{"id":"https://openalex.org/W7216004154","doi":"https://doi.org/10.61155/gen.v65i4.303","title":"Epidemiolog\u00eda, evoluci\u00f3n y respuesta a tratamiento con diferentes esquemas de la hepatitis B cr\u00f3nica en pacientes pedi\u00e1tricos","display_name":"Epidemiolog\u00eda, evoluci\u00f3n y respuesta a tratamiento con diferentes esquemas de la hepatitis B cr\u00f3nica en pacientes pedi\u00e1tricos","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W7216004154","doi":"https://doi.org/10.61155/gen.v65i4.303"},"language":"es","primary_location":{"id":"pmh:oai:ojs.genindex.ddns.net:article/303","doi":"https://doi.org/10.61155/gen.v65i4.303","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/303","pdf_url":"https://revistagen.com/index.php/GEN/article/download/303/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://revistagen.com/index.php/GEN/article/download/303/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083855679","display_name":"Elena Pesta\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100657","display_name":"Hospital San Juan de Dios","ror":"https://ror.org/0166mge61","country_code":"VE","type":"healthcare","lineage":["https://openalex.org/I4210100657"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Pestana, Elena","raw_affiliation_strings":["1) Hospital San Juan de Dios. Caracas.\r\n2) Fundaci\u00f3n Zuliana del H\u00edgado, Zulia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1) Hospital San Juan de Dios. Caracas.\r\n2) Fundaci\u00f3n Zuliana del H\u00edgado, Zulia","institution_ids":["https://openalex.org/I4210100657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156158639","display_name":"Mar\u00eda Gabriela Soriano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soriano, Mar\u00eda Gabriela","raw_affiliation_strings":["Hospital Central de Valera, Trujillo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Central de Valera, Trujillo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156167983","display_name":"Rafael Santiago","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santiago, Rafael","raw_affiliation_strings":["Hospital Central de Valera, Trujillo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Central de Valera, Trujillo","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082233110","display_name":"Mar\u00eda Teresa Art\u00eds","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Art\u00eds, Mar\u00eda Teresa","raw_affiliation_strings":["Complejo Hospitalario Universitario Dr. Luis Razzetti, Anzo\u00e1tegui"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complejo Hospitalario Universitario Dr. Luis Razzetti, Anzo\u00e1tegui","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154802201","display_name":"Maritza Serisawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serisawa, Maritza","raw_affiliation_strings":["Fundaci\u00f3n Zuliana del H\u00edgado, Zulia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n Zuliana del H\u00edgado, Zulia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153799097","display_name":"Karolina L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L\u00f3pez, Karolina","raw_affiliation_strings":["Hospital Miguel P\u00e9rez Carre\u00f1o, Caracas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Miguel P\u00e9rez Carre\u00f1o, Caracas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155461450","display_name":"Dianora Navarro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Navarro, Dianora","raw_affiliation_strings":["Hospital Miguel P\u00e9rez Carre\u00f1o, Caracas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Miguel P\u00e9rez Carre\u00f1o, Caracas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089459265","display_name":"Katiuska Belandria","orcid":"https://orcid.org/0009-0006-0780-0459","observed_orcids":["https://orcid.org/0009-0006-0780-0459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Belandria, Katiuska","raw_affiliation_strings":["Hospital Miguel P\u00e9rez Carre\u00f1o, Caracas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Miguel P\u00e9rez Carre\u00f1o, Caracas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049298044","display_name":"Reinaldo