{"id":"https://openalex.org/W7216002569","doi":"https://doi.org/10.1001/jamanetworkopen.2026.37545","title":"Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality","display_name":"Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7216002569","doi":"https://doi.org/10.1001/jamanetworkopen.2026.37545","pmid":"https://pubmed.ncbi.nlm.nih.gov/42826016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13633536"},"language":"en","primary_location":{"id":"doi:10.1001/jamanetworkopen.2026.37545","doi":"https://doi.org/10.1001/jamanetworkopen.2026.37545","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.37545","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1001/jamanetworkopen.2026.37545","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051832898","display_name":"Eleni Armeni","orcid":"https://orcid.org/0000-0003-3310-1521","observed_orcids":["https://orcid.org/0000-0003-3310-1521"]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]},{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eleni Armeni","raw_affiliation_strings":["Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom","Royal Free Hospital NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Royal Free Hospital NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024040992","display_name":"\u0130pek Bet\u00fcl \u00d6z\u00e7ivit Erkan","orcid":"https://orcid.org/0000-0002-5645-7064","observed_orcids":["https://orcid.org/0000-0002-5645-7064"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ipek Betul Ozcivit Erkan","raw_affiliation_strings":["Cerrahpasa Faculty of Medicine, Institute of Graduate Studies, Istanbul University\u2013Cerrahpasa, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cerrahpasa Faculty of Medicine, Institute of Graduate Studies, Istanbul University\u2013Cerrahpasa, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027548347","display_name":"Punith Kempegowda","orcid":"https://orcid.org/0000-0003-0954-6512","observed_orcids":["https://orcid.org/0000-0003-0954-6512"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Punith Kempegowda","raw_affiliation_strings":["Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom","Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Endocrinology, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I2799307867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5027548347"],"corresponding_institution_ids":["https://openalex.org/I2799307867","https://openalex.org/I79619799"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52460875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"10","first_page":"e2637545","last_page":"e2637545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iatrogenic-menopause","display_name":"iatrogenic menopause","score":0.8960000276565552},{"id":"https://openalex.org/keywords/age-at-menopause","display_name":"age at menopause","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cardiovascular-morbidity","display_name":"cardiovascular morbidity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.9929999709129333},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9570000171661377},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9860000014305115},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.5270000100135803},{"id":"https://openalex.org/keywords/surgical-menopause","display_name":"surgical menopause","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.35899999737739563},{"id":"https://openalex.org/keywords/moderating-effect-of-age","display_name":"age as moderator","score":0.3610000014305115},{"id":"https://openalex.org/keywords/meta-regression","display_name":"meta-regression","score":0.5120000243186951},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"hazard ratio","score":0.41499999165534973},{"id":"https://openalex.org/keywords/women-s-health-disparities","display_name":"women's health disparities","score":0.35600000619888306},{"id":"https://openalex.org/keywords/health-equity","display_name":"health equity","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9193999767303467},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.8518999814987183},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5698999762535095},{"id":"https://openalex.org/C2910557164","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Surgical