{"id":"https://openalex.org/W7216638862","doi":null,"title":"VASCULAR REMODELLING IN BRONCHIAL MUCOSA OF SMOKERS WITH AND WITHOUT AIRWAY OBSTRUCTION","display_name":"VASCULAR REMODELLING IN BRONCHIAL MUCOSA OF SMOKERS WITH AND WITHOUT AIRWAY OBSTRUCTION","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W7216638862"},"language":"en","primary_location":{"id":"pmh:oai:iris.unicampania.it:11591/208737","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/208737","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028562273","display_name":"Cecilia Calabrese","orcid":"https://orcid.org/0000-0003-4293-4461","observed_orcids":["https://orcid.org/0000-0003-4293-4461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CALABRESE, Cecilia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038906869","display_name":"Vincenzo Bocchino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"BOCCHINO V","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154323886","display_name":"VATRELLA A.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VATRELLA A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156062440","display_name":"Sergio Mascitti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MASCITTI S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076091153","display_name":"Ilaria Pedicelli","orcid":"https://orcid.org/0009-0001-9282-9443","observed_orcids":["https://orcid.org/0009-0001-9282-9443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PEDICELLI I","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155828460","display_name":"MARZO C.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARZO C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154350771","display_name":"GUARINO C.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GUARINO C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155033456","display_name":"SQUILLANTE F","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SQUILLANTE F","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5155655202","display_name":"MARSICO S. A.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARSICO SA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.9290000200271606},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5929999947547913},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8899999856948853},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7720000147819519},{"id":"https://openalex.org/keywords/alpha-v-beta3-integrin","display_name":"alpha v beta 3 integrin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.7250000238418579},{"id":"https://openalex.org/keywords/vascular-area","display_name":"vascular area","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7089999914169312},{"id":"https://openalex.org/C99322962","wikidata":"https://www.wikidata.org/wiki/Q17165464","display_name":"Vascular remodelling in the embryo","level":2,"score":0.6747999787330627},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6536999940872192},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.652999997138977},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6065999865531921},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.5414999723434448},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5371999740600586},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5213000178337097},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44130000472068787},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.3749000132083893},{"id":"https://openalex.org/C2780314925","wikidata":"https://www.wikidata.org/wiki/Q181602","display_name":"Bronchus","level":4,"score":0.3434000015258789},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.33489999175071716},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.29179999232292175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2881999909877777},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:iris.unicampania.it:11591/208737","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/208737","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2302744668","https://openalex.org/W2125981106","https://openalex.org/W2921427995","https://openalex.org/W2077444786","https://openalex.org/W2080365662","https://openalex.org/W2108877784","https://openalex.org/W1988175420","https://openalex.org/W2160926771","https://openalex.org/W2142926742","https://openalex.org/W2154778264"],"abstract_inverted_index":{"The":[0,160],"role":[1],"played":[2],"by":[3],"bronchial":[4,70,222],"vasculature":[5],"in":[6,11,55,59,94,149,158,179,206,211,233],"the":[7,12,29,95,99,104,110,117,126,130,133,138,183,187,197,207,212,229],"remodelling":[8,231],"process":[9],"occurring":[10,232],"airways":[13],"of":[14,101,106,113,120,128,136,142,177,189,221,228],"smokers":[15,77,86,156,168,235],"with":[16,78,87,236,241],"and":[17,32,84,103,115,140,153,165,186,240],"without":[18],"COPD":[19,89],"has":[20],"been":[21],"poorly":[22],"investigated.Vascular":[23],"endothelial":[24],"growth":[25],"factor":[26,36],"(VEGF)":[27],"is":[28,53,224],"most":[30],"potent":[31],"widely":[33],"distributed":[34],"angiogenic":[35,62],"known":[37],"to":[38,61],"date.":[39],"\u03b1v\u03b23":[40,143,190],"integrin,":[41],"an":[42,66],"adhesion":[43],"molecule":[44],"expressed":[45],"only":[46],"at":[47],"low":[48],"levels":[49],"on":[50,69],"resting":[51],"endothelium,":[52],"upregulated":[54],"new":[56],"capillaries":[57],"proliferating":[58],"response":[60],"stimuli.":[63],"We":[64,92],"performed":[65],"immunohistochemical":[67],"study":[68],"biopsies":[71],"taken":[72],"from":[73],"8":[74],"non-smokers,":[75],"9":[76,85],"normal":[79,237],"lung":[80,238],"function":[81,239],"(GOLD":[82,90],"0)":[83],"moderate":[88],"2).":[91],"evaluated":[93],"lamina":[96],"propria:":[97],"1)":[98],"number":[100,127,139,176],"vessels":[102,145,178,192,223],"percentage":[105,141,188],"vascular":[107,118,131,184],"area":[108,185],"2)":[109],"cellular":[111,134],"expression":[112,119,135,203],"VEGF":[114,202],"3)":[116],"\u03b1v\u03b23.":[121],"Results":[122],"did":[123,169,193],"show":[124,170],"that":[125,219],"vessels,":[129],"area,":[132],"VEGF,":[137],"positive":[144,191],"were":[146],"significantly":[147,174],"higher":[148,201],"both":[150],"GOLD":[151,154,163,166,180,208,213],"0":[152,164,214],"2":[155,167,209],"than":[157,210],"non-smokers.":[159],"comparison":[161],"between":[162,196],"a":[171,225],"weak":[172],"but":[173],"lower":[175],"2,":[181],"while":[182],"not":[194],"differ":[195],"two":[198],"groups.":[199],"A":[200],"was":[204],"detected":[205],"group.":[215],"Our":[216],"data":[217],"suggest":[218],"angiogenesis":[220],"significant":[226],"component":[227],"airway":[230],"symptomatic":[234],"COPD.":[242]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-03T00:00:00"}