Pierre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre, Reinaldo","raw_affiliation_strings":["Cl\u00ednica Razzetti Lara, Barquisimeto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cl\u00ednica Razzetti Lara, Barquisimeto","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103991191","display_name":"Keira Le\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Le\u00f3n, Keira","raw_affiliation_strings":["Hospital Domingo Luciani. Caracas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Domingo Luciani. Caracas","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.7120000123977661},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5559999942779541},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.382999986410141},{"id":"https://openalex.org/keywords/adefovir","display_name":"adefovir","score":0.6240000128746033},{"id":"https://openalex.org/keywords/lamivudine","display_name":"lamivudine","score":0.7960000038146973},{"id":"https://openalex.org/keywords/zalcitabine","display_name":"zalcitabine","score":0.597000002861023},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.6639999747276306},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.640999972820282},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.5630000233650208},{"id":"https://openalex.org/keywords/hbcag","display_name":"HBcAg","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hbeag","display_name":"HBeAg","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hbv-dna","display_name":"HBV DNA","score":0.6779999732971191},{"id":"https://openalex.org/keywords/viral-transmission-routes","display_name":"viral transmission routes","score":0.38499999046325684},{"id":"https://openalex.org/keywords/venezuela","display_name":"Venezuela","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8962000012397766},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5561000108718872},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.22759999334812164},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.20819999277591705},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.1973000019788742},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.1680999994277954},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.16349999606609344},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.1623000055551529},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.16019999980926514}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ojs.genindex.ddns.net:article/303","doi":"https://doi.org/10.61155/gen.v65i4.303","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/303","pdf_url":"https://revistagen.com/index.php/GEN/article/download/303/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ojs.genindex.ddns.net:article/303","doi":"https://doi.org/10.61155/gen.v65i4.303","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/303","pdf_url":"https://revistagen.com/index.php/GEN/article/download/303/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216004154.pdf","grobid_xml":"https://content.openalex.org/works/W7216004154.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7008503306","https://openalex.org/W2073050650","https://openalex.org/W2283701485","https://openalex.org/W4320020488","https://openalex.org/W2100267258","https://openalex.org/W4393974754","https://openalex.org/W4392887237","https://openalex.org/W7217948936","https://openalex.org/W4285060811","https://openalex.org/W2329901641"],"abstract_inverted_index":{"Introducci\u00f3n":[0],"y":[1,16,41,55,61,138,157,167,226,251,266,283,324,390,455],"Objetivo:":[2],"La":[3,402],"hepatitis":[4,106],"B":[5,74,107,428],"cr\u00f3nica":[6,71,108,188,220,404,425],"constituye":[7],"un":[8,158,171],"problema":[9],"de":[10,24,33,44,80,95,98,117,124,154,160,163,173,180,185,279,307,313,329,341,375,398,420],"salud":[11],"p\u00fablica":[12],"a":[13,47,77,93,290,304,412,430],"nivel":[14],"mundial":[15],"la":[17,31,42,183,186,229],"poblaci\u00f3n":[18],"pedi\u00e1trica":[19],"no":[20,331],"se":[21,227,299,407],"encuentra":[22,408],"excluida":[23],"este":[25],"problema.":[26],"El":[27],"objetivo":[28],"fue":[29