{"id":"https://openalex.org/W7215748593","doi":"https://doi.org/10.64898/2026.09.30.755589","title":"Fed-batch production of antiviral \u201eOP7 chimera\u201d defective interfering influenza A particles","display_name":"Fed-batch production of antiviral \u201eOP7 chimera\u201d defective interfering influenza A particles","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215748593","doi":"https://doi.org/10.64898/2026.09.30.755589"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.30.755589","doi":"https://doi.org/10.64898/2026.09.30.755589","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755589","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755589.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755589.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010430400","display_name":"Wiebke Holste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wiebke Holste","raw_affiliation_strings":["Fraunhofer Institute for Toxicology and Experimental Medicine, Pharmaceutical Biotechnology, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Toxicology and Experimental Medicine, Pharmaceutical Biotechnology, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016107448","display_name":"Sascha Young Kupke","orcid":"https://orcid.org/0000-0003-3943-9718","observed_orcids":["https://orcid.org/0000-0003-3943-9718"]},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sascha Y. Kupke","raw_affiliation_strings":["Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering, Magdeburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3943-9718","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081902738","display_name":"Claudius Seitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudius Seitz","raw_affiliation_strings":["Fraunhofer Institute for Toxicology and Experimental Medicine, Pharmaceutical Biotechnology, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Toxicology and Experimental Medicine, Pharmaceutical Biotechnology, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210111966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082695733","display_name":"Udo Reichl","orcid":"https://orcid.org/0000-0001-6538-1332","observed_orcids":["https://orcid.org/0000-0001-6538-1332"]},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Udo Reichl","raw_affiliation_strings":["Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering, Magdeburg, Germany","Otto von Guericke University, Bioprocess Engineering, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Dynamics of Complex Technical Systems, Bioprocess Engineering, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]},{"raw_affiliation_string":"Otto von Guericke University, Bioprocess Engineering, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001414287","display_name":"Holger Ziehr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Ziehr","raw_affiliation_strings":["Fraunhofer Institute for Toxicology and Experimental Medicine, Pharmaceutical Biotechnology, Braunschweig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Toxicology and Experimental Medicine, Pharmaceutical Biotechnology, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210111966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016107448"],"corresponding_institution_ids":["https://openalex.org/I4210127568"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.19910000264644623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.765999972820282},{"id":"https://openalex.org/keywords/defective-interfering-particles","display_name":"defective interfering particles","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/fed-batch-production","display_name":"fed-batch production","score":0.8970000147819519},{"id":"https://openalex.org/keywords/perfusion-culture","display_name":"perfusion culture","score":0.6439999938011169},{"id":"https://openalex.org/keywords/biomanufacturing","display_name":"bioproduction","score":0.578000009059906},{"id":"https://openalex.org/keywords/gmp-manufacturing","display_name":"GMP manufacturing","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-density-effects","display_name":"cell density effects","score":0.5450000166893005},{"id":"https://openalex.org/keywords/virus-titer","display_name":"viral titer","score":0.6830000281333923},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.8646000027656555},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6471999883651733},{"id":"https://openalex.org/C2775893736","wikidata":"https://www.wikidata.org/wiki/Q25324110","display_name":"Biomanufacturing","level":2,"score":0.5440999865531921},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.4803999960422516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47530001401901245},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45010000467300415},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4392000138759613},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.43619999289512634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41190