{"id":"https://openalex.org/W7215114377","doi":"https://doi.org/10.64898/2026.09.25.754349","title":"A Normative Model Reveals Functional Optimization of Synaptic Nano-Architecture","display_name":"A Normative Model Reveals Functional Optimization of Synaptic Nano-Architecture","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215114377","doi":"https://doi.org/10.64898/2026.09.25.754349"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.754349","doi":"https://doi.org/10.64898/2026.09.25.754349","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754349","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754349.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754349.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090327752","display_name":"Camille Gontier","orcid":"https://orcid.org/0000-0001-8433-3491","observed_orcids":["https://orcid.org/0000-0001-8433-3491"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["CH","FR"],"is_corresponding":true,"raw_author_name":"Camille Gontier","raw_affiliation_strings":["Department of Physiology, University of Bern, 3012 Bern, Switzerland","Inria center at University of Lorraine, 67000 Strasbourg, France"],"raw_orcid":"https://orcid.org/0000-0001-8433-3491","affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Bern, 3012 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Inria center at University of Lorraine, 67000 Strasbourg, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023254017","display_name":"Katharina Maria Schmidt","orcid":"https://orcid.org/0000-0003-2797-9952","observed_orcids":["https://orcid.org/0000-0003-2797-9952"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Katharina Schmidt","raw_affiliation_strings":["Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2797-9952","affiliations":[{"raw_affiliation_string":"Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065321688","display_name":"Mart\u0131\u0144 Baccino-Calace","orcid":"https://orcid.org/0000-0003-4143-4166","observed_orcids":["https://orcid.org/0000-0003-4143-4166"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mart\u00edn Baccino-Calace","raw_affiliation_strings":["Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4143-4166","affiliations":[{"raw_affiliation_string":"Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093694371","display_name":"Wayan Gauthey","orcid":"https://orcid.org/0000-0003-0916-7934","observed_orcids":["https://orcid.org/0000-0003-0916-7934"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Wayan Gauthey","raw_affiliation_strings":["Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland","Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA"],"raw_orcid":"https://orcid.org/0000-0003-0916-7934","affiliations":[{"raw_affiliation_string":"Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113493550","display_name":"Markus Sauer","orcid":"https://orcid.org/0000-0002-1692-3219","observed_orcids":["https://orcid.org/0000-0002-1692-3219"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Sauer","raw_affiliation_strings":["Department of Biotechnology and Biophysics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Biophysics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031292165","display_name":"Sina W\u00e4ldchen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sina W\u00e4ldchen","raw_affiliation_strings":["Department of Biotechnology and Biophysics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074 W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Biophysics, Biocenter, University of W\u00fcrzburg, Am Hubland, 97074 W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088067400","display_name":"Divya Sachidanandan","orcid":"https://orcid.org/0000-0001-8219-8177","observed_orcids":["https://orcid.org/0000-0001-8219-8177"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Divya Sachidanandan","raw_affiliation_strings":["Department of Animal Physiology, Institute of Biology, Universit\u00e4t Leipzig, 04103 Germany"],"raw_orcid":"https://orcid.org/0000-0001-8219-8177","affiliations":[{"raw_affiliation_string":"Department of Animal Physiology, Institute of Biology, Universit\u00e4t Leipzig, 04103 Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017403142","display_name":"Robert J. Kittel","orcid":"https://orcid.org/0000-0002-9199-4826","observed_orcids":["https://orcid.org/0000-0002-9199-4826"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert J. Kittel","raw_affiliation_strings":["Department of Animal Physiology, Institute of Biology, Universit\u00e4t Leipzig, 04103 Germany"],"raw_orcid":"https://orcid.org/0000-0002-9199-4826","affiliations":[{"raw_affiliation_string":"Department of Animal Physiology, Institute of Biology, Universit\u00e4t Leipzig, 04103 Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090585459","display_name":"Martin