{"id":"https://openalex.org/W7215837729","doi":"https://doi.org/10.64898/2026.10.01.26364480","title":"Rapid Molecular Assessment of Kidney Allograft Rejection Using the Biopsy Transport Medium","display_name":"Rapid Molecular Assessment of Kidney Allograft Rejection Using the Biopsy Transport Medium","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7215837729","doi":"https://doi.org/10.64898/2026.10.01.26364480"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.01.26364480","doi":"https://doi.org/10.64898/2026.10.01.26364480","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.26364480","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/02/2026.10.01.26364480.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/02/2026.10.01.26364480.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100422855","display_name":"Ziyang Li","orcid":"https://orcid.org/0009-0004-8887-3590","observed_orcids":["https://orcid.org/0009-0004-8887-3590","https://orcid.org/0000-0001-9506-3212"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Ziyang Li","raw_affiliation_strings":["Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0004-8887-3590","affiliations":[{"raw_affiliation_string":"Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140554806","display_name":"Nienke Kalverboer","orcid":"https://orcid.org/0009-0009-7988-6206","observed_orcids":["https://orcid.org/0009-0009-7988-6206"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nienke Kalverboer","raw_affiliation_strings":["Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0009-7988-6206","affiliations":[{"raw_affiliation_string":"Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009026732","display_name":"Danny van der Helm","orcid":"https://orcid.org/0000-0002-8227-3998","observed_orcids":["https://orcid.org/0000-0002-8227-3998"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Danny van der Helm","raw_affiliation_strings":["Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-8227-3998","affiliations":[{"raw_affiliation_string":"Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004790453","display_name":"Giulia Callegaro","orcid":"https://orcid.org/0000-0002-7627-7271","observed_orcids":["https://orcid.org/0000-0002-7627-7271"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Giulia Callegaro","raw_affiliation_strings":["Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-7627-7271","affiliations":[{"raw_affiliation_string":"Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081295579","display_name":"Bob van de Water","orcid":"https://orcid.org/0000-0002-5839-2380","observed_orcids":["https://orcid.org/0000-0002-5839-2380"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bob van de Water","raw_affiliation_strings":["Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5839-2380","affiliations":[{"raw_affiliation_string":"Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038991313","display_name":"Soufian Meziyerh","orcid":"https://orcid.org/0000-0001-7694-8381","observed_orcids":["https://orcid.org/0000-0001-7694-8381"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Soufian Meziyerh","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-7694-8381","affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078210024","display_name":"Aiko P. J. de Vries","orcid":"https://orcid.org/0000-0002-9284-3595","observed_orcids":["https://orcid.org/0000-0002-9284-3595"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aiko P.J. de Vries","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9284-3595","affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000085661","display_name":"Hans J. Baelde","orcid":"https://orcid.org/0000-0002-1214-500X","observed_orcids":["https://orcid.org/0000-0002-1214-500X"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hans J. Baelde","raw_affiliation_strings":["Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1214-500X","affiliations":[{"raw_affiliation_string":"Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016991213","display_name":"Jesper Kers","orcid":"https://orcid.org/0000-0002-2418-5279","observed_orcids":["https://orcid.org/0000-0002-2418-5279"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152854","display_name":"Erasmus MC Transplant Institute","ror":"https://ror.org/0585v6057","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4387152854"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jesper Kers","raw_affiliation_strings":["Department of Pathology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands","Department of Pathology, Erasmus MC Transplant Institute, Erasmus Medical Center, Rotterdam, The Netherlands","Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2418-5279","affiliations":[{"raw_affiliation_string":"Department of Pathology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Pathology, Erasmus MC Transplant Institute, Erasmus Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I4387152854"]},{"raw_affiliation_string":"Department of Pathology, Systems Pathology Research Group, Leiden University Medical Center, Leiden University, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100422855"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-allograft-rejection","display_name":"renal allograft rejection","score":0.9559999704360962},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.49300000071525574},{"id":"https://openalex.org/keywords/histological-activity-index","display_name":"histological activity index","score":0.6650000214576721},{"id":"https://openalex.org/keywords/rejection-prediction","display_name":"rejection prediction","score":0.5130000114440918},{"id":"https://openalex.org/keywords/post-transplant-care","display_name":"post-transplant care","score":0.6669999957084656},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.765999972820282},{"id":"https://openalex.org/keywords/machine-learning-classification","display_name":"machine learning classification","score":0.593999981880188},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.7702999711036682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6171000003814697},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5569000244140625},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.5062000155448914},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4855000078678131},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3840999901294708},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.3619999885559082},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C2781087799","wikidata":"https://www.wikidata.org/wiki/Q7312483","display_name":"Renal biopsy","level":3,"score":0.29660001397132874},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.27079999446868896},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C3019646584","wikidata":"https://www.wikidata.org/wiki/Q2311855","display_name":"Molecular biomarkers","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.01.26364480","doi":"https://doi.org/10.64898/2026.10.01.26364480","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.26364480","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/02/2026.10.01.26364480.