{"id":"https://openalex.org/W7215112155","doi":"https://doi.org/10.1016/j.celrep.2026.118088","title":"An extramedullary bone model of metastatic dormancy reveals an increased rate of metastatic reactivation upon distant insults","display_name":"An extramedullary bone model of metastatic dormancy reveals an increased rate of metastatic reactivation upon distant insults","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7215112155","doi":"https://doi.org/10.1016/j.celrep.2026.118088","pmid":"https://pubmed.ncbi.nlm.nih.gov/42822459"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2026.118088","doi":"https://doi.org/10.1016/j.celrep.2026.118088","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.118088","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2026.118088","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068642854","display_name":"Stefania Di Blasio","orcid":"https://orcid.org/0000-0002-7585-8277","observed_orcids":["https://orcid.org/0000-0002-7585-8277"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stefania Di Blasio","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK. Electronic address: stefania.diblasio@crick.ac.uk"],"raw_orcid":"https://orcid.org/0000-0002-7585-8277","affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK. Electronic address: stefania.diblasio@crick.ac.uk","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000613400","display_name":"Tatiana Rizou","orcid":"https://orcid.org/0000-0002-0165-3519","observed_orcids":["https://orcid.org/0000-0002-0165-3519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatiana Rizou","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023532814","display_name":"Laurie J. Gay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie J. Gay","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033284983","display_name":"Nicolas Rabas","orcid":"https://orcid.org/0000-0002-8118-8134","observed_orcids":["https://orcid.org/0000-0002-8118-8134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Rabas","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150940766","display_name":"Xuanxuan Fan","orcid":"https://orcid.org/0009-0006-7395-8609","observed_orcids":["https://orcid.org/0009-0006-7395-8609"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Xuanxuan Fan","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK; Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0009-0006-7395-8609","affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK; Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435055","display_name":"Xingyu Liu","orcid":"https://orcid.org/0009-0003-3815-4953","observed_orcids":["https://orcid.org/0009-0003-3815-4953"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing-Yu Liu","raw_affiliation_strings":["Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Center for Integrative Spatial-Omics Research, Human Phenome Institute, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Center for Integrative Spatial-Omics Research, Human Phenome Institute, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050331091","display_name":"Victoria Louise Bridgeman","orcid":"https://orcid.org/0000-0002-9322-3363","observed_orcids":["https://orcid.org/0000-0002-9322-3363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria L. Bridgeman","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-9322-3363","affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028891344","display_name":"Ernesto Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-3855-5664","observed_orcids":["https://orcid.org/0000-0002-3855-5664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernesto Rodriguez","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-3855-5664","affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049365839","display_name":"Probir Chakravarty","orcid":"https://orcid.org/0000-0003-1146-8824","observed_orcids":["https://orcid.org/0000-0003-1146-8824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Probir Chakravarty","raw_affiliation_strings":["Bioinformatics Core and Biostatistics STP, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Core and Biostatistics STP, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031902333","display_name":"Thomas J. A. Snoeks","orcid":"https://orcid.org/0000-0003-3866-346X","observed_orcids":["https://orcid.org/0000-0003-3866-346X"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Snoeks","raw_affiliation_strings":["In vivo Imaging Operations, The Francis Crick Institute, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-3866-346X","affiliations":[{"raw_affiliation_string":"In vivo Imaging Operations, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052625226","display_name":"Adam Karoutas","orcid":"https://orcid.org/0000-0003-4264-8203","observed_orcids":["https://orcid.org/0000-0003-4264-8203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Karoutas","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-4264-8203","affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082422765","display_name":"Felipe Silva Rodrigues","orcid":"https://orcid.org/0000-0003-2139-8161","observed_orcids":["https://orcid.org/0000-0003-2139-8161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felipe S. Rodrigues","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-2139-8161","affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017101736","display_name":"\u00c9lodie Montaudon","orcid":"https://orcid.org/0009-0002-5197-8300","observed_orcids":["https://orcid.org/0009-0002-5197-8300"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Montaudon","raw_affiliation_strings":["Laboratory of Preclinical Investigation, Department of Translational Research, Institut Curie, PSL University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Investigation, Department of Translational Research, Institut Curie, PSL University, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077166294","display_name":"Cristina Lo Celso","orcid":"https://orcid.org/0000-0002-1163-4207","observed_orcids":["https://orcid.org/0000-0002-1163-4207"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cristina