{"id":"https://openalex.org/W7215710849","doi":"https://doi.org/10.61155/gen.v74i3.525","title":"Patolog\u00edas asociadas al gluten: similitudes y diferencias cl\u00ednicas, bioqu\u00edmicas e histol\u00f3gicas","display_name":"Patolog\u00edas asociadas al gluten: similitudes y diferencias cl\u00ednicas, bioqu\u00edmicas e histol\u00f3gicas","publication_year":2024,"publication_date":"2024-10-22","ids":{"openalex":"https://openalex.org/W7215710849","doi":"https://doi.org/10.61155/gen.v74i3.525"},"language":"es","primary_location":{"id":"pmh:oai:ojs.genindex.ddns.net:article/525","doi":"https://doi.org/10.61155/gen.v74i3.525","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/525","pdf_url":"https://revistagen.com/index.php/GEN/article/download/525/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://revistagen.com/index.php/GEN/article/download/525/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037434866","display_name":"Gleidys Villarroel","orcid":"https://orcid.org/0009-0004-2297-7071","observed_orcids":["https://orcid.org/0009-0004-2297-7071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Villarroel, Gleidys","raw_affiliation_strings":["Residente de Primer A\u00f1o del Postgrado de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residente de Primer A\u00f1o del Postgrado de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155461450","display_name":"Dianora Navarro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Navarro, Dianora","raw_affiliation_strings":["Hospital Dr. Miguel P\u00e9rez Carre\u00f1o, Caracas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Dr. Miguel P\u00e9rez Carre\u00f1o, Caracas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154717903","display_name":"C Nu\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nu\u00f1ez, C","raw_affiliation_strings":["Gastroenter\u00f3logo Pediatra, M\u00e9dico Adjunto de la Unidad de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenter\u00f3logo Pediatra, M\u00e9dico Adjunto de la Unidad de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5155531920","display_name":"K L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L\u00f3pez, K","raw_affiliation_strings":["Gastroenter\u00f3logo Pediatra. Jefe de la Unidad de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenter\u00f3logo Pediatra. Jefe de la Unidad de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154703709","display_name":"A Marcano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcano, A","raw_affiliation_strings":["Residente de Primer A\u00f1o del Postgrado de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residente de Primer A\u00f1o del Postgrado de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050979593","display_name":"Milagros Guerrero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guerrero, Milagros","raw_affiliation_strings":["Residente de Segundo A\u00f1o del Postgrado de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Residente de Segundo A\u00f1o del Postgrado de Gastroenterolog\u00eda y Nutrici\u00f3n Pedi\u00e1trica","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5155416917","display_name":"L Alonso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alonso, L","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gluten-related-disorders","display_name":"gluten-related disorders","score":0.7390000224113464},{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/non-celiac-gluten-sensitivity","display_name":"non-celiac gluten sensitivity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/wheat-allergy","display_name":"wheat allergy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6269999742507935},{"id":"https://openalex.org/keywords/gluten-introduction","display_name":"gluten introduction","score":0.6359999775886536},{"id":"https://openalex.org/keywords/weaning","display_name":"weaning","score":0.8330000042915344},{"id":"https://openalex.org/keywords/serological-markers","display_name":"serological markers","score":0.7860000133514404},{"id":"https://openalex.org/keywords/anti-tissue-transglutaminase-iga","display_name":"anti-tissue transglutaminase IgA","score":0.7730000019073486},{"id":"https://openalex.org/keywords/anti-gliadin-antibodies","display_name":"anti-gliadin antibodies","score":0.8019999861717224},{"id":"https://openalex.org/keywords/intestinal-histology","display_name":"intestinal histology","score":0.4569999873638153},{"id":"https://openalex.org/keywords/villous-atrophy","display_name":"villous atrophy","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8043000102043152},{"id":"https://openalex.org/C2776336767","wikidata":"https://www.wikidata.org/wiki/Q188251","display_name":"Gluten","level":2,"score":0.5291000008583069},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.24819999933242798},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.23569999635219574},{"id":"https://openalex.org/C2991794364","wikidata":"https://www.wikidata.org/wiki/Q69949253","display_name":"Family studies","level":2,"score":0.22910000383853912},{"id":"https://openalex.org/C3019037309","wikidata":"https://www.wikidata.org/wiki/Q188251","display_name":"Wheat