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.01.26364480","doi":"https://doi.org/10.64898/2026.10.01.26364480","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.01.26364480","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/02/2026.10.01.26364480.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215837729.pdf","grobid_xml":"https://content.openalex.org/works/W7215837729.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2045030989","https://openalex.org/W2094113221","https://openalex.org/W2114925869","https://openalex.org/W2115660072","https://openalex.org/W2122776035","https://openalex.org/W2127001878","https://openalex.org/W2153644496","https://openalex.org/W2774126255","https://openalex.org/W2889747697","https://openalex.org/W2924188020","https://openalex.org/W2949097641","https://openalex.org/W3212504472","https://openalex.org/W4311927299","https://openalex.org/W4380422282","https://openalex.org/W4388002801","https://openalex.org/W4392198339","https://openalex.org/W4409132083","https://openalex.org/W4412088344","https://openalex.org/W4412450788","https://openalex.org/W4414461512","https://openalex.org/W4416688140","https://openalex.org/W4417296978","https://openalex.org/W7125804160","https://openalex.org/W7133668077"],"related_works":["https://openalex.org/W4410194095","https://openalex.org/W4415423982","https://openalex.org/W4403833205","https://openalex.org/W4319321594","https://openalex.org/W4409860017","https://openalex.org/W4318755677","https://openalex.org/W7135025969","https://openalex.org/W3011416305","https://openalex.org/W4242558193","https://openalex.org/W2607512484"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Timely":[2],"diagnosis":[3],"of":[4,40,62,127,151,174,202,209,215,267,287,342,345],"kidney":[5,203,256,289,334],"allograft":[6,41,204],"rejection":[7,114,205,210,358],"is":[8,228,250,262,373],"critical":[9,263],"for":[10,58,145,176,179,183,254,264],"post-transplant":[11,260],"management,":[12],"yet":[13],"treatment":[14,253,273],"decisions":[15,274],"may":[16],"need":[17],"to":[18,77,112,236,310,317,326,356,383],"be":[19],"made":[20],"empirically":[21],"while":[22,92,224,370],"awaiting":[23],"the":[24,122,166,213,234,251,268,307,315,340,375],"final":[25,284],"pathology":[26],"report.":[27],"We":[28],"previously":[29],"demonstrated":[30,142],"that":[31],"biopsy":[32,133,186,226,290,303,312,336],"transport":[33,304,311],"medium":[34,305],"(BTM)":[35],"contains":[36],"molecular":[37,60,200,222,297,381],"signals":[38],"reflective":[39],"rejection.":[42,63],"Building":[43],"on":[44,302],"these":[45],"findings,":[46],"we":[47],"developed":[48,111],"a":[49,54,148,281,288,343],"rapid":[50,231,324],"BTM\u2013qPCR":[51,197,376],"workflow":[52,198],"using":[53,99,300],"targeted":[55],"gene":[56,84,351],"panel":[57,85,344],"early":[59,243],"assessment":[61,286,321,372],"Methods":[64],"Kidney":[65,248],"transplant":[66,335],"biopsies":[67],"assessed":[68],"at":[69],"Leiden":[70],"University":[71],"Medical":[72],"Center":[73],"from":[74,121,359],"April":[75],"2023":[76],"November":[78],"2024":[79],"were":[80,97,110,135,354],"eligible.":[81],"A":[82,125,296],"predefined":[83],"was":[86],"quantified":[87],"in":[88,348],"BTM":[89,130,139,168],"by":[90,322],"qPCR,":[91],"matched":[93],"formalin-fixed":[94],"paraffin-embedded":[95],"tissues":[96,134],"profiled":[98],"Tempo-Seq.":[100],"Elastic":[101],"Net,":[102],"Random":[103],"Forest,":[104],"and":[105,115,132,153,181,206,241,258,275,283,338,361],"support":[106,242,327,384],"vector":[107],"machine":[108],"models":[109,141,170,188],"classify":[113],"predict":[116,362],"continuous":[117,163,216,363],"histological":[118,164,364],"indices":[119],"directly":[120],"BTM.":[123,349],"Results":[124],"total":[126],"134":[128,333],"paired":[129],"samples":[131,337],"analyzed.":[136],"The":[137,196],"best-performing":[138,167],"gene-panel":[140,169,187],"good":[143,154],"discrimination":[144],"rejection,":[146],"with":[147],"median":[149,159],"AUC":[150],"0.80,":[152],"calibration":[155],"(median":[156],"slope,":[157],"0.92;":[158],"intercept,":[160],"0.08).":[161],"For":[162],"indices,":[165],"achieved":[171],"R\u00b2":[172],"values":[173],"0.33":[175],"Activity,":[177],"0.31":[178],"TCMR/TI,":[180],"0.27":[182],"AMR/MVI.":[184],"Corresponding":[185],"showed":[189],"similar":[190],"patterns":[191],"across":[192],"diagnostic":[193,298],"outcomes.":[194],"Conclusions":[195],"captures":[199],"features":[201],"enables":[207],"prediction":[208],"status":[211],"along":[212],"spectrum":[214],"activity":[217],"indices.":[218,365],"By":[219],"providing":[220,323],"same-day":[221,380],"information":[223,325,382],"definitive":[225],"interpretation":[227],"pending,":[229,374],"this":[230],"approach":[232,299,377],"has":[233,314],"potential":[235,316],"complement":[237,318],"conventional":[238,319],"histopathological":[239],"diagnostics":[240],"clinical":[244,328,386],"decision-making.":[245,329,387],"Lay":[246],"Summary":[247],"transplantation":[249],"optimal":[252],"end-stage":[255],"disease,":[257],"effective":[259],"management":[261],"long-term":[265],"survival":[266],"transplanted":[269],"kidney.":[270],"Therefore,":[271],"prompt":[272],"timely":[276],"interventions":[277],"are":[278],"essential.":[279],"However,":[280],"complete":[282],"pathological":[285,320,371],"can":[291],"sometimes":[292],"take":[293],"several":[294],"days.":[295],"qPCR":[301],"(BTM),":[306],"liquid":[308],"used":[309],"samples,":[313],"Our":[330,366],"study":[331],"included":[332],"measured":[339],"expression":[341,352],"19":[346],"genes":[347],"These":[350],"measurements":[353],"able":[355],"distinguish":[357],"non-rejection":[360],"findings":[367],"suggest":[368],"that,":[369],"could":[378],"provide":[379],"earlier":[385]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-03T00:00:00"}
