{"id":"https://openalex.org/W7216007070","doi":"https://doi.org/10.64898/2026.09.30.755739","title":"Proteostasis in Podocytes: Role of Cargo Receptor Surf4 and Collagen IV Trafficking","display_name":"Proteostasis in Podocytes: Role of Cargo Receptor Surf4 and Collagen IV Trafficking","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216007070","doi":"https://doi.org/10.64898/2026.09.30.755739"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.30.755739","doi":"https://doi.org/10.64898/2026.09.30.755739","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755739","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755739.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755739.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043984170","display_name":"Andrey V. Cybulsky","orcid":"https://orcid.org/0000-0003-4348-2348","observed_orcids":["https://orcid.org/0000-0003-4348-2348"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Andrey V. Cybulsky","raw_affiliation_strings":["Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada"],"raw_orcid":"https://orcid.org/0000-0003-4348-2348","affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110040206","display_name":"Joan Papillon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joan Papillon","raw_affiliation_strings":["Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114433169","display_name":"Christian-Landry Konde Bilogui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christian-Landry Konde Bilogui","raw_affiliation_strings":["Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136682339","display_name":"Rachel Shih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405263283","display_name":"Research Institute of the McGill University Health Centre","ror":"https://ror.org/04pemf943","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405263283","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rachel Shih","raw_affiliation_strings":["Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043984170"],"corresponding_institution_ids":["https://openalex.org/I2801766832","https://openalex.org/I4405263283","https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.3617999851703644,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surf4","display_name":"SURF4","score":0.9200000166893005},{"id":"https://openalex.org/keywords/col4a5","display_name":"COL4A5","score":0.7390000224113464},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8220000267028809},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ire1alpha","display_name":"IRE1\u03b1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autophagosomes","display_name":"autophagosomes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.8220000267028809},{"id":"https://openalex.org/keywords/focal-segmental-glomerulosclerosis","display_name":"focal segmental glomerulosclerosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/membranous-nephropathy","display_name":"membranous nephropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glomerular-epithelial-cells","display_name":"glomerular epithelial cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cargo-receptors","display_name":"cargo receptors","score":0.5740000009536743},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.876800000667572},{"id":"https://openalex.org/C2777575526","wikidata":"https://www.wikidata.org/wiki/Q3542091","display_name":"Tunicamycin","level":4,"score":0.8427000045776367},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7871000170707703},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.7735999822616577},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.762499988079071},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6789000034332275},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.5942999720573425},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.516700029373169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.489300012588501},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4300999939441681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42309999465942383},{"id":"https://openalex.org/C2777390665","wikidata":"https://www.wikidata.org/wiki/Q5571239","display_name":"Glomerulosclerosis","level":4,"score":0.41449999809265137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4133000075817108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34850001335144043},{"id":"https://openalex.org/C2778415529","wikidata":"https://www.wikidata.org/wiki/Q1435223","display_name":"Focal segmental glomerulosclerosis","level":4,"score":0.33160001039505005},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.3075999915599823},{"id":"https://openalex.org/C2777877921","wikidata":"https://www.wikidata.org/wiki/Q6005532","display_name":"Immunolabeling","level":3,"score":0.30640000104904175},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26570001244544983},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2565000057220459},{"id":"https://openalex.org/C2993140218","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Immunoelectron microscopy","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.30.755739","doi":"https://doi.org/10.64898/2026.09.30.755739","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755739","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755739.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.30.755739","doi":"https://doi.org/10.64898/2026.09.30.755739","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755739","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755739.