{"id":"https://openalex.org/W7216274759","doi":"https://doi.org/10.1002/advs.77632","title":"Self\u2010Assembling Peptide\u2010Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy","display_name":"Self\u2010Assembling Peptide\u2010Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216274759","doi":"https://doi.org/10.1002/advs.77632","pmid":"https://pubmed.ncbi.nlm.nih.gov/42827008","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13633104"},"language":"en","primary_location":{"id":"doi:10.1002/advs.77632","doi":"https://doi.org/10.1002/advs.77632","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77632","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.77632","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5154404836","display_name":"Yang\u2010Fan Wu","orcid":"https://orcid.org/0000-0002-9932-208X","observed_orcids":["https://orcid.org/0000-0002-9932-208X"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yang\u2010Fan Wu","raw_affiliation_strings":["Centre of Cancer Medicine School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong People's Republic of China","School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-9932-208X","affiliations":[{"raw_affiliation_string":"Centre of Cancer Medicine School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong People's Republic of China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102828441","display_name":"Jingchu Hu","orcid":"https://orcid.org/0000-0001-6144-7226","observed_orcids":["https://orcid.org/0000-0001-6144-7226"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jing\u2010Chu Hu","raw_affiliation_strings":["School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-6144-7226","affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021719279","display_name":"Ye\u2010Fan Hu","orcid":"https://orcid.org/0000-0002-7834-1476","observed_orcids":["https://orcid.org/0000-0002-7834-1476"]},"institutions":[{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Ye\u2010Fan Hu","raw_affiliation_strings":["BayVax Biotech Limited Hong Kong Science Park Pak Shek Kok New Territories Hong Kong People's Republic of China","Shenzhen BayVax Biotech Limited Shenzhen People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-7834-1476","affiliations":[{"raw_affiliation_string":"BayVax Biotech Limited Hong Kong Science Park Pak Shek Kok New Territories Hong Kong People's Republic of China","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"Shenzhen BayVax Biotech Limited Shenzhen People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155001222","display_name":"Wen\u2010Jun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Wen\u2010Jun Li","raw_affiliation_strings":["School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101499428","display_name":"Rong Li","orcid":"https://orcid.org/0000-0002-8614-9687","observed_orcids":["https://orcid.org/0000-0002-8614-9687"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405273091","display_name":"Shenzhen Institute of Synthetic Biology","ror":"https://ror.org/058rt6c45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Rong","raw_affiliation_strings":["Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405273091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090208732","display_name":"Renhao Li","orcid":"https://orcid.org/0000-0002-6383-3240","observed_orcids":["https://orcid.org/0000-0002-6383-3240"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ren\u2010Hao Li","raw_affiliation_strings":["Centre of Cancer Medicine School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong People's Republic of China","School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-6383-3240","affiliations":[{"raw_affiliation_string":"Centre of Cancer Medicine School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong People's Republic of China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026622584","display_name":"Yuan Yao","orcid":"https://orcid.org/0000-0002-9833-5639","observed_orcids":["https://orcid.org/0000-0002-9833-5639","https://orcid.org/0009-0001-6101-3804","https://orcid.org/0000-0002-6907-6789"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yuan Yao","raw_affiliation_strings":["School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0001-6101-3804","affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041925478","display_name":"Lehan Hu","orcid":"https://orcid.org/0009-0009-9574-0151","observed_orcids":["https://orcid.org/0009-0009-9574-0151","https://orcid.org/0000-0003-4668-7744"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Lehan Hu","raw_affiliation_strings":["School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0009-9574-0151","affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154998807","display_name":"Xiao\u2010Lei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Lei Wang","raw_affiliation_strings":["School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664717","display_name":"Baozhong