{"id":"https://openalex.org/W7215128291","doi":"https://doi.org/10.64898/2026.09.25.754160","title":"Homecage-Like Monitoring Reveals Domain-Specific Rescue of Central SPTAN1 R1098Q Phenotypes by Wild-Type Partner Co-Housing","display_name":"Homecage-Like Monitoring Reveals Domain-Specific Rescue of Central SPTAN1 R1098Q Phenotypes by Wild-Type Partner Co-Housing","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215128291","doi":"https://doi.org/10.64898/2026.09.25.754160"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.754160","doi":"https://doi.org/10.64898/2026.09.25.754160","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754160","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754160.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754160.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116935016","display_name":"Patrycja Ziuzia","orcid":"https://orcid.org/0009-0007-8932-6507","observed_orcids":["https://orcid.org/0009-0007-8932-6507"]},"institutions":[{"id":"https://openalex.org/I27912750","display_name":"Wroc\u0142aw University of Environmental and Life Sciences","ror":"https://ror.org/05cs8k179","country_code":"PL","type":"education","lineage":["https://openalex.org/I27912750"]},{"id":"https://openalex.org/I4210149847","display_name":"\u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development","ror":"https://ror.org/03rvn3n08","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210149847"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Patrycja Ziuzia","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland","Research Group Biology of Astrocytes, P4Health Center, Lukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, Poland"],"raw_orcid":"https://orcid.org/0009-0007-8932-6507","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland","institution_ids":["https://openalex.org/I27912750"]},{"raw_affiliation_string":"Research Group Biology of Astrocytes, P4Health Center, Lukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, Poland","institution_ids":["https://openalex.org/I4210149847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081300131","display_name":"Micha\u0142 \u015al\u0119zak","orcid":"https://orcid.org/0000-0003-2224-3989","observed_orcids":["https://orcid.org/0000-0003-2224-3989"]},"institutions":[{"id":"https://openalex.org/I4210149847","display_name":"\u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development","ror":"https://ror.org/03rvn3n08","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210149847"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Micha\u0142 \u015al\u0119zak","raw_affiliation_strings":["Research Group Biology of Astrocytes, P4Health Center, Lukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, Poland"],"raw_orcid":"https://orcid.org/0000-0003-2224-3989","affiliations":[{"raw_affiliation_string":"Research Group Biology of Astrocytes, P4Health Center, Lukasiewicz Research Network - PORT Polish Center for Technology Development, Wroclaw, Poland","institution_ids":["https://openalex.org/I4210149847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050753956","display_name":"Arkadiusz Mi\u0105\u017cek","orcid":"https://orcid.org/0000-0002-7210-2706","observed_orcids":["https://orcid.org/0000-0002-7210-2706"]},"institutions":[{"id":"https://openalex.org/I27912750","display_name":"Wroc\u0142aw University of Environmental and Life Sciences","ror":"https://ror.org/05cs8k179","country_code":"PL","type":"education","lineage":["https://openalex.org/I27912750"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Arkadiusz Mi\u0105\u017cek","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-7210-2706","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland","institution_ids":["https://openalex.org/I27912750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5116935016"],"corresponding_institution_ids":["https://openalex.org/I27912750","https://openalex.org/I4210149847"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.4259999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.4259999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.21850000321865082,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.12680000066757202,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infantile-epileptic-encephalopathy","display_name":"infantile epileptic encephalopathy","score":0.921999990940094},{"id":"https://openalex.org/keywords/cohousing","display_name":"cohousing","score":0.8080000281333923},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nest-building-behavior","display_name":"nest building behavior","score":0.7940000295639038},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/3rs","display_name":"3Rs","score":0.6240000128746033},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.631600022315979},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5884000062942505},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5685999989509583},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.49779999256134033},{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.4973999857902527},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4542999863624573},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44920000433921814},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4043999910354614},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.34869998693466187},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C170320452","wikidata":"https://www.wikidata.org/wiki/Q3111072","display_name":"Social neuroscience","level":4,"score":0.28600001335144043},{"id":"https://openalex.org/C2776893239","wikidata":"https://www.wikidata.org/wiki/Q1778765","display_name":"Social isolation","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.27480000257492065},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2637999951839447},{"id":"https://openalex.org/C152198750","wikidata":"https://www.wikidata.org/wiki/Q17165278","display_name":"Neurogenetics","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C2777616661","wikidata":"https://www.wikidata.org/wiki/Q7226416","display_name":"Polyglutamine tract","level":5,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.25.754160","doi":"https://doi.org/10.64898/2026.09.25.754160","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754160","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754160.