{"id":"https://openalex.org/W7216430679","doi":"https://doi.org/10.3390/biom16101434","title":"Spatial Metabolomics-Based Integrated Analysis Provides Evidence for the Mechanism of Salvianolic Acid A-Induced Mitochondrial Apoptosis in Non-Small Cell Lung Cancer via the ROS-Dependent Caspase Pathway","display_name":"Spatial Metabolomics-Based Integrated Analysis Provides Evidence for the Mechanism of Salvianolic Acid A-Induced Mitochondrial Apoptosis in Non-Small Cell Lung Cancer via the ROS-Dependent Caspase Pathway","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216430679","doi":"https://doi.org/10.3390/biom16101434","pmid":"https://pubmed.ncbi.nlm.nih.gov/42939688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13702214"},"language":"en","primary_location":{"id":"doi:10.3390/biom16101434","doi":"https://doi.org/10.3390/biom16101434","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101434","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biom16101434","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140717394","display_name":"Ruyu Jiang","orcid":"https://orcid.org/0009-0004-8236-7048","observed_orcids":["https://orcid.org/0009-0004-8236-7048"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruyu Jiang","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":"https://orcid.org/0009-0004-8236-7048","affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140597540","display_name":"Hairong Xiang","orcid":"https://orcid.org/0009-0007-5753-941X","observed_orcids":["https://orcid.org/0009-0007-5753-941X"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hairong Xiang","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":"https://orcid.org/0009-0007-5753-941X","affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092950755","display_name":"XIE Lu\u2043shuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lushuang Xie","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140638347","display_name":"Linfeng Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linfeng Zhao","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140722135","display_name":"Dawei Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dawei Zeng","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154585618","display_name":"Yue Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhang","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140637152","display_name":"Jiazhen Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiazhen Xie","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155755645","display_name":"Zhenxu Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxu Pan","raw_affiliation_strings":["School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 611731, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116230499","display_name":"Gong Yanju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanju Gong","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103878653","display_name":"Lan Yang","orcid":"https://orcid.org/0000-0002-0676-5608","observed_orcids":["https://orcid.org/0000-0002-0676-5608"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lan Yang","raw_affiliation_strings":["College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103878653","https://openalex.org/A5116230499"],"corresponding_institution_ids":["https://openalex.org/I53411278"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61115235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"1434","last_page":"1434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.46239998936653137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.46239998936653137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.09040000289678574,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salvianolic-acid-a","display_name":"salvianolic acid A","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9879999756813049},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9290000200271606},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7409999966621399},{"id":"https://openalex.org/keywords/metabolic-remodeling","display_name":"metabolic remodeling","score":0.6489999890327454},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.7680000066757202},{"id":"https://openalex.org/keywords/glycerophospholipids","display_name":"glycerophospholipids","score":0.9919999837875366},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9319999814033508},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.694599986076355},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6650999784469604},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5562000274658203},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5026000142097473},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4950999915599823},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42260000109672546},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4016000032424927},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.38989999890327454},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.37549999356269836},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.3684999942779541},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3675000071525574},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.362199991941452},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.35839998722076416},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3474999964237213},{"id":"https://openalex.org/C163421366","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Intrinsic apoptosis","level":5,"score":0.3303999900817871},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3294000029563904},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.32010000944137573},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3037000000476837},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27160000801086426},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.25760000944137573}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/biom16101434","doi":"https://doi.org/10.3390/biom16101434","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101434","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13702214","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702214/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702214/pdf/biomolecules-16-01434.