Zhang","orcid":"https://orcid.org/0000-0002-3273-3626","observed_orcids":["https://orcid.org/0000-0002-3273-3626"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405273091","display_name":"Shenzhen Institute of Synthetic Biology","ror":"https://ror.org/058rt6c45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao\u2010Zhong Zhang","raw_affiliation_strings":["Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405273091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100938384","display_name":"Yicheng Lu","orcid":"https://orcid.org/0009-0007-9717-5112","observed_orcids":["https://orcid.org/0009-0007-9717-5112"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yicheng Lu","raw_affiliation_strings":["Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam Hong Kong People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0007-9717-5112","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam Hong Kong People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086132807","display_name":"Shing Fung Chow","orcid":"https://orcid.org/0000-0002-4588-5346","observed_orcids":["https://orcid.org/0000-0002-4588-5346"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Shing\u2010Fung Chow","raw_affiliation_strings":["Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam Hong Kong People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-4588-5346","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine, The University of Hong Kong Pokfulam Hong Kong People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154472342","display_name":"Canhui Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Canhui Su","raw_affiliation_strings":["School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155680227","display_name":"Thomas Yau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Thomas Yau","raw_affiliation_strings":["Centre of Cancer Medicine School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Cancer Medicine School of Clinical Medicine The University of Hong Kong Pokfulam Hong Kong People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006947389","display_name":"Clive Yik\u2010Sham Chung","orcid":"https://orcid.org/0000-0003-1382-719X","observed_orcids":["https://orcid.org/0000-0003-1382-719X"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Clive Yik\u2010Sham Chung","raw_affiliation_strings":["Department of Pathology School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong People's Republic of China","School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-1382-719X","affiliations":[{"raw_affiliation_string":"Department of Pathology School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong People's Republic of China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113217968","display_name":"Jian\u2010Dong Huang","orcid":"https://orcid.org/0000-0001-7531-2816","observed_orcids":["https://orcid.org/0000-0001-7531-2816"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2800906782","display_name":"Hong Kong Science and Technology Parks Corporation","ror":"https://ror.org/05q8mqd91","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I2800906782"]},{"id":"https://openalex.org/I4210141719","display_name":"University of Hong Kong - Shenzhen Hospital","ror":"https://ror.org/047w7d678","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141719"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405273091","display_name":"Shenzhen Institute of Synthetic Biology","ror":"https://ror.org/058rt6c45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273091"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Jian\u2010Dong Huang","raw_affiliation_strings":["Centre for Virology, Vaccinology and Therapeutics Hong Kong Science and Technology Park Hong Kong Special Administrative Region People's Republic of China","Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen People's Republic of China","Materials Innovation Institute for Life Sciences and Energy (MILES) HKU\u2010SIRI Shenzhen People's Republic of China","School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","Shenzhen Key Laboratory for Cancer Metastasis and Personalized Therapy Department of Clinical Oncology The University of Hong Kong\u2010Shenzhen Hospital Shenzhen Guangdong Province People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-7531-2816","affiliations":[{"raw_affiliation_string":"Centre for Virology, Vaccinology and Therapeutics Hong Kong Science and Technology Park Hong Kong Special Administrative Region People's Republic of China","institution_ids":["https://openalex.org/I2800906782"]},{"raw_affiliation_string":"Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405273091"]},{"raw_affiliation_string":"Materials Innovation Institute for Life Sciences and Energy (MILES) HKU\u2010SIRI Shenzhen People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Sciences and School of Biomedical Engineering Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR