{"id":"https://openalex.org/W7216078461","doi":"https://doi.org/10.1021/acsomega.6c04220","title":"Signaling Pathways Mediating the Cytotoxicity of (E)-4-(1-Epoxy-7,8-propenyl)phenyl Benzoate, a Phenylpropanoid from Croton velutinus , in MCF-7 Cells","display_name":"Signaling Pathways Mediating the Cytotoxicity of (E)-4-(1-Epoxy-7,8-propenyl)phenyl Benzoate, a Phenylpropanoid from Croton velutinus , in MCF-7 Cells","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216078461","doi":"https://doi.org/10.1021/acsomega.6c04220","pmid":"https://pubmed.ncbi.nlm.nih.gov/42890088","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13670846"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.6c04220","doi":"https://doi.org/10.1021/acsomega.6c04220","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c04220","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04220/68733885/acsomega.6c04220.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04220/68733885/acsomega.6c04220.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078758789","display_name":"Renata Albuquerque de Abrantes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renata A. de Abrantes","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032669369","display_name":"S\u00e2mia Sousa Duarte","orcid":"https://orcid.org/0000-0002-5238-9594","observed_orcids":["https://orcid.org/0000-0002-5238-9594"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sa\u0302mia S. Duarte","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038779562","display_name":"Rafael Carlos Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael C. Ferreira","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154335708","display_name":"Ana Paula G. M. Farias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Paula G. M. Farias","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155651957","display_name":"Geraldo M. W. Amorim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Geraldo M. W. Amorim","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155713595","display_name":"Paulo B. A. Loureiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo B. A. Loureiro","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113051948","display_name":"Ramon Ramos Marques de Souza","orcid":"https://orcid.org/0009-0002-0651-163X","observed_orcids":["https://orcid.org/0009-0002-0651-163X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ramon R. M. de Souza","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":"https://orcid.org/0009-0002-0651-163X","affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027093024","display_name":"Valgr\u00edcia Matias de Sousa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Valgri\u0301cia M. de Sousa","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154794535","display_name":"Gabriela B. de Lyra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriela B. de Lyra","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154404593","display_name":"Isabela C. F. Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabela C. F. Silva","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029591466","display_name":"Lucas Silva Abreu","orcid":"https://orcid.org/0000-0001-5620-8095","observed_orcids":["https://orcid.org/0000-0001-5620-8095"]},"institutions":[{"id":"https://openalex.org/I161127581","display_name":"Universidade Federal Fluminense","ror":"https://ror.org/02rjhbb08","country_code":"BR","type":"education","lineage":["https://openalex.org/I161127581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lucas S. Abreu","raw_affiliation_strings":["Fluminense Federal University , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-5620-8095","affiliations":[{"raw_affiliation_string":"Fluminense Federal University , , , ,","institution_ids":["https://openalex.org/I161127581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154791513","display_name":"Eudes da S. Velozo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126158947","display_name":"Universidade Federal da Bahia","ror":"https://ror.org/03k3p7647","country_code":"BR","type":"education","lineage":["https://openalex.org/I126158947"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eudes da S. Velozo","raw_affiliation_strings":["Federal University of Bahia , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Bahia , , , ,","institution_ids":["https://openalex.org/I126158947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003530843","display_name":"Juan Carlos Ramos Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-1702-1102","observed_orcids":["https://orcid.org/0000-0002-1702-1102"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juan C. R. Gonc\u0327alves","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-1702-1102","affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155757121","display_name":"Marcelo Felipe Rodrigues da Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo S. da Silva","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085730158","display_name":"Josean Fechine Tavares","orcid":"https://orcid.org/0000-0003-0293-2605","observed_orcids":["https://orcid.org/0000-0003-0293-2605"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Josean F. Tavares","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-0293-2605","affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085177956","display_name":"Marianna Vieira Sobral","orcid":"https://orcid.org/0000-0002-7740-034X","observed_orcids":["https://orcid.org/0000-0002-7740-034X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Marianna V. Sobral","raw_affiliation_strings":["Federal University of Parai\u0301ba (UFPB) , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7740-034X","affiliations":[{"raw_affiliation_string":"Federal University of Parai\u0301ba (UFPB) , , , ,","institution_ids":["https://openalex.org/I169045520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085177956"],"corresponding_institution_ids":["https://openalex.org/I169045520"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72878457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"40","first_page":"60877","last_page":"60896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.1809999942779541,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.11810000240802765,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylpropanoids","display_name":"phenylpropanoids","score":0.9150000214576721},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9290000200271606},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8859999775886536},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8519999980926514},{"id":"https://openalex.org/keywords/zebrafish-embryo-toxicity","display_name":"zebrafish embryo toxicity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.5889999866485596},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8313999772071838},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6133000254631042},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5480999946594238},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5425999760627747},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5364999771118164},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5184000134468079},{"id":"https://openalex.org/C2776559899","wikidata":"https://www.wikidata.org/wiki/Q417181","display_name":"Phenylpropanoid","level":4,"score":0.49219998717308044},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4855000078678131},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47609999775886536},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4494999945163727},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4244000017642975},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4023999869823456},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39410001039505005},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.37139999866485596},{"id":"https://openalex.org/C2778942509","wikidata":"https://www.wikidata.org/wiki/Q456053","display_name":"Croton oil","level":3,"score":0.36739999055862427},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32120001316070557},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29649999737739563},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2549999952316284}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.6c04220","doi":"https://doi.org/10.1021/acsomega.6c04220","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c04220","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04220/68733885/acsomega.6c04220.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13670846","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42890088/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13670846/pdf/ao6c04220.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:42890088","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42890088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:88a2f446d9e940679f8ed8fe0fb2a06d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/88a2f446d9e940679f8ed8fe0fb2a06d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 11, Iss 40, Pp 60877-60896 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.6c04220","doi":"https://doi.org/10.1021/acsomega.6c04220","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c04220","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c04220/68733885/acsomega.6c04220.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G103296194","display_name":null,"funder_award_id":"465536/2014\u20130","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1196282521","display_name":null,"funder_award_id":"CAPES-FINANCE CODE 001","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1207375514","display_name":null,"funder_award_id":"Code 001","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1620329843","display_name":null,"funder_award_id":"(Finance Code 001)","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1677423749","display_name":null,"funder_award_id":"2014\u20100","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G22113365","display_name":null,"funder_award_id":"00x0ma614","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G9000848214","display_name":null,"funder_award_id":"465536/2014-0","funder_id":"https://openalex.org/F4320322904","funder_display_name":"Financiadora de Estudos e Projetos"},{"id":"https://openalex.org/G931167877","display_name":null,"funder_award_id":"465536/2014-0","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"},{"id":"https://openalex.org/F4320330029","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216078461.pdf","grobid_xml":"https://content.openalex.org/works/W7216078461.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W201808626","https://openalex.org/W1928058926","https://openalex.org/W1978057567","https://openalex.org/W2001932120","https://openalex.org/W2011044704","https://openalex.org/W2011215202","https://openalex.org/W2012208226","https://openalex.org/W2017821950","https://openalex.org/W2022205209","https://openalex.org/W2029939478","https://openalex.org/W2030397985","https://openalex.org/W2039981234","https://openalex.org/W2063148361","https://openalex.org/W2072091107","https://openalex.org/W2083453016","https://openalex.org/W2084981004","https://openalex.org/W2088845519","https://openalex.org/W2093557429","https://openalex.org/W2097348057","https://openalex.org/W2107495112","https://openalex.org/W2114918609","https://openalex.org/W2117692326","https://openalex.org/W2135086805","https://openalex.org/W2150026213","https://openalex.org/W2156131378","https://openalex.org/W2164575467","https://openalex.org/W2167229817","