{"id":"https://openalex.org/W7216086617","doi":"https://doi.org/10.64898/2026.10.01.755872","title":"Oncogenic ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture","display_name":"Oncogenic ESR1 fusions form chromatin-anchored condensates that remodel nuclear architecture","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216086617","doi":"https://doi.org/10.64898/2026.10.01.755872"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.01.755872","doi":"https://doi.org/10.64898/2026.10.01.755872","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.755872","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.10.01.755872.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.10.01.755872.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123799607","display_name":"Ana-Maria Gherghelas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana-Maria Gherghelas","raw_affiliation_strings":["School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081604457","display_name":"Natalia Fili","orcid":"https://orcid.org/0000-0002-0898-0766","observed_orcids":["https://orcid.org/0000-0002-0898-0766"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Natalia Fili","raw_affiliation_strings":["School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154572800","display_name":"Adam Boulger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam Boulger","raw_affiliation_strings":["School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003928093","display_name":"Alison E. Twelvetrees","orcid":"https://orcid.org/0000-0002-1796-1508","observed_orcids":["https://orcid.org/0000-0002-1796-1508"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alison E. Twelvetrees","raw_affiliation_strings":["School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK"],"raw_orcid":"https://orcid.org/0000-0002-1796-1508","affiliations":[{"raw_affiliation_string":"School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155147428","display_name":"Lin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1286704778","display_name":"Rutherford Appleton Laboratory","ror":"https://ror.org/03gq8fr08","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1286704778","https://openalex.org/I162524378","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I162524378","display_name":"Science and Technology Facilities Council","ror":"https://ror.org/057g20z61","country_code":"GB","type":"government","lineage":["https://openalex.org/I162524378","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I4210092957","display_name":"Research Complex at Harwell","ror":"https://ror.org/00gqx0331","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210092957"]},{"id":"https://openalex.org/I4391767682","display_name":"Central Laser Facility","ror":"https://ror.org/05efe5r97","country_code":"GB","type":"facility","lineage":["https://openalex.org/I162524378","https://openalex.org/I4210087105","https://openalex.org/I4391767682"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lin Wang","raw_affiliation_strings":["Central Laser Facility, Research Complex at Harwell, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell, Didcot, Oxford, OX11 0QX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laser Facility, Research Complex at Harwell, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell, Didcot, Oxford, OX11 0QX, UK","institution_ids":["https://openalex.org/I1286704778","https://openalex.org/I162524378","https://openalex.org/I4210092957","https://openalex.org/I4391767682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020568316","display_name":"Lewis Frame","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lewis Frame","raw_affiliation_strings":["School of Physics, Engineering and Technology, University of York, York YO10 5DD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics, Engineering and Technology, University of York, York YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155650481","display_name":"Jamieson Anthony Leyland Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jamieson A.L. Howard","raw_affiliation_strings":["School of Physics, Engineering and Technology, University of York, York YO10 5DD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics, Engineering and Technology, University of York, York YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154718317","display_name":"Matthew Newton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew D. Newton","raw_affiliation_strings":["School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074311677","display_name":"Mark C. Leake","orcid":"https://orcid.org/0000-0002-1715-1249","observed_orcids":["https://orcid.org/0000-0002-1715-1249"]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark C. Leake","raw_affiliation_strings":["Department of Biology, University of York, York YO10 5DD, UK","School of Physics, Engineering and Technology, University of York, York YO10 5DD, UK"],"raw_orcid":"https://orcid.org/0000-0002-1715-1249","affiliations":[{"raw_affiliation_string":"Department of Biology, University of York, York YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"School of Physics, Engineering and Technology, University of York, York YO10 5DD, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051163780","display_name":"Christopher P. Toseland","orcid":"https://orcid.org/0000-0002-1641-7535","observed_orcids":["https://orcid.org/0000-0002-1641-7535"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher P. Toseland","raw_affiliation_strings":["School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK"],"raw_orcid":"https://orcid.org/0000-0002-1641-7535","affiliations":[{"raw_affiliation_string":"School of Medicine and Population Health, University of Sheffield, Sheffield, S10 2RX, UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5051163780"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nuclear-condensates","display_name":"nuclear condensates","score":0.8119999766349792},{"id":"https://openalex.org/keywords/phase-separation","display_name":"phase separation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nuclear-stiffness","display_name":"nuclear stiffness","score":0.7860000133514404},{"id":"https://openalex.org/keywords/chromatin-decompaction","display_name":"chromatin decompaction","score":0.9810000061988831},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.8949999809265137},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8126000165939331},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5885999798774719},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5015000104904175},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.5005999803543091},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49570000171661377},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.453900009393692},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4431000053882599},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.43630000948905945},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.42289999127388},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.4065999984741211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3982999920845032},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.39160001277923584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38370001316070557},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.37929999828338623},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.37130001187324524},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.33739998936653137},{"id":"https://openalex.org/C126725582","wikidata":"https://www.wikidata.org/wiki/Q30679","display_name":"Nuclear pore","level":3,"score":0.32260000705718994},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30799999833106995},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.25679999589920044},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.01.755872","doi":"https://doi.org/10.64898/2026.10.01.755872","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.755872","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.10.01.755872.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.01.755872","doi":"https://doi.org/10.64898/2026.10.01.755872","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.755872","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/02/2026.10.01.755872.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G120957038","display_name":null,"funder_award_id":"EP/P02470X/1","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1876265278","display_name":null,"funder_award_id":"EP /P02470X/1","funder_id":"https://openalex.org/F4320316365","funder_display_name":"Henry Royce Institute"},{"id":"https://openalex.org/G2063598450","display_name":null,"funder_award_id":"EP/S019367/1","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2072291230","display_name":null,"funder_award_id":"EP/S019367/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G2149950934","display_name":null,"funder_award_id":"EP/P025285/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G2158237762","display_name":null,"funder_award_id":"EP/S019367","funder_id":"https://openalex.org/F4320316365","funder_display_name":"Henry Royce Institute"},{"id":"https://openalex.org/G2219480757","display_name":null,"funder_award_id":"EP/R00661X/1","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2438624709","display_name":"The Biophysics of Mesoscale, Reversible, Biomolecular Assemblies","funder_award_id":"EP/Y000501/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2550352914","display_name":null,"funder_award_id":"EP/P025285/1","funder_id":"https://openalex.org/F4320316365","funder_display_name":"Henry Royce Institute"},{"id":"https://openalex.org/G2573251597","display_name":"DTP Bid Led by University of Sheffield","funder_award_id":"MR/W006944/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2703599441","display_name":null,"funder_award_id":"EP /S019367/1","funder_id":"https://openalex.org/F4320316365","funder_display_name":"Henry Royce Institute"},{"id":"https://openalex.org/G3389515625","display_name":null,"funder_award_id":"EP/P025285/1","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3473440229","display_name":null,"funder_award_id":"EP/P025285/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3621172555","display_name":null,"funder_award_id":"EP/P02470X","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G36854682","display_name":"Sir Henry Royce Institute -Sheffield Equipment","funder_award_id":"EP/P02470X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3767274333","display_name":"Molecular mechanisms of slow axonal transport","funder_award_id":"220192","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3988987169","display_name":null,"funder_award_id":"EP/P02470X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G461713102","display_name":"Sir Henry Royce Institute - Sheffield Build","funder_award_id":"EP/P025285/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G4776755045","display_name":"Understanding