M\u00fcller","orcid":"https://orcid.org/0000-0003-1624-6761","observed_orcids":["https://orcid.org/0000-0003-1624-6761"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martin M\u00fcller","raw_affiliation_strings":["Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland","Neuroscience Center Zurich, University of Zurich/ETH Zurich, Zurich, 8057 Switzerland","University Research Priority Program \u2018Adaptive Brain Circuits in Development and Learning (AdaBD)\u2019, University of Zurich, Zurich, 8057 Switzerland","Zurich Ph.D. Program in Molecular Life Sciences, Zurich, 8057 Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1624-6761","affiliations":[{"raw_affiliation_string":"Department of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Neuroscience Center Zurich, University of Zurich/ETH Zurich, Zurich, 8057 Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]},{"raw_affiliation_string":"University Research Priority Program \u2018Adaptive Brain Circuits in Development and Learning (AdaBD)\u2019, University of Zurich, Zurich, 8057 Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Zurich Ph.D. Program in Molecular Life Sciences, Zurich, 8057 Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061157913","display_name":"Jean-Pascal Pfister","orcid":"https://orcid.org/0000-0002-1847-3389","observed_orcids":["https://orcid.org/0000-0002-1847-3389"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jean-Pascal Pfister","raw_affiliation_strings":["Department of Physiology, University of Bern, 3012 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Bern, 3012 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5090327752"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I90183372"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normative-modeling","display_name":"normative modeling","score":0.7089999914169312},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.7319999933242798},{"id":"https://openalex.org/keywords/multivesicular-release","display_name":"multivesicular release","score":0.9190000295639038},{"id":"https://openalex.org/keywords/presynaptic-release-sites","display_name":"presynaptic release sites","score":0.8659999966621399},{"id":"https://openalex.org/keywords/active-zone","display_name":"active zone","score":0.8870000243186951},{"id":"https://openalex.org/keywords/drosophila-neuromuscular-junction","display_name":"Drosophila neuromuscular junction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.5289999842643738},{"id":"https://openalex.org/keywords/sted-microscopy","display_name":"STED microscopy","score":0.5429999828338623},{"id":"https://openalex.org/keywords/dstorm","display_name":"dSTORM","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cost-function-minimization","display_name":"cost function minimization","score":0.6779999732971191},{"id":"https://openalex.org/keywords/synaptic-strength","display_name":"synaptic efficacy","score":0.47099998593330383},{"id":"https://openalex.org/keywords/vesicle-release","display_name":"vesicle release","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.7915999889373779},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6456000208854675},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6245999932289124},{"id":"https://openalex.org/C187102610","wikidata":"https://www.wikidata.org/wiki/Q4677599","display_name":"Active zone","level":5,"score":0.6017000079154968},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5911999940872192},{"id":"https://openalex.org/C2910581834","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Postsynaptic Current","level":4,"score":0.5192000269889832},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48660001158714294},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4544999897480011},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.43950000405311584},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.4357999861240387},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3995000123977661},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.3982999920845032},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.37059998512268066},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.36070001125335693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35120001435279846},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.3418000042438507},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.296999990940094},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2653999924659729},{"id":"https://openalex.org/C2908668639","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle recycling","level":5,"score":0.2612999975681305},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2596000134944916}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.25.754349","doi":"https://doi.org/10.64898/2026.09.25.754349","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754349","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754349.