001368522644},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36320000886917114},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.36160001158714294},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3215000033378601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3149999976158142},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.31200000643730164},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C190818770","wikidata":"https://www.wikidata.org/wiki/Q6964123","display_name":"Nanoreactor","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.30.755589","doi":"https://doi.org/10.64898/2026.09.30.755589","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755589","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755589.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.30.755589","doi":"https://doi.org/10.64898/2026.09.30.755589","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.30.755589","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.30.755589.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215748593.pdf","grobid_xml":"https://content.openalex.org/works/W7215748593.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390839481","https://openalex.org/W7135097626","https://openalex.org/W4389088396","https://openalex.org/W3109132986","https://openalex.org/W6926864606","https://openalex.org/W3158189707","https://openalex.org/W2775505123","https://openalex.org/W3200137906","https://openalex.org/W2901514971","https://openalex.org/W2920781917"],"abstract_inverted_index":{"Abstract":[0],"Influenza":[1],"A":[2],"virus":[3,130,148,205,216,234,287,300],"(IAV)":[4],"defective":[5],"interfering":[6,175],"particles":[7],"(DIPs)":[8],"are":[9,236],"regarded":[10],"as":[11,190],"promising":[12],"broad-spectrum":[13],"antivirals":[14],"due":[15,60],"to":[16,38,61,70,121,157,162,192,303],"their":[17],"high":[18,147,189,298,314],"efficacy":[19,36,186],"demonstrated":[20,171,312],"in":[21,56,76,132,180,199],"animal":[22],"trials.":[23],"Previously,":[24],"an":[25,179],"\u201cOP7":[26,232],"chimera\u201d":[27,233],"DIP":[28,195,214,261,285,309],"was":[29,54,119,187],"generated":[30],"that":[31,81,104,118],"showed":[32],"markedly":[33],"enhanced":[34],"antiviral":[35,315],"compared":[37,161,191],"conventional":[39],"IAV":[40],"DIPs.":[41],"In":[42,90,244],"addition,":[43],"a":[44,83,96,106,115,137,146,158,163,172,251],"high-yield":[45],"cell":[46,124,138,230],"culture-based":[47],"production":[48,98,112,264,288],"process":[49,99,249,296],"for":[50,100,239,256,269,274,290],"OP7":[51,101,193,212,259,283,307],"chimera":[52,102,194,213,260,284,308],"DIPs":[53,103],"established":[55,95,247],"perfusion":[57,75,200],"mode.":[58],"However,":[59],"the":[62,72,91,123,168,246],"technical":[63],"complexity":[64],"of":[65,74,78,82,140,150,211,282],"this":[66,185],"technology,":[67],"we":[68,94,127,144,208],"aimed":[69],"combine":[71],"advantages":[73],"terms":[77],"yield":[79],"with":[80],"simple":[84],"and":[85,231,273],"less":[86],"complex":[87],"batch":[88,165],"process.":[89],"present":[92],"work,":[93],"fed-batch":[97,248,295],"allows":[105],"more":[107],"straightforward":[108],"implementation":[109],"into":[110],"existing":[111],"facilities.":[113],"Using":[114],"feeding":[116],"regime":[117],"able":[120],"overcome":[122],"density":[125,139],"effect,":[126],"achieved":[128],"productive":[129],"infection":[131],"stirred":[133],"tank":[134],"reactors":[135],"until":[136],"10E+6":[141],"cells/mL.":[142],"Furthermore,":[143],"obtained":[145],"titer":[149],"3.8":[151],"log":[152],"10":[153],"(HAU/100":[154],"\u00b5L),":[155],"corresponding":[156,227],"3.4-fold":[159],"increase":[160],"reference":[164],"production.":[166,225],"Moreover,":[167],"produced":[169,198],"material":[170,196,310],"significantly":[173],"increased":[174],"bioactivity":[176],"shown":[177],"by":[178],"vitro":[181],"potency":[182],"assay.":[183],"Interestingly,":[184],"similarly":[188],"previously":[197],"mode,":[201],"despite":[202],"twofold":[203],"lower":[204],"titers.":[206],"Finally,":[207],"demonstrate":[209],"robustness":[210],"seed":[215,286],"trains,":[217],"which":[218],"is":[219],"significant":[220],"step":[221],"towards":[222],"later":[223,240,275],"pharmaceutical":[224,257],"Further,":[226],"GMP":[228,262,266,291],"\u201cMDCK-PB2(sus)\u201d":[229],"banks":[235],"now":[237],"available":[238],"biomanufacturing":[241],"further":[242],"use.":[243],"conclusion,":[245],"offers":[250],"valid":[252],"n":[253],"additional":[254],"option":[255],"grade":[258],"manufacturing":[263,292],"under":[265],"conditions":[267],"required":[268],"subsequent":[270],"clinical":[271],"testing":[272],"large-scale":[276],"manufacturing.":[277],"Key":[278],"points":[279],"-":[280,293,306],"Robustness":[281],"confirmed":[289],"Scalable":[294],"enabled":[297],"infectious":[299],"titers":[301],"up":[302],"7E+9":[304],"PFU/mL":[305],"harvested":[311],"very":[313],"activity":[316]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-03T00:00:00"}
