{"id":"https://openalex.org/W7215933290","doi":"https://doi.org/10.59736/ijp.18.04.600","title":"Potentiation of Hepatotoxic Effects of Methotrexate by Isoniazid in Mice; an Explorative Study","display_name":"Potentiation of Hepatotoxic Effects of Methotrexate by Isoniazid in Mice; an Explorative Study","publication_year":2021,"publication_date":"2021-03-30","ids":{"openalex":"https://openalex.org/W7215933290","doi":"https://doi.org/10.59736/ijp.18.04.600"},"language":"en","primary_location":{"id":"doi:10.59736/ijp.18.04.600","doi":"https://doi.org/10.59736/ijp.18.04.600","is_oa":true,"landing_page_url":"https://doi.org/10.59736/ijp.18.04.600","pdf_url":null,"source":{"id":"https://openalex.org/S5406964250","display_name":"International Journal of Pathology","issn_l":"1810-0155","issn":["1810-0155","2079-7516"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.59736/ijp.18.04.600","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5155496186","display_name":"Amna Khokar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amna Khokar","raw_affiliation_strings":["Department of Pharmacology, Islamabad Medical and Dental college, Islamabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Islamabad Medical and Dental college, Islamabad","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155892252","display_name":"Sadia Shaukat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadia Shaukat","raw_affiliation_strings":["Anatomy Department, Rehman Medical College, Peshawar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy Department, Rehman Medical College, Peshawar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110284616","display_name":"Aisha Qayyum","orcid":"https://orcid.org/0009-0003-7100-5220","observed_orcids":["https://orcid.org/0009-0003-7100-5220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aisha Qayyum","raw_affiliation_strings":["Department of Pharmacology, Fazaia Medical College, Islamabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Fazaia Medical College, Islamabad","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154394687","display_name":"Jawaria Iftikhar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jawaria Iftikhar","raw_affiliation_strings":["Department of Pharmacology, WATIM Medical and Dental College, Rawalpindi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, WATIM Medical and Dental College, Rawalpindi","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075564119","display_name":"Rukhsana Munawar","orcid":"https://orcid.org/0009-0006-1297-4533","observed_orcids":["https://orcid.org/0009-0006-1297-4533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rukhsana Munawar","raw_affiliation_strings":["Depmartment of Pharmacology, Islamic International Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depmartment of Pharmacology, Islamic International Medical College","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"112","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.972000002861023},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":1.0},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/drug-potentiation","display_name":"drug potentiation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6380000114440918},{"id":"https://openalex.org/keywords/serum-alt","display_name":"serum ALT","score":0.5529999732971191},{"id":"https://openalex.org/keywords/serum-ast","display_name":"serum AST","score":0.9769999980926514},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.8729000091552734},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8166999816894531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8120999932289124},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6039999723434448},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5508999824523926},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.48539999127388},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4237000048160553},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3707999885082245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35850000381469727},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.335999995470047},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.3325999975204468},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.3206999897956848},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31540000438690186},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C2780678043","wikidata":"https://www.wikidata.org/wiki/Q743241","display_name":"Group A","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.26969999074935913}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.59736/ijp.18.04.600","doi":"https://doi.org/10.59736/ijp.18.04.600","is_oa":true,"landing_page_url":"https://doi.org/10.59736/ijp.18.04.600","pdf_url":null,"source":{"id":"https://openalex.org/S5406964250","display_name":"International