Menopause","level":3,"score":0.5663999915122986},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5095999836921692},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4855000078678131},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4528000056743622},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.40369999408721924},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4032000005245209},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.38089999556541443},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.36320000886917114},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.33160001039505005},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3061000108718872},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2759999930858612},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.26600000262260437},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2529999911785126}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007049","descriptor_name":"Iatrogenic Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1001/jamanetworkopen.2026.37545","doi":"https://doi.org/10.1001/jamanetworkopen.2026.37545","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.37545","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13633536","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13633536/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/instance/13633536/bin/jamanetwopen-e2637545-s001.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Netw Open","raw_type":"Text"},{"id":"pmid:42826016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42826016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA network open","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/05583f04-02fb-42f9-af78-ddc0866cc394","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/05583f04-02fb-42f9-af78-ddc0866cc394","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Armeni, E, Erkan, I B O & Kempegowda, P 2026, 'Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality : A Systematic Review and Meta-Analysis', JAMA network open, vol. 9, no. 10, e2637545. https://doi.org/10.1001/jamanetworkopen.2026.37545","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":{"id":"doi:10.1001/jamanetworkopen.2026.37545","doi":"https://doi.org/10.1001/jamanetworkopen.2026.37545","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2026.37545","pdf_url":null,"source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7216002569.pdf","grobid_xml":"https://content.openalex.org/works/W7216002569.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W164674300","https://openalex.org/W1965787256","https://openalex.org/W1970499787","https://openalex.org/W1970801031","https://openalex.org/W1981214453","https://openalex.org/W2002077931","https://openalex.org/W2033068288","https://openalex.org/W2041638034","https://openalex.org/W2064601540","https://openalex.org/W2078896802","https://openalex.org/W2084478135","https://openalex.org/W2099163504","https://openalex.org/W2105336986","https://openalex.org/W2116832131","https://openalex.org/W2118949079","https://openalex.org/W2119486233","https://openalex.org/W2121154755","https://openalex.org/W2144111174","https://openalex.org/W2155658630","https://openalex.org/W2175762087","https://openalex.org/W2329328722","https://openalex.org/W2524870530","https://openalex.org/W2586772518","https://openalex.org/W2627140922","https://openalex.org/W2735381369","https://openalex.org/W2804877404","https://openalex.org/W2885357480","https://openalex.org/W2896323841","https://openalex.org/W2904009020","https://openalex.org/W2917591863","https://openalex.org/W2970684805","https://openalex.org/W2978261942","https://openalex.org/W2986916985","https://openalex.org/W3009662284","https://openalex.org/W3023436896","https://openalex.org/W3035902913","https://openalex.org/W3036314380","https://openalex.org/W3159297879","https://openalex.org/W3176092375","https://openalex.org/W3209329767","https://openalex.org/W4210954872","https://openalex.org/W4235348522","https://openalex.org/W4281975821","https://openalex.org/W4283776205","https://openalex.org/W4284883308","https://openalex.org/W4285083971","https://openalex.org/W4321600733","https://openalex.org/W4375853754","https://openalex.org/W4376636181","https://openalex.org/W4381598293","https://openalex.org/W4381951304","https://openalex.org/W4382982943","https://openalex.org/W4392044412","https://openalex.org/W4399721712","https://openalex.org/W4402555011","https://openalex.org/W4404741530","https://openalex.org/W4404836773","https://openalex.org/W4405523773","https://openalex.org/W4411055937","https://openalex.org/W4411372759","https://openalex.org/W4413141393","https://openalex.org/W4415766565","https://openalex.org/W4416701726","https://openalex.org/W7203834261"],"related_works":["https://openalex.org/W6887822938","https://openalex.org/W4283776205","https://openalex.org/W2520538161","https://openalex.org/W1997021052","https://openalex.org/W2978261942","https://openalex.org/W3136120036","https://openalex.org/W2085559421","https://openalex.org/W2152860648","https://openalex.org/W137975887","https://openalex.org/W4295181130"],"abstract_inverted_index":{"Importance:":[0],"Iatrogenic":[1,219],"menopause":[2,23,35,86,89,169,203,220,264,323,349,376],"is":[3,36],"common,":[4],"but":[5],"its":[6],"long-term":[7],"cardiovascular":[8,25,78,137,139,147,150,236,354,361,384],"consequences":[9],"remain":[10],"uncertain,":[11],"particularly":[12],"by":[13,109,177],"age":[14,32,90,167,266,289,320,367,373,395],"at":[15,33,168,286,321,370,374],"menopause.":[16,371],"Objective:":[17],"To":[18],"quantify":[19],"associations":[20],"between":[21],"iatrogenic":[22,34,85,202,263,322,348,375],"and":[24,27,29,45,59,73,102,126,132,140,143,149,165,205,251,343,359,362,386],"morbidity":[26,79,148,385],"mortality":[28,81,230,364],"evaluate":[30],"whether":[31],"a":[37,144,171,307,389,400],"modifier.":[38],"Data":[39,100,104],"Sources:":[40],"In":[41,306,345],"this":[42,346],"systematic":[43],"review":[44],"meta-analysis,":[46],"Scopus,":[47],"MEDLINE,":[48],"PubMed,":[49],"Embase,":[50],"Cochrane":[51],"Central":[52],"Register":[53],"of":[54,146,163,228,383,391],"Controlled":[55],"Trials":[56],"(CENTRAL),":[57],"CINAHL,":[58],"PsycINFO":[60],"were":[61,98,105,136,175,187,260],"searched":[62],"from":[63,338],"January":[64],"2004":[65],"to":[66,262],"March":[67],"2026.":[68],"Study":[69],"Selection:":[70],"Observational":[71],"studies":[72,186],"randomized":[74],"clinical":[75],"trials":[76],"reporting":[77,128],"or":[80,95,287],"among":[82],"women":[83,193],"with":[84,92,113,159,166,189,225,283,326,352,360,379],"before":[87,265,366,394],"natural":[88],"compared":[91],"naturally":[93],"menopausal":[94],"age-matched":[96],"controls":[97],"included.":[99],"Extraction":[101],"Synthesis:":[103],"extracted":[106],"in":[107,319],"duplicate":[108],"2":[110,190],"independent":[111,340],"reviewers,":[112],"consensus":[114],"resolution.":[115],"The":[116],"study":[117],"followed":[118],"the":[119,201,312],"Preferred":[120],"Reporting":[121],"Items":[122],"for":[123,200,209],"Systematic":[124],"Reviews":[125],"Meta-Analyses":[127],"guideline.":[129],"Main":[130],"Outcomes":[131],"Measures:":[133],"Primary":[134],"outcomes":[135],"morbidity,":[138,355],"all-cause":[141,229,276,299,363],"mortality,":[142,151,387],"composite":[145,313],"quantified":[152],"as":[153,170],"random-effects":[154],"pooled":[155],"hazard":[156],"ratios":[157],"(PHRs)":[158],"95%":[160,233,240,248,255,331],"CIs,":[161],"irrespective":[162],"heterogeneity":[164],"moderator.":[172],"Meta-regression":[173],"estimates":[174,285,337],"clustered":[176],"source":[178],"cohort.":[179],"Results:":[180],"Of":[181],"14":[182],"409":[183],"records,":[184],"36":[185],"included":[188],"617":[191],"942":[192],"(mean":[194],"[SD]":[195],"age,":[196],"55.52":[197],"[12.41]":[198],"years":[199,208,215,268,291,369,397],"cohort":[204],"45.58":[206],"[16.02]":[207],"comparators);":[210],"median":[211],"follow-up":[212],"was":[213,223,324,350,377],"16.0":[214],"(range,":[216],"4.8-36.0":[217],"years).":[218],"vs":[221],"comparators":[222],"associated":[224,325,351,378],"higher":[226,353],"risk":[227,328,382,393],"(PHR,":[231,238,246,253],"1.08;":[232],"CI,":[234,241,249,256,274,281,297,304,332],"1.01-1.16),":[235],"events":[237],"1.25;":[239],"1.12-1.39),":[242],"coronary":[243],"heart":[244],"disease":[245],"1.48;":[247],"1.07-2.03),":[250],"stroke":[252],"1.22;":[254],"1.15-1.28).":[257],"Mortality":[258],"excesses":[259,365],"confined":[261],"45":[267,290,368,396],"(cardiovascular":[269,292],"mortality:":[270,277,293,300],"PHR,":[271,278,294,301],"1.20":[272],"[95%":[273,280,296,303],"1.04-1.37];":[275],"1.15":[279],"1.06-1.25]),":[282],"null":[284],"after":[288],"0.95":[295],"0.81-1.11];":[298],"0.99":[302],"0.89-1.09]).":[305],"post":[308],"hoc":[309],"meta-regression":[310],"on":[311,335],"outcome,":[314],"each":[315],"increasing":[316],"5-year":[317],"increment":[318],"lower":[327,381],"(HR,":[329],"0.89;":[330],"0.83-0.97)":[333],"based":[334],"37":[336],"11":[339],"populations.":[341],"Conclusions":[342],"Relevance:":[344],"study,":[347],"most":[356],"consistently":[357],"stroke,":[358],"Older":[372],"progressively":[380],"supporting":[388],"period":[390],"elevated":[392],"rather":[398],"than":[399],"single":[401],"threshold":[402],"age.":[403]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-03T00:00:00"}