Lo Celso","raw_affiliation_strings":["Imperial College London, London, UK; Bone Marrow Dynamics Satellite Group, Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, London, UK; Bone Marrow Dynamics Satellite Group, Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059398124","display_name":"Elisabetta Marangoni","orcid":"https://orcid.org/0000-0002-3337-6448","observed_orcids":["https://orcid.org/0000-0002-3337-6448"]},"institutions":[{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabetta Marangoni","raw_affiliation_strings":["Laboratory of Preclinical Investigation, Department of Translational Research, Institut Curie, PSL University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Investigation, Department of Translational Research, Institut Curie, PSL University, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016016794","display_name":"Dominique A. Bonnet","orcid":"https://orcid.org/0000-0002-4735-5226","observed_orcids":["https://orcid.org/0000-0002-4735-5226"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dominique Bonnet","raw_affiliation_strings":["Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024701619","display_name":"Bin\u2010Zhi Qian","orcid":"https://orcid.org/0000-0002-5796-1078","observed_orcids":["https://orcid.org/0000-0002-5796-1078"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin-Zhi Qian","raw_affiliation_strings":["Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Center for Integrative Spatial-Omics Research, Human Phenome Institute, Fudan University, Shanghai 200032, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-5796-1078","affiliations":[{"raw_affiliation_string":"Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Center for Integrative Spatial-Omics Research, Human Phenome Institute, Fudan University, Shanghai 200032, P.R. China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077765874","display_name":"Ander Abarrategi","orcid":"https://orcid.org/0000-0002-6510-2337","observed_orcids":["https://orcid.org/0000-0002-6510-2337"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ander Abarrategi","raw_affiliation_strings":["Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-6510-2337","affiliations":[{"raw_affiliation_string":"Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060776127","display_name":"Ilaria Malanchi","orcid":"https://orcid.org/0000-0003-4867-3311","observed_orcids":["https://orcid.org/0000-0003-4867-3311"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ilaria Malanchi","raw_affiliation_strings":["Tumour-Host Interaction Laboratory, London, UK. Electronic address: ilaria.malanchi@crick.ac.uk"],"raw_orcid":"https://orcid.org/0000-0003-4867-3311","affiliations":[{"raw_affiliation_string":"Tumour-Host Interaction Laboratory, London, UK. Electronic address: ilaria.malanchi@crick.ac.uk","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5060776127","https://openalex.org/A5068642854"],"corresponding_institution_ids":[],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.70556517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"10","first_page":"118088","last_page":"118088"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-dormancy","display_name":"metastatic dormancy","score":0.890999972820282},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/breast-cancer-bone-metastasis","display_name":"breast cancer bone metastasis","score":0.875},{"id":"https://openalex.org/keywords/metastatic-relapse","display_name":"metastatic relapse","score":0.8510000109672546},{"id":"https://openalex.org/keywords/skeletal-progenitor-cells","display_name":"skeletal progenitor cells","score":0.7480000257492065},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hmgb2","display_name":"HMGB2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6790000200271606},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5073999762535095},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.5073999762535095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5037999749183655},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5005000233650208},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4936999976634979},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.49160000681877136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4860999882221222},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45419999957084656},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4494999945163727},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42489999532699585},{"id":"https://openalex.org/C3527866","wikidata":"https://www.wikidata.org/wiki/Q162267","display_name":"Dormancy","level":3,"score":0.40299999713897705},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.36910000443458557},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.36059999465942383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3158999979496002},{"id":"https://openalex.org/C2776035513","wikidata":"https://www.wikidata.org/wiki/Q1328805","display_name":"Bone cancer","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.29420000314712524},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2897999882698059},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.2777999937534332},{"id":"https://openalex.org/C109335069","wikidata":"https://www.wikidata.org/wiki/Q5421165","display_name":"Experimental pathology","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.2599000036716461},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2574000060558319}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.celrep.2026.118088","doi":"https://doi.org/10.1016/j.celrep.2026.118088","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.118088","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5167106","doi":"https://doi.org/10.2139/ssrn.5167106","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5167106","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:42822459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42822459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bb044b70192b4a5999573e7467defe84","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bb044b70192b4a5999573e7467defe84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 