{"id":"https://openalex.org/W7215108471","doi":"https://doi.org/10.7759/cureus.117270","title":"Cutaneous Adverse Events With Semaglutide: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","display_name":"Cutaneous Adverse Events With Semaglutide: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7215108471","doi":"https://doi.org/10.7759/cureus.117270","pmid":"https://pubmed.ncbi.nlm.nih.gov/42966951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722923"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.117270","doi":"https://doi.org/10.7759/cureus.117270","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117270","pdf_url":"https://www.cureus.com/articles/537350-cutaneous-adverse-events-with-semaglutide-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/537350-cutaneous-adverse-events-with-semaglutide-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067127403","display_name":"Samyak Ganjre","orcid":"https://orcid.org/0000-0003-1124-1021","observed_orcids":["https://orcid.org/0000-0003-1124-1021"]},"institutions":[{"id":"https://openalex.org/I129734738","display_name":"All India Institute of Medical Sciences Raipur","ror":"https://ror.org/02ys8pq62","country_code":"IN","type":"education","lineage":["https://openalex.org/I129734738"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Samyak Ganjre","raw_affiliation_strings":["Dermatology, Raipur Institute of Medical Sciences, Raipur, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Raipur Institute of Medical Sciences, Raipur, IND","institution_ids":["https://openalex.org/I129734738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081940529","display_name":"Liza Borah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129734738","display_name":"All India Institute of Medical Sciences Raipur","ror":"https://ror.org/02ys8pq62","country_code":"IN","type":"education","lineage":["https://openalex.org/I129734738"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Liza Borah","raw_affiliation_strings":["Dermatology, Raipur Institute of Medical Sciences, Raipur, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Raipur Institute of Medical Sciences, Raipur, IND","institution_ids":["https://openalex.org/I129734738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038718664","display_name":"Archit Khardenavis","orcid":"https://orcid.org/0009-0007-8242-0840","observed_orcids":["https://orcid.org/0009-0007-8242-0840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Archit Khardenavis","raw_affiliation_strings":["Community Medicine, Ram Krishna Medical College Hospital and Research Centre, Bhopal, IND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Community Medicine, Ram Krishna Medical College Hospital and Research Centre, Bhopal, IND","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067127403"],"corresponding_institution_ids":["https://openalex.org/I129734738"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52188705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"e117270","last_page":"e117270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.3732999861240387,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.3732999861240387,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.24899999797344208,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.19529999792575836,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/semaglutide","display_name":"semaglutide","score":1.0},{"id":"https://openalex.org/keywords/cutaneous-adverse-effects","display_name":"cutaneous adverse events","score":0.9860000014305115},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.9950000047683716},{"id":"https://openalex.org/keywords/injection-site-reactions","display_name":"injection site reactions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6290000081062317},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8790000081062317},{"id":"https://openalex.org/keywords/adverse-event-reporting","display_name":"adverse event reporting","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9825999736785889},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7544999718666077},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6802999973297119},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3828999996185303},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3589000105857849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3221000134944916},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3165999948978424},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.2556999921798706}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.117270","doi":"https://doi.org/10.7759/cureus.117270","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117270","pdf_url":"https://www.cureus.com/articles/537350-cutaneous-adverse-events-with-semaglutide-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722923","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722923/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722923/pdf/cureus-0018-00000117270.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:42966951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42966951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.117270","doi":"https://doi.org/10.7759/cureus.117270","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.117270","pdf_url":"https://www.cureus.com/articles/537350-cutaneous-adverse-events-with-semaglutide-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7215108471.pdf","grobid_xml":"https://content.openalex.org/works/W7215108471.