{"id":"https://openalex.org/W7216458032","doi":"https://doi.org/10.3390/jcm15197651","title":"Contemporary Endovascular Treatment of Femoropopliteal Disease: Lesion Preparation, Antiproliferative Therapies, and Emerging Technologies","display_name":"Contemporary Endovascular Treatment of Femoropopliteal Disease: Lesion Preparation, Antiproliferative Therapies, and Emerging Technologies","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216458032","doi":"https://doi.org/10.3390/jcm15197651","pmid":"https://pubmed.ncbi.nlm.nih.gov/42882111","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13666167"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15197651","doi":"https://doi.org/10.3390/jcm15197651","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15197651","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jcm15197651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037401571","display_name":"Ma Lourdes del R\u00edo Sol\u00e1","orcid":"https://orcid.org/0000-0001-8239-2498","observed_orcids":["https://orcid.org/0000-0001-8239-2498"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]},{"id":"https://openalex.org/I2801392616","display_name":"Universidad Europea Miguel de Cervantes","ror":"https://ror.org/02p350r61","country_code":"ES","type":"education","lineage":["https://openalex.org/I2801392616"]},{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mar\u00eda Lourdes del R\u00edo Sol\u00e1","raw_affiliation_strings":["Departamento de Ciencias de la Salud, Universidad Europea Miguel de Cervantes, 47012 Valladolid, Spain","Departamento de Cirug\u00eda, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain","Servicio de Angiolog\u00eda y Cirug\u00eda Vascular, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8239-2498","affiliations":[{"raw_affiliation_string":"Departamento de Ciencias de la Salud, Universidad Europea Miguel de Cervantes, 47012 Valladolid, Spain","institution_ids":["https://openalex.org/I2801392616"]},{"raw_affiliation_string":"Departamento de Cirug\u00eda, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]},{"raw_affiliation_string":"Servicio de Angiolog\u00eda y Cirug\u00eda Vascular, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain","institution_ids":["https://openalex.org/I4210157802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004587238","display_name":"Sandra P\u00e9rez Fern\u00e1ndez","orcid":"https://orcid.org/0000-0003-4150-4742","observed_orcids":["https://orcid.org/0000-0003-4150-4742"]},"institutions":[{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sandra P\u00e9rez Fern\u00e1ndez","raw_affiliation_strings":["Servicio de Angiolog\u00eda y Cirug\u00eda Vascular, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4150-4742","affiliations":[{"raw_affiliation_string":"Servicio de Angiolog\u00eda y Cirug\u00eda Vascular, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain","institution_ids":["https://openalex.org/I4210157802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115978826","display_name":"Sergio Asensio-Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Asensio Rodr\u00edguez","raw_affiliation_strings":["Servicio de Angiolog\u00eda y Cirug\u00eda Vascular, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Angiolog\u00eda y Cirug\u00eda Vascular, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain","institution_ids":["https://openalex.org/I4210157802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037401571"],"corresponding_institution_ids":["https://openalex.org/I108103353","https://openalex.org/I2801392616","https://openalex.org/I4210157802"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6013938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"19","first_page":"7651","last_page":"7651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11554","display_name":"Vascular Procedures and Complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endovascular-treatment","display_name":"endovascular treatment","score":0.8740000128746033},{"id":"https://openalex.org/keywords/lesion-preparation","display_name":"lesion preparation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/antiproliferative-therapy","display_name":"antiproliferative therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/drug-coated-balloon","display_name":"drug-coated balloon","score":0.9079999923706055},{"id":"https://openalex.org/keywords/paclitaxel-coated-balloon","display_name":"paclitaxel-coated balloon","score":0.8999999761581421},{"id":"https://openalex.org/keywords/sirolimus-coated-balloon","display_name":"sirolimus-coated