45, Iss 10, Pp 118088- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2026.118088","doi":"https://doi.org/10.1016/j.celrep.2026.118088","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.118088","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1959736688","display_name":null,"funder_award_id":"2023SHZDZX02","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G2444098496","display_name":null,"funder_award_id":"CC2051","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3742178122","display_name":null,"funder_award_id":"CC1045","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4253700228","display_name":null,"funder_award_id":"ERC CoG-H2020-725492","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G9000384468","display_name":null,"funder_award_id":"2023YFC3402500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G9000850027","display_name":null,"funder_award_id":"2023YFC3402501","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G9000850200","display_name":null,"funder_award_id":"FudanX24A1031","funder_id":"https://openalex.org/F4320336342","funder_display_name":"Shanghai Medical College, Fudan University"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320336342","display_name":"Shanghai Medical College, Fudan University","ror":"https://ror.org/01zntxs11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1596258860","https://openalex.org/W1753721256","https://openalex.org/W1966560779","https://openalex.org/W1969826234","https://openalex.org/W1972228155","https://openalex.org/W1993322072","https://openalex.org/W2006986876","https://openalex.org/W2022228053","https://openalex.org/W2037236573","https://openalex.org/W2039885332","https://openalex.org/W2078318577","https://openalex.org/W2089254126","https://openalex.org/W2091015937","https://openalex.org/W2106738771","https://openalex.org/W2155542819","https://openalex.org/W2167378116","https://openalex.org/W2167409896","https://openalex.org/W2169456326","https://openalex.org/W2170140374","https://openalex.org/W2194404144","https://openalex.org/W2303309927","https://openalex.org/W2316940504","https://openalex.org/W2552831679","https://openalex.org/W2569978261","https://openalex.org/W2613604676","https://openalex.org/W2737206084","https://openalex.org/W2744884733","https://openalex.org/W2766437506","https://openalex.org/W2782234272","https://openalex.org/W2797407068","https://openalex.org/W2810726220","https://openalex.org/W2907514116","https://openalex.org/W2932926289","https://openalex.org/W2938743723","https://openalex.org/W2949177718","https://openalex.org/W2951506174","https://openalex.org/W2952481429","https://openalex.org/W2989679054","https://openalex.org/W2992151131","https://openalex.org/W3002770500","https://openalex.org/W3016522056","https://openalex.org/W3030806006","https://openalex.org/W3038262479","https://openalex.org/W3048466431","https://openalex.org/W3087157621","https://openalex.org/W3090557239","https://openalex.org/W3103368541","https://openalex.org/W3111378927","https://openalex.org/W3114696276","https://openalex.org/W3134921838","https://openalex.org/W3165305177","https://openalex.org/W3206010422","https://openalex.org/W3215583707","https://openalex.org/W3215605612","https://openalex.org/W4225607470","https://openalex.org/W4281725021","https://openalex.org/W4285393715","https://openalex.org/W4304809085","https://openalex.org/W4307301643","https://openalex.org/W4310785445","https://openalex.org/W4324032711","https://openalex.org/W4361299044","https://openalex.org/W4365449901","https://openalex.org/W4385638567","https://openalex.org/W4386707527","https://openalex.org/W4388126491","https://openalex.org/W4390661708","https://openalex.org/W4391484698","https://openalex.org/W4403186285","https://openalex.org/W7128438646"],"related_works":["https://openalex.org/W4385285410","https://openalex.org/W2102602989","https://openalex.org/W2394985122","https://openalex.org/W2158957824","https://openalex.org/W2396599501","https://openalex.org/W4417194320","https://openalex.org/W2903503766","https://openalex.org/W2886114757","https://openalex.org/W2970681032","https://openalex.org/W3203815193"],"abstract_inverted_index":{"Bone":[0],"metastatic":[1,54,112,148],"relapse":[2],"can":[3],"emerge":[4],"years":[5],"after":[6],"cancer":[7,56,61],"diagnosis,":[8],"driven":[9],"by":[10,28],"the":[11,29,71,101],"reactivation":[12],"of":[13,81,87,104],"disseminated":[14],"tumor":[15],"cells":[16,62,106],"(DTCs)":[17],"that":[18,45,128],"remain":[19],"dormant":[20,105],"in":[21,43,53,107,114,135],"secondary":[22],"organs.":[23],"This":[24],"behavior":[25],"is":[26,133],"controlled":[27,79],"tissue":[30],"microenvironment.":[31],"We":[32,117],"developed":[33],"a":[34,126,143],"tuneable,":[35],"skeletal":[36],"progenitor-based":[37],"engineered":[38],"extramedullary":[39],"(EM)":[40],"bone":[41,49,96,109,137,141],"model":[42,72],"mice":[44],"closely":[46],"mimics":[47],"endogenous":[48,115],"and":[50,77,110,132],"induces":[51],"dormancy":[52],"breast":[55],"cells.":[57],"Within":[58],"EM":[59,108,140],"bone,":[60],"remained":[63],"quiescent,":[64],"with":[65,74],"occasional":[66],"transient":[67],"proliferative":[68,102],"episodes.":[69],"Because":[70],"integrates":[73],"host":[75],"vasculature":[76],"permits":[78],"release":[80],"specific":[82],"factors,":[83],"it":[84],"enables":[85],"investigation":[86],"systemic":[88],"influences":[89],"on":[90],"dormancy.":[91,149],"Systemic":[92],"inflammation,":[93],"which":[94],"increases":[95],"marrow":[97],"cell":[98],"production,":[99],"raised":[100],"fraction":[103],"increased":[111],"incidence":[113],"bone.":[116],"also":[118],"identified":[119],"high-mobility":[120],"group":[121],"box":[122],"2":[123],"(HMGB2)":[124],"as":[125],"factor":[127],"promotes":[129],"overt":[130],"metastasis":[131],"present":[134],"human":[136],"metastases.":[138],"Therefore,":[139],"represents":[142],"powerful":[144],"platform":[145],"for":[146],"studying":[147]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-02T00:00:00"}
