{"id":"https://openalex.org/W7216282160","doi":"https://doi.org/10.64898/2026.09.30.755827","title":"Multi-omics profiling identifies a metabolic and energetic signature associated with neuronal dENL/AF9 suppression in aged flies","display_name":"Multi-omics profiling identifies a metabolic and energetic signature associated with neuronal dENL/AF9 suppression in aged flies","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216282160","doi":"https://doi.org/10.64898/2026.09.30.755827"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.30.755827","doi":"https://doi.org/10.64898/2026.09.30.755827","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755827","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755827.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755827.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005453660","display_name":"Ranchana Yeewa","orcid":"https://orcid.org/0000-0003-3915-0260","observed_orcids":["https://orcid.org/0000-0003-3915-0260"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ranchana Yeewa","raw_affiliation_strings":["Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-3915-0260","affiliations":[{"raw_affiliation_string":"Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093907290","display_name":"Pitiporn Noisagul","orcid":"https://orcid.org/0000-0001-5351-9998","observed_orcids":["https://orcid.org/0000-0001-5351-9998"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pitiporn Noisagul","raw_affiliation_strings":["Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050154672","display_name":"Sivamoke Dissook","orcid":"https://orcid.org/0000-0002-0695-6682","observed_orcids":["https://orcid.org/0000-0002-0695-6682"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sivamoke Dissook","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021937344","display_name":"Chansunee Panto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chansunee Panto","raw_affiliation_strings":["Drosophila Centre for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drosophila Centre for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134469211","display_name":"Puttachat Poound","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Puttachat Poound","raw_affiliation_strings":["Drosophila Centre for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drosophila Centre for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043600286","display_name":"Salinee Jantrapirom","orcid":"https://orcid.org/0000-0002-3111-5658","observed_orcids":["https://orcid.org/0000-0002-3111-5658"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Salinee Jantrapirom","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","Drosophila Centre for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]},{"raw_affiliation_string":"Drosophila Centre for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072003261","display_name":"Luca Lo Piccolo","orcid":"https://orcid.org/0000-0003-0558-356X","observed_orcids":["https://orcid.org/0000-0003-0558-356X"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Luca Lo Piccolo","raw_affiliation_strings":["Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-0558-356X","affiliations":[{"raw_affiliation_string":"Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072003261"],"corresponding_institution_ids":["https://openalex.org/I48076826"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enl","display_name":"ENL","score":0.8149999976158142},{"id":"https://openalex.org/keywords/af9","display_name":"AF9","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neuronal-aging","display_name":"neuronal aging","score":0.8140000104904175},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.7900000214576721},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fatty-acid-degradation","display_name":"fatty acid degradation","score":0.734000027179718},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.7960000038146973},{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nad-nadh-ratio","display_name":"NAD+/NADH ratio","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.8130000233650208},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.7440000176429749},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8159000277519226},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5842999815940857},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5767999887466431},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5338000059127808},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.5174999833106995},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4894999861717224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48809999227523804},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.46639999747276306},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.46230000257492065},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.460999995470047},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4564000070095062},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.44179999828338623},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4359000027179718},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.4251999855041504},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4196000099182129},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.39750000834465027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3937000036239624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.37220001220703125},{"id":"https://openalex.org/C8051207","wikidata":"https://www.wikidata.org/wiki/Q4678003","display_name":"Monoacylglycerol lipase","level":4,"score":0.3643999993801117},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3544999957084656},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.3377000093460083},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.3287999927997589},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.3073999881744385},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.2870999872684479},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.2824000120162964},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.25850000977516174},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.30.755827","doi":"https://doi.org/10.64898/2026.09.30.755827","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755827","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755827.