{"id":"https://openalex.org/W7216633258","doi":null,"title":"Yo\u011fun Bak\u0131m Hastalar\u0131nda Propofol, Deksmedetomidin ve Midazolam \u0130nfuzyonlar\u0131n\u0131n Sedasyon, Oksidan \u2013 Antioksidan Sistem \u00dczerine Etkilerinin Kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131","display_name":"Yo\u011fun Bak\u0131m Hastalar\u0131nda Propofol, Deksmedetomidin ve Midazolam \u0130nfuzyonlar\u0131n\u0131n Sedasyon, Oksidan \u2013 Antioksidan Sistem \u00dczerine Etkilerinin Kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131","publication_year":2022,"publication_date":"2022-10-22","ids":{"openalex":"https://openalex.org/W7216633258"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.ijcmbs.com:article/67","doi":null,"is_oa":true,"landing_page_url":"https://ijcmbs.com/index.php/ijcmbs/article/view/67","pdf_url":"https://ijcmbs.com/index.php/ijcmbs/article/download/67/87","source":{"id":"https://openalex.org/S4386622020","display_name":"International Journal of Current Medical and Biological Sciences","issn_l":"2791-8815","issn":["2791-8815"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2791-8815","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ijcmbs.com/index.php/ijcmbs/article/download/67/87","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029520626","display_name":"Mehmet Kenan Erol","orcid":"https://orcid.org/0000-0003-1493-8828","observed_orcids":["https://orcid.org/0000-0003-1493-8828"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Erol, Mehmet Kenan","raw_affiliation_strings":["Harran University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harran University","institution_ids":["https://openalex.org/I80538482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029520626"],"corresponding_institution_ids":["https://openalex.org/I80538482"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/midazolam","display_name":"midazolam","score":1.0},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9539999961853027},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.9340000152587891},{"id":"https://openalex.org/keywords/total-antioxidant-capacity","display_name":"total antioxidant capacity","score":0.781000018119812},{"id":"https://openalex.org/keywords/total-oxidant-status","display_name":"total oxidant status","score":0.8989999890327454},{"id":"https://openalex.org/keywords/oxidative-stress-index","display_name":"oxidative stress index","score":0.9520000219345093},{"id":"https://openalex.org/keywords/prolidase","display_name":"prolidase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hemodynamic-parameters","display_name":"hemodynamic parameters","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.9348999857902527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7901999950408936},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6948000192642212},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.679099977016449},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.651199996471405},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.5496000051498413},{"id":"https://openalex.org/C2778000748","wikidata":"https://www.wikidata.org/wiki/Q423071","display_name":"Midazolam","level":3,"score":0.5346999764442444},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.531499981880188},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.3043000102043152},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.30230000615119934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2831000089645386},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2551000118255615},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.25369998812675476}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ojs2.ijcmbs.com:article/67","doi":null,"is_oa":true,"landing_page_url":"https://ijcmbs.com/index.php/ijcmbs/article/view/67","pdf_url":"https://ijcmbs.com/index.php/ijcmbs/article/download/67/87","source":{"id":"https://openalex.org/S4386622020","display_name":"International Journal of Current Medical and Biological Sciences","issn_l":"2791-8815","issn":["2791-8815"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2791-8815","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ojs2.ijcmbs.com:article/67","doi":null,"is_oa":true,"landing_page_url":"https://ijcmbs.com/index.php/ijcmbs/article/view/67","pdf_url":"https://ijcmbs.com/index.php/ijcmbs/article/download/67/87","source":{"id":"https://openalex.org/S4386622020","display_name":"International Journal of Current Medical and Biological Sciences","issn_l":"2791-8815","issn":["2791-8815"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2791-8815","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216633258.pdf","grobid_xml":"https://content.openalex.org/works/W7216633258.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310694473","https://openalex.org/W2033969347","https://openalex.org/W3146672199","https://openalex.org/W3195049410","https://openalex.org/W2210316402","https://openalex.org/W2941383394","https://openalex.org/W6911714208","https://openalex.org/W6911757335","https://openalex.org/W2328587505","https://openalex.org/W6948965172"],"abstract_inverted_index":{"Purpose:":[0],"This":[1],"study":[2,205],"aimed":[3],"to":[4,42,47,80,127,149,172,203,222,231],"compare":[5],"the":[6,43,102,128,173,197,204,214],"impact":[7],"of":[8],"midazolam,":[9,57],"propofol,":[10,65],"dexmedetomidine":[11,73],"infusions":[12,74],"for":[13],"24th":[14],"hour":[15,111,133],"on":[16],"total":[17,21],"antioxidant":[18],"status":[19,23],"(TAS),":[20],"oxidant":[22],"(TOS),":[24],"oxidative":[25],"stres":[26],"index":[27],"(OSI)":[28],"and":[29,95,117,120,139,142,161,239],"prolidase":[30,119,141,162],"levels.":[31],"Material/Metots:":[32],"75":[33],"patient":[34,36],"ICU":[35],"who":[37],"were":[38,78,88,98,114,123,136,145,164,169,181,192,208],"mechanically":[39],"ventilated":[40],"enrolled":[41],"study.":[44],"Patients":[45],"randomised":[46],"three":[48],"groups.":[49,215],"Group":[50,58,66],"I":[51],"(n=25,":[52,68],"midazolam):":[53],"0.02":[54],"mg/":[55],"kg/h":[56,72],"II":[59],"(n":[60],"=":[61],"25,":[62],"propofol):":[63],"1mg/kg/h":[64],"III":[67],"dexmedetomidine):":[69],"0.2":[70],"\u00b5g/":[71],"was":[75,220],"started.":[76],"Dosage":[77],"arrange":[79],"achieve":[81],"Ramsay":[82],"sedation":[83],"score":[84],"3.":[85],"Blood":[86],"samples":[87],"collected":[89],"in":[90,101,152,178,229],"basal,":[91],"6.,12.,18.,":[92],"24.":[93,110,132],"hour,":[94],"hemodynamic":[96,217],"parameters":[97,218],"also":[99],"recorded":[100],"same":[103],"time":[104],"intervals.":[105],"Results:":[106],"In":[107,156],"midazolam":[108],"group":[109,154],"TAS":[112,134,160],"levels":[113,122,135,144,163,168,175,180,191],"significantly":[115,124,137,146,165,195],"decreased":[116,138],"TOS,":[118,140,188],"OSI":[121,143,167,190],"increased":[125,147,170],"compared":[126,148,171],"basal":[129,150,174],"level":[130,151],"(p<0.05).":[131,176],"propofol":[153],"(p<0,05).":[155],"dexmedotimidine":[157],"groups":[158,199],"24.hour":[159],"decreased,":[166],"Increase":[177],"TOS":[179],"not":[182,193],"statistically":[183,194,210,225],"significant":[184,211,226],"(p>0.05).":[185,200],"Basal":[186],"TAS,":[187],"prolidase,":[189],"between":[196,213],"different":[198],"Conlusions:":[201],"According":[202],"results,":[206],"there":[207,234],"no":[209],"differences":[212],"Among":[216],"Dexmedetomidine":[219],"found":[221],"be":[223,237],"having":[224],"favorable":[227],"results":[228,235],"comparison":[230],"others.":[232],"However":[233],"should":[236],"clinically":[238],"molecularity":[240],"verified":[241],"with":[242],"large":[243],"scale":[244],"further":[245],"studies":[246]},"counts_by_year":[],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2026-10-03T00:00:00"}