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1897910008","https://openalex.org/W1974084046","https://openalex.org/W2150000105","https://openalex.org/W2165010366","https://openalex.org/W2263572070","https://openalex.org/W2519510391","https://openalex.org/W2572398654","https://openalex.org/W2885588864","https://openalex.org/W2970684805","https://openalex.org/W3118615836","https://openalex.org/W3127371223","https://openalex.org/W3129305070","https://openalex.org/W3133746780","https://openalex.org/W3177122952","https://openalex.org/W4210417346","https://openalex.org/W4304080455","https://openalex.org/W4381953540","https://openalex.org/W4388592674","https://openalex.org/W4388824619","https://openalex.org/W4400012935","https://openalex.org/W4400178611","https://openalex.org/W4403502673","https://openalex.org/W4408382107","https://openalex.org/W4410277932","https://openalex.org/W4413291145","https://openalex.org/W4414160143","https://openalex.org/W4414189914","https://openalex.org/W4417319939","https://openalex.org/W7160062099","https://openalex.org/W7161568206","https://openalex.org/W7162104885","https://openalex.org/W7165364505","https://openalex.org/W7170070278"],"related_works":["https://openalex.org/W4393320784","https://openalex.org/W4413768302","https://openalex.org/W7221075931","https://openalex.org/W4408482054","https://openalex.org/W4400012935","https://openalex.org/W4407960221","https://openalex.org/W7214028544","https://openalex.org/W7125022082","https://openalex.org/W7163742872","https://openalex.org/W7163367059"],"abstract_inverted_index":{"Semaglutide":[0,234],"is":[1],"widely":[2],"used":[3],"for":[4,114],"metabolic":[5],"disease,":[6],"but":[7],"cutaneous":[8],"adverse":[9],"events":[10],"are":[11],"inconsistently":[12],"reported.":[13],"This":[14],"systematic":[15],"review":[16],"and":[17,54,79,89,109,138,168,213,228],"meta-analysis":[18],"evaluated":[19],"randomized":[20],"comparisons":[21,205],"of":[22,41,107,132,188,238],"semaglutide":[23,166,211],"with":[24,194],"placebo,":[25],"usual":[26],"care,":[27],"or":[28,86,152,159,240,258,270],"non-semaglutide":[29],"active":[30],"treatment.":[31],"The":[32,183,262],"protocol":[33],"was":[34,65,162],"registered":[35],"in":[36,81,144,164,209],"the":[37,115,127,189,200],"International":[38],"Prospective":[39],"Register":[40],"Systematic":[42],"Reviews":[43],"(PROSPERO;":[44],"CRD420261464289).":[45],"PubMed,":[46],"Europe":[47],"PubMed":[48],"Central,":[49],"trial":[50,193],"registers,":[51],"sponsor":[52],"reports,":[53],"regulatory":[55],"sources":[56],"were":[57,94,112,231],"examined":[58],"through":[59],"September":[60,68],"9,":[61],"2026;":[62],"source":[63],"verification":[64],"completed":[66],"on":[67,246],"21,":[69],"2026.":[70],"Meta-analysis":[71],"required":[72],"directly":[73],"available,":[74],"source-verified":[75],"participant":[76],"event":[77,260],"counts":[78],"denominators":[80],"both":[82,145],"groups.":[83,146],"Reported":[84],"alopecia":[85,158,239],"hair":[87,160,241],"loss":[88,161],"source-defined":[90],"participant-level":[91],"injection-site":[92,142,207,247,271],"reactions":[93,143,208,248],"analyzed":[95],"separately":[96],"using":[97],"common-effect":[98],"Mantel-Haenszel":[99],"odds":[100],"ratios":[101],"(ORs)":[102],"without":[103],"continuity":[104],"correction.":[105],"Risk":[106],"bias":[108],"evidence":[110,130],"certainty":[111],"assessed":[113],"primary":[116,128,201],"syntheses.":[117],"Thirty-one":[118],"trials":[119,125,149],"contributed":[120,135],"verified":[121],"outcome":[122],"data.":[123],"Twenty":[124],"formed":[126],"placebo/common-control":[129],"set,":[131],"which":[133],"19":[134],"relative-effect":[136],"estimates":[137],"one":[139],"reported":[140,163,206],"zero":[141],"Eleven":[147,203],"additional":[148],"provided":[150],"active-comparator":[151],"design-specific":[153,229],"evidence.":[154],"Across":[155],"nine":[156],"comparisons,":[157],"191/11,564":[165],"recipients":[167,212],"36/9,799":[169],"comparators":[170,215,227],"(OR:":[171,216],"2.92,":[172],"95%":[173,218],"confidence":[174],"interval":[175],"(CI):":[176],"1.99-4.27;":[177],"p":[178,221],"<":[179],"0.001;":[180],"low-certainty":[181],"evidence).":[182,225],"association":[184],"persisted":[185],"after":[186],"exclusion":[187],"largest":[190],"cardiovascular":[191],"outcomes":[192],"restricted":[195],"ascertainment;":[196],"random-effects":[197],"analyses":[198],"supported":[199],"interpretations.":[202],"informative":[204],"156/5,066":[210],"114/3,483":[214],"0.86,":[217],"CI:":[219],"0.67-1.11;":[220],"=":[222],"0.256;":[223],"very-low-certainty":[224],"Active":[226],"results":[230],"described":[232],"separately.":[233],"may":[235],"increase":[236],"reports":[237],"loss;":[242],"its":[243],"comparative":[244],"effect":[245],"remains":[249],"uncertain.":[250],"Available-count":[251],"synthesis":[252],"does":[253],"not":[254,265],"resolve":[255],"selective":[256],"non-reporting":[257],"incomplete":[259],"ascertainment.":[261],"findings":[263],"do":[264],"establish":[266],"a":[267],"hair-loss":[268],"mechanism":[269],"safety":[272],"equivalence.":[273]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-02T00:00:00"}