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.754349","doi":"https://doi.org/10.64898/2026.09.25.754349","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754349","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/01/2026.09.25.754349.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215114377.pdf","grobid_xml":"https://content.openalex.org/works/W7215114377.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4297548862"],"related_works":["https://openalex.org/W4400036046","https://openalex.org/W4308146264","https://openalex.org/W2484055001","https://openalex.org/W2951096450","https://openalex.org/W4285745107","https://openalex.org/W4407569158","https://openalex.org/W4413102840","https://openalex.org/W2774185546","https://openalex.org/W3033163957","https://openalex.org/W2799399472"],"abstract_inverted_index":{"Abstract":[0],"Super-resolution":[1],"microscopy":[2,75],"approaches":[3],"have":[4],"revealed":[5],"that":[6,21,66,91,150,232,261,321],"synaptic":[7,27,52,68,77,264,272,291,308,311,346,354],"proteins":[8,53,292],"are":[9],"not":[10,228],"randomly":[11],"distributed":[12],"within":[13],"individual":[14,111],"synapses.":[15,112],"Rather,":[16],"they":[17],"form":[18],"sub-synaptic":[19],"clusters":[20,92,201,262],"may":[22,248,330],"be":[23,249],"coordinated":[24],"between":[25,211],"the":[26,34,49,83,159,166,178,186,193,203,209,243,271,275,288,294,314,322,340,350],"compartments,":[28],"thereby":[29],"forming":[30],"transsynaptic":[31,246],"nanocolumns.":[32],"However,":[33,192,274],"functional":[35,276],"significance":[36],"of":[37,51,93,118,189,197,263,278,290,296,325,342],"this":[38,164,279],"nano-architecture":[39,69,247,309],"remains":[40],"under":[41],"debate.":[42],"In":[43],"particular,":[44],"it":[45,284],"is":[46,170,174,235,259,281,285],"unclear":[47,286],"whether":[48,287],"positions":[50,196,289,324],"optimize":[54,224],"a":[55,62,154,303],"specific":[56,297],"cost":[57,298],"function.":[58],"Here,":[59,300],"we":[60,301],"present":[61],"normative":[63,304],"modeling":[64],"framework":[65],"integrates":[67],"imaged":[70],"with":[71,76,80,132,310],"STED":[72],"and":[73,101,199,207,214,283,335],"dSTORM":[74],"transmission":[78],"recorded":[79,133],"electrophysiology":[81],"at":[82,242,313],"Drosophila":[84,244,315],"neuromuscular":[85,316],"junction":[86],"(NMJ).":[87],"Model-based":[88],"quantification":[89],"showed":[90],"Unc13A,":[94],"which":[95,329],"likely":[96,348],"demark":[97],"presynaptic":[98,123,240,253,326,332],"release":[99,124,213,234,241,254,333],"sites,":[100,334],"postsynaptic":[102,134,167,204,336,343],"glutamate":[103,151,173],"receptors":[104,338],"(GluRs)":[105],"adopt":[106],"aligned":[107],"ring-like":[108],"arrangements":[109],"in":[110,183],"We":[113],"developed":[114,302],"an":[115],"analytical":[116],"description":[117],"GluR":[119,200],"activation":[120,216],"relative":[121,195],"to":[122,127,177,185,251,306],"position,":[125],"enabling":[126],"link":[128],"super-resolution":[129],"imaging":[130],"data":[131],"current":[135,168,205],"amplitudes":[136],"without":[137],"relying":[138],"on":[139],"costly":[140],"Markov":[141],"chain":[142],"Monte":[143],"Carlo":[144],"(MCMC)":[145],"simulations.":[146],"Our":[147,318],"model":[148],"predicts":[149],"released":[152,175],"from":[153],"single":[155],"vesicle":[156,212],"spreads":[157],"across":[158,270],"entire":[160],"receptor":[161,215],"population.":[162],"Given":[163,231],"spread,":[165],"amplitude":[169,206,341],"maximized":[171],"when":[172],"close":[176],"active":[179],"zone":[180],"(AZ)":[181],"center,":[182],"contradiction":[184],"observed":[187,194,237,323],"offset":[188],"Unc13A":[190,198,327],"clusters.":[191],"maximize":[202,339],"minimize":[208],"delay":[210],"during":[217,238,356],"multivesicular":[218,226,357],"release.":[219,230,358],"Hence,":[220,345],"transsynaptically-aligned":[221],"Unc13A-GluR":[222],"rings":[223],"for":[225,353],"but":[227],"univesicular":[229],"multi-vesicular":[233],"mainly":[236],"enhanced":[239],"NMJ,":[245],"adapted":[250],"elevated":[252],"states.":[255],"Significance":[256],"statement":[257],"There":[258],"evidence":[260],"proteins,":[265],"including":[266],"neurotransmitter":[267,337],"receptors,":[268],"align":[269],"cleft.":[273],"role":[277],"organization":[280],"debated,":[282],"allow":[293],"optimization":[295],"functions.":[299],"approach":[305,319],"relate":[307],"physiology":[312],"junction.":[317],"suggests":[320],"clusters,":[328],"represent":[331],"currents.":[344],"nano-organization":[347],"provides":[349],"structural":[351],"basis":[352],"strength":[355]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-02T00:00:00"}
