{"id":"https://openalex.org/W7215122807","doi":"https://doi.org/10.25259/sni_776_2026","title":"Comparative barriers to molecular therapy and immunotherapy in glioblastoma: A systematic review","display_name":"Comparative barriers to molecular therapy and immunotherapy in glioblastoma: A systematic review","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215122807","doi":"https://doi.org/10.25259/sni_776_2026","pmid":"https://pubmed.ncbi.nlm.nih.gov/42974574","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13726856"},"language":"en","primary_location":{"id":"doi:10.25259/sni_776_2026","doi":"https://doi.org/10.25259/sni_776_2026","is_oa":false,"landing_page_url":"https://doi.org/10.25259/sni_776_2026","pdf_url":null,"source":{"id":"https://openalex.org/S170704854","display_name":"Surgical Neurology International","issn_l":"2152-7806","issn":["2152-7806","2229-5097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Neurology International","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13726856/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075494714","display_name":"Haneen A. Salih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15873915","display_name":"Mustansiriyah University","ror":"https://ror.org/05s04wy35","country_code":"IQ","type":"education","lineage":["https://openalex.org/I15873915"]},{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Haneen A. Salih","raw_affiliation_strings":["Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq","Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq","institution_ids":["https://openalex.org/I15873915"]},{"raw_affiliation_string":"Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052427904","display_name":"Ali Z. Al\u2010Saffar","orcid":"https://orcid.org/0000-0001-6398-2193","observed_orcids":["https://orcid.org/0000-0001-6398-2193"]},"institutions":[{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ali Z. Al-Saffar","raw_affiliation_strings":["Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019348431","display_name":"Zaid Nsaif Abbas","orcid":"https://orcid.org/0009-0008-1235-3475","observed_orcids":["https://orcid.org/0009-0008-1235-3475"]},"institutions":[{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Zaid Nsaif Abbas","raw_affiliation_strings":["Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038080230","display_name":"Samer S. Hoz","orcid":"https://orcid.org/0000-0003-4584-5931","observed_orcids":["https://orcid.org/0000-0003-4584-5931"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samer S. Hoz","raw_affiliation_strings":["Department of Neurosurgery, University of Cincinnati, Cincinnati, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Cincinnati, Cincinnati, United States","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038080230"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56422569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"551","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/molecular-therapy","display_name":"molecular therapy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/barriers-to-treatment","display_name":"barriers to treatment","score":0.6909999847412109},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9309999942779541},{"id":"https://openalex.org/keywords/blood-brain-tumor-barrier","display_name":"blood-brain tumor barrier","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.9190000295639038},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5920000076293945},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8015000224113464},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7303000092506409},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5145000219345093},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.42579999566078186},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41370001435279846},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.35280001163482666},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3402000069618225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31349998712539673},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28369998931884766},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.2833999991416931},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.25259/sni_776_2026","doi":"https://doi.org/10.25259/sni_776_2026","is_oa":false,"landing_page_url":"https://doi.org/10.25259/sni_776_2026","pdf_url":null,"source":{"id":"https://openalex.org/S170704854","display_name":"Surgical Neurology International","issn_l":"2152-7806","issn":["2152-7806","2229-5097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical Neurology International","raw_type":"journal-article"},{"id":"pmid:42974574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42974574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgical neurology international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13726856","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13726856/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surg Neurol Int","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13726856","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13726856/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surg Neurol Int","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W1853392249","https://openalex.org/W1974213137","https://openalex.org/W2072943045","https://openalex.org/W2120862613","https://openalex.org/W2142636931","https://openalex.org/W2288672745","https://openalex.org/W2318368210","https://openalex.org/W2329974159","https://openalex.org/W2407382202","https://openalex.org/W2600281432","https://openalex.org/W2600452401","https://openalex.org/W2626614537","https://openalex.org/W2738678436","https://openalex.org/W2790446992","https://openalex.org/W2800469107","https://openalex.org/W2830175972","https://openalex.org/W2936671056","https://openalex.org/W2946140916","https://openalex.org/W2974227664","https://openalex.org/W3020099303","https://openalex.org/W3079191246","https://openalex.org/W3081569001","https://openalex.org/W3099876323","https://openalex.org/W3113105122","https://openalex.org/W3118615836","https://openalex.org/W3125634926","https://