balloon","score":0.9919999837875366},{"id":"https://openalex.org/keywords/drug-eluting-stents","display_name":"drug-eluting stents","score":0.9660000205039978},{"id":"https://openalex.org/keywords/atherectomy","display_name":"atherectomy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/intravascular-lithotripsy","display_name":"intravascular lithotripsy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/in-stent-restenosis","display_name":"in-stent restenosis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/chronic-total-occlusion","display_name":"chronic total occlusion","score":0.7279999852180481},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.6439999938011169},{"id":"https://openalex.org/keywords/popliteal-artery","display_name":"popliteal artery","score":0.6209999918937683},{"id":"https://openalex.org/keywords/balloon-angioplasty","display_name":"balloon angioplasty","score":0.6389999985694885},{"id":"https://openalex.org/keywords/stent-implantation","display_name":"stenting","score":0.460999995470047},{"id":"https://openalex.org/keywords/intravascular-imaging","display_name":"intravascular imaging","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9495999813079834},{"id":"https://openalex.org/C2777209855","wikidata":"https://www.wikidata.org/wiki/Q755475","display_name":"Atherectomy","level":4,"score":0.6567999720573425},{"id":"https://openalex.org/C2780326628","wikidata":"https://www.wikidata.org/wiki/Q539795","display_name":"Angioplasty","level":2,"score":0.6025000214576721},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5543000102043152},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5418000221252441},{"id":"https://openalex.org/C139059822","wikidata":"https://www.wikidata.org/wiki/Q183951","display_name":"Balloon","level":2,"score":0.5245000123977661},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.5005000233650208},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4390999972820282},{"id":"https://openalex.org/C2777303625","wikidata":"https://www.wikidata.org/wiki/Q707468","display_name":"Popliteal artery","level":2,"score":0.41280001401901245},{"id":"https://openalex.org/C2781464078","wikidata":"https://www.wikidata.org/wiki/Q7685898","display_name":"Target lesion","level":4,"score":0.4027000069618225},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.3917999863624573},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3865000009536743},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.3686999976634979},{"id":"https://openalex.org/C3018386432","wikidata":"https://www.wikidata.org/wiki/Q426449","display_name":"Endovascular treatment","level":3,"score":0.36079999804496765},{"id":"https://openalex.org/C2776931568","wikidata":"https://www.wikidata.org/wiki/Q1671577","display_name":"Intravascular ultrasound","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C2781099653","wikidata":"https://www.wikidata.org/wiki/Q7316059","display_name":"Critical limb ischemia","level":4,"score":0.25380000472068787},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/jcm15197651","doi":"https://doi.org/10.3390/jcm15197651","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15197651","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13666167","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13666167/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13666167/pdf/jcm-15-07651.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmid:42882111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42882111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/jcm15197651","doi":"https://doi.org/10.3390/jcm15197651","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15197651","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216458032.pdf","grobid_xml":"https://content.openalex.org/works/W7216458032.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W76788954","https://openalex.org/W1977671695","https://openalex.org/W2118501388","https://openalex.org/W2615032818","https://openalex.org/W2739447339","https://openalex.org/W2756389977","https://openalex.org/W2891944790","https://openalex.org/W3024808255","https://openalex.org/W3173616222","https://openalex.org/W4221088743","https://openalex.org/W4387217767","https://openalex.org/W4389345701","https://openalex.org/W4390226634","https://openalex.org/W4390238459","https://openalex.org/W4392883850","https://openalex.org/W4392922093","https://openalex.org/W4401438401","https://openalex.org/W4408280039","https://openalex.org/W4409572338","https