Journal of Pathology","issn_l":"1810-0155","issn":["1810-0155","2079-7516"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pathology","raw_type":"journal-article"},{"id":"pmh:oai:jpathology.com:article/600","doi":null,"is_oa":true,"landing_page_url":"https://jpathology.com/index.php/OJS/article/view/600","pdf_url":"https://jpathology.com/index.php/OJS/article/download/600/366","source":{"id":"https://openalex.org/S5406964250","display_name":"International Journal of Pathology","issn_l":"1810-0155","issn":["1810-0155","2079-7516"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1810-0155","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.59736/ijp.18.04.600","doi":"https://doi.org/10.59736/ijp.18.04.600","is_oa":true,"landing_page_url":"https://doi.org/10.59736/ijp.18.04.600","pdf_url":null,"source":{"id":"https://openalex.org/S5406964250","display_name":"International Journal of Pathology","issn_l":"1810-0155","issn":["1810-0155","2079-7516"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215933290.pdf","grobid_xml":"https://content.openalex.org/works/W7215933290.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1480683052","https://openalex.org/W1886329923","https://openalex.org/W1964710206","https://openalex.org/W1972549422","https://openalex.org/W2006917513","https://openalex.org/W2021961666","https://openalex.org/W2028777217","https://openalex.org/W2040200462","https://openalex.org/W2123471555","https://openalex.org/W2159112035","https://openalex.org/W2161158919","https://openalex.org/W2166822423","https://openalex.org/W2191871043","https://openalex.org/W2208379232","https://openalex.org/W2229566603","https://openalex.org/W2318362411","https://openalex.org/W2900127287","https://openalex.org/W2950588997"],"related_works":["https://openalex.org/W3200129502","https://openalex.org/W1976868099","https://openalex.org/W2161742453","https://openalex.org/W4387039522","https://openalex.org/W3199354755","https://openalex.org/W2107526772","https://openalex.org/W4404460941","https://openalex.org/W2911821816","https://openalex.org/W2581433922","https://openalex.org/W2386014190"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"evaluate":[2],"the":[3],"effect":[4],"of":[5,19,22,61,81,146,172,219],"isoniazid":[6],"on":[7],"methotrexate":[8,82,116],"induced":[9,174],"hepatotoxicity.":[10],"Study":[11],"design:":[12],"Laboratory-based":[13],"experimental":[14],"study":[15],"Place":[16],"and":[17,34,115,130,182,228],"Duration":[18],"Study:":[20],"Department":[21],"Pharmacology":[23],"Army":[24],"Medical":[25],"College,":[26],"from":[27,212],"November":[28,31],"2015":[29],"to":[30,188],"2016.":[32],"Material":[33],"Methods:":[35],"Thirty":[36],"mice":[37,222],"were":[38,141,155,198],"randomly":[39],"divided":[40],"into":[41],"five":[42],"groups":[43,168],"(n=6).":[44],"Group":[45,56,75,85,100],"\u2160":[46],"was":[47,210],"given":[48],"0.2":[49,59],"ml":[50,60],"normal":[51],"saline":[52],"by":[53,64,176,225],"intraperitoneal":[54,79],"injection.":[55],"\u2161":[57],"received":[58,77,87,102],"distilled":[62],"water":[63],"oral":[65,91,106],"gavage":[66],"for":[67,72,92,97,107,112,125,136],"5":[68,93,108],"days":[69,94,109],"a":[70,95,110],"week":[71,96,111],"4":[73,98,113],"weeks.":[74,99,122],"\u2162":[76],"single":[78],"injection":[80],"20":[83,117],"mg/kg.":[84],"\u2163":[86],"Isoniazid":[88,103,215],"25":[89,104],"mg/kg":[90,105,118],"\u2164":[101],"weeks":[114],"i.p":[119],"after":[120,143],"two":[121],"Blood":[123],"samples":[124,135],"measuring":[126],"serum":[127],"ALT,":[128,151],"AST":[129],"ALP":[131,153],"along":[132],"with":[133,203],"liver":[134],"hepatic":[137,230],"histological":[138,226],"H&E":[139],"examination":[140],"taken":[142],"24":[144],"hours":[145],"last":[147],"dose.":[148],"Results:":[149],"Serum":[150],"AST,":[152],"levels":[154],"significantly":[156],"raised":[157],"in":[158,221],"group":[159,179,183,193],"V":[160,194],"(MTX":[161,195],"+":[162,196],"INH)":[163,197],"higher":[164],"than":[165],"all":[166],"other":[167],"exhibiting":[169],"significant":[170],"potentiation":[171],"MTX":[173],"hepatotoxicity":[175,202],"INH.":[177],"Histologically":[178],"III":[180],"(MTX)":[181],"IV":[184],"(INH)":[185],"showed":[186],"mild":[187],"moderate":[189],"inflammatory":[190],"changes":[191,207,227],"whereas":[192],"graded":[199],"as":[200,223],"severe":[201],"Central":[204],"vein":[205],"ischemic":[206],"Conclusion:":[208],"It":[209],"concluded":[211],"results":[213],"that":[214],"Potentiates":[216],"Hepatotoxic":[217],"effects":[218],"Methotrexate":[220],"evidenced":[224],"elevated":[229],"enzymes.":[231]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}