People's Republic of China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Shenzhen Key Laboratory for Cancer Metastasis and Personalized Therapy Department of Clinical Oncology The University of Hong Kong\u2010Shenzhen Hospital Shenzhen Guangdong Province People's Republic of China","institution_ids":["https://openalex.org/I4210141719"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006947389","https://openalex.org/A5021719279","https://openalex.org/A5113217968","https://openalex.org/A5155680227"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2800906782","https://openalex.org/I4210141719","https://openalex.org/I4210145761","https://openalex.org/I4405273091","https://openalex.org/I889458895"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65692608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e77632","last_page":"e77632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr7-agonist","display_name":"TLR7 agonist","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cancer-vaccine-adjuvant","display_name":"cancer vaccine adjuvant","score":0.6290000081062317},{"id":"https://openalex.org/keywords/lymphatic-drainage","display_name":"lymphatic drainage","score":0.6600000262260437},{"id":"https://openalex.org/keywords/antigen-presenting-cell-maturation","display_name":"antigen-presenting cell maturation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cd8-t-cell-priming","display_name":"CD8+ T cell priming","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nk-cell-infiltration","display_name":"NK cell infiltration","score":0.6370000243186951},{"id":"https://openalex.org/keywords/anti-pd-1-combination-therapy","display_name":"anti-PD-1 combination therapy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6940000057220459},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6581000089645386},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5940999984741211},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.5139999985694885},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4999000132083893},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.446399986743927},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.43779999017715454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42669999599456787},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41769999265670776},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.41589999198913574},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4133000075817108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40059998631477356},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.3939000070095062},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39169999957084656},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.3840000033378601},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3702000081539154},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.366100013256073},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.36090001463890076},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.3458000123500824},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3449999988079071},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3416999876499176},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3407000005245209},{"id":"https://openalex.org/C2781274730","wikidata":"https://www.wikidata.org/wiki/Q4669679","display_name":"Abscopal effect","level":4,"score":0.3118000030517578},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.29980000853538513},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.2815999984741211},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2736999988555908},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.26440000534057617},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.25780001282691956}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/advs.77632","doi":"https://doi.org/10.1002/advs.77632","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77632","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13633104","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13633104/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13633104/pdf/ADVS-9999-e77632.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmid:42827008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42827008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/advs.77632","doi":"https://doi.org/10.1002/advs.77632","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.77632","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1679743855","display_name":null,"funder_award_id":"92369201","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G169353513","display_name":null,"funder_award_id":"2021YFA0910700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6662135534","display_name":null,"funder_award_id":"2021YFA0910700","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7335588866","display_name":null,"funder_award_id":"ZDSYS20210623091811035","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321920","display_name":"Innovation and Technology Commission","ror":"https://ror.org/04vf9tr09"},{"id":"https://openalex.org/F4320335227","display_name":"Bijzonder Onderzoeksfonds UGent","ror":"https://ror.org/00cv9y106"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216274759.pdf","grobid_xml":"https://content.openalex.org/works/W7216274759.