the role of nuclear myosin in the spatial organisation of transcription","funder_award_id":"BB/X008460/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G504327055","display_name":null,"funder_award_id":"EP/R00661X/1\u00e2\u20ac\u00b3","funder_id":"https://openalex.org/F4320316365","funder_display_name":"Henry Royce Institute"},{"id":"https://openalex.org/G5171000724","display_name":null,"funder_award_id":"EP/R00661X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5820086322","display_name":null,"funder_award_id":"EP/R00661X/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G5876728471","display_name":"Function of Nuclear Myosin Motors: A Biochemical and Single Molecule Characterization.","funder_award_id":"MR/M020606/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5997058914","display_name":"Single-molecule studies of T-loop formation and telomerase recruitment at telomeres","funder_award_id":"225139","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6148779978","display_name":null,"funder_award_id":"EP/S019367/","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6229724750","display_name":"Molecular mechanisms of slow axonal transport","funder_award_id":"220192/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6567113825","display_name":"Single-molecule studies of T-loop formation and telomerase recruitment at telomeres","funder_award_id":"225139/Z/22/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6935963053","display_name":"The Royce: Capitalising on the investment","funder_award_id":"EP/S019367/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G708391930","display_name":null,"funder_award_id":"EP/R00661X","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7445816383","display_name":null,"funder_award_id":"EP/R00661X","funder_id":"https://openalex.org/F4320316365","funder_display_name":"Henry Royce Institute"},{"id":"https://openalex.org/G7771625495","display_name":null,"funder_award_id":"EP/P02470X/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G8090655982","display_name":null,"funder_award_id":"EP/S019367/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8181482213","display_name":"Sir Henry Royce InsStitute - recurrent grant","funder_award_id":"EP/R00661X/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8686880783","display_name":null,"funder_award_id":"MR/M020606/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320316365","display_name":"Henry Royce Institute","ror":"https://ror.org/013a0r905"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334632","display_name":"Science and Technology Facilities Council","ror":"https://ror.org/057g20z61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216086617.pdf","grobid_xml":"https://content.openalex.org/works/W7216086617.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7161169899","https://openalex.org/W2887208641","https://openalex.org/W2887861528","https://openalex.org/W1925661138","https://openalex.org/W2954026569","https://openalex.org/W7123517671","https://openalex.org/W7047294262","https://openalex.org/W2897779677","https://openalex.org/W3181076312","https://openalex.org/W3013169782"],"abstract_inverted_index":{"ABSTRACT":[0],"Estrogen":[1],"receptor":[2],"(":[3],"ESR1":[4,107,131,151],")":[5],"fusions":[6,50,132,152],"are":[7],"recurrent":[8],"drivers":[9],"of":[10,17,90,125],"endocrine-resistant":[11],"breast":[12],"cancer,":[13],"yet":[14],"their":[15,103],"mechanisms":[16],"action":[18],"remain":[19],"poorly":[20],"understood.":[21],"Here,":[22],"we":[23],"show":[24],"that":[25,48,74,97,130,140],"ESR1-e6":[26],"fusion":[27,108],"proteins,":[28],"including":[29],"ESR1-DAB2":[30],",":[31,33,36],"ESR1-SOX9":[32],"and":[34,61,70,105,117,160],"ESR1-YAP1":[35],"assemble":[37],"into":[38,82],"nuclear":[39,115,126,143],"condensates":[40,75,109],"across":[41],"multiple":[42],"cell":[43],"types.":[44],"Sequence":[45],"analysis":[46],"reveals":[47],"these":[49],"combine":[51],"chromatin-targeting":[52],"domains":[53],"with":[54,122],"increased":[55],"intrinsic":[56],"disorder,":[57],"promoting":[58],"multivalent":[59],"interactions":[60],"phase":[62,134],"separation.":[63],"Live-cell":[64],"imaging,":[65],"fluorescence":[66],"recovery":[67],"after":[68],"photobleaching,":[69],"mechanical":[71],"perturbation":[72],"demonstrate":[73],"exhibit":[76],"liquid-like":[77],"properties,":[78],"but":[79],"progressively":[80],"mature":[81],"stable,":[83],"viscoelastic":[84],"assemblies":[85,139],"constrained":[86],"by":[87],"chromatin.":[88],"Disruption":[89],"DNA":[91],"binding":[92],"abolishes":[93],"condensate":[94],"formation,":[95],"indicating":[96],"chromatin":[98,119],"engagement":[99],"is":[100],"essential":[101],"for":[102],"assembly":[104],"organisation.":[106],"localise":[110],"to":[111,136],"chromatin-depleted":[112],"regions,":[113],"reduce":[114],"stiffness,":[116],"promote":[118],"decompaction,":[120],"consistent":[121],"active":[123],"remodelling":[124],"architecture.":[127],"We":[128],"propose":[129],"exploit":[133],"separation":[135],"generate":[137],"chromatin-anchored":[138],"reorganise":[141],"the":[142],"microenvironment,":[144],"providing":[145],"a":[146],"physical":[147],"framework":[148],"through":[149],"which":[150],"may":[153],"support":[154],"sustained":[155],"transcriptional":[156],"activity,":[157],"endocrine":[158],"resistance":[159],"tumour":[161],"progression.":[162]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-03T00:00:00"}