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.754160","doi":"https://doi.org/10.64898/2026.09.25.754160","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754160","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754160.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215128291.pdf","grobid_xml":"https://content.openalex.org/works/W7215128291.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1481250329","https://openalex.org/W1965079560","https://openalex.org/W1969606502","https://openalex.org/W1980351491","https://openalex.org/W1991980982","https://openalex.org/W2012359887","https://openalex.org/W2016194769","https://openalex.org/W2023707870","https://openalex.org/W2043335534","https://openalex.org/W2054356301","https://openalex.org/W2065490663","https://openalex.org/W2101915570","https://openalex.org/W2114729904","https://openalex.org/W2119219767","https://openalex.org/W2122067690","https://openalex.org/W2149950551","https://openalex.org/W2165199196","https://openalex.org/W2169893009","https://openalex.org/W2305304932","https://openalex.org/W2388068718","https://openalex.org/W2547301742","https://openalex.org/W2767231256","https://openalex.org/W2783565857","https://openalex.org/W2792117329","https://openalex.org/W2946882801","https://openalex.org/W2951209026","https://openalex.org/W3005432512","https://openalex.org/W3026633449","https://openalex.org/W3030873387","https://openalex.org/W3031518915","https://openalex.org/W3109845586","https://openalex.org/W3174213828","https://openalex.org/W3197573532","https://openalex.org/W4200479217","https://openalex.org/W4223962547","https://openalex.org/W4281759205","https://openalex.org/W4315785247","https://openalex.org/W4389975662","https://openalex.org/W4399859823","https://openalex.org/W4401307635","https://openalex.org/W4402473972","https://openalex.org/W4409181106","https://openalex.org/W4413097020","https://openalex.org/W7125644982","https://openalex.org/W7162330844"],"related_works":["https://openalex.org/W2157119343","https://openalex.org/W2408075781","https://openalex.org/W4319317486","https://openalex.org/W3206384225","https://openalex.org/W1966423560","https://openalex.org/W4393211469","https://openalex.org/W2605440796","https://openalex.org/W1964421218","https://openalex.org/W234660793","https://openalex.org/W807342270"],"abstract_inverted_index":{"Abstract":[0],"Neurodegenerative":[1],"disorders":[2],"manifest":[3],"with":[4,8,139],"markedly":[5],"different":[6],"phenotypes,":[7],"motor-":[9],"and":[10,16,33,55,89,92,96,129,149,168],"memory":[11],"impairments":[12],"dominating":[13],"both":[14],"clinical":[15],"preclinical":[17],"phenotyping":[18,50],"efforts.":[19],"However,":[20],"neurodegeneration":[21],"in":[22,58,113,189],"unlikely":[23],"to":[24,27,52],"be":[25,193],"confined":[26],"these":[28,162],"two":[29],"functional":[30],"domains":[31],"alone,":[32],"its":[34],"broader":[35],"behavioral":[36,163],"consequences,":[37],"including":[38],"social":[39,54,90,157,167,197],"alterations":[40,170],"remain":[41],"underexplored.":[42],"Here,":[43],"we":[44],"present":[45],"a":[46,62,130,140],"non-invasive,":[47],"high-content":[48],"home-cage":[49],"framework":[51],"investigate":[53],"exploratory":[56,169],"dysfunction":[57],"SPTAN1":[59,106],"R1098Q":[60,107],"mice,":[61],"model":[63],"of":[64,87,98,126,133],"early":[65],"infantile":[66],"epileptic":[67],"encephalopathy":[68],"(EIEE5).":[69],"Our":[70],"pipeline":[71,178],"integrates":[72],"three":[73],"open-source":[74],"AI":[75],"engines:":[76],"SLEAP.ai":[77],"for":[78,84,94],"markerless":[79],"multi-animal":[80],"pose":[81],"estimation,":[82],"DeepOF":[83],"automated":[85],"classification":[86],"autonomous":[88],"behaviors,":[91],"SAM2":[93],"segmentation":[95],"quantification":[97],"nest-building":[99,134],"material":[100],"usage.":[101],"Long-term":[102],"monitoring":[103],"revealed":[104],"that":[105,156,171,184],"mutants":[108],"exhibit":[109],"impaired":[110],"spatial":[111],"habituation":[112],"mutant-mutant":[114],"(MUT":[115,143],"-":[116,144],"MUT)":[117],"pairs.":[118],"Mutants":[119],"also":[120],"displayed":[121],"persistent,":[122],"unreciprocated":[123],"trailing":[124],"(following)":[125],"cage":[127],"mates":[128],"pronounced":[131],"reduction":[132],"behavior":[135],"alongside.":[136],"Notably,":[137],"co-housing":[138],"wild-type":[141],"littermate":[142],"WT)":[145],"attenuated":[146],"mutant":[147],"hyperactivity":[148],"restored":[150],"more":[151],"typical":[152],"rest":[153],"pattern,":[154],"suggesting":[155],"context":[158],"can":[159,192],"partially":[160],"buffer":[161],"abnormalities.":[164],"By":[165],"revealing":[166,183],"expand":[172],"conventional":[173],"phenotyping,":[174],"this":[175],"computational":[176],"ethology":[177],"advances":[179],"3R":[180],"principles":[181],"while":[182],"intrinsic":[185],"executive":[186],"state-switching":[187],"failures":[188],"neurodegenerative":[190],"models":[191],"functionally":[194],"buffered":[195],"by":[196],"dynamics.":[198]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-02T00:00:00"}