{"id":"https://openalex.org/W7216144332","doi":"https://doi.org/10.1158/0008-5472.34055615","title":"Figure S1 from TLR9 Agonists Potentiate Adoptive T-cell Therapy in Cancer through a B-cell\u2013CD2 Costimulatory Axis","display_name":"Figure S1 from TLR9 Agonists Potentiate Adoptive T-cell Therapy in Cancer through a B-cell\u2013CD2 Costimulatory Axis","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216144332","doi":"https://doi.org/10.1158/0008-5472.34055615"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.34055615","doi":"https://doi.org/10.1158/0008-5472.34055615","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.34055615","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.34055615","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023682016","display_name":"Ayana T. Ruffin","orcid":"https://orcid.org/0000-0002-5837-5871","observed_orcids":["https://orcid.org/0000-0002-5837-5871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayana T. Ruffin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5837-5871","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120685924","display_name":"Vasili Toliopoulos","orcid":"https://orcid.org/0009-0004-4069-9570","observed_orcids":["https://orcid.org/0009-0004-4069-9570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vasili Toliopoulos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-4069-9570","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064779694","display_name":"Aubrey S. Smith","orcid":"https://orcid.org/0000-0003-3693-4262","observed_orcids":["https://orcid.org/0000-0003-3693-4262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aubrey S. Smith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3693-4262","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037389353","display_name":"Soundharya Kumaresan","orcid":"https://orcid.org/0000-0001-5946-1678","observed_orcids":["https://orcid.org/0000-0001-5946-1678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soundharya Kumaresan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5946-1678","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057476943","display_name":"Megan M. Wyatt","orcid":"https://orcid.org/0000-0003-1316-260X","observed_orcids":["https://orcid.org/0000-0003-1316-260X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan M. Wyatt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1316-260X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114524893","display_name":"Meredith Salzinger","orcid":"https://orcid.org/0009-0006-3512-7054","observed_orcids":["https://orcid.org/0009-0006-3512-7054"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meredith Salzinger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-3512-7054","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062852910","display_name":"Anna C. Cole","orcid":"https://orcid.org/0000-0002-2832-2824","observed_orcids":["https://orcid.org/0000-0002-2832-2824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna C. Cole","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2832-2824","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031983216","display_name":"Megen C Wittling","orcid":"https://orcid.org/0000-0002-3631-4955","observed_orcids":["https://orcid.org/0000-0002-3631-4955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megen C. Wittling","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3631-4955","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140141320","display_name":"Rachel L. Mason","orcid":"https://orcid.org/0009-0006-1547-5588","observed_orcids":["https://orcid.org/0009-0006-1547-5588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel L. Mason","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-1547-5588","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120639570","display_name":"James H. Carmouche","orcid":"https://orcid.org/0009-0001-5289-7732","observed_orcids":["https://orcid.org/0009-0001-5289-7732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James H. Carmouche","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5289-7732","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009087135","display_name":"Mahmoud A. Abdelbary","orcid":"https://orcid.org/0000-0002-6989-5194","observed_orcids":["https://orcid.org/0000-0002-6989-5194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahmoud A. Abdelbary","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6989-5194","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022272969","display_name":"Yuan Liu","orcid":"https://orcid.org/0000-0001-8926-3058","observed_orcids":["https://orcid.org/0000-0001-8926-3058"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8926-3058","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081974926","display_name":"Avery D. Posey","orcid":"https://orcid.org/0000-0001-8711-629X","observed_orcids":["https://orcid.org/0000-0001-8711-629X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avery D. Posey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8711-629X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032094154","display_name":"Gregory B. Lesinski","orcid":"https://orcid.org/0000-0002-8787-7678","observed_orcids":["https://orcid.org/0000-0002-8787-7678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory B. Lesinski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8787-7678","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044271217","display_name":"Chrystal Mary Paulos","orcid":"https://orcid.org/0000-0002-0784-2601","observed_orcids":["https://orcid.org/0000-0002-0784-2601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chrystal M. Paulos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0784-2601","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr9-agonist","display_name":"TLR9 agonist","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cpg-oligodeoxynucleotides","display_name":"CpG oligodeoxynucleotides","score":0.8629999756813049},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.949999988079071},{"id":"https://openalex.org/keywords/cd2","display_name":"CD2","score":0.5080000162124634},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.9779999852180481},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.8377000093460083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7390000224113464},{"id":"https://openalex.org/C22801619","wikidata":"https://www.wikidata.org/wiki/Q477471","display_name":"CpG Oligodeoxynucleotide","level":5,"score":0.6044999957084656},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6040999889373779},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5982999801635742},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5788999795913696},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5705000162124634},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5184999704360962},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.505299985408783},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4659000039100647},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4246000051498413},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.39100000262260437},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C3019255331","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive immunotherapy","level":4,"score":0.33889999985694885},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3199000060558319},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.30250000953674316},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2908999202","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"Toll-Like Receptor 9","level":5,"score":0.2800999879837036},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.34055615","doi":"https://doi.org/10.1158/0008-5472.34055615","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.34055615","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.34055615","doi":"https://doi.org/10.1158/0008-5472.34055615","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.34055615","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7216138734","https://openalex.org/W7216549295","https://openalex.org/W7216120613","https://openalex.org/W7216367456","https://openalex.org/W7167502514","https://openalex.org/W7215725960","https://openalex.org/W7216200359","https://openalex.org/W3101754398","https://openalex.org/W7215915741","https://openalex.org/W3213251178"],"abstract_inverted_index":{"CpG":[0,4],"conditioning":[1],"by":[2],"distinct":[3],"classes":[5],"on":[6],"pmel-1":[7],"CD8":[8],"increases":[9],"T":[10],"cell":[11],"activation":[12],"and":[13],"cytokine":[14],"production":[15]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-03T00:00:00"}