534","https://openalex.org/W2035458748","https://openalex.org/W2039737646","https://openalex.org/W2039848901","https://openalex.org/W2041061895","https://openalex.org/W2041846270","https://openalex.org/W2042466557","https://openalex.org/W2045461902","https://openalex.org/W2045777307","https://openalex.org/W2046474853","https://openalex.org/W2046640957","https://openalex.org/W2049081577","https://openalex.org/W2049328517","https://openalex.org/W2052497884","https://openalex.org/W2054474302","https://openalex.org/W2059586921","https://openalex.org/W2060991245","https://openalex.org/W2065504621","https://openalex.org/W2068124454","https://openalex.org/W2070924960","https://openalex.org/W2072907135","https://openalex.org/W2076386951","https://openalex.org/W2076606535","https://openalex.org/W2079032147","https://openalex.org/W2079619166","https://openalex.org/W2080706525","https://openalex.org/W2084168484","https://openalex.org/W2084394815","https://openalex.org/W2084876450","https://openalex.org/W2084938264","https://openalex.org/W2086777165","https://openalex.org/W2090407227","https://openalex.org/W2093060517","https://openalex.org/W2093315532","https://openalex.org/W2094104389","https://openalex.org/W2094372926","https://openalex.org/W2095244258","https://openalex.org/W2096579721","https://openalex.org/W2097297452","https://openalex.org/W2098293220","https://openalex.org/W2100265094","https://openalex.org/W2100872519","https://openalex.org/W2102455999","https://openalex.org/W2105267309","https://openalex.org/W2106048402","https://openalex.org/W2106983618","https://openalex.org/W2107266464","https://openalex.org/W2107424466","https://openalex.org/W2108468328","https://openalex.org/W2108667717","https://openalex.org/W2109662957","https://openalex.org/W2109801386","https://openalex.org/W2114049739","https://openalex.org/W2117692658","https://openalex.org/W2117761303","https://openalex.org/W2119975890","https://openalex.org/W2120024428","https://openalex.org/W2120477407","https://openalex.org/W2120794334","https://openalex.org/W2121772019","https://openalex.org/W2122219094","https://openalex.org/W2126645370","https://openalex.org/W2131397186","https://openalex.org/W2133303552","https://openalex.org/W2136657922","https://openalex.org/W2136799027","https://openalex.org/W2136812627","https://openalex.org/W2137559379","https://openalex.org/W2138455245","https://openalex.org/W2139200038","https://openalex.org/W2139570905","https://openalex.org/W2143952529","https://openalex.org/W2144065739","https://openalex.org/W2145387518","https://openalex.org/W2147415107","https://openalex.org/W2152506486","https://openalex.org/W2152629654","https://openalex.org/W2153104756","https://openalex.org/W2157617104","https://openalex.org/W2160973386","https://openalex.org/W2162695817","https://openalex.org/W2162838110","https://openalex.org/W2163074450","https://openalex.org/W2163818708","https://openalex.org/W2165730820","https://openalex.org/W2168056522","https://openalex.org/W2172114433","https://openalex.org/W2179438025","https://openalex.org/W2193892683","https://openalex.org/W2210986517","https://openalex.org/W2223021721","https://openalex.org/W2231087889","https://openalex.org/W2232816331","https://openalex.org/W2280474849","https://openalex.org/W2295460934","https://openalex.org/W2322561651","https://openalex.org/W2325674170","https://openalex.org/W2326387016","https://openalex.org/W2334109273","https://openalex.org/W2343055141","https://openalex.org/W2518735686","https://openalex.org/W2531317809","https://openalex.org/W2541874381","https://openalex.org/W2550575905","https://openalex.org/W2608055428","https://openalex.org/W2616922646","https://openalex.org/W2617667835","https://openalex.org/W2622627787","https://openalex.org/W2743054773","https://openalex.org/W2749710285","https://openalex.org/W2750391729","https://openalex.org/W2762074697","https://openalex.org/W2766900039","https://openalex.org/W2767029153","https://openalex.org/W2767862668","https://openalex.org/W2782426736","https://openalex.org/W2782647397","https://openalex.org/W2785337517","https://openalex.org/W2793805814","https://openalex.org/W2806153555","https://openalex.org/W2809554459","https://openalex.org/W2892033200","https://openalex.org/W2895487437","https://openalex.org/W2897319037","https://openalex.org/W2904223696","https://openalex.org/W2911385463","https://openalex.org/W2921299578","https://openalex.org/W2947734442","https://openalex.org/W2947747649","https://openalex.org/W2953305792","https://openalex.org/W2955417896","https://openalex.org/W2963050688","https://openalex.org/W2967499662","https://openalex.org/W2969645849","https://openalex.org/W2970988466","https://openalex.org/W2971951026","https://openalex.org/W2987932879","https://openalex.org/W3001053834","https://openalex.org/W3003331854","https://openalex.org/W3007815320","https://openalex.org/W3033214241","https://openalex.org/W3035132831","https://openalex.org/W3041938542","https://openalex.org/W3109200525","https