gluten","level":3,"score":0.22380000352859497},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.21719999611377716},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.21060000360012054},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.20399999618530273}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ojs.genindex.ddns.net:article/525","doi":"https://doi.org/10.61155/gen.v74i3.525","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/525","pdf_url":"https://revistagen.com/index.php/GEN/article/download/525/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ojs.genindex.ddns.net:article/525","doi":"https://doi.org/10.61155/gen.v74i3.525","is_oa":true,"landing_page_url":"https://revistagen.com/index.php/GEN/article/view/525","pdf_url":"https://revistagen.com/index.php/GEN/article/download/525/pdf","source":{"id":"https://openalex.org/S4387292041","display_name":"Revista GEN","issn_l":"0016-3503","issn":["0016-3503","2477-975X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0016-3503","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215710849.pdf","grobid_xml":"https://content.openalex.org/works/W7215710849.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1987057451","https://openalex.org/W2080069514","https://openalex.org/W2735212485","https://openalex.org/W2782545984","https://openalex.org/W2892064680","https://openalex.org/W2947399611","https://openalex.org/W2963827666"],"related_works":["https://openalex.org/W6986292367","https://openalex.org/W3191944679","https://openalex.org/W1986839411","https://openalex.org/W7056481818","https://openalex.org/W7030681981","https://openalex.org/W7009008437","https://openalex.org/W4401317137","https://openalex.org/W2522219426","https://openalex.org/W4296164617","https://openalex.org/W2735179963"],"abstract_inverted_index":{"Introducci\u00f3n:":[0],"Trastornos":[1],"relacionados":[2],"con":[3,56],"el":[4,252,256],"gluten":[5,25,47,60,98,222],"y":[6,29,37,77,92,103,108,134,138,141,156,185,193,214,233,269],"su":[7],"car\u00e1cter":[8],"de":[9,17,43,97,207,231,238,258],"enfermedades":[10],"inmunomediadas":[11],"se":[12],"acrecientan,":[13],"surgiendo":[14],"la":[15,19,240],"necesidad":[16],"explorar":[18],"enfermedad":[20],"celiaca":[21],"(EC),":[22],"sensibilidad":[23],"al":[24,31,46,59,221],"no":[26,181,198],"celiaco":[27],"(SGNC)":[28],"alergia":[30],"trigo":[32],"(AT).":[33],"Objetivo:":[34],"investigar":[35],"similitudes":[36,232],"diferencias":[38,234],"cl\u00ednicas,":[39],"bioqu\u00edmicas":[40],"e":[41,247],"histol\u00f3gicas,":[42],"patolog\u00edas":[44,57,219],"asociadas":[45,58,220],"en":[48,62,105,118,150,153,177],"ni\u00f1os.":[49],"M\u00e9todo:":[50],"Estudio":[51],"retrospectivo,":[52],"descriptivo,":[53],"transversal.":[54],"Pacientes":[55],"evaluados":[61],"3":[63],"a\u00f1os.":[64],"Variables:":[65],"edad,":[66],"sexo,":[67],"introducci\u00f3n":[68],"del":[69],"gluten,":[70],"destete,":[71],"sintomatolog\u00eda,":[72],"marcadores":[73],"serol\u00f3gicos,":[74],"gen\u00e9ticos,":[75],"histol\u00f3gicos":[76],"nutricionales.":[78],"Resultados:":[79],"70":[80],"pacientes,":[81],"37/70(52,86%)":[82],"masculinos,":[83],"predominando":[84],"edad":[85],"1-2a\u00f1os":[86],"(34,29%).":[87],"EC":[88,164],"17/70(24,29%),":[89],"SGNC":[90,107,119,183,213],"19/70(27,14%)":[91],"AT":[93,109,186],"34/70(48,57%).":[94],"Introducci\u00f3n":[95],"temprana":[96],"<4":[99],"meses":[100,114],"70,58%,":[101],"68,42":[102],"64,70%":[104],"EC,":[106,124,211],"respectivamente,":[110,143],"p>0,05.":[111,144],"Destete:":[112],"<6":[113],"60,56%,":[115],"mayor":[116],"porcentaje":[117],"78,94%,":[120],"p":[121],"<0,05.":[122],"En":[123],"s\u00edntoma":[125,148],"frecuente":[126],"diarrea":[127],"cr\u00f3nica":[128],"64,70%;":[129],"SGNC,":[130,172],"distensi\u00f3n":[131,136],"abdominal":[132,137],"52,63%":[133],"AT,":[135,168,216],"diarrea,":[139],"41,17%":[140],"32,35%":[142],"Predomin\u00f3":[145],"anemia":[146],"como":[147],"extradigestivo":[149],"EC(47,05%),":[151],"manifestaciones":[152],"piel":[154],"SGNC(47,36%)":[155],"respiratorias":[157],"AT(50%),":[158],"p<0,05.":[159,173,188,203,217],"Marcadores":[160],"serol\u00f3gicos":[161],"anti-transglutaminasa":[162],"IgA+":[163],"10/17(58,8%),":[165],"IgE/IgG-trigo":[166],"32/34(94%)":[167],"anti":[169],"gliadina+":[170],"5/19(26,31%)":[171],"Estado":[174],"nutricional;":[175],"afectaci\u00f3n":[176,182],"peso/talla":[178],"100%":[179],"EC;":[180,196],"73,68%":[184],"76,47%,":[187],"Gen\u00e9tica:":[189],"HLA":[190],"9/70":[191],"DQ2+(12,85%)":[192],"4/70":[194],"DQ8+(5,71%)":[195],"48/70":[197],"realizaron":[199],"pruebas":[200,244],"gen\u00e9ticas":[201,246],"(68,57%)":[202],"Hallazgos":[204],"histol\u00f3gicos:":[205],"alteraci\u00f3n":[206],"mucosa":[208],"intestinal":[209],"13/17(76,47%)":[210],"6/19(31,57%)":[212],"2/32(6,25%)":[215],"Conclusiones:":[218],"constituyen":[223],"un":[224,266],"desaf\u00edo":[225],"diagn\u00f3stico,":[226],"\u00e9ste":[227],"estudio":[228],"a":[229],"trav\u00e9s":[230],"caracteriz\u00f3":[235],"los":[236,263],"factores":[237],"riesgo,":[239],"sintomatolog\u00eda":[241],"cl\u00ednica,":[242],"las":[243],"serol\u00f3gicas,":[245],"histol\u00f3gicas":[248],"que":[249],"permiten":[250],"realizar":[251],"diagn\u00f3stico.":[253],"De":[254],"importancia":[255],"conocimiento":[257],"avances":[259],"para":[260,265],"orientar":[261],"mejor":[262],"casos":[264],"tratamiento":[267],"adecuado":[268],"oportuno.":[270]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-03T00:00:00"}