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W964387587","https://openalex.org/W1969342260","https://openalex.org/W1993607703","https://openalex.org/W2140898147","https://openalex.org/W2144733364","https://openalex.org/W2179438025","https://openalex.org/W2204416339","https://openalex.org/W2592811885","https://openalex.org/W2617240724","https://openalex.org/W2724264513","https://openalex.org/W2724823461","https://openalex.org/W2808820218","https://openalex.org/W2904803926","https://openalex.org/W2922510644","https://openalex.org/W2951912016","https://openalex.org/W2952001873","https://openalex.org/W2972438906","https://openalex.org/W2995389725","https://openalex.org/W2999404032","https://openalex.org/W3024570138","https://openalex.org/W3027458630","https://openalex.org/W3032855415","https://openalex.org/W3093383535","https://openalex.org/W3094151083","https://openalex.org/W3127371223","https://openalex.org/W3177104437","https://openalex.org/W3201364149","https://openalex.org/W3204254871","https://openalex.org/W4289261964","https://openalex.org/W4293043553","https://openalex.org/W4318472464","https://openalex.org/W4321459314","https://openalex.org/W4385954728","https://openalex.org/W4394063358","https://openalex.org/W4408505242","https://openalex.org/W4409852004","https://openalex.org/W4410211450","https://openalex.org/W4412033714","https://openalex.org/W4412392064","https://openalex.org/W4413270682"],"related_works":["https://openalex.org/W7169808708","https://openalex.org/W4393089584","https://openalex.org/W2028266083","https://openalex.org/W2999404032","https://openalex.org/W4417422416","https://openalex.org/W4401088848","https://openalex.org/W2912560724","https://openalex.org/W4353015293","https://openalex.org/W3192209904","https://openalex.org/W2575567718"],"abstract_inverted_index":{"ABSTRACT":[0],"Peptide":[1],"cancer":[2,149],"vaccines":[3],"often":[4],"suffer":[5],"from":[6],"poor":[7],"lymphatic":[8,77],"drainage,":[9],"limited":[10],"antigen\u2010presenting":[11],"cell":[12,95],"uptake,":[13],"and":[14,79,96,107,126,140,158,182],"weak":[15],"innate":[16,181],"immune":[17],"activation.":[18],"To":[19],"overcome":[20],"these":[21],"barriers,":[22],"we":[23],"engineered":[24],"the":[25,37,89,165],"Self\u2010Assembling":[26],"Peptide\u2010Adjuvant":[27],"Conjugate":[28],"(SaPAC)":[29],"platform,":[30],"which":[31],"covalently":[32],"links":[33],"neoantigen":[34],"epitopes":[35],"to":[36,111,164],"TLR7":[38],"agonist":[39],"1V209":[40],"through":[41],"site\u2010selective":[42],"lysine":[43],"conjugation.":[44],"Synthesized":[45],"by":[46,131],"Fmoc":[47],"solid\u2010phase":[48],"peptide":[49,68],"synthesis,":[50],"SaPAC":[51,74,87,118,152,173],"conjugates":[52],"self\u2010assemble":[53],"into":[54],"cationic":[55],"nanoparticles":[56,69,75],"with":[57,65,71,155],"hydrodynamic":[58],"diameters":[59],"of":[60,135],"approximately":[61],"100\u2013200":[62],"nm.":[63],"Compared":[64],"unconjugated":[66],"self\u2010assembling":[67],"mixed":[70],"soluble":[72],"adjuvant,":[73],"enhanced":[76,108],"drainage":[78],"antigen":[80],"persistence":[81],"in":[82,123],"draining":[83],"lymph":[84],"nodes.":[85],"Mechanistically,":[86],"activated":[88,136],"TLR7\u2010MyD88":[90],"axis,":[91],"promoted":[92],"plasmacytoid":[93],"dendritic":[94],"macrophage":[97],"recruitment,":[98],"drove":[99],"APC":[100],"maturation":[101],"(CD80":[102],"+":[103,105],"CD86":[104],"),":[106],"MHC\u2010I":[109],"cross\u2010presentation":[110],"amplify":[112],"antigen\u2010specific":[113],"CD8+":[114,137],"T\u2010cell":[115],"priming.":[116],"Therapeutically,":[117],"monotherapy":[119],"suppressed":[120],"tumor":[121,161],"growth":[122],"B16\u2010OVA":[124],"melanoma":[125],"MB49":[127],"bladder":[128],"carcinoma":[129],"models":[130],"increasing":[132],"intratumoral":[133],"infiltration":[134],"T":[138],"cells":[139],"NK":[141],"cells.":[142],"In":[143],"an":[144],"orthotopic":[145],"4T1":[146],"triple\u2010negative":[147],"breast":[148],"model,":[150],"multivalent":[151],"vaccination":[153],"synergized":[154],"anti\u2010PD\u20101":[156],"blockade":[157],"achieved":[159],"durable":[160],"suppression":[162],"comparable":[163],"Poly(I:C)\u2010adjuvanted":[166],"benchmark":[167],"without":[168],"detectable":[169],"systemic":[170],"toxicity.":[171],"Collectively,":[172],"represents":[174],"a":[175],"chemically":[176],"defined":[177],"platform":[178],"that":[179],"bridges":[180],"adaptive":[183],"anti\u2010tumor":[184],"immunity.":[185]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-03T00:00:00"}