://openalex.org/W4409646568","https://openalex.org/W4409817337","https://openalex.org/W4410548204","https://openalex.org/W4411291907","https://openalex.org/W4412432537","https://openalex.org/W4416898109","https://openalex.org/W7119499847","https://openalex.org/W7130408230","https://openalex.org/W7133786586","https://openalex.org/W7134840251","https://openalex.org/W7153102521","https://openalex.org/W7160937018","https://openalex.org/W7164830776","https://openalex.org/W7168138476","https://openalex.org/W7168186789","https://openalex.org/W7197037166","https://openalex.org/W7204130125"],"related_works":["https://openalex.org/W4407633679","https://openalex.org/W2977615861","https://openalex.org/W4401438401","https://openalex.org/W7143318702","https://openalex.org/W7130316125","https://openalex.org/W4409817337","https://openalex.org/W4224660089","https://openalex.org/W3097688352","https://openalex.org/W4296455782","https://openalex.org/W3004205233"],"abstract_inverted_index":{"Background:":[0],"Endovascular":[1],"treatment":[2],"of":[3,35,85,225],"femoropopliteal":[4,104,217],"atherosclerotic":[5],"disease":[6],"has":[7,48,53,141,147],"evolved":[8],"from":[9],"plain":[10],"balloon":[11],"angioplasty":[12],"and":[13,29,45,65,77,99,117,123,126,159,197,232,242],"routine":[14],"stenting":[15,251],"toward":[16],"lesion-oriented":[17,69],"strategies":[18],"that":[19],"combine":[20],"plaque":[21],"assessment,":[22],"selective":[23,78,228,233],"vessel":[24,73,132],"preparation,":[25,74,229],"antiproliferative":[26,75,230],"drug":[27],"delivery,":[28],"provisional":[30],"scaffolding.":[31,79,234],"The":[32],"increasing":[33],"availability":[34],"drug-coated":[36],"balloons,":[37],"drug-eluting":[38],"stents,":[39],"atherectomy,":[40],"intravascular":[41,43],"lithotripsy,":[42],"imaging,":[44],"sirolimus-based":[46],"technologies":[47],"improved":[49],"therapeutic":[50],"options":[51],"but":[52],"also":[54],"made":[55],"device":[56],"selection":[57],"more":[58],"complex.":[59],"Objective:":[60],"To":[61],"synthesize":[62],"comparative":[63],"evidence":[64,87,151,171],"present":[66],"a":[67,165,210,223],"practical":[68],"framework":[70],"for":[71,152],"selecting":[72],"therapy,":[76,168,231],"Methods:":[80],"A":[81],"structured":[82],"narrative":[83],"review":[84],"contemporary":[86,170,199],"was":[88],"performed,":[89],"prioritizing":[90],"randomized":[91,150,188],"controlled":[92],"trials,":[93],"head-to-head":[94],"comparisons,":[95],"systematic":[96],"reviews,":[97],"meta-analyses,":[98],"consensus":[100],"documents":[101],"relevant":[102],"to":[103,239],"intervention.":[105],"Results:":[106],"Lesion":[107],"morphology\u2014particularly":[108],"length,":[109],"chronic":[110],"total":[111],"occlusion,":[112],"calcification":[113],"pattern,":[114],"popliteal":[115],"involvement,":[116],"in-stent":[118],"restenosis\u2014strongly":[119],"influences":[120],"procedural":[121],"strategy":[122,213],"durability.":[124],"Atherectomy":[125],"specialty":[127],"balloons":[128,163,181],"can":[129],"optimize":[130],"acute":[131],"preparation":[133],"in":[134],"selected":[135],"lesions,":[136,155],"although":[137],"consistent":[138],"long-term":[139],"superiority":[140],"not":[142,172],"been":[143],"demonstrated.":[144],"Intravascular":[145],"lithotripsy":[146],"the":[148,174,185,243],"strongest":[149],"heavily":[153],"calcified":[154],"reducing":[156],"flow-limiting":[157],"dissection":[158,253],"bailout":[160],"stenting.":[161],"Paclitaxel-coated":[162],"remain":[164,201],"central":[166],"leave-nothing-behind":[167],"with":[169,187,247],"confirming":[173],"previously":[175],"proposed":[176],"late":[177],"mortality":[178],"signal.":[179],"Sirolimus-coated":[180],"have":[182],"now":[183],"entered":[184],"field":[186],"noninferiority":[189],"data":[190],"versus":[191],"paclitaxel":[192],"through":[193],"2":[194],"years.":[195],"Drug-eluting":[196],"other":[198],"stents":[200],"important":[202],"when":[203,252],"recoil,":[204],"dissection,":[205],"or":[206,250,254],"complex":[207],"anatomy":[208],"make":[209],"purely":[211],"scaffold-free":[212],"unreliable.":[214],"Conclusions:":[215],"Contemporary":[216],"intervention":[218],"is":[219],"best":[220],"approached":[221],"as":[222],"sequence":[224],"lesion":[226,240],"characterization,":[227],"Treatment":[235],"should":[236],"be":[237],"matched":[238],"morphology":[241],"final":[244],"mechanical":[245],"result,":[246],"focal":[248],"repair":[249],"recoil":[255],"compromises":[256],"flow.":[257]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-03T00:00:00"}