{"id":"https://openalex.org/W7216619662","doi":null,"title":"\u0e04\u0e27\u0e32\u0e21\u0e0a\u0e38\u0e01\u0e41\u0e25\u0e30\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2a\u0e35\u0e48\u0e22\u0e07\u0e43\u0e19\u0e01\u0e32\u0e23\u0e40\u0e01\u0e34\u0e14\u0e20\u0e32\u0e27\u0e30 methotrexate-induced liver injury \u0e02\u0e2d\u0e07\u0e04\u0e19\u0e44\u0e02\u0e49\u0e2a\u0e30\u0e40\u0e01\u0e47\u0e14\u0e40\u0e07\u0e34\u0e19\u0e43\u0e19\u0e42\u0e23\u0e07\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25\u0e1e\u0e2b\u0e25\u0e1e\u0e25\u0e1e\u0e22\u0e38\u0e2b\u0e40\u0e2a\u0e19\u0e32 \u0e08\u0e31\u0e07\u0e2b\u0e27\u0e31\u0e14\u0e01\u0e32\u0e0d\u0e08\u0e19\u0e1a\u0e38\u0e23\u0e35","display_name":"\u0e04\u0e27\u0e32\u0e21\u0e0a\u0e38\u0e01\u0e41\u0e25\u0e30\u0e20\u0e32\u0e27\u0e30\u0e40\u0e2a\u0e35\u0e48\u0e22\u0e07\u0e43\u0e19\u0e01\u0e32\u0e23\u0e40\u0e01\u0e34\u0e14\u0e20\u0e32\u0e27\u0e30 methotrexate-induced liver injury \u0e02\u0e2d\u0e07\u0e04\u0e19\u0e44\u0e02\u0e49\u0e2a\u0e30\u0e40\u0e01\u0e47\u0e14\u0e40\u0e07\u0e34\u0e19\u0e43\u0e19\u0e42\u0e23\u0e07\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25\u0e1e\u0e2b\u0e25\u0e1e\u0e25\u0e1e\u0e22\u0e38\u0e2b\u0e40\u0e2a\u0e19\u0e32 \u0e08\u0e31\u0e07\u0e2b\u0e27\u0e31\u0e14\u0e01\u0e32\u0e0d\u0e08\u0e19\u0e1a\u0e38\u0e23\u0e35","publication_year":2026,"publication_date":"2026-04-17","ids":{"openalex":"https://openalex.org/W7216619662"},"language":"th","primary_location":{"id":"pmh:oai:he04.tci-thaijo.org:article/4021","doi":null,"is_oa":true,"landing_page_url":"https://he04.tci-thaijo.org/index.php/PPHJ/article/view/4021","pdf_url":"https://he04.tci-thaijo.org/index.php/PPHJ/article/download/4021/2942","source":{"id":"https://openalex.org/S7407068123","display_name":"Phaholpolpayuhasena Hospital Journal","issn_l":"3057-0026","issn":["3057-0026"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3057-0026","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://he04.tci-thaijo.org/index.php/PPHJ/article/download/4021/2942","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024903452","display_name":"Saranya Srivarasat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405278247","display_name":"Phaholpolpayuhasena Hospital","ror":"https://ror.org/05fcty689","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405278247"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Srivarasat, Saranya","raw_affiliation_strings":["Department of internal medicine , Phaholpolpayuhasena Hospital , Kanchanaburi Province 71000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of internal medicine , Phaholpolpayuhasena Hospital , Kanchanaburi Province 71000","institution_ids":["https://openalex.org/I4405278247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024903452"],"corresponding_institution_ids":["https://openalex.org/I4405278247"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.953000009059906},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9729999899864197},{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cumulative-methotrexate-dose","display_name":"cumulative methotrexate dose","score":0.8610000014305115},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.8579999804496765},{"id":"https://openalex.org/keywords/liver-function-monitoring","display_name":"liver function monitoring","score":0.7749999761581421},{"id":"https://openalex.org/keywords/misdiagnosis","display_name":"misdiagnosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.930400013923645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6747000217437744},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.6347000002861023},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5674999952316284},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.477400004863739},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.45989999175071716},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4465999901294708},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.439300000667572},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.43849998712539673},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4359999895095825},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.42500001192092896},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.4050000011920929},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C2994039464","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative risk","level":2,"score":0.3617999851703644},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.357699990272522},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3476000130176544},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C3018561737","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver