{"id":"https://openalex.org/W72162586","doi":null,"title":"L-dopa-carbidopa: combined therapy for the treatment of Parkinson's disease.","display_name":"L-dopa-carbidopa: combined therapy for the treatment of Parkinson's disease.","publication_year":1976,"publication_date":"1976-03-01","ids":{"openalex":"https://openalex.org/W72162586","mag":"72162586","pmid":"https://pubmed.ncbi.nlm.nih.gov/1253661"},"language":"en","primary_location":{"id":"pmid:1253661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1253661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the nervous system","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108386782","display_name":"Gastone G. Celesia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G G Celesia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034787651","display_name":"William M. Wanamaker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W M Wanamaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.00652482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"37","issue":"3","first_page":"123","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.703000009059906},{"id":"https://openalex.org/keywords/carbidopa","display_name":"carbidopa","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dopa-decarboxylase-inhibitors","display_name":"dopa decarboxylase inhibitors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8320000171661377},{"id":"https://openalex.org/keywords/l-dopa-side-effects","display_name":"L-DOPA side effects","score":0.746999979019165},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2776754145","wikidata":"https://www.wikidata.org/wiki/Q71133637","display_name":"Carbidopa","level":5,"score":0.9473776817321777},{"id":"https://openalex.org/C2908591018","wikidata":"https://www.wikidata.org/wiki/Q4795512","display_name":"Decarboxylase inhibitor","level":5,"score":0.7937605381011963},{"id":"https://openalex.org/C58824617","wikidata":"https://www.wikidata.org/wiki/Q421186","display_name":"Aromatic L-amino acid decarboxylase","level":3,"score":0.6917397975921631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6554051637649536},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.6347717046737671},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5879825949668884},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5158709287643433},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4909825623035431},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.48052462935447693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2562352418899536}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002230","descriptor_name":"Carbidopa","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002230","descriptor_name":"Carbidopa","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:1253661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1253661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the nervous system","raw_type":"Comparative Study"},{"id":"mag:72162586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1253661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2397215206","https://openalex.org/W2411178516","https://openalex.org/W2420673225","https://openalex.org/W2397798351","https://openalex.org/W2395574012","https://openalex.org/W2404922718","https://openalex.org/W2425194829","https://openalex.org/W2442553097","https://openalex.org/W2413475045","https://openalex.org/W2406184337"],"abstract_inverted_index":{"It":[0,21],"is":[1,7,129],"now":[2],"generally":[3],"acknowledged":[4],"that":[5,64,74],"L-Dopa":[6,16,89,115,128,133,160],"the":[8,26,52,109,117,143,148,151],"therapy":[9,87,158],"of":[10,36,44,125,150,153],"choice":[11],"for":[12,62,139],"Parkinson's":[13],"Disease.":[14],"However,":[15,84],"has":[17,41,57,79,94],"some":[18],"short":[19],"comings:":[20],"requires":[22],"large":[23,103],"daily":[24],"dosage,":[25],"therapeutic":[27],"benefits":[28],"are":[29,65,120],"achieved":[30],"only":[31],"after":[32],"a":[33,42,85,102],"delayed":[34],"onset":[35],"1-2":[37],"months,":[38],"and":[39,49,70,90,116,136],"it":[40],"number":[43],"side":[45],"effects":[46],"both":[47],"central":[48],"peripheral.":[50],"In":[51,142],"last":[53],"few":[54],"years":[55],"there":[56],"been":[58,82],"an":[59],"intense":[60],"search":[61],"agents":[63],"less":[66],"toxic,":[67],"more":[68,71,134],"efficient":[69],"rapidly":[72,137],"acting":[73],"L-Dopa.":[75],"The":[76,97],"ideal":[77],"agent":[78],"not":[80,107],"yet":[81],"found.":[83],"combination":[86],"with":[88,162],"dopa":[91],"decarboxylase":[92,98,118],"inhibitors":[93,99],"shown":[95],"promise.":[96],"used":[100],"have":[101],"molecule":[104],"which":[105],"does":[106],"cross":[108],"blood":[110],"brain":[111,140],"barrier.":[112],"Thus":[113],"when":[114],"inhibitor":[119],"given":[121],"togehher,":[122],"peripheral":[123],"production":[124],"dopamine":[126],"from":[127],"inhibited,":[130],"therefore,":[131],"rendering":[132],"readily":[135],"available":[138],"metabolism.":[141],"present":[144,147],"paper":[145],"we":[146],"results":[149],"treatment":[152],"50":[154],"patients":[155],"on":[156],"combined":[157,161],"using":[159],"Carbidopa.":[163]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