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319947","display_name":"Kidney Foundation of Canada","ror":"https://ror.org/019a0gk53"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216007070.pdf","grobid_xml":"https://content.openalex.org/works/W7216007070.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1989142233","https://openalex.org/W1994772574","https://openalex.org/W2005039062","https://openalex.org/W2008100303","https://openalex.org/W2012034410","https://openalex.org/W2012371191","https://openalex.org/W2022387069","https://openalex.org/W2089230333","https://openalex.org/W2099429838","https://openalex.org/W2121596834","https://openalex.org/W2131355460","https://openalex.org/W2150737519","https://openalex.org/W2164934883","https://openalex.org/W2168287443","https://openalex.org/W2168453644","https://openalex.org/W2263498456","https://openalex.org/W2375150125","https://openalex.org/W2551668015","https://openalex.org/W2606110324","https://openalex.org/W2625879429","https://openalex.org/W2738033609","https://openalex.org/W2764162783","https://openalex.org/W2794038182","https://openalex.org/W2799819345","https://openalex.org/W2903915228","https://openalex.org/W2951666921","https://openalex.org/W2952034853","https://openalex.org/W2955889508","https://openalex.org/W3009733240","https://openalex.org/W3012098554","https://openalex.org/W3043429322","https://openalex.org/W3044253363","https://openalex.org/W3083466538","https://openalex.org/W3109535487","https://openalex.org/W3117836548","https://openalex.org/W3163731104","https://openalex.org/W3177828909","https://openalex.org/W4221028349","https://openalex.org/W4225435600","https://openalex.org/W4297236272","https://openalex.org/W4307429082","https://openalex.org/W4313427355","https://openalex.org/W4324089271","https://openalex.org/W4376130805","https://openalex.org/W4385303130","https://openalex.org/W4387137323","https://openalex.org/W4387665784","https://openalex.org/W4398185485","https://openalex.org/W4398201100","https://openalex.org/W4401835150","https://openalex.org/W4404269963","https://openalex.org/W4404399948","https://openalex.org/W4407864944","https://openalex.org/W7160844234"],"related_works":["https://openalex.org/W7104524679","https://openalex.org/W7161836543","https://openalex.org/W4396994820","https://openalex.org/W4221028349","https://openalex.org/W4297236272","https://openalex.org/W3109535487","https://openalex.org/W4396998184","https://openalex.org/W2594930732","https://openalex.org/W2168007689","https://openalex.org/W2768992940"],"abstract_inverted_index":{"Abstract":[0],"Protein":[1],"misfolding":[2],"in":[3,51,59,84,102,127,137,157,175,201,239],"the":[4,19,29,42,121,132,143,162,202,218],"endoplasmic":[5],"reticulum":[6],"(ER)":[7],"of":[8,21,25,44,134,147,186,199,204,211],"podocytes/glomerular":[9],"epithelial":[10],"cells":[11],"(GECs)":[12],"induces":[13],"ER":[14,111,208,228],"stress":[15,112],"and":[16,27,34,46,75,87,131,145,155,194,213],"contributes":[17],"to":[18,69,91,106,160,180,192,197,221],"pathogenesis":[20],"glomerular":[22],"disease.":[23],"Activation":[24],"IRE1\u03b1":[26,107],"consequently":[28],"unfolded":[30],"protein":[31,56],"response":[32],"(UPR)":[33],"autophagy":[35,125],"sustains":[36],"proteostasis.":[37,53],"The":[38],"present":[39],"study":[40],"examines":[41],"role":[43],"Surf4":[45,55,79,98,118,135,156,174,212,223],"collagen":[47],"IV-\u03b15":[48],"(COL4A5)":[49],"trafficking":[50],"podocyte":[52],"Glomerular":[54,78],"expression":[57,81,99],"increased":[58,142],"IRE1\u03b1-replete":[60,103],"mice":[61,72],"with":[62,73,173],"experimental":[63],"focal":[64],"segmental":[65],"glomerulosclerosis":[66],"(FSGS)":[67],"compared":[68,90,105,191],"podocyte-IRE1\u03b1":[70],"knockout":[71,108],"FSGS":[74,86],"control":[76],"mice.":[77],"gene":[80],"was":[82,100,178,188,195],"greater":[83,101],"human":[85,163],"membranous":[88],"nephropathy":[89],"healthy":[92],"controls.":[93],"In":[94,139],"cultured":[95],"GECs,":[96,109,140],"basal":[97,171],"(control)":[104],"although":[110],"(tunicamycin":[113],"treatment)":[114],"did":[115],"not":[116],"increase":[117],"despite":[119],"activating":[120],"UPR.":[122],"Tunicamycin":[123],"enhanced":[124,170],"(LC3-II)":[126],"an":[128],"IRE1\u03b1-dependent":[129],"manner,":[130],"amount":[133,144],"localized":[136],"autophagosomes.":[138,158],"tunicamycin":[141,183],"colocalization":[146,172,177],"endogenous":[148],"COL4A5":[149,214,232],"or":[150],"ectopically-expressed":[151],"COL4A5-wild":[152],"type":[153],"(WT)":[154],"Compared":[159],"COL4A5-WT,":[161],"COL4A5-C1567R":[164,187],"mutant":[165],"(which":[166],"is":[167],"misfolded)":[168],"showed":[169],"autophagosomes;":[176],"similar":[179],"COL4A5-WT":[181,193,200],"after":[182],"treatment.":[184],"Degradation":[185],"more":[189],"rapid":[190],"comparable":[196],"degradation":[198],"presence":[203],"tunicamycin.":[205],"Thus,":[206],"during":[207],"stress,":[209],"subsets":[210],"are":[215],"redirected":[216],"from":[217],"secretory":[219],"pathway":[220],"autophagy.":[222],"may":[224],"help":[225],"deliver":[226],"misfolded":[227],"cargo,":[229],"such":[230],"as":[231],"for":[233],"autosomal":[234],"degradation,":[235],"thereby":[236],"sustaining":[237],"proteostasis":[238],"podocytes.":[240]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-03T00:00:00"}