https://openalex.org/W2169558425","https://openalex.org/W2222744272","https://openalex.org/W2288735625","https://openalex.org/W2340525378","https://openalex.org/W2476704480","https://openalex.org/W2557531334","https://openalex.org/W2560140416","https://openalex.org/W2593137377","https://openalex.org/W2767765728","https://openalex.org/W2769216006","https://openalex.org/W2780032723","https://openalex.org/W2785091318","https://openalex.org/W2889101189","https://openalex.org/W2913357005","https://openalex.org/W2941724686","https://openalex.org/W2965262235","https://openalex.org/W2970933730","https://openalex.org/W2999534237","https://openalex.org/W3013726226","https://openalex.org/W3023752815","https://openalex.org/W3026448624","https://openalex.org/W3042581723","https://openalex.org/W3080766128","https://openalex.org/W3080953833","https://openalex.org/W3083057988","https://openalex.org/W3087617819","https://openalex.org/W3137431864","https://openalex.org/W3152791694","https://openalex.org/W3198894769","https://openalex.org/W4200483382","https://openalex.org/W4220703955","https://openalex.org/W4229029734","https://openalex.org/W4248636029","https://openalex.org/W4283584100","https://openalex.org/W4291366502","https://openalex.org/W4293150252","https://openalex.org/W4296336213","https://openalex.org/W4300960642","https://openalex.org/W4308527042","https://openalex.org/W4309512373","https://openalex.org/W4311051500","https://openalex.org/W4322486493","https://openalex.org/W4322617777","https://openalex.org/W4323669894","https://openalex.org/W4327573938","https://openalex.org/W4367838943","https://openalex.org/W4378906417","https://openalex.org/W4380990587","https://openalex.org/W4385456232","https://openalex.org/W4385986528","https://openalex.org/W4386498159","https://openalex.org/W4386995658","https://openalex.org/W4388233322","https://openalex.org/W4389266070","https://openalex.org/W4390582547","https://openalex.org/W4390600173","https://openalex.org/W4390732311","https://openalex.org/W4390906364","https://openalex.org/W4392343318","https://openalex.org/W4392360685","https://openalex.org/W4393935425","https://openalex.org/W4396634145","https://openalex.org/W4399296868","https://openalex.org/W4399670992","https://openalex.org/W4400513914","https://openalex.org/W4404303717","https://openalex.org/W4406087423","https://openalex.org/W4409339440","https://openalex.org/W4411612719","https://openalex.org/W4411975940","https://openalex.org/W4411992253","https://openalex.org/W4412371075","https://openalex.org/W4412519963","https://openalex.org/W4413007154","https://openalex.org/W4413799593","https://openalex.org/W4415873396","https://openalex.org/W7091363280","https://openalex.org/W7117115001","https://openalex.org/W7126111491","https://openalex.org/W7128528232","https://openalex.org/W7128596342","https://openalex.org/W7128700466","https://openalex.org/W7131629389","https://openalex.org/W7133216968","https://openalex.org/W7140146216","https://openalex.org/W7140283170","https://openalex.org/W7140304439","https://openalex.org/W7153212922","https://openalex.org/W7154690732","https://openalex.org/W7154983313","https://openalex.org/W7155493865","https://openalex.org/W7160502248"],"related_works":["https://openalex.org/W7120647739","https://openalex.org/W4411612719","https://openalex.org/W2100995727","https://openalex.org/W4402218093","https://openalex.org/W2286727149","https://openalex.org/W3167869297","https://openalex.org/W2383964178","https://openalex.org/W3048222231","https://openalex.org/W2119111279","https://openalex.org/W3112680194"],"abstract_inverted_index":{"Abstract":[0],"Natural":[1],"products":[2],"represent":[3],"an":[4,127],"important":[5],"source":[6],"of":[7,19,98,129],"candidates":[8],"for":[9,160],"breast":[10,31,153],"cancer":[11,32,154],"therapy.":[12],"Here,":[13],"we":[14],"investigated":[15],"the":[16,96,158],"antitumor":[17,150],"activity":[18,49,151],"(E)-4-(1-epoxy-7,8-propen)phenylbenzoate":[20],"(CV2),":[21],"a":[22],"phenylpropanoid":[23],"isolated":[24],"from":[25],"Croton":[26],"velutinus":[27],"roots,":[28],"in":[29,39,104,132,138],"MCF-7":[30,51],"cells":[33,41,52,65,118,155],"and":[34,42,58,77,81,101,126,169],"evaluated":[35],"its":[36,105,166],"toxicity":[37,109],"profile":[38,168],"nontumor":[40],"zebrafish":[43,133],"embryos.":[44],"CV2":[45,69,111,147],"exhibited":[46,112],"potent":[47],"cytotoxic":[48],"against":[50,152],"(IC50=":[53],"4.63":[54],"\u00b1":[55,123],"0.16":[56],"\u03bcM)":[57,125],"showed":[59],"selectivity":[60],"relative":[61],"to":[62,163],"nontumorigenic":[63],"MCF-10A":[64],"(SI":[66],"=":[67,121],"9.69).":[68],"also":[70],"induced":[71],"apoptosis,":[72],"increased":[73],"intracellular":[74],"ROS":[75],"levels,":[76],"modulated":[78],"MAPK,":[79],"NF-\u03baB,":[80],"PKB/AKT":[82],"signaling":[83,103],"pathways.":[84],"Pretreatment":[85],"with":[86],"N-acetylcysteine":[87],"or":[88],"MAPK":[89,102],"inhibitors":[90],"significantly":[91],"attenuated":[92],"CV2-induced":[93],"cytotoxicity,":[94],"supporting":[95],"involvement":[97],"oxidative":[99,139],"stress":[100],"biological":[106],"effects.":[107],"In":[108],"studies,":[110],"cytotoxicity":[113],"toward":[114],"peripheral":[115],"blood":[116],"mononuclear":[117],"(PBMCs;":[119],"IC50":[120],"1.75":[122],"0.06":[124],"LC50":[128],"3.07":[130],"\u03bcM":[131],"embryos,":[134],"accompanied":[135],"by":[136],"alterations":[137],"stress-related":[140],"enzymes.":[141],"Collectively,":[142],"these":[143],"findings":[144],"demonstrate":[145],"that":[146],"possesses":[148],"significant":[149],"while":[156],"highlighting":[157],"need":[159],"further":[161],"studies":[162],"better":[164],"define":[165],"safety":[167],"therapeutic":[170],"potential.":[171]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-03T00:00:00"}