openalex.org/W3127206684","https://openalex.org/W3132416547","https://openalex.org/W3138663032","https://openalex.org/W3155289023","https://openalex.org/W3177104437","https://openalex.org/W3185517073","https://openalex.org/W3193555135","https://openalex.org/W3200401126","https://openalex.org/W3216204685","https://openalex.org/W4210374199","https://openalex.org/W4210583557","https://openalex.org/W4214509794","https://openalex.org/W4214566503","https://openalex.org/W4223458606","https://openalex.org/W4280614820","https://openalex.org/W4288033321","https://openalex.org/W4301368483","https://openalex.org/W4308804494","https://openalex.org/W4309721564","https://openalex.org/W4316671822","https://openalex.org/W4317393968","https://openalex.org/W4321238186","https://openalex.org/W4366590730","https://openalex.org/W4383343009","https://openalex.org/W4385428909","https://openalex.org/W4385580351","https://openalex.org/W4386255830","https://openalex.org/W4386621462","https://openalex.org/W4386837057","https://openalex.org/W4387500798","https://openalex.org/W4389545874","https://openalex.org/W4391404460","https://openalex.org/W4396592138","https://openalex.org/W4399180360","https://openalex.org/W4399364062","https://openalex.org/W4399715656","https://openalex.org/W4399920136","https://openalex.org/W4400057120","https://openalex.org/W4400234806","https://openalex.org/W4400736462","https://openalex.org/W4402884771","https://openalex.org/W4403876756","https://openalex.org/W4405327807","https://openalex.org/W4405894799","https://openalex.org/W4406077105","https://openalex.org/W4406215510","https://openalex.org/W4408002778","https://openalex.org/W4408026947","https://openalex.org/W4408188856","https://openalex.org/W4408241752","https://openalex.org/W4408659271","https://openalex.org/W4409300625","https://openalex.org/W4409397354","https://openalex.org/W4410040799","https://openalex.org/W4411243704","https://openalex.org/W4411251850","https://openalex.org/W4411427641","https://openalex.org/W4411505413","https://openalex.org/W4412724147","https://openalex.org/W4413027173","https://openalex.org/W4413304198","https://openalex.org/W4413304900","https://openalex.org/W4413495563","https://openalex.org/W4414799576","https://openalex.org/W4415494720","https://openalex.org/W4415959286","https://openalex.org/W4416398326","https://openalex.org/W4417244577","https://openalex.org/W4417415245","https://openalex.org/W7118698171","https://openalex.org/W7119518540","https://openalex.org/W7122564356","https://openalex.org/W7135027556","https://openalex.org/W7136066203"],"related_works":["https://openalex.org/W3114996910","https://openalex.org/W4403432106","https://openalex.org/W3092869618","https://openalex.org/W4378783569","https://openalex.org/W4401946297","https://openalex.org/W3000973482","https://openalex.org/W4402884771","https://openalex.org/W4416796937","https://openalex.org/W4391027128","https://openalex.org/W7171724666"],"abstract_inverted_index":{"Background:":[0],"Glioblastoma":[1],"(GBM)":[2],"remains":[3],"refractory":[4],"to":[5,12,32,247],"molecular":[6,72,128,179,198],"and":[7,25,39,49,54,79,126,137,144,161,200,215,222,240],"immunotherapy,":[8,74],"yet":[9],"the":[10,23,248],"barriers":[11,27,239],"each":[13],"treatment":[14],"class":[15],"are":[16],"often":[17],"discussed":[18],"together.":[19],"We":[20],"systematically":[21],"compared":[22,97],"efficacy":[24],"delivery":[26,238],"reported":[28],"for":[29,46,108],"these":[30],"approaches":[31],"clarify":[33],"where":[34],"their":[35],"failure":[36],"mechanisms":[37],"overlap":[38],"diverge.":[40],"Methods:":[41],"A":[42],"Preferred":[43],"Reporting":[44],"Items":[45],"Systematic":[47],"reviews":[48],"Meta-Analyses-guided":[50],"review":[51],"of":[52],"PubMed":[53],"ScienceDirect":[55],"was":[56,176,195],"conducted":[57],"from":[58],"database":[59],"inception":[60],"through":[61,226],"April":[62],"4":[63],"th":[64],",":[65],"2026.":[66],"Eligible":[67],"adult":[68],"GBM":[69,218],"studies":[70,115,181,202],"addressing":[71],"therapy,":[73],"or":[75,92,192],"both":[76,120,236],"were":[77,88,96,116,140],"screened":[78],"categorized":[80],"by":[81,104],"therapy":[82,121,152,180,199,214],"type.":[83],"Ten":[84],"predefined":[85],"barrier":[86,132,135,147],"domains":[87,148],"coded":[89],"as":[90],"present":[91],"absent.":[93],"Barrier":[94],"frequencies":[95],"across":[98,151],"groups":[99],"using":[100],"Chi-square":[101],"tests,":[102],"followed":[103],"Fisher\u2019s":[105],"exact":[106],"tests":[107],"pairwise":[109],"comparisons":[110],"when":[111],"appropriate.":[112],"Results:":[113],"Eighty-two":[114],"included:":[117],"41":[118],"addressed":[119],"classes,":[122],"34":[123],"immunotherapies":[124],"only,":[125],"seven":[127],"therapies":[129],"only.":[130],"Blood\u2013brain":[131],"(BBB)/blood\u2013brain":[133],"tumor":[134,138,155],"restriction":[136,221],"heterogeneity":[139,223],"nearly":[141],"universal":[142,196],"(98.8%":[143],"96.3%).":[145],"Six":[146],"differed":[149],"significantly":[150],"groups.":[153],"Immunosuppressive":[154],"microenvironment,":[156],"T-cell":[157],"exhaustion,":[158],"low":[159],"immunogenicity,":[160],"impaired":[162],"central":[163],"nervous":[164],"system":[165],"immune":[166],"trafficking":[167],"clustered":[168],"with":[169,243],"immunotherapy":[170,216],"studies,":[171],"whereas":[172],"BBB":[173,220],"efflux":[174],"transport":[175],"concentrated":[177],"in":[178,185,197,205,217],"(85.7%":[182],"vs.":[183],"2.9%":[184],"immunotherapy-only":[186,206],"studies;":[187],"P":[188,209],"<":[189,210],"0.001).":[190,211],"Intrinsic":[191],"adaptive":[193],"resistance":[194],"combined-therapy":[201],"but":[203,224],"lower":[204],"sources":[207],"(73.5%;":[208],"Conclusion:":[212],"Molecular":[213],"share":[219],"fail":[225],"distinct":[227],"dominant":[228],"mechanisms.":[229],"Combination":[230],"trials":[231],"should":[232],"be":[233],"designed":[234],"around":[235],"pharmacokinetic":[237],"immune-microenvironmental":[241],"resistance,":[242],"patient":[244],"selection":[245],"matched":[246],"biology":[249],"being":[250],"targeted.":[251]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-10-02T00:00:00"}