{"id":"https://openalex.org/W7216631437","doi":null,"title":"A Review on Gene Therapy","display_name":"A Review on Gene Therapy","publication_year":2024,"publication_date":"2024-04-08","ids":{"openalex":"https://openalex.org/W7216631437"},"language":"en","primary_location":{"id":"pmh:oai:ijpba.in:article/486","doi":null,"is_oa":true,"landing_page_url":"https://ijpba.in/index.php/ijpba/article/view/486","pdf_url":"https://ijpba.in/index.php/ijpba/article/download/486/463","source":{"id":"https://openalex.org/S4306514027","display_name":"International Journal of Pharmaceutical and Biological Science Archive","issn_l":"2349-2678","issn":["2349-2678"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2349-2678","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ijpba.in/index.php/ijpba/article/download/486/463","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115492852","display_name":"G. Pravalika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pravalika, Golla","raw_affiliation_strings":["Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana","institution_ids":["https://openalex.org/I10874241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154423772","display_name":"K. Maheshwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Maheshwari, K.","raw_affiliation_strings":["Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana","institution_ids":["https://openalex.org/I10874241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154602921","display_name":"Bakka Divya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Divya, Bakka","raw_affiliation_strings":["Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana","institution_ids":["https://openalex.org/I10874241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156090765","display_name":"Golla Shirisha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shirisha, Golla","raw_affiliation_strings":["Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana","institution_ids":["https://openalex.org/I10874241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5097250451","display_name":"Jarupula Balakoti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Balakoti, Jarupula","raw_affiliation_strings":["Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Joginpally B R Pharmacy College, JNTUH, Bhaskar Nagar, Yenkapally, Moinabad-500075, Telangana","institution_ids":["https://openalex.org/I10874241"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I10874241"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38360007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":1.0},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.8059999942779541},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/adenovirus","display_name":"adenovirus","score":0.7149999737739563},{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/retroviruses","display_name":"retroviruses","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lentivirus","display_name":"lentivirus","score":1.0},{"id":"https://openalex.org/keywords/genetic-disorders","display_name":"genetic disorders","score":0.7599999904632568},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6549999713897705},{"id":"https://openalex.org/keywords/vector-toxicity","display_name":"vector toxicity","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.8264999985694885},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5519999861717224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5367000102996826},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5200999975204468},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.49619999527931213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4837999939918518},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4814999997615814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45809999108314514},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4535999894142151},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.41130000352859497},{"id":"https://openalex.org/C43953973","wikidata":"https://www.wikidata.org/wiki/Q7917858","display_name":"Vectors in gene therapy","level":5,"score":0.30149999260902405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29829999804496765},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.29409998655319214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2671000063419342},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2540000081062317}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ijpba.in:article/486","doi":null,"is_oa":true,"landing_page_url":"https://ijpba.in/index.php/ijpba/article/view/486","pdf_url":"https://ijpba.in/index.php/ijpba/article/download/486/463","source":{"id":"https://openalex.org/S4306514027","display_name":"International Journal of Pharmaceutical and Biological Science Archive","issn_l":"2349-2678","issn":["2349-2678"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2349-2678","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ijpba.in:article/486","doi":null,"is_oa":true,"landing_page_url":"https://ijpba.in/index.php/ijpba/article/view/486","pdf_url":"https://ijpba.in/index.php/ijpba/article/download/486/463","source":{"id":"https://openalex.org/S4306514027","display_name":"International Journal of Pharmaceutical and Biological Science Archive","issn_l":"2349-2678","issn":["2349-2678"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2349-2678","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216631437.pdf","grobid_xml":"https://content.openalex.org/works/W7216631437.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100067309","https://openalex.org/W2170533808","https://openalex.org/W2156754275","https://openalex.org/W2031024419","https://openalex.org/W7131828295","https://openalex.org/W2094669370","https://openalex.org/W4366826949","https://openalex.org/W71296418","https://openalex.org/W4415068082","https://openalex.org/W7056361711"],"abstract_inverted_index":{"In":[0],"general,":[1],"the":[2,8,21,29,33,63,69,86,105],"idea":[3],"of":[4,10,23,39,43,50,65,76,108],"gene":[5,66,91,137],"therapy":[6,67,138],"is":[7,58,130],"introduction":[9],"genetic":[11,97],"material":[12],"into":[13],"a":[14,25,48,59,74,132],"cell,":[15],"tissue,":[16],"or":[17],"entire":[18],"organ":[19],"with":[20],"intention":[22],"treating":[24],"disease":[26],"or,":[27],"at":[28],"very":[30],"least,":[31],"enhancing":[32],"patient's":[34],"clinical":[35],"condition":[36],".The":[37],"creation":[38],"delivery":[40,92],"mechanisms":[41],"capable":[42],"efficiently":[44],"transferring":[45],"genes":[46],"across":[47],"range":[49],"tissues":[51],"without":[52],"inducing":[53],"any":[54],"related":[55],"harmful":[56],"effects":[57],"critical":[60],"component":[61],"in":[62,111],"success":[64],".At":[68],"moment,":[70],"vectors":[71],"based":[72,103],"on":[73,104],"variety":[75],"viral":[77,146],"systems\u2014such":[78],"as":[79],"retroviruses,":[80],"lentiviruses,":[81],"adenoviruses,":[82],"and":[83,99,117,148],"adeno-associated":[84],"viruses\u2014represent":[85],"best":[87],"option":[88],"for":[89,135],"effective":[90],".Clinical":[93],"trials":[94,122],"to":[95],"treat":[96],"disorders":[98],"acquired":[100],"diseases":[101],"are":[102],"favorable":[106],"results":[107],"their":[109,115],"evaluation":[110],"animal":[112],"models":[113],"about":[114],"toxicity":[116],"performance":[118],".Even":[119],"though":[120],"these":[121],"have":[123],"shown":[124],"some":[125],"initial":[126],"success,":[127],"vector":[128],"development":[129],"still":[131],"major":[133],"challenge":[134],"enhanced":[136],"methods":[139],"(2).":[140],"Key":[141],"words:":[142],"adenovirus,":[143],"AAV,":[144],"retrovirus/lentivirus,":[145],"vectors,":[147],"clinics.":[149]},"counts_by_year":[],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2026-10-03T00:00:00"}