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.30.755827","doi":"https://doi.org/10.64898/2026.09.30.755827","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755827","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.09.30.755827.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3078843775","display_name":null,"funder_award_id":"66-124","funder_id":"https://openalex.org/F4320326599","funder_display_name":"Health Systems Research Institute"},{"id":"https://openalex.org/G3849098433","display_name":null,"funder_award_id":"68-060","funder_id":"https://openalex.org/F4320326599","funder_display_name":"Health Systems Research Institute"},{"id":"https://openalex.org/G4844720877","display_name":null,"funder_award_id":"66-124","funder_id":"https://openalex.org/F4320321529","funder_display_name":"Chiang Mai University"},{"id":"https://openalex.org/G642082821","display_name":null,"funder_award_id":"N42A670768","funder_id":"https://openalex.org/F4320322817","funder_display_name":"National Research Council of Thailand"}],"funders":[{"id":"https://openalex.org/F4320321529","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25"},{"id":"https://openalex.org/F4320322817","display_name":"National Research Council of Thailand","ror":"https://ror.org/018wfhg78"},{"id":"https://openalex.org/F4320326599","display_name":"Health Systems Research Institute","ror":"https://ror.org/04yz0nm53"},{"id":"https://openalex.org/F4320329659","display_name":"Thailand Science Research and Innovation","ror":"https://ror.org/000025p04"},{"id":"https://openalex.org/F4320335535","display_name":"Faculty of Medicine, Chiang Mai University","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216282160.pdf","grobid_xml":"https://content.openalex.org/works/W7216282160.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2290069354","https://openalex.org/W2507896428","https://openalex.org/W4403276748","https://openalex.org/W4413304947","https://openalex.org/W1970026878","https://openalex.org/W4410224583","https://openalex.org/W7153998912","https://openalex.org/W2048903522","https://openalex.org/W2429953250","https://openalex.org/W2146725851"],"abstract_inverted_index":{"Abstract":[0],"Maintenance":[1],"of":[2,49,56,103,144,200,235,246],"neuronal":[3,83,213,247],"function":[4],"during":[5],"aging":[6,248],"requires":[7],"metabolic":[8,109,136,222],"adaptation,":[9],"yet":[10],"how":[11],"metabolite-sensitive":[12],"chromatin":[13],"regulators":[14],"contribute":[15],"to":[16,76,212],"this":[17,117],"process":[18],"remains":[19],"unclear.":[20],"YEATS-domain":[21],"proteins,":[22],"including":[23],"ENL":[24,58],"and":[25,31,40,59,65,73,106,137,147,158,164,172,192,197,219,223,241],"AF9,":[26,60],"recognize":[27],"histone":[28],"acylation":[29],"marks":[30],"are":[32],"positioned":[33],"at":[34],"the":[35,52,78,112,201,236],"interface":[36],"between":[37],"cellular":[38],"metabolism":[39],"transcriptional":[41,119,210],"regulation.":[42],"We":[43],"previously":[44,237],"showed":[45],"that":[46],"pan-neuronal":[47],"suppression":[48,215],"dENL/AF9":[50,84,214],",":[51],"single":[53],"Drosophila":[54],"orthologue":[55],"mammalian":[57],"extends":[61],"lifespan,":[62],"preserves":[63],"healthspan,":[64],"enhances":[66],"oxidative-stress":[67],"resistance.":[68],"Here,":[69],"we":[70,121],"used":[71],"multi-omics":[72],"biochemical":[74],"analyses":[75],"define":[77],"molecular":[79,130,202,225,233],"state":[80],"associated":[81,188],"with":[82,100,189],"suppression.":[85],"Transcriptomic":[86],"profiling":[87,124],"revealed":[88,153],"a":[89,134,173,184,208,220,242],"markedly":[90],"stronger":[91,209],"response":[92,211],"in":[93,111,155,216,227],"aged":[94,113,126,217,228],"than":[95],"young":[96],"male":[97],"fly":[98,229],"heads,":[99,127,230],"prominent":[101],"enrichment":[102],"fatty-acid":[104],"degradation":[105],"several":[107],"intermediary":[108],"pathways":[110],"dataset.":[114],"Guided":[115],"by":[116,168],"age-related":[118],"response,":[120],"focused":[122],"subsequent":[123],"on":[125,133],"where":[128],"independent":[129],"layers":[131],"converged":[132],"distinct":[135,221],"energetic":[138,224],"signature.":[139,203],"Lipidomics":[140],"identified":[141,181],"reduced":[142],"abundance":[143,171],"multiple":[145],"triglyceride-related":[146],"fatty":[148],"acid":[149],"derivatives,":[150],"while":[151],"metabolomics":[152],"changes":[154],"central-carbon/TCA-,":[156],"nicotinamide-,":[157],"purine-associated":[159],"features.":[160],"Proteomics":[161],"implicated":[162],"mitochondrial":[163],"ATP-associated":[165],"processes,":[166],"accompanied":[167],"increased":[169],"ATP":[170],"higher":[174],"NAD/NADH":[175],"ratio.":[176],"Matched":[177],"lipidome-metabolome":[178],"integration":[179],"further":[180],"citrate":[182],"as":[183],"cross-omics":[185],"feature":[186],"inversely":[187],"altered":[190],"triglyceride":[191],"ceramide":[193],"species,":[194],"linking":[195],"central-carbon":[196],"lipid-associated":[198],"components":[199],"Together,":[204],"these":[205],"findings":[206],"identify":[207],"flies":[218],"signature":[226],"providing":[231],"candidate":[232],"correlates":[234],"established":[238],"longevity":[239],"phenotype":[240],"framework":[243],"for":[244],"studies":[245],"biology.":[249],"Graphical":[250],"abstract":[251]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-03T00:00:00"}