://openalex.org/W3134012764","https://openalex.org/W3134902941","https://openalex.org/W3137409168","https://openalex.org/W3155397815","https://openalex.org/W3165347333","https://openalex.org/W3182748185","https://openalex.org/W3206982163","https://openalex.org/W3213309159","https://openalex.org/W4200048470","https://openalex.org/W4213018777","https://openalex.org/W4221006253","https://openalex.org/W4229376509","https://openalex.org/W4245814297","https://openalex.org/W4285604462","https://openalex.org/W4304892153","https://openalex.org/W4376131051","https://openalex.org/W4376138860","https://openalex.org/W4385556721","https://openalex.org/W4385871875"],"related_works":["https://openalex.org/W3206982163","https://openalex.org/W7169559384","https://openalex.org/W2466995145","https://openalex.org/W4304892153","https://openalex.org/W3018497614","https://openalex.org/W3159388394","https://openalex.org/W7048931203","https://openalex.org/W2891194230","https://openalex.org/W6925024492","https://openalex.org/W2119975890"],"abstract_inverted_index":{"Tutti":[0],"i":[1,21,72,267,297,328],"processi":[2,16],"biologici":[3],"dipendono,":[4],"in":[5,35,57,121,189,312],"qualche":[6],"misura,":[7],"dal":[8],"trasporto":[9],"e":[10,37,70,93,97,126,142,148,181,210,233,311,322],"dalla":[11,291],"secrezione":[12],"delle":[13,44,201],"proteine.":[14,41],"Questi":[15],"sono":[17,88,196,219,254],"svolti":[18],"da":[19,221],"tutti":[20,266,327],"tipi":[22],"cellulari,":[23,269],"ma":[24,193,235],"cellule":[25,45,63,87],"specializzate":[26],"possono":[27,103],"convertirsi,":[28],"attraverso":[29,78],"il":[30,67,129,178,182,208],"loro":[31,68,116,124,205],"programma":[32,100,130,162],"di":[33,40,53,101,131,140,143,163,167,185,213,230,265,304,326],"differenziamento,":[34],"vere":[36],"proprie":[38],"fabbriche":[39],"La":[42],"decidualizzazione":[43,102,125],"endometriali":[46],"stromali":[47],"(EnSC)":[48],"e\u0300":[49,166],"un":[50,262,288],"chiaro":[51],"esempio":[52],"differenziamento":[54,132,164],"secretorio":[55,165],"inducibile:":[56],"risposta":[58,238],"a":[59,138,239,280],"stimolazione":[60],"ormonale,":[61],"queste":[62,86],"fibroblastoidi":[64],"cambiano":[65],"completamente":[66],"fenotipo,":[69],"forniscono":[71,300],"fattori":[73,229],"necessari":[74],"per":[75,90],"l\u2019impianto":[76],"dell\u2019embrione":[77],"un\u2019attivita\u0300":[79],"secretoria":[80],"massiccia":[81,273,316],"ed":[82],"efficiente.":[83],"Di":[84],"conseguenza,":[85],"fondamentali":[89],"la":[91,94,115,123,211,237],"salute":[92],"fertilita\u0300":[95],"umane,":[96],"difetti":[98],"nel":[99],"avere":[104],"serie":[105],"implicazioni":[106],"patologiche.":[107],"Per":[108],"capire":[109],"come":[110,187,305],"le":[111,306],"EnSC":[112,252,307],"possano":[113,308],"sviluppare":[114],"capacita\u0300":[117,317],"secretoria,":[118,192,318],"ho":[119,127,156,260],"indotto":[120],"vitro":[122],"analizzato":[128],"con":[133,158,199,287],"diversi":[134],"approcci":[135],"(analisi":[136],"dell\u2019espressione":[137],"livello":[139],"trascrittoma":[141],"singoli":[144],"geni,":[145],"saggi":[146],"biochimici":[147],"microscopia":[149],"ad":[150],"alta":[151],"risoluzione).":[152],"Nel":[153],"mio":[154],"progetto,":[155],"dimostrato":[157],"chiarezza":[159],"che":[160,172,225,270],"questo":[161],"gran":[168],"lunga":[169],"piu\u0300":[170,176],"complicato":[171],"semplicemente":[173],"costruire":[174],"organelli":[175,257],"grossi:":[177],"reticolo":[179,246],"endoplasmico":[180],"Golgi":[183],"aumentano":[184],"volume,":[186],"atteso":[188],"una":[190,272,281,301,315,323],"cellula":[191],"alcuni":[194,214],"compartimenti":[195,268,329],"chiaramente":[197],"prioritizzati,":[198],"modificazioni":[200,217],"caratteristiche":[202],"chimiche":[203],"del":[204,245,275,284],"lume":[206],"(inclusi":[207],"pH":[209],"concentrazione":[212],"ioni).":[215],"Queste":[216],"morfologiche":[218],"regolate":[220],"complessi":[222],"network":[223],"trascrizionali,":[224],"includono":[226],"l\u2019attivazione":[227],"dei":[228],"trascrizione":[231],"CREB3L1":[232],"CREB3L2,":[234],"non":[236,241,253],"proteine":[240],"correttamente":[242],"ripiegate":[243],"(UPR)":[244],"endoplasmico.":[247],"I":[248],"riarrangiamenti":[249],"osservati":[250],"nelle":[251],"limitati":[255],"agli":[256],"secretori:":[258],"infatti,":[259],"osservato":[261],"rimodellamento":[263],"coordinato":[264],"include":[271],"espansione":[274,324],"compartimento":[276],"mitocondriale.":[277,295],"Questo":[278],"corrisponde":[279],"completa":[282],"riorganizzazione":[283],"metabolismo":[285],"cellulare,":[286],"radicale":[289],"passaggio":[290],"glicolisi":[292],"alla":[293],"respirazione":[294],"Collettivamente,":[296],"miei":[298],"risultati":[299],"rappresentazione":[302],"dettagliata":[303],"acquisire":[309],"rapidamente":[310],"modo":[313],"efficiente":[314],"tramite":[319],"un\u2019attenta":[320],"preparazione":[321],"coordinata":[325],"cellulari.":[330]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}