damage","level":2,"score":0.32919999957084656},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.30410000681877136},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27390000224113464},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2554999887943268},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.2524000108242035},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:he04.tci-thaijo.org:article/4021","doi":null,"is_oa":true,"landing_page_url":"https://he04.tci-thaijo.org/index.php/PPHJ/article/view/4021","pdf_url":"https://he04.tci-thaijo.org/index.php/PPHJ/article/download/4021/2942","source":{"id":"https://openalex.org/S7407068123","display_name":"Phaholpolpayuhasena Hospital Journal","issn_l":"3057-0026","issn":["3057-0026"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3057-0026","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:he04.tci-thaijo.org:article/4021","doi":null,"is_oa":true,"landing_page_url":"https://he04.tci-thaijo.org/index.php/PPHJ/article/view/4021","pdf_url":"https://he04.tci-thaijo.org/index.php/PPHJ/article/download/4021/2942","source":{"id":"https://openalex.org/S7407068123","display_name":"Phaholpolpayuhasena Hospital Journal","issn_l":"3057-0026","issn":["3057-0026"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3057-0026","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216619662.pdf","grobid_xml":"https://content.openalex.org/works/W7216619662.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1967627641","https://openalex.org/W2059714773","https://openalex.org/W2060637877","https://openalex.org/W2159637561","https://openalex.org/W2166476687","https://openalex.org/W2593503957","https://openalex.org/W2769869798","https://openalex.org/W2924328881","https://openalex.org/W3005664296","https://openalex.org/W3111825449","https://openalex.org/W3138454927","https://openalex.org/W3191431033","https://openalex.org/W4210980460"],"related_works":["https://openalex.org/W2111018828","https://openalex.org/W2260515353","https://openalex.org/W2126714545","https://openalex.org/W137065417","https://openalex.org/W1493374308","https://openalex.org/W2028969057","https://openalex.org/W2127426526","https://openalex.org/W2979177488","https://openalex.org/W1994790375","https://openalex.org/W2116434948"],"abstract_inverted_index":{"Objectives:":[0],"To":[1],"determine":[2],"the":[3,53,95,116,155,225,233],"prevalence":[4,96,117,208],"of":[5,30,44,49,97,118,194,209,227,235,241],"MTX-DILI":[6,119,180,210],"and":[7,39,74,76,92,110,224,238,251],"identify":[8],"associated":[9,140,178,189],"risk":[10,108,164,226,236],"factors":[11,109],"among":[12],"psoriasis":[13,31],"patients":[14,32,46,123,145],"receiving":[15,146],"MTX":[16,35,65],"at":[17],"Phaholpolpayuhasena":[18],"Hospital,":[19],"Kanchanaburi,":[20],"Thailand.":[21],"Methods:":[22],"This":[23],"retrospective":[24],"observational":[25],"study":[26],"reviewed":[27],"medical":[28],"records":[29],"treated":[33],"with":[34,124,141,144,179,190,212],"between":[36,106,200,220],"October":[37],"2023":[38],"September":[40],"2024.":[41],"A":[42,217],"total":[43],"165":[45],"were":[47,86],"identified,":[48],"whom":[50],"115":[51,114],"met":[52],"calculated":[54],"sample":[55],"size.":[56],"The":[57,131,206],"collected":[58],"data":[59],"included":[60],"demographics,":[61],"clinical":[62],"characteristics,":[63],"cumulative":[64,149,221],"dose,":[66],"folic":[67,195],"acid":[68,183,196],"supplementation,":[69],"comorbidities,":[70],"health":[71],"behaviors":[72],"(alcohol":[73],"smoking),":[75],"liver":[77,228,242],"function":[78,243],"tests":[79],"(ALT,":[80],"AST,":[81],"ALP,":[82],"bilirubin).":[83],"Descriptive":[84],"statistics":[85],"used":[87],"to":[88,93,103],"summarize":[89],"baseline":[90],"characteristics":[91],"estimate":[94],"MTX-DILI.":[98,111,142],"Multivariate":[99],"analysis":[100],"was":[101,120,134,138,175,185,230],"performed":[102],"evaluate":[104],"associations":[105],"potential":[107],"Results:":[112],"Among":[113],"patients,":[115,246],"5.22%":[121],"(6":[122],"ALT":[125],"or":[126],"AST":[127],">":[128],"120":[129],"U/L).":[130],"misdiagnosis":[132],"rate":[133],"10.43%.":[135],"Cumulative":[136],"dose":[137,150,223],"significantly":[139,162,177,188,199],"Compared":[143],"a":[147,161],"low":[148],"(\u22641.5":[151],"g),":[152],"those":[153],"in":[154,244],"high-dose":[156],"group":[157],"(\u22653.5":[158],"g)":[159],"had":[160],"increased":[163],"(adjusted":[165],"OR":[166],"=":[167],"6.21,":[168],"95%":[169],"CI":[170],"1.01\u201338.2;":[171],"p=0.048).":[172],"Alcohol":[173],"consumption":[174],"not":[176,187],"(p=0.107).":[181],"Folic":[182],"supplementation":[184],"also":[186],"MTX-DILI;":[191],"however,":[192],"patterns":[193],"prescription":[197],"differed":[198],"clinics":[201],"(p":[202],"<":[203],"0.001).":[204],"Conclusions:":[205],"observed":[207],"aligns":[211],"previously":[213],"reported":[214],"rates":[215],"(2\u20138%),":[216],"clear":[218],"association":[219],"methotrexate":[222],"injury":[229],"observed,":[231],"highlighting":[232],"importance":[234],"assessment":[237],"regular":[239],"monitoring":[240],"all":[245],"both":[247],"before":[248],"treatment":[249],"initiation":[250],"during":[252],"follow-up":[253],"by":[254],"dermatology":[255],"specialists.":[256]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-03T00:00:00"}