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:42939688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42939688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:074e77cef2e44cef8feb13ef07c0ce47","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/074e77cef2e44cef8feb13ef07c0ce47","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 16, Iss 10, p 1434 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom16101434","doi":"https://doi.org/10.3390/biom16101434","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101434","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2442200933","display_name":null,"funder_award_id":"2024NSFSC0705","funder_id":"https://openalex.org/F4320322922","funder_display_name":"Department of Science and Technology of Sichuan Province"},{"id":"https://openalex.org/G8906687817","display_name":null,"funder_award_id":"XCZX2022001","funder_id":"https://openalex.org/F4320325093","funder_display_name":"Chengdu University of Traditional Chinese Medicine"},{"id":"https://openalex.org/G9000847927","display_name":null,"funder_award_id":"2024NSFSC0705","funder_id":"https://openalex.org/F4320325093","funder_display_name":"Chengdu University of Traditional Chinese Medicine"}],"funders":[{"id":"https://openalex.org/F4320322922","display_name":"Department of Science and Technology of Sichuan Province","ror":"https://ror.org/04323m874"},{"id":"https://openalex.org/F4320325093","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216430679.pdf","grobid_xml":"https://content.openalex.org/works/W7216430679.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1821806054","https://openalex.org/W1965313915","https://openalex.org/W1972947830","https://openalex.org/W2020047881","https://openalex.org/W2194585050","https://openalex.org/W2322580831","https://openalex.org/W2483736282","https://openalex.org/W2769023869","https://openalex.org/W2771022510","https://openalex.org/W2791822480","https://openalex.org/W2810763069","https://openalex.org/W2905280797","https://openalex.org/W2905485852","https://openalex.org/W2966269048","https://openalex.org/W2969456983","https://openalex.org/W2995708286","https://openalex.org/W2996717182","https://openalex.org/W3041426930","https://openalex.org/W3091953196","https://openalex.org/W3167114338","https://openalex.org/W3188222451","https://openalex.org/W3214314965","https://openalex.org/W4285090947","https://openalex.org/W4318934803","https://openalex.org/W4379386601","https://openalex.org/W4393238329","https://openalex.org/W4400319530","https://openalex.org/W4414992278","https://openalex.org/W7128552556","https://openalex.org/W7168285015"],"related_works":["https://openalex.org/W1653690037","https://openalex.org/W4224242642","https://openalex.org/W4409534090","https://openalex.org/W2034061233","https://openalex.org/W4205277681","https://openalex.org/W7154899843","https://openalex.org/W7162416178","https://openalex.org/W3129161663","https://openalex.org/W2605697993","https://openalex.org/W7204009681"],"abstract_inverted_index":{"Salvianolic":[0],"acid":[1,82],"A":[2],"(SAA)":[3],"exhibits":[4],"antitumor":[5,189],"activity":[6],"against":[7],"non-small":[8],"cell":[9,54,126,157],"lung":[10],"cancer":[11],"(NSCLC),":[12],"but":[13],"the":[14,45,91,115,150],"metabolic":[15,70,169,185],"regulatory":[16],"mechanisms":[17],"underlying":[18,187],"its":[19,188],"effects":[20,46],"remain":[21],"incompletely":[22],"understood.":[23],"In":[24],"this":[25],"study,":[26],"we":[27],"integrated":[28],"desorption":[29],"electrospray":[30],"ionization":[31],"mass":[32],"spectrometry":[33],"imaging":[34],"(DESI-MSI),":[35],"network":[36],"pharmacology,":[37],"molecular":[38,87],"docking,":[39],"and":[40,57,59,80,86,96,108,128,134,139,147,159,171,176],"functional":[41],"validation":[42],"to":[43],"investigate":[44],"of":[47,64,93,125,131,145],"SAA":[48,51,73,100,167],"on":[49],"NSCLC.":[50],"inhibited":[52],"H1299":[53],"viability,":[55,127],"migration,":[56],"invasion":[58],"induced":[60],"apoptosis.":[61,160],"DESI-MSI":[62],"analysis":[63],"xenograft":[65],"tumor":[66],"tissues":[67],"revealed":[68],"marked":[69],"alterations":[71],"after":[72],"treatment,":[74],"including":[75],"changes":[76],"in":[77,179],"ceramides,":[78],"glycerophospholipids,":[79],"arachidonic":[81],"candidates.":[83],"Network":[84],"pharmacology":[85],"docking":[88],"further":[89],"suggested":[90],"involvement":[92],"oxidative":[94],"stress-":[95],"apoptosis-related":[97],"pathways.":[98],"Functionally,":[99],"increased":[101,129],"intracellular":[102],"ROS":[103,116,122],"levels,":[104],"impaired":[105],"mitochondrial":[106,110,174],"function,":[107],"reduced":[109],"membrane":[111],"potential.":[112],"Treatment":[113],"with":[114],"scavenger":[117],"NAC":[118],"partially":[119],"reversed":[120],"SAA-induced":[121,156],"accumulation,":[123],"loss":[124],"levels":[130],"cleaved":[132],"Caspase-9":[133,146],"Caspase-3.":[135],"Consistently,":[136],"Western":[137],"blotting":[138],"immunofluorescence":[140],"analyses":[141],"showed":[142],"concentration-dependent":[143],"activation":[144],"Caspase-3,":[148],"whereas":[149],"pan-caspase":[151],"inhibitor":[152],"Z-VAD-FMK":[153],"significantly":[154],"attenuated":[155],"death":[158],"Collectively,":[161],"these":[162],"findings":[163],"provide":[164],"evidence":[165],"that":[166],"induces":[168],"remodeling":[170],"promotes":[172],"ROS-associated":[173],"dysfunction":[175],"caspase-mediated":[177],"apoptosis":[178],"NSCLC,":[180],"thereby":[181],"suggesting":[182],"a":[183],"potential":[184],"mechanism":[186],"activity.":[190]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-03T00:00:00"}