],"evaluar":[30],"epidemiolog\u00eda":[32],"esta":[34],"patolog\u00eda":[35],"en":[36,39,83,143,231,444],"pacientes":[37,46,67,89,104,126,131,196,237,258,296,306,344,413,422,431,435],"pedi\u00e1tricos":[38,68,90],"Venezuela":[40],"respuesta":[43,351,389,447],"estos":[45],"las":[48,178,192],"diferentes":[49,78,99],"opciones":[50],"terap\u00e9uticas":[51],"que":[52,75,91,120,193,436],"disponemos.":[53],"Pacientes":[54],"M\u00e9todos:":[56],"Se":[57,63,176],"realiz\u00f3":[58,301],"estudio":[59],"multic\u00e9ntrico":[60],"retrospectivo.":[62],"incluyeron":[64],"todos":[65],"los":[66,125,129,235,256,294,308,336,421,434],"con":[69,105,152,170,348,350,361,364,368,371,379,388,392,394,414,423],"infecci\u00f3n":[70,187,314,403,424],"por":[72,110,115,189,244,315,334,405,426,450],"virus":[73,459],"consultan":[76],"consultas":[79,94],"Gastroenterolog\u00eda":[81,96],"Pedi\u00e1trica":[82],"el":[84,122,339,418],"pa\u00eds.":[85],"Resultados:":[86],"De":[87,128,234,255,293],"15537":[88],"acudieron":[92],"pedi\u00e1tricas":[97],"centros":[100],"hospitalarios":[101],"encontramos":[102],"148":[103,130,236],"dado":[109,243],"persistencia":[111],"Ags":[112,245],"VHB":[113,190,246,249,253,277,335,406],"positivo":[114,250],"m\u00e1s":[116,409],"6":[118],"meses":[119,166],"representan":[121],"1%":[123],"evaluados.":[127],"111":[132],"(75%)":[133],"pertenecen":[134],"al":[135,140,352],"sexo":[136,141],"masculino":[137],"37(25%)":[139],"femenino,":[142],"edades":[144],"comprendidas":[145],"desde":[146],"1":[147,224,321,347],"a\u00f1o":[148],"hasta":[149],"18":[150],"a\u00f1os":[151,156,169],"promedio":[153,172],"11,25":[155],"tiempo":[159],"seguimiento":[161],"comprendido":[162],"entre":[164,191,288],"3":[165,208,325,370,384],"14":[168,378],"4,45":[174],"a\u00f1os.":[175],"evaluaron":[177],"formas":[179],"transmisi\u00f3n":[181,210,214],"para":[182,276],"adquisici\u00f3n":[184],"tenemos":[194],"65":[195],"(44%)":[197],"hab\u00edan":[198],"tenido":[199],"patolog\u00edas":[200,203,415],"oncol\u00f3gicas,":[201],"3(2%)":[202],"hematol\u00f3gicas,":[204],"antecedentes":[205],"intervenciones":[206],"quir\u00fargicas":[207],"(2%),":[209],"vertical":[211],"11":[212],"(7%),":[213],"horizontal":[215],"4":[216],"(3%),":[217],"insuficiencia":[218],"renal":[219],"2":[221,373,391],"(1,3%),":[222],"cardi\u00f3patas":[223],"(0,7%)":[225],"desconoce":[228],"causa":[230],"59":[232],"(40%).":[233],"72":[238,257,295],"(49%)":[239],"son":[240],"portadores":[241,259,297],"activos":[242,260,298],"positivo,":[247],"Age":[248],"ADN":[252,376,399,458],"positivo.":[254],"44":[261],"(61%)":[262],"ten\u00edan":[263,269,273,311,332],"aminotranferasas":[264,270],"normales":[265],"28":[267],"(39%)":[268],"elevadas,":[271],"34(47%)":[272],"carga":[274,286,396],"viral":[275,287,397],"mayor":[278],"20000":[280,291],"UI/":[281],"ml":[282],"38":[284],"(53%)":[285],"2000":[289],"UI/ml.":[292],"les":[300],"biopsia":[302],"hep\u00e1tica":[303],"55":[305],"cuales":[309,337],"52":[310,343],"hallazgos":[312],"VHB,":[316,377],"17":[317],"(31%)":[318],"ten\u00eda":[319],"fibrosis,":[320],"presentaba":[322],"cirrosis":[323],"(2%":[326],"del":[327,452,457],"total":[328],"pacientes)":[330],"lesi\u00f3n":[333],"constituyen":[338],"grupo":[340],"inmunotolerantes.":[342,432],"recibieron":[345,437],"tratamiento":[346,387],"Lamivudine":[349,365],"mismo,":[353],"12":[354],"Interferon":[355],"pegilado":[356,382,439],"como":[357],"terapia":[358],"\u00fanica":[359],"7":[360],"respuesta,":[362,369],"20":[363],"+IFNpeg":[366],"13":[367],"Entecavir":[372,380],"negativizaci\u00f3n":[374,456],"+IFN":[381],"solo":[383,442],"han":[385],"finalizado":[386],"Telbivudine":[393],"disminuci\u00f3n":[395],"VHB.":[400],"Conclusi\u00f3n:":[401],"frecuentemente":[410],"asociada":[411],"oncol\u00f3gicas.":[416],"Solo":[417,433],"2%":[419],"Virus":[427],"corresponden":[429],"interfer\u00f3n":[438],"bien":[440],"sea":[441],"o":[443],"combinaci\u00f3n":[445],"presentaron":[446],"completa":[448],"dada":[449],"seroconversi\u00f3n":[451],"ant\u00edgeno":[453],"e":[454],"B.":[460]},"counts_by_year":[],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2026-10-03T00:00:00"}